更新于：2024-12-08
Trifluoperazine Hydrochloride
盐酸三氟拉嗪
更新于：2024-12-08
概要
基本信息
原研机构 |
在研机构 |
最高研发阶段批准上市 |
首次获批日期 美国 (1959-04-16), |
最高研发阶段(中国)批准上市 |
特殊审评- |
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结构
分子式C21H26Cl2F3N3S |
InChIKeyBXDAOUXDMHXPDI-UHFFFAOYSA-N |
CAS号440-17-5 |
关联
7
项与 盐酸三氟拉嗪 相关的临床试验Evaluation of Trifluoperazine Effectiveness in Treatment Process, Survival rate and Cure rate of COVID-19 Patients
Evaluation of the Effect of Trifluoperazin in Treatment of Patients with Confirmed 2019 Novel Coronavirus(COVID- 19): An Open-Label Randomized Clinical Trial
Prescriber Based, Active Post Marketing Surveillance Study (PMS) to Generate the Safety & Efficacy Data of Chlordiazepoxide and Trifluoperazine In the Treatment of Chronic Anxiety & Insomnia in Actual Field Conditions of Use
100 项与 盐酸三氟拉嗪 相关的临床结果
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100 项与 盐酸三氟拉嗪 相关的转化医学
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100 项与 盐酸三氟拉嗪 相关的专利（医药）
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4,293
项与 盐酸三氟拉嗪 相关的文献（医药）2024-12-01JOURNAL OF PLANT PHYSIOLOGY
Crosstalk of methylglyoxal and calcium signaling in maize (Zea mays L.) thermotolerance through methylglyoxal-scavenging system
Article
作者: Li, Zhong-Guang ; Xiang, Ru-Hua ; Wang, Jia-Qi
Methylglyoxal (MG) and calcium ion (Ca2+) can increase multiple-stress tolerance including plant thermotolerance. However, whether crosstalk of MG and Ca2+ exists in the formation of maize thermotolerance and underlying mechanism still remain elusive. In this paper, maize seedlings were irrigated with MG and calcium chloride alone or in combination, and then exposed to heat stress (HS). The results manifested that, compared with the survival percentage (SP, 45.3%) of the control seedlings, the SP of MG and Ca2+ alone or in combination was increased to 72.4%, 74.2%, and 83.4% under HS conditions, indicating that Ca2+ and MG alone or in combination could upraise seedling thermotolerance. Also, the MG-upraised SP was separately weakened to 42.2%, 40.3%, 52.1%, and 39.4% by Ca2+ chelator (ethylene glycol tetraacetic acid, EGTA), plasma membrane Ca2+ channel blocker (lanthanum chloride, LaCl3), intracellular Ca2+ channel blocker (neomycin, NEC), and calmodulin (CaM) antagonist (trifluoperazine, TFP). However, significant effect of MG scavengers N-acetylcysteine (NAC) and aminoguanidine (AG) on Ca2+-induced thermotolerance was not observed. Similarly, an endogenous Ca2+ level in seedlings was increased by exogenous MG under non-HS and HS conditions, while exogenous Ca2+ had no significant effect on endogenous MG. These data implied that Ca2+ signaling, at least partly, mediated MG-upraised thermotolerance in maize seedlings. Moreover, the activity and gene expression of glyoxalase system (glyoxalase I, glyoxalase II, and glyoxalase III) and non-glyoxalase system (MG reductase, aldehyde reductase, aldo-keto reductase, and lactate dehydrogenase) were up-regulated to a certain extent by Ca2+ and MG alone in seedlings under non-HS and HS conditions. The up-regulated MG-scavenging system by MG was enhanced by Ca2+, while impaired by EGTA, LaCl3, NEC, or TFP. These data suggest that the crosstalk of MG and Ca2+ signaling in maize thermotolerance through MG-scavenging system. These findings provided a theoretical basis for breeding climate-resilient maize crop and developing smart agriculture.
2024-12-01REPRODUCTIVE TOXICOLOGY
Trifluoperazine effect on human sperm: The accumulation of reactive oxygen species and the decrease in the mitochondrial membrane potential
Article
作者: Luo, Tao ; Zheng, Liping ; Cheng, Cheng ; Wang, Houpeng ; Ding, Jing ; Chen, Ying ; Qian, Ruirui
A strong link between antipsychotic drug use and reduced human sperm quality has been reported. Trifluoperazine (TFP), a commonly used antipsychotic, is now being explored for anticancer applications. Although there are hints that TFP might affect the male reproductive system, its impact on human sperm quality remains uncertain. Using a human sperm and TFP in vitro coculture system, we examined the effect of TFP (12.5, 25, 50 and 100 μM) on human sperm function and physiological parameters. The results showed that 50 μM and 100 μM TFP induced the accumulation of reactive oxygen species (ROS) and a decrease in the mitochondrial membrane potential (MMP) of human sperm, leading to decreased sperm viability, while 25 μM TFP inhibited only the penetration ability, total sperm motility, and progressive motility. Although 12.5 μM and 25 μM TFP increased [Ca2+]i in human sperm, they did not affect capacitation or the acrosome reaction. These results may be explained by the observation that 12.5 μM and 25 μM TFP did not increase tyrosine phosphorylation in human sperm, although TFP increased [Ca2+]i in a time-course traces similar to that of progesterone. Our results indicated that TFP could cause male reproductive toxicity by inducing the accumulation of ROS and a decrease in the MMP in human sperm.
2024-12-01RADIOTHERAPY AND ONCOLOGY
Effects of dopamine receptor antagonists and radiation on mouse neural stem/progenitor cells
Article
作者: Pajonk, Frank ; Ioannidis, Angeliki ; He, Ling ; Bhat, Kruttika
BACKGROUND:
Dopamine receptor antagonists have recently been identified as potential anti-cancer agents in combination with radiation, and a first drug of this class is in clinical trials against pediatric glioma. Radiotherapy causes cognitive impairment primarily by eliminating neural stem/progenitor cells and subsequent loss of neurogenesis, along with inducing inflammation, vascular damage, and synaptic alterations. Here, we tested the combined effects of dopamine receptor antagonists and radiation on neural stem/progenitor cells.
METHODS:
Using transgenic mice that report the presence of neural stem/progenitor cells through Nestin promoter-driven expression of EGFP, the effects of dopamine receptor antagonists alone or in combination with radiation on neural stem/progenitor cells were assessed in sphere-formation assays, extreme limiting dilution assays, flow cytometry and real-time PCR in vitro and in vivo in both sexes.
RESULTS:
We report that hydroxyzine and trifluoperazine exhibited sex-dependent effects on murine newborn neural stem/progenitor cells in vitro. In contrast, amisulpride, nemonapride, and quetiapine, when combined with radiation, significantly increased the number of neural stem/progenitor cells in both sexes. In vivo, trifluoperazine showed sex-dependent effects on adult neural stem/progenitor cells, while amisulpride demonstrated significant effects in both sexes. Further, amisulpride increased sphere forming capacity and stem cell frequency in both sexes when compared to controls.
CONCLUSION:
We conclude that a therapeutic window for dopamine receptor antagonists in combination with radiation potentially exists, making it a novel combination therapy against glioblastoma. Normal tissue toxicity following this treatment scheme likely differs depending on age and sex and should be taken into consideration when designing clinical trials.
1
项与 盐酸三氟拉嗪 相关的新闻（医药）2024-09-20
·药闻康策
100 项与 盐酸三氟拉嗪 相关的药物交易
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研发状态
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 抑郁症 | 中国 | 1995-01-01 | |
| 精神分裂症 | 中国 | 1995-01-01 | |
| 焦虑症 | 美国 | 1959-04-16 |
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临床结果
临床结果
适应症
分期
评价
查看全部结果
临床1/2期 | 2 | 築壓獵襯鹹網積齋鏇廠(築齋積衊願顧網糧願糧) = 顧鏇範衊鹹築遞鑰網窪 範積艱壓壓願願獵襯齋 (獵範襯廠蓋夢鏇顧築鹽, 範觸築淵獵蓋範糧願淵 ~ 製衊蓋簾鬱顧壓廠醖願) 更多 | - | 2022-12-14 | |||
N/A | - | - | 範衊遞遞夢夢醖餘餘鹹(鏇積膚網遞願獵憲齋網) = 壓齋選醖觸願積艱憲選 獵繭願鹽網齋醖壓積積 (顧憲廠鑰憲餘遞簾鏇艱 ) | - | 2012-05-20 | ||
(Ionizing radiation) | 範衊遞遞夢夢醖餘餘鹹(鏇積膚網遞願獵憲齋網) = 淵鹹選膚鏇鬱築遞艱鹽 獵繭願鹽網齋醖壓積積 (顧憲廠鑰憲餘遞簾鏇艱 ) |
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