作者: Sieving, Paul A ; Hartnett, M Elizabeth ; Harper, Clio Armitage ; Wood, Edward H ; Moshfeghi, Darius M ; Capone, Antonio ; Williams, George A ; Drenser, Kimberly A ; Blumenkranz, Mark S

Michael T. Trese, MD (1946–2022), a vitreoretinal surgeon, made significant contributions to the field of retina. Although most known for his work in pediatric retina surgery, he was a pioneer in areas such as medical retina, translational research, and telemedicine. This article reviews his major contributions to spread his knowledge more widely to vitreoretinal trainees and specialists. We discuss six areas where Trese made a lasting impact: lens-sparing vitrectomy, familial exudative vitreoretinopathy, congenital X-linked retinoschisis, autologous plasmin enzyme, regenerative medicine, and telemedicine. [ Ophthalmic Surg Lasers Imaging Retina 2023;54:701–712.]

2013-02-01·Retina2区 · 医学

Update and Review

2区 · 医学

Review

作者: Wong, S Chien ; Capone, Antonio

PURPOSETo discuss the potential role of microplasmin (ocriplasmin) as a surgical adjunct to vitrectomy in pediatric vitreoretinopathies.METHODSLiterature review of the laboratory and clinical evidence to date for the use of both autologous plasmin enzyme as an adjunct to vitrectomy and more recently recombinant microplasmin (ocriplasmin) as monotherapy for focal vitreomacular traction in adults.RESULTSAutologous plasmin enzyme is currently being used as a surgical adjunct to vitrectomy, with supporting Levels 2 and 3 published evidence in a range of pediatric vitreoretinopathies including Stage 5 retinopathy of prematurity and congenital X-linked retinoschisis. The availability of autologous plasmin enzyme is limited. In recent Phase 3 clinical trials, intravitreal ocriplasmin versus sham injection resulted in resolution of focal vitreomacular traction in 27% versus 10% (P < 0.001, n = 652).CONCLUSIONOcriplasmin may potentially be used as a surgical adjunct to vitrectomy in place of autologous plasmin enzyme. A Phase 2, randomized, placebo-controlled surgical trial is under way to assess this.

2011-08-01·American Journal of Ophthalmology

Intravitreal Injection of Autologous Plasmin Enzyme for Macular Edema Associated With Branch Retinal Vein Occlusion

Letter

作者: Patricia Udaondo ; David Salom ; Manuel Díaz-Llopis ; Salvador Garcia-Delpech ; Maria Garcia-Pous

100 项与纤溶酶相关的药物交易

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研发状态

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适应症	国家/地区	公司	日期
脑梗塞	中国	吉林津升制药有限公司	2003-05-22
血栓闭塞性血管炎	中国	北京赛升药业股份有限公司	1999-01-01
血栓性脑梗塞	中国	北京赛升药业股份有限公司	1999-01-01

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


PA022 (AAO2008)	N/A	糖尿病性黄斑水肿	-	Intravitreal Plasmin	(鹽廠襯鹹廠膚積衊窪選) = 願壓鹹鏇願構淵積淵壓積網餘顧範淵築蓋構鹽 (築蓋築鬱蓋衊糧壓構觸, 0.24) 更多	积极	2008-11-09
ARVO2002	N/A	-	16	Plasmin 1U combined with hyaluronidase 20U	淵顧繭衊鏇衊範齋鑰淵(醖觸願蓋選夢醖鹹範遞) = 壓顧廠餘餘夢顧餘選獵鑰餘窪顧積願鹹襯簾繭 (壓遞淵顧廠齋鹹獵積糧 )	积极	2002-12-01
				Plasmin 1U alone	淵顧繭衊鏇衊範齋鑰淵(醖觸願蓋選夢醖鹹範遞) = 觸積鑰遞齋窪壓繭遞膚鑰餘窪顧積願鹹襯簾繭 (壓遞淵顧廠齋鹹獵積糧 )
AAO2000	N/A	糖尿病性视网膜病变	-	Autologous Plasmin Enzyme (APE)	(範襯憲淵鹽醖獵窪艱網) = 獵遞艱簾網淵齋鑰壓鹹顧顧積齋窪願餘願蓋鑰 (憲鏇鬱製醖鬱鏇淵鏇範 )	积极	2000-10-23
				Autologous Plasmin Enzyme	(範襯憲淵鹽醖獵窪艱網) = 齋範窪顧簾鏇鏇鹹壓憲顧顧積齋窪願餘願蓋鑰 (憲鏇鬱製醖鬱鏇淵鏇範 )