复方地舍平(Deserpidine/Methyclothiazide) - 药物靶点：NCC_在研适应症：高血压_专利_临床

概要

基本信息

药物类型

小分子化药

别名

Compound Deserpidine、Deserpidine Compound、地舍平/甲氧噻嗪

+ [3]

靶点

NCC

作用机制

NCC抑制剂(噻嗪类敏感氯化钠协同转运蛋白抑制剂)

治疗领域

心血管疾病

在研适应症

高血压

非在研适应症-

原研机构

Abbott Laboratories

在研机构

哈药集团股份有限公司

非在研机构

Abbott Laboratories

最高研发阶段批准上市

首次获批日期

美国 (1961-08-01),

高血压

最高研发阶段(中国)批准上市

特殊审评-

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结构

分子式C32H38N2O8

InChIKeyCVBMAZKKCSYWQR-WCGOZPBSSA-N

CAS号131-01-1

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关联

100 项与复方地舍平相关的临床结果

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100 项与复方地舍平相关的转化医学

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100 项与复方地舍平相关的专利（医药）

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3

项与复方地舍平相关的文献（医药）

2002-11-01·Clinical Physiology and Functional Imaging4区 · 医学

Effects of a Ginkgo biloba extract on forearm haemodynamics in healthy volunteers

4区 · 医学

Article

作者: K. Winther ; N. Wiinberg ; J. Mehlsen ; H. Drabaek

SummaryThe aim was to validate possible vasodilating effects of a Ginkgo biloba extract with a secondary aim of finding a pharmacodynamic signal relating to the active component of these extracts. We studied the effect of G. biloba extract on forearm haemodynamics in 16 healthy subjects (nine females, seven males) with a median age of 32 years (range: 21–47). The study was conducted as a randomized, double‐blinded cross‐over design using oral treatment with G. biloba extract (Gibidyl Forte® t.i.d. or placebo for 6 weeks. Forearm blood flow and venous capacity were measured by strain‐gauge plethysmography. Blood pressure was measured by standard sphygmomanometry, and forearm vascular resistance (FVR) was derived. Measurements were made at baseline and after 3, 6, 9 and 12 weeks of treatment. Forearm blood flow was significantly higher during active treatment after 3 and 6 weeks as compared with placebo treatment for 3 and 6 weeks (P<0·05). Mean arterial blood pressure was unchanged, making the calculated FVR significantly lower during active treatment (P<0·02). It is concluded that oral treatment with a G. biloba extract (Gibidyl Forte®) is able to dilate forearm blood vessels causing increments in regional blood flow without changing blood pressure levels in healthy subjects. The increments in blood flow may be used as a biological signal for pharmacokinetic studies.

1980-05-11·Orvosi hetilap4区 · 医学

Krónikus urticaria Corontin Forte kezelése.

4区 · 医学

Article

作者: Szatlóczky, E ; Rácz, I ; Temesvári, E ; Soós, G

1968-01-01·Therapia Hungarica (English edition)

Effect of corontin forte on angina pectoris.

Article

作者: Balogh, P

100 项与复方地舍平相关的药物交易

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