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更新于：2025-04-17
Doxapram Hydrochloride
盐酸多沙普仑
更新于：2025-04-17
概要
基本信息
非在研机构- |
最高研发阶段批准上市 |
首次获批日期 美国 (1965-06-23), |
最高研发阶段(中国)批准上市 |
特殊审评- |
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结构/序列
分子式C24H33ClN2O3 |
InChIKeyZOMBFZRWMLIDPX-UHFFFAOYSA-N |
CAS号7081-53-0 |
关联
20
项与 盐酸多沙普仑 相关的临床试验NCT06585163
A Phase 1, Randomized, Double-blind, Crossover Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of QEV-817 Oral Suspension in Healthy Volunteers
ACTRN12621001163897
Oral Doxapram for Apnoea of Prematurity: Dosage Study in Preterm Infants
IRCT20200825048515N51
Comparative study of the effect of caffeine and doxapram on respiratory parameters of patients admitted to intensive care units after spinal surgery
100 项与 盐酸多沙普仑 相关的临床结果
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100 项与 盐酸多沙普仑 相关的转化医学
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100 项与 盐酸多沙普仑 相关的专利（医药）
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451
项与 盐酸多沙普仑 相关的文献（医药）2025-06-01FOOD CHEMISTRY
High-throughput screening of new psychoactive substances and related compounds in food by UHPLC-Q/Orbitrap
Article
作者: Huang, Xia ; Wan, Yuping ; Shi, Peiyu ; Wu, Wenlin ; Xiao, Quanwei ; Liu, Shiyao ; Guo, Tianrong ; Chen, Xiaoqi ; Zhou, Yan ; Xia, Bing ; Zhang, Min
Currently, there is concern about food products to which new psychoactive substances (NPS) have been added illegally. However, rapid, high-sensitivity, and high-throughput screening methods for such harmful substances have not been reported yet. In this study, a high-throughput non-targeted screening strategy was developed based on UHPLC-Q/Orbitrap. First, optimized pretreatment methods for typical high-risk matrices were established. Second, an accurate, efficient, and scalable high resolution mass spectrometry database containing 206 NPS and related compounds was constructed. The fragmentation pathways of three different types of fentanyl-related compounds were then systematically investigated to enhance compound identification. Additionally, a non-targeted screening strategy was developed using warning ions derived from 24 fentanyl-related compounds, streamlining the identification of NPS. This strategy was applied to 100 food samples with possible illegal additives and demonstrated its effectiveness. In summary, this study provides robust technical support for regulatory authorities in combating the illegal addition of food products.
2025-01-01GENE
Evidence for high-risk pollutants and emerging microbial contaminants at two major bathing ghats of the river Ganga using high-resolution mass spectrometry and metagenomics
Article
作者: Kumar Tripathi, Anil ; Pandey, Parul ; Narain Singh, Durgesh ; Shankar Singh, Vijay
An efficient wastewater treatment plant is imperative to limit the entry of emerging pollutants (EPs) and emerging microbial contaminants (EMCs) in the river ecosystem. The detection of emerging EPs in aquatic environments is challenging due to complex sample preparation methods, and the need for sophisticated accurate analytical tools. In Varanasi (India), the river Ganga holds immense significance as a holy river but is consistently polluted with municipal (MWW) and hospital wastewater (HWW). We developed an efficient method for untargeted detection of EPs in the water samples using High-resolution mass spectrometry (HRMS), and identified 577 and 670 chemicals (or chemical components) in the water samples from two major bathing ghats, Assi Ghat (AG) and Dashashwamedh Ghat (DG), respectively. The presence of EPs of different categories viz chemicals from research labs, diagnostic labs, lifestyle and industrial chemicals, toxins, flavor and food additives indicated the unsafe disposal of MWW and HWW or inefficient wastewater treatment plants (WWTPs). Besides, shotgun metagenomic analysis depicted the presence of bacteria associated with MWW viz Cloacibacterium normanse, Sphaerotilus natans (sewage fungi), E. coli, and Prevotella. Also, the presence of human pathogens Arcobacter, Polynucleobacter, Pseudomonas, Klebsiella, Aeromonas, Acinetobacter, Vibrio, and Campylobacter suggests the discharge of HWW. EPs are linked to the development, and transmission of antimicrobial resistance (AMR). Occurrence of antibiotic resistance genes (ARGs), plasmid-borne β-lactamases, aminoglycoside transferases, and ARGs associated with integrons, transposons and plasmids viz mcr-3 gene that confer resistance to colistin, the last resort of antibiotics confirmed the presence of emerging microbial contaminants. Subsequent genome reconstruction studies showed the presence of uncultivable ARB and transmission of ARGs through horizontal gene transfer. This study can be used to monitor the health of aquatic bodies as well as the efficiency of WWTPs and raise an urgent need for efficient WWTPs to safeguard the river, Ganga.
2024-11-01JOURNAL OF COMPARATIVE PHYSIOLOGY A-NEUROETHOLOGY SENSORY NEURAL AND BEHAVIORAL PHYSIOLOGY
The effects of doxapram and its potential interactions with K2P channels in experimental model preparations
Article
作者: Elliott, Elizabeth R ; Harrison, Douglas A ; Brock, Kaitlyn E ; Vacassenno, Rachael M ; Cooper, Robin L
The channels commonly responsible for maintaining cell resting membrane potentials are referred to as K2P (two-P-domain K+ subunit) channels. These K+ ion channels generally remain open but can be modulated by their local environment. These channels are classified based on pharmacology, pH sensitivity, mechanical stretch, and ionic permeability. Little is known about the physiological nature of these K2P channels in invertebrates. Acidic conditions depolarize neurons and muscle fibers, which may be caused by K2P channels given that one subtype can be blocked by acidic conditions. Doxapram is used clinically as a respiratory aid known to block acid-sensitive K2P channels; thus, the effects of doxapram on the muscle fibers and synaptic transmission in larval Drosophila and crawfish were monitored. A dose-dependent response was observed via depolarization of the larval Drosophila muscle and an increase in evoked synaptic transmission, but doxapram blocked the production of action potentials in the crawfish motor neuron and had a minor effect on the resting membrane potential of the crawfish muscle. This indicates that the nerve and muscle tissues in larval Drosophila and crawfish likely express different K2P channel subtypes. Since these organisms serve as physiological models for neurobiology and physiology, it would be of interest to further investigate what types of K2P channel are expressed in these tissues. (212 words).
9
项与 盐酸多沙普仑 相关的新闻（医药）2025-03-09
·信狐药迅
疫苗抗体药物偶联物申请上市临床申请
2025-01-12
·健识局
带量采购核酸药物AHA会议
2025-01-08
·赛柏蓝
带量采购一致性评价
100 项与 盐酸多沙普仑 相关的药物交易
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研发状态
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 呼吸功能不全 | 中国 | 1991-01-01 | |
| 呼吸功能不全 | 中国 | 1991-01-01 | |
| 高碳酸血症 | 日本 | 1979-07-06 | |
| 呼吸暂停 | 日本 | 1976-02-14 | |
| 肺部疾病 | 美国 | 1965-06-23 |
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临床结果
临床结果
适应症
分期
评价
查看全部结果
N/A | - | - | 窪糧憲顧選餘構觸衊繭(繭顧襯鏇窪築獵製築顧) = 製築壓鹹襯鹽簾鹽積夢 鹹膚顧淵鹹衊窪鏇簾壓 (廠遞壓顧夢範簾製願遞 ) 更多 | - | 2022-08-27 | ||
Ketodoxapram | 窪糧憲顧選餘構觸衊繭(繭顧襯鏇窪築獵製築顧) = 壓糧廠夢鬱鑰膚選選糧 鹹膚顧淵鹹衊窪鏇簾壓 (廠遞壓顧夢範簾製願遞 ) 更多 | ||||||
N/A | - | 網蓋遞網鹽壓構構夢膚(選簾簾築願醖廠鹽憲鬱) = 淵鑰獵窪廠夢鹹鏇衊網 夢遞觸鏇夢構憲鏇築憲 (壓廠鏇衊壓廠鏇廠網鑰 ) | - | 2019-09-01 | |||
临床4期 | 呼吸暂停 三线 | 85 | Doxapram dosing adjusted for gender and postmenstrual age (GrA) | 積遞鬱築壓壓齋範淵構(窪淵廠窪蓋淵製衊選鑰) = 願構淵遞蓋糧觸窪糧製 繭鹽淵淵蓋簾繭憲窪廠 (餘鹽糧廠廠餘廠壓鹽遞 ) | - | 2016-12-01 | |
(Infants' weight alone (GrW)) | 積遞鬱築壓壓齋範淵構(窪淵廠窪蓋淵製衊選鑰) = 襯網範衊壓憲衊鹹願積 繭鹽淵淵蓋簾繭憲窪廠 (餘鹽糧廠廠餘廠壓鹽遞 ) |
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