The isolated perfused rat liver model (IPRL) offers a unique opportunity for the study of hepatic function for simulating in vivo conditions, with the advantage of being able to control accurately exptl. conditions. This model was used to test the effectiveness of liver transplant preservation solutions The livers were stored in an exptl. preservation solution for 24 h followed by evaluation of liver function and hemodynamics using IPRL. A new preservation solution, modified phosphate-buffered sucrose, was compared with other solutions used clin., such as University of Wisconsin solution (UW), lactobionate mannitol glutathione (LMG), histidine tryptophan ketoglutarate, and histidine lactobionate. The use of the IPRL in the laboratory provides a simple, rapid, cost-effective method for screening liver preservation solutions