聚乙二醇3350/氯化钾/碳酸氢钠/氯化钠/硫酸钠(Polyethylene glycol 3350/Potassium chloride/Sodium bicarbonate/Sodium chloride/Sodium sulfate)

概要

基本信息

药物类型

小分子化药

别名

COLYTE-FLAVORED、Colyte、Colyte With Flavor Packs

+ [1]

靶点-

作用机制-

治疗领域

其他疾病

在研适应症

肠道准备

非在研适应症-

原研机构

Braintree Laboratories, Inc.

在研机构

Braintree Laboratories, Inc.

非在研机构

Mylan Specialty LP

Hospira, Inc.

最高研发阶段批准上市

首次获批日期

美国 (1984-07-13),

肠道准备

最高研发阶段(中国)-

特殊审评-

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结构

分子式ClNa

InChIKeyFAPWRFPIFSIZLT-UHFFFAOYSA-M

CAS号7647-14-5

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关联

10

项与聚乙二醇3350/氯化钾/碳酸氢钠/氯化钠/硫酸钠相关的临床试验

JPRN-UMIN000025815 / CompletedIIT

Trial of mechanical bowel preparation in laparoscopic colorectal surgery with Moviprep - TLUMP

开始日期2017-03-01

申办/合作机构-

JPRN-UMIN000026944 / Recruiting临床4期IIT

Randomized Comparative Study on the Clinical Usefulness of PICOPREP and MOVIPREP - Comparative examination of laxatives

开始日期2017-02-01

申办/合作机构-

NCT03011788 / Unknown statusN/AIIT

A Randomized Study of Single vs Two-Day Polyethylene Glycol Cleansing in Patients at High Risk for Poor Bowel Preparation

The aim of this randomized trial is to compare the proportion of patients achieving an adequate bowel preparation after a 1-day split-dose 4-liter PEG-based bowel preparation regimen (Golytely, Braintree Laboratory Inc, MA, USA) vs. the same regimen given on 2 consecutive days in a population identified as high risk for an inadequate bowel preparation.
2. Research Design: This study is a single-center prospective randomized study at the West Haven VAMC.
3. Methodology:
Primary endpoint: Adequate bowel preparation as defined by a Boston Bowel Preparation Scale (BBPS) score of 2 or 3 (on scale of 0-3) in all 3 colon segments (left, transverse, and right).
Secondary endpoints: Adenoma detection rate, polyp detection rate, sessile serrated polyp/adenoma detection rate, patient tolerability of preparation using the validated Mayo clinic bowel prep tolerability questionnaire, adverse events potentially related to bowel preparation
Patients scheduled for routine outpatient colonoscopy will be eligible if they are at high risk for poor bowel preparation,

开始日期2017-01-01

申办/合作机构-

100 项与聚乙二醇3350/氯化钾/碳酸氢钠/氯化钠/硫酸钠相关的临床结果

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100 项与聚乙二醇3350/氯化钾/碳酸氢钠/氯化钠/硫酸钠相关的转化医学

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100 项与聚乙二醇3350/氯化钾/碳酸氢钠/氯化钠/硫酸钠相关的专利（医药）

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109

项与聚乙二醇3350/氯化钾/碳酸氢钠/氯化钠/硫酸钠相关的文献（医药）

2024-06-01·Cureus

Cardiac Arrest Following GoLytely Consumption: A Potential Trigger for Hypovolemic Shock

Article

作者: Zaher, Eli A ; Patel, Parth ; Adhikari, Bibek ; Ebrahim, Mohamed A

This case report presents a rare but severe complication of polyethylene glycol (PEG) used for colonoscopic bowel preparation. A 71-year-old male developed cardiac arrest secondary to hypovolemic shock following consumption of GoLytely. Despite being hemodynamically stable prior to ingestion, the patient experienced extreme weakness, dizziness, and orthostatic hypotension post-consumption. Evaluation ruled out other causes of arrest. While serious complications from PEG are rare, this case underscores the importance of vigilance. Further investigation is warranted to elucidate the relationship between PEG use and cardiac events and to identify potential risk factors for adverse outcomes associated with bowel preparation regimens.

2023-01-01·Therapeutic Advances in Rare Disease

A novel case of homozygous PAX1 mutation associated with hypoparathyroidism

作者: Heidenreich, Leah ; Asumda, Faizal Z. ; Hamel, Benjamin L. ; Kumar, Seema ; DaSilva, Christiana ; Joshi, Avni

The PAX1 gene plays an important role in the development of the parathyroid glands and the thymus. Mouse knockout models of PAX1, PAX3, and PAX9 have been found to have hypoplastic or absent parathyroid glands. To our knowledge, there are no reported cases of PAX1-associated hypoparathyroidism in humans. We present a case of hypoparathyroidism in a 23-month-old boy with a homozygous pathogenic variant in the PAX1 gene ( PAX1 NM_006192.5 c.463_465del variant), predicted to cause an in-frame deletion of asparagine at position 155 (p.Asn155del) of the PAX1 protein. The hypoparathyroidism was unmasked after the patient developed significant hypocalcemia while receiving GoLYTELY (polyethylene glycol 3350, sodium sulfate anhydrous, sodium bicarbonate, sodium chloride, potassium chloride) for bowel cleanout. The patient had mild and asymptomatic hypocalcemia prior to hospitalization. The patient was noted to have inappropriately normal parathyroid hormone (PTH) level at the time of documented hypocalcemia thereby suggesting a diagnosis of hypoparathyroidism. Plain language summary The first human case of hypoparathyroidism associated with a rare genetic disorder: a case report of PAX1 gene mutation The paired box ( PAX) gene family is important for embryo development. One subfamily, PAX1, is necessary for development of the spinal column, thymus (important for the immune system development), and parathyroid (helps regulate the amount of calcium in the body). We present the case of a 23-month-old boy with known PAX1 gene mutation who came in with episodes of vomiting and poor growth. His presentation was thought to be most likely related to constipation. He was started on bowel cleanout medication and intravenous fluids. However, his calcium that had been mildly low subsequently dropped to very low levels. The level of parathyroid hormone (which helps regulate calcium levels) was inappropriately normal, meaning that his body was unable to make more, and was consistent with hypoparathyroidism. He was treated with calcium supplements and vitamin D and calcium levels normalized. He continues to be on calcium and vitamin D and calcium levels have remained stable. Doctors should keep this complication in mind when treating patients with PAX1 gene mutation.

2022-03-01·Annals of Pharmacotherapy4区 · 医学

A Galvanizing Solution: Colonoscopy Bowel Preparation as a Trigger for Supraventricular Tachycardia

4区 · 医学

Article

作者: Ramappa, Preeti ; Kajy, Marvin

Background: Polyethylene glycol (PEG)-based solutions are among the most commonly used bowel preparation regimens for colonoscopy. Although these solutions are well tolerated, rare adverse cardiac events have been reported. Objectives: We sought to identify the characteristics that may predispose patients to develop supraventricular tachycardia (SVT) after ingestion of GoLYTELY (PEG 3350 and electrolytes oral solution) in anticipation for their colonoscopy. Methods: We performed a retrospective observational cohort study of the electronic medical record of all patients who developed SVT after ingestion of GoLYTELY solution from April 2012 to March 2019 at the John D. Dingell VA Medical Center. Clinical data were obtained through review of medical records. Results: We identified 16 patients with new-onset SVT after ingestion of bowel preparation solution before undergoing the colonoscopy procedure. In all, 12 (75%) patients developed atrial fibrillation, 3 (18.8%) patients developed atrial tachycardia, and 1 patient (6.3%) developed atrial flutter. Most patients were male (93.8%), and the mean age was 69 ± 8.2 years. The commonly associated comorbidities were hypertension (87.5%), hyperlipidemia (56.3%), and diabetes (37.5%). Laboratory testing demonstrated a normal electrolyte panel and thyroid stimulating hormone level. A significant percentage of patients had dilated atria and left-ventricular hypertrophy on echocardiogram. Conclusion: Our case series suggests that there may be certain individuals who are predisposed to development of atrial arrhythmias, more so than others, after ingestion of PEG based solution for colonoscopy. We hypothesize that the combination of atrial dilation, sympathovagal discharge, and transient electrolyte shifts at the cellular level led to the development of SVTs.

100 项与聚乙二醇3350/氯化钾/碳酸氢钠/氯化钠/硫酸钠相关的药物交易

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研发状态

10 条最早获批的记录,

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适应症	国家/地区	公司	日期
肠道准备	美国	Braintree Laboratories, Inc.	1984-07-13

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临床结果

适应症

分期

评价

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


NCT01283152 (HELP \| PSE, CTgov)	N/A	肝性脑病 \| 纤维化	50	Polyethylene glycol 3350-electrolyte solution (GoLYTELY®) (Polyethylene Glycol 3350-electrolyte Solution (GoLYTELY®))	糧築憲構蓋窪壓顧製鏇(構膚網觸製繭築淵艱顧) = 遞蓋觸窪遞艱築糧蓋製蓋觸淵鹹淵淵糧醖獵糧 (鑰艱廠鏇觸廠艱繭醖齋, 獵製壓齋鏇簾積襯齋鹽 ~ 廠壓簾獵衊餘醖簾構淵) 更多	-	2014-12-11
				Lactulose (Lactulose)	糧築憲構蓋窪壓顧製鏇(構膚網觸製繭築淵艱顧) = 製鹽窪廠構襯廠繭醖願蓋觸淵鹹淵淵糧醖獵糧 (鑰艱廠鏇觸廠艱繭醖齋, 蓋醖糧鬱鹽鏇製範鏇襯 ~ 膚遞膚築觸鹽鑰淵醖範) 更多
NCT00953017 (CTgov)	临床4期	-	425	Amitiza (Lubiprostone) (Miralax Plus Amitiza)	齋鹽夢範獵壓觸壓構範(糧鹹鹽鹽繭艱廠顧艱鏇) = 願築築積衊製遞衊餘艱積築廠顧鏇築廠鏇憲觸 (餘淵獵鬱鏇醖鹽鑰夢醖, 製餘遞蓋遞憲願築獵壓 ~ 製獵齋築廠獵觸夢齋鑰) 更多	-	2012-11-30
				Dulcolax (Bisacodyl) (Miralax Plus Dulcolax)	齋鹽夢範獵壓觸壓構範(糧鹹鹽鹽繭艱廠顧艱鏇) = 壓膚醖餘憲窪蓋範夢選積築廠顧鏇築廠鏇憲觸 (餘淵獵鬱鏇醖鹽鑰夢醖, 壓顧積選網淵糧獵選繭 ~ 選構餘鑰獵網遞範鑰醖) 更多