NP-C86(NP-C86) - 在研适应症：炎症性肠病，性传播疾病_专利_临床

概要

基本信息

药物类型

小分子化药

别名-

靶点-

作用方式-

作用机制-

治疗领域

免疫系统疾病感染消化系统疾病+ [1]

在研适应症

炎症性肠病性传播疾病

非在研适应症-

原研机构

University of South Florida

在研机构

The Salk Institute for Biological Studies

Novartis AG

非在研机构-

最高研发阶段临床前

首次获批日期-

最高研发阶段(中国)-

特殊审评-

关联

100 项与 NP-C86 相关的临床结果

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100 项与 NP-C86 相关的转化医学

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100 项与 NP-C86 相关的专利（医药）

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1

项与 NP-C86 相关的文献（医药）

Scientific Reports

Small molecule targeting long noncoding RNA GAS5 administered intranasally improves neuronal insulin signaling and decreases neuroinflammation in an aged mouse model

Article

作者: Patel, Rekha S ; Blair, Laura J ; Cai, Jianfeng ; Shi, Yan ; Moss, Lauren ; Bickford, Paula C ; Hudson, Charles ; Lui, Ashley ; Patel, Niketa A ; Sparks, Robert P ; Hill, Shannon E

AbstractShifts in normal aging set stage for neurodegeneration and dementia affecting 1 in 10 adults. The study demonstrates that lncRNA GAS5 is decreased in aged and Alzheimer’s disease brain. The role and targets of lncRNA GAS5 in the aging brain were elucidated using a GAS5-targeting small molecule NPC86, a frontier in lncRNA-targeting therapeutic. Robust techniques such as molecular dynamics simulation of NPC86 binding to GAS5, in vitro functional assays demonstrating that GAS5 regulates insulin signaling, neuronal survival, phosphorylation of tau, and neuroinflammation via toll-like receptors support the role of GAS5 in maintaining healthy neurons. The study demonstrates the safety and efficacy of intranasal NPC86 treatment in aged mice to improve cellular functions with transcriptomic analysis in response to NPC86. In summary, the study demonstrates that GAS5 contributes to pathways associated with neurodegeneration and NPC86 has tremendous therapeutic potential to prevent the advent of neurodegenerative diseases and dementias.

100 项与 NP-C86 相关的药物交易

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