Effect of capsule containing valerian and capsule containing valerian and lemongrass versus placebo on sleep quality of postmenopausal women: a double-blind randomized clinical trial

开始日期2024-10-06

申办/合作机构

Hamedan University of Medical Sciences

NCT05185219 / RecruitingN/AIIT

The Effect of Valerian on Insomnia in Menopausal Women: Randomized Placebo-controlled Trial

Menopausal women often complain that it is difficult to fall asleep and easy to wake up at night and early in the morning and it is in the middle of night difficult to fall asleep again. If the above symptoms persist for at least three months and occur at least three times a week, plus the impact on daytime work and rest, and meet the International Classification of Sleep Disorders (ICSD-3) )'S s "Insomnia" diagnostic criteria. According to statistics, 30% to 60% of women face sleep disorders during menopause.

开始日期2021-12-14

申办/合作机构

中国医药大学附设医院

NCT01178632 / Unknown status临床3期

A Double-blind, Randomized, Controlled, Phase III Study of an Herbal Medicine Association for Generalized Anxiety Disorder

Phase III, double blind, randomized study, controlled by Valeriana officinalis L for evaluating the efficacy of association of Passiflora incarnata L; Crataegus Oxyacantha L and Salix alba L. in generalized anxiety disorder. The treatment period will last four weeks and be followed by a post treatment visit.

开始日期2010-10-01

申办/合作机构

Millet Roux

100 项与缬草提取物相关的临床结果

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100 项与缬草提取物相关的转化医学

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100 项与缬草提取物相关的专利（医药）

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项与缬草提取物相关的文献（医药）

2024-12-01·Journal of Ethnopharmacology

Safety evaluation of aqueous extract from Valeriana officinalis L. roots: Genotoxicity, acute, subchronic and teratology toxicity

Article

作者: Du, Bing ; Bao, Hanxiao ; Pan, Xiangmin ; Li, Guosen ; Tao, Qian ; Peng, Dong ; Ding, Wanyue ; Zhang, Guifang ; Li, Pan

ETHNOPHARMACOLOGICAL RELEVANCEValeriana officinalis L., commonly known as "valerian", is a traditional herbal medicine distributed in the north temperate zones of America, Europe and Asia. In traditional Chinese medicine, valerian and its roots were used for the treatment of restlessness of the heart and mind, palpitation and insomnia caused by internal depression of emotions and moods. However, safety evaluation of valerian remains deeply unclear.AIM OF THE STUDYThis study aimed to evaluate the genotoxicity, 14-days acute oral toxicity test, 90-day subchronic oral toxicity test and teratogenicity test of aqueous extract of valerian root (AEVR).MATERIALS AND METHODSThe genotoxicity of AEVR was evaluated with bacterial reverse mutation, mouse erythrocyte micronucleus test and in vitro mammalian cell chromosome aberration test. In the 14-days acute toxicity study, Kunming mice were administered at a dosage of 96 g/kg body weigh by gavage. In the 90-day subchronic toxicity study, Sprague-Dawley rats received oral doses of 0, 3.5, 7 and 14 g/kg body weight of AEVR. In the teratogenicity study, pregnant Sprague-Dawley rats received a dose of 0, 3.5, 7 and 14 g/kg body weight of AEVR.RESULTSAEVR did not show any genotoxicity based on the bacterial reverse mutation, mouse erythrocyte micronucleus test and in vitro mammalian cell chromosome aberration test. In the acute toxicity study, AEVR at a dose of 96 g/kg body weight did not cause death or abnormal behavior in male or female mice. In the subchronic toxicity study, at the doses of 0, 3.5, 7, 14 g/kg body weight, no dose-related effects on clinical observation, body weight, organ weight, hematology, serum biochemistry and urinalysis of AEVR were detected in male or female rats. Teratogenicity test shown that there were no significant toxicologically changes in embryonic formation, body weight of pregnant rats, external, skeletal and visceral examination observed in pregnant and fetal rats at the dosage of 0, 3.5, 7, 14 g/kg body weight.CONCLUSIONIn vivo or in vitro assays demonstrated that AEVR does not exhibit genotoxicity. The LD₅₀ of AEVR was greater than 96 g/kg body weight in both sex of mice according to acute oral toxicity study. Subchronic toxicity and teratogenicity tests showed that the no observed adverse effect level (NOAEL) of AEVR was no less than 14 g/kg body weight. This study established a non-toxic dose of AEVR, providing a foundation for the use of valerian as a new resource food in some countries and regions.

2024-10-01·Endocrine, Metabolic & Immune Disorders - Drug Targets

Molecular Targets of Valeric Acid: A Bioactive Natural Product for Endocrine, Metabolic, and Immunological Disorders

Review

作者: Shakya, Anshul ; Singh, Dhananjay Kumar ; Singh, Gireesh Kumar ; Singh, Ravi Bhushan ; Kumari, Bindu ; Husain, Gulam Mohammed ; Modi, Gyan Prakash ; Kumari, Usha ; Patel, Dinesh Kumar

Backgrounds:Postbiotics produced by gut microbiota have exhibited diverse pharmacological activities. Valeric acid, a postbiotic material produced by gut microbiota and some plant species like valerian, has been explored to have diverse pharmacological activities.Methods:This narrative review aims to summarise the beneficial role of valeric acid for different health conditions along with its underlying mechanism. In order to get ample scientific evidence, various databases like Science Direct, PubMed, Scopus, Google Scholar and Google were exhaustively explored to collect relevant information. Collected data were arranged and analyzed to reach a meaningful conclusion regarding the bioactivity profiling of valeric acid, its mechanism, and future prospects.Results:Valeric acid belongs to short-chain fatty acids (SCFAs) compounds like acetate, propionate, butyrate, pentanoic (valeric) acid, and hexanoic (caproic) acid. Valeric acid has been identified as one of the potent histone deacetylase (HDAC) inhibitors. In different preclinical in -vitro and in-vivo studies, valeric acid has been found to have anti-cancer, anti-diabetic, antihypertensive, anti-inflammatory, and immunomodulatory activity and affects molecular pathways of different diseases like Alzheimer’s, Parkinson’s, and epilepsy.Conclusion:These findings highlight the role of valeric acid as a potential novel therapeutic agent for endocrine, metabolic and immunity-related health conditions, and it must be tested under clinical conditions to develop as a promising drug.

2024-08-25·Psychiatry Investigation

Herbal and Natural Supplements for Improving Sleep: A Literature Review

Article

作者: Cho, Chul-Hyun ; Yeom, Ji Won

Objective Herbal and natural supplements have gained popularity as alternative treatments to insomnia and sleep disorders due to their perceived safety and potential effectiveness. This literature review summarizes the current evidence on the efficacy, safety, and mechanisms of action of commonly used supplements for sleep, including valerian, hops, kava, German chamomile, cherry, tryptophan, theanine, melatonin, magnesium, and zinc.Methods We conducted literature review of clinical research on herbal and supplements for sleep reported to date. We summarized key findings and reviewed outcomes related to clinical efficacy and side effects.Results Findings suggest that certain supplements, particularly valerian, hops, and melatonin, could be effective in improving sleep quality and reducing insomnia symptoms through modulation of neurotransmitter systems and regulation of sleep-wake cycles. However, the strength of the evidence varies with unestablished optimal dosages, formulations, and treatment durations. Although generally considered safe, these supplements are not without risks, such as rare but serious adverse effects associated with kava and potential interactions with prescription medications. The quality and purity of supplements also vary widely due to a lack of strict regulations.Conclusion Healthcare providers should remain informed about the latest research and work closely with patients to develop personalized treatment plans. Herbal and natural supplements may offer promising alternatives or adjunct treatments for insomnia and sleep disorders, but their use should be guided by the best available evidence and individual patient requirements. Larger, well-designed clinical trials are needed to establish the efficacy and safety of these supplements for clinical decision-making.

项与缬草提取物相关的新闻（医药）

2022-08-22

·PRNewswire

GNC Continues Expansion of Women's Wellness Portfolio with New Exclusive Launch from The Honest Company

Global retailer adds additional, uniquely crafted products from Jessica Alba's mission driven brand PITTSBURGH, Aug. 22, 2022 /PRNewswire/ -- With an extensive assortment of products online and in-store focused on helping women Live Well through science-backed products designed for all life stages, GNC announced today that is has deepened its partnership with The Honest Company, a digitally-native, mission-driven brand focused on leading the clean lifestyle movement, through an exclusive retail partnership launching four new products available only at GNC and The Honest Company beginning in August. The two companies first announced their partnership in May in honor of National Women's Health Month, launching six products primarily focused on new and expectant mothers. Continue Reading GNC Continues Expansion of Women’s Wellness Portfolio with New Exclusive Launch from The Honest Company "Our relationship with The Honest Company has allowed us to continue our commitment to women's health and wellness," said Karlyn Mattson, EVP, Chief Merchandising Officer, GNC. "With the launch of four new exclusive products, we're aiming to further connect with our female consumers to support them on their journey to Live Well. The Honest Company has been a great partner and consistently surpasses our expectations with formulas that not only use great ingredients but are also backed by rigorous testing and improve women's everyday health." Building upon the success of the initial launch with The Honest Company, GNC is introducing four new supplements from Honest – three for overall wellness and one for postpartum – to round out a 10-product assortment tailored to support wellbeing. Available at GNC.com and in select stores, these supplements help consumers give their bodies the care they deserve. The products include: Nightly Sleep Health: Featuring a proprietary blend of active ingredients including theanine and valerian to help calm the mind and support healthy sleep.* Daily Mood Balance: Featuring a proprietary blend containing rhodiola and phosphatidylcholine to help manage everyday stress and a balanced mood.* Daily Immune Support: Featuring a powerhouse blend of zinc, vitamin D and organic green propolis, to support everyday immune health.* Postnatal Hair Wellness: Formulated with clinically tested keranat oil to help maintain hair and scalp health.* "After our initial partnership announcement earlier this year, we immediately noticed a significant and positive consumer response and as demand continued, it was only natural for our teams to strengthen our partnership," said Nick Vlahos, Chief Executive Officer of The Honest Company. "The launch of these new products, alongside GNC, showcases our strong commitment to valuing and supporting women's wellness needs. We're confident our efforts will ultimately position us both for long-term success and continue to move our retail strategy forward." These new products from The Honest Company join GNC's growing portfolio of popular women's wellness brands including GNC Women's, Vital Proteins®, Womaness™ and Hers®. About GNC GNC is a leading global health and wellness brand that provides high-quality, science-based products and solutions consumers need to live mighty, live fit and live well. The brand touches consumers worldwide by providing its products and services through company-owned retail locations, domestic and international franchise locations, digital commerce and strong wholesale and retail partnerships across the globe. GNC's diversified, multi-channel business model has worldwide reach and a well-recognized, trusted brand. By combining exceptional innovation, product development capabilities and an extensive global distribution network, GNC manages a best-in-class product portfolio. . About The Honest Company The Honest Company (NASDAQ: HNST) is a mission-driven, digitally-native brand focused on leading the clean lifestyle movement, creating a community for conscious consumers and seeking to disrupt multiple consumer product categories. Since its launch in 2012, Honest has been dedicated to creating thoughtfully formulated, safe and effective personal care, beauty, baby and household products, which are available via honest.com, third-party ecommerce partners and approximately 43,000 retail locations across the United States, Canada and Europe. Based in Los Angeles, CA, the Company's mission, to inspire everyone to love living consciously, is driven by its values of transparency, trust, sustainability and a deep sense of purpose around what matters most to its consumers: their health, their families and their homes. For more information about the Honest Standard and the Company, please visit . *This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease SOURCE GNC