聚乙二醇3350/氯化钠/碳酸氢钠/氯化钠/硫酸钠(Polyethylene glycol 3350/Potassium chloride/Sodium bicarbonate/Sodium chloride/Sodium sulfate)

概要

基本信息

药物类型

小分子化药

别名

COLYTE-FLAVORED、Colyte、Colyte With Flavor Packs

+ [1]

靶点-

作用机制-

治疗领域

其他疾病

在研适应症

肠道准备

非在研适应症-

原研机构

Braintree Laboratories, Inc.

在研机构

Braintree Laboratories, Inc.

非在研机构

Mylan Specialty LP

Hospira, Inc.

最高研发阶段批准上市

首次获批日期

美国 (1984-07-13),

肠道准备

最高研发阶段(中国)-

特殊审评-

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结构

分子式ClNa

InChIKeyFAPWRFPIFSIZLT-UHFFFAOYSA-M

CAS号7647-14-5

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关联

14

项与聚乙二醇3350/氯化钠/碳酸氢钠/氯化钠/硫酸钠相关的临床试验

JPRN-UMIN000025815 / CompletedIIT

Trial of mechanical bowel preparation in laparoscopic colorectal surgery with Moviprep - TLUMP

开始日期2017-03-01

申办/合作机构-

JPRN-UMIN000026944 / Recruiting临床4期

Randomized Comparative Study on the Clinical Usefulness of PICOPREP and MOVIPREP - Comparative examination of laxatives

开始日期2017-02-01

申办/合作机构-

NCT03011788 / Unknown statusN/AIIT

A Randomized Study of Single vs Two-Day Polyethylene Glycol Cleansing in Patients at High Risk for Poor Bowel Preparation

The aim of this randomized trial is to compare the proportion of patients achieving an adequate bowel preparation after a 1-day split-dose 4-liter PEG-based bowel preparation regimen (Golytely, Braintree Laboratory Inc, MA, USA) vs. the same regimen given on 2 consecutive days in a population identified as high risk for an inadequate bowel preparation.
2. Research Design: This study is a single-center prospective randomized study at the West Haven VAMC.
3. Methodology:
Primary endpoint: Adequate bowel preparation as defined by a Boston Bowel Preparation Scale (BBPS) score of 2 or 3 (on scale of 0-3) in all 3 colon segments (left, transverse, and right).
Secondary endpoints: Adenoma detection rate, polyp detection rate, sessile serrated polyp/adenoma detection rate, patient tolerability of preparation using the validated Mayo clinic bowel prep tolerability questionnaire, adverse events potentially related to bowel preparation
Patients scheduled for routine outpatient colonoscopy will be eligible if they are at high risk for poor bowel preparation,

开始日期2017-01-01

申办/合作机构-

100 项与聚乙二醇3350/氯化钠/碳酸氢钠/氯化钠/硫酸钠相关的临床结果

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100 项与聚乙二醇3350/氯化钠/碳酸氢钠/氯化钠/硫酸钠相关的转化医学

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100 项与聚乙二醇3350/氯化钠/碳酸氢钠/氯化钠/硫酸钠相关的专利（医药）

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108

项与聚乙二醇3350/氯化钠/碳酸氢钠/氯化钠/硫酸钠相关的文献（医药）

2022-03-01·Annals of Pharmacotherapy4区 · 医学

A Galvanizing Solution: Colonoscopy Bowel Preparation as a Trigger for Supraventricular Tachycardia

4区 · 医学

Article

作者: Ramappa, Preeti ; Kajy, Marvin

Background: Polyethylene glycol (PEG)-based solutions are among the most commonly used bowel preparation regimens for colonoscopy. Although these solutions are well tolerated, rare adverse cardiac events have been reported. Objectives: We sought to identify the characteristics that may predispose patients to develop supraventricular tachycardia (SVT) after ingestion of GoLYTELY (PEG 3350 and electrolytes oral solution) in anticipation for their colonoscopy. Methods: We performed a retrospective observational cohort study of the electronic medical record of all patients who developed SVT after ingestion of GoLYTELY solution from April 2012 to March 2019 at the John D. Dingell VA Medical Center. Clinical data were obtained through review of medical records. Results: We identified 16 patients with new-onset SVT after ingestion of bowel preparation solution before undergoing the colonoscopy procedure. In all, 12 (75%) patients developed atrial fibrillation, 3 (18.8%) patients developed atrial tachycardia, and 1 patient (6.3%) developed atrial flutter. Most patients were male (93.8%), and the mean age was 69 ± 8.2 years. The commonly associated comorbidities were hypertension (87.5%), hyperlipidemia (56.3%), and diabetes (37.5%). Laboratory testing demonstrated a normal electrolyte panel and thyroid stimulating hormone level. A significant percentage of patients had dilated atria and left-ventricular hypertrophy on echocardiogram. Conclusion: Our case series suggests that there may be certain individuals who are predisposed to development of atrial arrhythmias, more so than others, after ingestion of PEG based solution for colonoscopy. We hypothesize that the combination of atrial dilation, sympathovagal discharge, and transient electrolyte shifts at the cellular level led to the development of SVTs.

2022-01-01·American journal of translational research

Enteral gabexate mesilate improves volume requirements and autonomic cardiovascular function after experimental trauma/hemorrhagic shock in the absence of blood reperfusion.

Article

作者: Aletti, Federico ; Kistler, Erik B ; Mazor, Rafi ; Li, Joyce B ; Dos Santos, Fernando ; Moreira, Nathalia Jd

The standard of care for fluid resuscitation of trauma/hemorrhagic shock (T/HS) is the infusion of blood. However, in many instances, blood product transfusion may not be feasible. Consequently, crystalloid solutions may be utilized as temporizing cost-effective resuscitation fluids. In this study, we explored an alternative therapeutic strategy of enteral protease inhibition adjunctive to intravenous Lactated Ringer's (LR) reperfusion after T/HS. Male Wistar rats underwent midline laparotomy (trauma) and an enteral catheter was inserted orally and positioned post-pyloric for the infusion of vehicle (Golytely®) with or without the serine protease inhibitor gabexate mesilate (GM) (n=8/group). Hemorrhagic shock was induced by blood removal to reduce the mean arterial blood pressure (MAP) to 35-40 mmHg for 90 minutes, before resuscitation with LR. Animals treated with enteral GM required significantly less crystalloid volume to achieve hemodynamic stability and displayed improvements in both blood pressure and autonomic function (via increased baroreflex sensitivity to vasopressors, heightened vascular sympathetic modulation, elevated levels of circulating catecholamines, and increased α1-adrenergic receptor density) compared to untreated (control) shocked animals. Resistance arteries isolated from healthy donor animals and perfused with plasma from untreated T/HS animals revealed impaired vascular response to the α1 adrenergic agonist phenylephrine and decreased reactivity to sodium nitroprusside that was preserved in the GM-treated group. These findings suggest that blockade of serine proteases within the intestinal lumen in non-blood resuscitated experimental T/HS preserves and enhances peripheral sympathetic modulation, improving hemodynamics. Enteral infusion of gabexate mesilate may be a new and promising approach to the management of trauma/hemorrhagic shock.

2021-12-18·Cureus

Magnesium Citrate Capsules in Colonoscopy Preparation: A Randomized Controlled Trial

Article

作者: Mond, Yisroel ; Dutta, Sudhir ; Formanowski, Brielle ; Labowitz, Isaac ; Greenberg, Patricia ; Eidensohn, Chaya ; Eidensohn, Yehuda ; Dubin, Ethan

INTRODUCTIONScreening colonoscopies are recommended for the detection and prevention of colon cancer. Liquid colonoscopy preparations may be poorly tolerated. We evaluated the adequacy and tolerability of a novel low-cost colonoscopy preparation consisting of magnesium citrate capsules and bisacodyl (MCCB).METHODSThis is a single-center, assessor-blinded, randomized controlled trial of 51 patients undergoing screening colonoscopies, who received a bowel preparation of either 4 liters of GoLYTELY (Braintree Laboratories, Inc., Braintree, MA) or MCCB. The primary outcome was the rate of adequate colon cleanliness, defined as a total score ≥ 6 on the Boston Bowel Preparation Scale and no colon segment with a score of zero. The secondary outcome was patient satisfaction, assessed by a validated questionnaire.RESULTSA total of 100% of patients in both arms achieved adequate colon cleanliness, and the magnesium citrate arm had superior patient satisfaction (mean satisfaction score: 54.8 vs. 172.8; p < 0.001).CONCLUSIONSA pill-based colonoscopy preparation of MCCB may be a low-cost option for patients reluctant to consume a liquid preparation.

100 项与聚乙二醇3350/氯化钠/碳酸氢钠/氯化钠/硫酸钠相关的药物交易

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研发状态

10 条最早获批的记录,

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适应症	国家/地区	公司	日期
肠道准备	美国	Braintree Laboratories, Inc.	1984-07-13

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临床结果

适应症

分期

评价

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


NCT01283152 (CTgov)	N/A	纤维化 \| 肝性脑病	50	Polyethylene glycol 3350-electrolyte solution (GoLYTELY®) (Polyethylene Glycol 3350-electrolyte Solution (GoLYTELY®))	齋鏇範繭觸齋鹹壓艱淵(願顧鹽糧衊齋鏇觸觸壓) = 蓋膚壓淵窪選積壓醖簾鬱餘廠齋選選鑰遞壓膚 (壓積糧製觸願廠鬱築範, 獵鑰鏇積艱願齋選製鑰 ~ 積醖膚鹹築餘齋積簾願) 更多	-	2014-12-11
				Lactulose (Lactulose)	齋鏇範繭觸齋鹹壓艱淵(願顧鹽糧衊齋鏇觸觸壓) = 網積餘餘憲鹽淵窪艱窪鬱餘廠齋選選鑰遞壓膚 (壓積糧製觸願廠鬱築範, 齋網願範觸窪夢齋淵鏇 ~ 鑰齋鹹糧餘鹽鏇構餘觸) 更多
NCT00953017 (CTgov)	临床4期	-	425	Amitiza (Lubiprostone) (Miralax Plus Amitiza)	簾窪壓鏇餘鹽簾餘衊製(鹹範積獵網獵築淵窪選) = 淵鹽繭窪簾製範繭願夢築艱憲壓顧蓋齋築觸遞 (築簾獵鬱齋淵獵衊糧積, 廠製鹽膚夢願糧製製壓 ~ 簾醖範網鹹構餘憲齋願) 更多	-	2012-11-30
				Dulcolax (Bisacodyl) (Miralax Plus Dulcolax)	簾窪壓鏇餘鹽簾餘衊製(鹹範積獵網獵築淵窪選) = 壓構獵醖願夢蓋醖鹹網築艱憲壓顧蓋齋築觸遞 (築簾獵鬱齋淵獵衊糧積, 襯獵糧網願蓋襯鹽簾選 ~ 淵憲網構艱鬱簾鹽繭衊) 更多