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更新于：2025-05-07

N-Hexacosanol

更新于：2025-05-07

概要

概要

基本信息

药物类型

小分子化药

别名

靶点

NGF

作用方式

刺激剂

作用机制

NGF刺激剂(神经生长因子刺激剂)

治疗领域

泌尿生殖系统疾病

在研适应症-

非在研适应症

膀胱过度活动症膀胱功能不全

原研机构

Meiji Seika Pharma Co., Ltd.

在研机构-

非在研机构

Taiho Pharmaceutical Co., Ltd.

权益机构-

最高研发阶段无进展临床2期

首次获批日期-

最高研发阶段(中国)-

特殊审评-

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结构/序列

分子式C24H44O2

InChIKeyFGMAOXGOTRUOKJ-UHFFFAOYSA-N

CAS号220757-88-0

关联

项与 N-Hexacosanol 相关的临床试验

NCT03175029

/ Completed临床2期

Exploratory Study of TAC-302 in Detrusor Underactivity Patients With Overactive Bladder.

The purpose of this study is to evaluate the efficacy and safety of TAC-302 in detrusor underactivity patients with overactive bladder.

开始日期2017-09-09

申办/合作机构

Taiho Pharmaceutical Co., Ltd.

100 项与 N-Hexacosanol 相关的临床结果

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100 项与 N-Hexacosanol 相关的转化医学

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100 项与 N-Hexacosanol 相关的专利（医药）

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项与 N-Hexacosanol 相关的文献（医药）

2024-12-01·Poultry Science

Multiomics analyses reveal high yield-related genes in the hypothalamic-pituitary-ovarian/liver axis of chicken

Article

作者: Xiong, Hanlin ; Yang, Chaowu ; Hu, Chenming ; Liu, Lingbin ; Wang, Haiwei ; Wang, Qigui ; Su, Junchao ; Cui, Zhifu ; Shi, Jun'an

Egg production, regulated by multiple tissues, is among the most important economic traits in poultry. However, current research only focuses on the hypothalamic-pituitary-ovarian axis, ignoring the most important organ for substance metabolism in the body, the liver. Eggs are rich in lipids, proteins, and other nutrients, which are biosynthesized in the liver. Therefore, here the liver was included in the study of the hypothalamic-pituitary axis. This study used hypothalamus (HH_vs_LH), pituitary (HP_vs_LP), liver (HL_vs_LL), and ovary (HO_vs_LO) tissue samples from high- and low-laying Chengkou mountain chickens (CMC) for epihistological, transcriptome and metabolomic analyses aimed at improving the reproductive performance of CMC. The results showed that the liver of the high-laying group was yellowish, the cell boundary was clear, and the lipid droplets were evenly distributed. The ovaries of the high-laying group had a complete sequence of hierarchical follicles, which were rich in yolk. In contrast, the ovaries of the low-laying group were atrophic, except for a few small yellow follicles, and numerous primordial follicles that remained. The transcriptome sequences yielded 167.11 Gb of clean data, containing 28,715 genes. Furthermore, 285, 822, 787, and 1,183 differentially expressed genes (DEG) were identified in HH_vs_LH, HP_vs_LP, HL_vs_LL and HO_vs_LO and the DEGs significantly enriched 77, 163, 170, 171 pathways, respectively. Metabolome sequencing yielded 21,808 peaks containing 4,006 metabolites. The differential metabolite analysis yielded 343 and 682 significantly different metabolites (SDM) that significantly enriched 136 and 87 pathways in the liver and ovaries, respectively. A combined analysis of the transcriptome and metabolome of the liver and ovaries identified "CYP51A1-4α-carboxy-stigmasta7, 24(24(1))-dien-3β-ol" and "ACSS1B-estrone 3-sulfate" and other multiple gene-metabolite pairs. The DEGs in the hypothalamus and pituitary mainly enriched signaling transduction. In contrast, the DEGs and SDMs in the liver and ovaries mainly enriched the substance metabolism pathways: "gap junction", "extracellular matrix (ECM)-receptor interaction", "Steroid biosynthesis", and "Steroid hormone biosynthesis". These results suggest that the hypothalamic-pituitary axis may affect egg production mainly by regulating lipid metabolism in the liver and ovaries.

2018-09-01·Neurourology and Urodynamics3区 · 医学

Therapeutic effect of TAC‐302, a cyclohexenoic fatty alcohol derivative, on bladder denervation‐related storage and voiding dysfunctions in rats

3区 · 医学

Article

作者: Hakozaki, Atsushi ; Yoshida, Shohei ; Miyoshi, Kazuhisa ; Noma, Takahisa ; Orimoto, Naoki ; Sasaki, Eiji ; Tsukihara, Hiroshi

AimsTo evaluate the therapeutic effect of TAC‐302, a cyclohexenoic fatty alcohol derivative, on bladder denervation‐related storage and voiding dysfunctions in rats with bladder outlet obstruction (BOO).MethodsBOO was achieved by partial ligature of the proximal urethra in female rats. Two weeks later, BOO rats were divided into two groups and treated orally with vehicle or 10 mg/kg TAC‐302 twice a day for 4 weeks. Urodynamic and immunohistochemical evaluation of the bladder muscle layer was performed. In another study, the BOO rats were treated with intravenous tamsulosin at cystometry. The detrusor contractility in each group was evaluated using the modified Shafer's nomogram.ResultsTwo weeks after BOO, the rats showed significant increases in non‐voiding contraction (NVCs) and residual urine volume (RUV) compared to the sham group. Moreover, 6 weeks after BOO, BOO vehicle rats showed significant increases in NVCs and RUV and decreases in detrusor contractility and in the nerve fiber density in the urinary bladder compared to the sham group. BOO‐induced denervation of the urinary bladder was partially improved by oral treatment with TAC‐302. Oral treatment with TAC‐302 significantly reduced the amplitude and frequency of NVCs (P < 0.05) and increased detrusor contractility and tended to reduce RUV compared with the BOO vehicle group. In contrast, the intravenous administration of tamsulosin significantly reduced the frequency of NVCs, but not RUV.ConclusionsTAC‐302 improved storage and voiding dysfunctions by improving bladder denervation and detrusor underactivity even when the treatment was started after storage and voiding dysfunctions had already occurred.

2018-02-01·Neurourology and Urodynamics

TAC‐302 promotes neurite outgrowth of isolated peripheral neurons and prevents bladder denervation related bladder dysfunctions following bladder outlet obstruction in rats

Article

作者: Noma, Takahisa ; Sasaki, Eiji ; Yoshida, Shohei ; Tsukihara, Hiroshi ; Orimoto, Naoki ; Hakozaki, Atsushi

AimsTo evaluate the ability of TAC‐302, a cyclohexenoic fatty alcohol derivative, to enhance neurite outgrowth in cultured rat dorsal root ganglion (DRG) neurons, and the preventive effects of TAC‐302 on bladder denervation‐related storage and voiding dysfunctions in rats with bladder outlet obstruction (BOO).MethodsRat DRG neurons were cultured in the presence of TAC‐302. Cell numbers and neurite lengths were quantified after a 24 h culture. BOO was achieved by partial ligature of the proximal urethra in female rats. BOO rats were divided into three groups and orally treated with vehicle of 3 or 30 mg/kg TAC‐302 twice a day for 4 weeks. Cystometry was performed under conscious conditions. Immunohistochemical staining using anti‐PGP9.5 of the bladder muscle layer was performed, and the innervation area was scored.ResultsTAC‐302 significantly and dose‐dependently increased neurite outgrowth in cultured DRG neurons. BOO rats showed a decreased innervation area in the urinary bladder compared to sham‐operated rats. BOO‐induced denervation of the urinary bladder was partially prevented by oral treatment with TAC‐302. TAC‐302 significantly reduced the frequency of non‐voiding contraction (NVC) and residual urine volume (RUV) compared with the BOO vehicle group (P < 0.05). The innervation area score exhibited significant negative correlations with NVC and RUV, indicating that they increased according to the progression of denervation.ConclusionsOur data indicate that TAC‐302 promotes neurite outgrowth in vitro. In addition, TAC‐302 prevents BOO‐induced bladder dysfunction in rats, and has a protective effect on bladder denervation.

100 项与 N-Hexacosanol 相关的药物交易

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研发状态

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适应症	最高研发状态	国家/地区	公司	日期
膀胱过度活动症	临床2期	日本	Taiho Pharmaceutical Co., Ltd.	2017-09-09
膀胱功能不全	临床2期	日本	Taiho Pharmaceutical Co., Ltd.	2017-09-09

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临床结果

适应症

分期

评价

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


NCT03175029 (CTgov)	临床2期	膀胱功能不全 \| 膀胱过度活动症	195	TAC-302 (TAC-302)	齋選構願鬱積廠鹹淵構(艱簾願簾構襯淵鑰壓醖) = 觸繭獵顧鹽窪鹽膚築夢衊遞夢憲襯願鏇選壓築 (餘鬱餘製築窪艱襯顧衊, 壓構獵觸糧醖餘廠鑰觸 ~ 鹹鬱積願蓋鹽觸願鑰構) 更多	-	2025-01-20
				Placebo (Placebo)	齋選構願鬱積廠鹹淵構(艱簾願簾構襯淵鑰壓醖) = 憲蓋積觸衊簾鏇廠鹹淵衊遞夢憲襯願鏇選壓築 (餘鬱餘製築窪艱襯顧衊, 製網襯艱網鹽積衊醖醖 ~ 廠鏇窪觸鑰廠壓艱夢窪) 更多