Efficacy and equity of exercise combined with education delivered via telehealth compared to in person for improving pain intensity and disability in chronic non specific low back pain: TECLI study with economic evaluation - TECLI Telehealth in Chronic nonspecific Low back pain

开始日期2025-08-21

申办/合作机构

Universidade Federal dos Vales do Jequitinhonha e Mucuri

[+1]

RBR-4d7kgrw / Not yet recruitingN/AIIT

Efficacy and equity of exercise combined with Education delivered via telehealth compared to in person for improving pain intensity and disability in chronic non specific low back pain: TECLI study with economic evaluation - TECLI Telerrehabilitation for Chronic nonspecific Low Back Pain

开始日期2024-04-04

申办/合作机构

Universidade Federal dos Vales do Jequitinhonha e Mucuri

[+1]

RBR-8fxzwfh / RecruitingN/AIIT

Comparative evaluation of the use or not of sutures in upper third molars surgery - a splith mouth randomized clinical trial

开始日期2024-04-01

申办/合作机构

Universidade Federal dos Vales do Jequitinhonha e Mucuri

[+1]

100 项与 Universidade Federal dos Vales do Jequitinhonha e Mucuri 相关的临床结果

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0 项与 Universidade Federal dos Vales do Jequitinhonha e Mucuri 相关的专利（医药）

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2,825

项与 Universidade Federal dos Vales do Jequitinhonha e Mucuri 相关的文献（医药）

2024-12-01·International Journal of Cardiology

Impact of cardiac structure and function on exercise intolerance in Chagas cardiomyopathy: Insights from CPET and echocardiography

Article

作者: Simões, Marcus Vinicius ; Gadioli, Leonardo Pippa ; Crescêncio, Júlio César ; Tanaka, Denise Mayumi ; Pereira, Jhessica Macieira ; Azevedo, Eduardo Rubio ; Damasceno, Thayrine Rosa ; Carvalho, Eduardo Elias Vieira de ; Magnani, Enrico de Francisco ; Pereira, Danielle Aparecida Gomes ; Oliveira, Rafael Dias de Brito ; Costa, Henrique Silveira ; Gallo Júnior, Lourenço ; de Oliveira, Luciano Fonseca Lemos

INTRODUCTIONChronic Chagas cardiomyopathy (CCC), the most severe clinical condition of Chagas disease, often leads to a reduction in functional capacity and the appearance of symptoms such as fatigue and dyspnea on exertion. However, its determinant factors remain unclear. We aimed to evaluate the peak oxygen consumption (VO_2peak) in patients with CCC and identify its determining factors.METHODSAn observational study with 97 CCC patients was conducted. Patients underwent clinical examination, cardiopulmonary exercise test (CPET), and echocardiography as part of the standard clinical evaluation. Multivariate linear regression was used to identify independent clinical and echocardiographic predictors of VO_2peak and percentage of predicted VO₂.RESULTSMean age of study patients was 55.9 ± 13.4 years, median left ventricle ejection fraction (LVEF) was 40 (26-61.5) % and median VO_2peak was 16.1 (12.1-20.8) ml/Kg/min. 36 patients presented preserved LVEF and 61 presented reduced LVEF. There were significant differences in almost all CPET variables (p < 0.05) between these two groups. VO_2peak was associated with age, male sex, NYHA functional class, LVEF, left atrium diameter, LV diastolic diameter, E wave, LV mass index, and pulmonary artery systolic pressure (PASP). Age, male sex, LVEF, and E wave remained independently associated with VO_2peak in the multivariate analysis (R² = 0.69), furthermore, only LVEF and E wave were associated with the predicted VO₂ percentage (R² = 0.53).CONCLUSIONIn patients with CCC, disease severity, male sex, LV systolic and diastolic function influence the functional capacity.

2024-10-01·Natural Product Research

Protease inhibitors characterisation by SDS-PAGE and MALDI-TOF from Alocasia macrorrhizos and their modulation of macrophage immune-inflammatory properties

Article

作者: Lima, Nerilson M. ; Alves, Caio Cesar S. ; Carli, Alessandra P. ; Castro, Sandra B. R. ; Cordeiro, Isac H. ; Andrade, Teresinha de Jesus A. S. ; Carli, Gabriela P. ; Scherrer, Elaine C. ; de Oliveira, Marcone A. L.

This study describes the extraction and identification by electrophoretic and spectrometric techniques of protease inhibitor from the medicinal plant Alocasia macrorrhizos as well as investigates their immunomodulatory properties and cell viability. The A. macrorrhizos tubers were subjected to protease inhibitor extractions and characterised using SDS-PAGE and MALDI-TOF. The protein extracts were assessed for activities trypsin inhibition stoichiometry, haemagglutinating, cell viability, NO and TNF-α production inhibition. Concerning the protease inhibitors analysis through SDS-PAGE, the results showed two bands with 11 and 24 kDa, and the MS analysis detected the ions more intense of m/z 4276.795 and 8563.361 in the roasted protein extract. The IC₅₀ of trypsin inhibition was 0.119 and 0.302 mg L^-1 in the roasted and crude tuber, respectively. The protease inhibitors extract from the roasted tubers showed a reduction in the production of NO and TNF-α at concentrations lower than 100 µg mL^-1, without a reduction in cell viability.

2024-10-01·European Archives of Paediatric Dentistry

“Association between caries in anterior teeth and bullying victimization in Brazilian schoolchildren aged 6 to 10 years.: a cross sectional study”

Article

作者: Soares, M E C ; Fonseca, P G ; Fernandes, I B ; Ramos-Jorge, M L ; Galo, R ; Neves, E P S

AIMTo investigate the association between presence of caries in anterior teeth and bullying victimization in schoolchildren.METHODSA cross-sectional study was conducted in Brazil with a sample of 387 schoolchildren aged 6 to 10 years. The presence of moderate/extensive dental caries was assessed using the International System for the Evaluation and Detection of Dental Caries (ICDAS-II). The children answered the "Olweus Bullying" (QBO). Descriptive analyses were performed, and the associations between bullying victimization and independent variables collected were determined by univariate and multivariate Poisson regression.RESULTSThe prevalence of bullying victimization was 66.4%. Bullying victimization was higher among children who had moderate/extensive caries in some anterior teeth (p = 0.010). 8-year-old (p = 0.048), 9-year-old (p = 0.001), and 10-year-old (p = 0.002) children reported greater bullying victimization when compared to 6-year-olds.CONCLUSIONThe presence of moderate/extensive dental caries in anterior teeth is associated with bullying victimization in schoolchildren.

100 项与 Universidade Federal dos Vales do Jequitinhonha e Mucuri 相关的药物交易

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100 项与 Universidade Federal dos Vales do Jequitinhonha e Mucuri 相关的转化医学

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