氟莱哌素(Fluorapacin) - 药物靶点：Tubulin_在研适应症：肺癌，非小细胞肺癌_专利_临床

概要

基本信息

药物类型

小分子化药

别名

BFBTS、FLP

靶点

Tubulin

作用机制

微管蛋白抑制剂

治疗领域

在研适应症

非在研适应症

原研机构

在研机构

ACEA Therapeutics, Inc.初创企业

非在研机构

安捷伦生物（杭州）有限公司

最高研发阶段临床2期

首次获批日期-

最高研发阶段(中国)临床2期

特殊审评-

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结构

分子式C14H12F2S3

InChIKeyXCOWUOOCXCXCNS-UHFFFAOYSA-N

CAS号869811-23-4

关联

3

项与氟莱哌素相关的临床试验

CTR20130893 / Completed临床1期

氟莱哌素注射液Ⅰ期临床试验（持续72h给药）

1)确定本品持续72h给药在人体的耐受性及在人体的剂量限制性毒性2)考察氟莱哌素及其代谢物药代动力学行为3)探讨本品剂量、药代动力学参数与药效的关系4)初步考察氟莱哌素疗效5)为Ⅱ期临床研究提供安全有效的合理方案

开始日期-

申办/合作机构-

CTR20130888 / Recruiting临床1期

氟莱哌素注射液联合培美曲赛治疗晚期NSCLC剂量探索I期临床试验

(1)确定联合给药下氟莱哌素注射液的剂量；(2)确定联合方案的MTD、DLT；(3)考察药代动力学行为并计算药代动力学参数。(4)评估耐受性和安全性。(5)初步考察联合给药的疗效。(6)为Ⅱ期临床提供安全有效的合理方案。

开始日期-

申办/合作机构-

NCT01361529 / Unknown status临床1期

Phase 1 Study of FLP Injection on Tumor Patients

The purpose of this study is to determine the tolerance and maximum tolerated dose (MTD) for FLP Injection with multiple dose in tumor patients.

开始日期2009-06-01

申办/合作机构

安捷伦生物（杭州）有限公司

100 项与氟莱哌素相关的临床结果

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100 项与氟莱哌素相关的转化医学

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100 项与氟莱哌素相关的专利（医药）

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71

项与氟莱哌素相关的文献（医药）

2024-06-01·Klinische Monatsblätter für Augenheilkunde

Effective Focal Laser Photocoagulation for Persistent Central Serous Chorioretinopathy: A Forgotten Technique

Article

作者: Kiraly, Peter

We report a case of a patient with persistent central serous chorioretinopathy (CSC) who was on the waiting list for half-dose photodynamic therapy (PDT). As the patient's visual function began to deteriorate, patient opted for focal laser photocoagulation (FLP) targeting the presumed leakage site in the superior part of the macula. One month after the FLP treatment, there was complete resolution of SRF accompanied by improved visual function. In light of global verteporfin shortages, limited access to PDT centers, and poor efficacy from other treatment modalities, FLP emerges as an effective treatment option for CSC patients with extrafoveal leakage. Yet, many CSC patients with extrafoveal leakage, who could be effectively treated with FLP, are often merely monitored, experiencing fluctuating SRF and a gradual, irreversible vision decline. Despite FLP's historical presence in CSC treatment, our case serves as an important reminder for retinal specialists to reconsider this treatment approach in selected CSC patients.

2023-12-25·Sheng wu gong cheng xue bao = Chinese journal of biotechnology

[Enzyme production mechanism of anaerobic fungus Orpinomyces sp. YF3 in yak rumen induced by different carbon source].

Article

作者: Wang, Lamei ; Cao, Yangchun ; Zhou, Linlin ; Li, Yong ; Yao, Junhu ; Zhao, Congcong ; Zhang, Fan ; DU, Xue'er

In order to investigate the enzyme production mechanism of yak rumen-derived anaerobic fungus Orpinomyces sp. YF3 under the induction of different carbon sources, anaerobic culture tubes were used for in vitro fermentation. 8 g/L of glucose (Glu), filter paper (Flp) and avicel (Avi) were respectively added to 10 mL of basic culture medium as the sole carbon source. The activity of fiber-degrading enzyme and the concentration of volatile fatty acid in the fermentation liquid were detected, and the enzyme producing mechanism of Orpinomyces sp. YF3 was explored by transcriptomics. It was found that, in glucose-induced fermentation solution, the activities of carboxymethyl cellulase, microcrystalline cellulase, filter paper enzyme, xylanase and the proportion of acetate were significantly increased (P < 0.05), the proportion of propionate, butyrate, isobutyrate were significantly decreased (P < 0.05). The results of transcriptome analysis showed that there were 5 949 differentially expressed genes (DEGs) between the Glu group and the Flp group, 10 970 DEGs between the Glu group and the Avi group, and 6 057 DEGs between the Flp group and the Avi group. It was found that the DEGs associated with fiber degrading enzymes were significantly up-regulated in the Glu group. Gene ontology (GO) function enrichment analysis identified that DEGs were mainly associated with the xylan catabolic process, hemicellulose metabolic process, β-glucan metabolic process, cellulase activity, endo-1,4-β-xylanase activity, cell wall polysaccharide metabolic process, carbohydrate catabolic process, glucan catabolic process and carbohydrate metabolic process. Moreover, the differentially expressed pathways associated with fiber degrading enzymes enriched by Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis were mainly starch and sucrose metabolic pathways and other glycan degradation pathways. In conclusion, Orpinomyces sp. YF3 with glucose as carbon source substrate significantly increased the activity of cellulose degrading enzyme and the proportion of acetate, decreased the proportion of propionate, butyrate and isobutyrate. Furthermore, the degradation ability and energy utilization efficiency of fungus in the presence of glucose were improved by means of regulating the expression of cellulose degrading enzyme gene and participating in starch and sucrose metabolism pathway, and other glycan degradation pathways, which provides a theoretical basis for the application of Orpinomyces sp. YF3 in practical production and facilitates the application of Orpinomyces sp. YF3 in the future.

2023-08-31·The European journal of prosthodontics and restorative dentistry

Mechanical Characteristics of Composite Resins Produced by Additive and Subtractive Manufacturing.

Article

作者: Kιlιçarslan, M A ; Sahin, Z ; Yιkιcι, C ; Ozer, N E

INTRODUCTIONThe aim of the study was to evaluate the mechanical characteristics of resin composites produced by additive and subtractive manufacturing.METHODSSix composite resin materials produced by subtractive (Vita Enamic-VE, Cerasmart-CE, Lava Ultimate-LU) and additive manufacturing (Varseo Smile Crown plus-VSC, Saremco Print Crowntec-SPC, Formlabs 3B Permanent crown-FLP) were selected. The three-point bending test was performed, and surface hardness of test specimens was measured.RESULTSThe flexural strength values of CE, SPC and LU test groups were found to be statistically higher when compared to VE, FLP and VSC test groups (p⟨0.0033). The modulus of elasticity values of the test specimens was listed as VE>LU>CE>SPC>FLP>VSC. The FLP group [35.11(4.46)] had the lowest surface hardness values, whereas the VE group [252.50 (21.5)] had the highest values. Other groups were listed as LU⟩CE⟩SPC⟩VSC in terms of surface hardness.CONCLUSIONSAccording to the ISO 6872:2015, the flexural strengths of all resin composites were found to be acceptable for single unit fixed restorations. However, the VSC group's flexural strength is suitable for inlay, onlay, veneer restorations or single-unit anterior fixed dental prostheses. Also, VSC may not be a suitable choice for posterior restorations due to its low flexural strength.

100 项与氟莱哌素相关的药物交易

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研发状态

10 条进展最快的记录,

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适应症	最高研发状态	国家/地区	公司	日期
肺癌	临床2期	中国	ACEA Therapeutics, Inc.初创企业	2022-01-30
非小细胞肺癌	临床1期	中国	-	2013-11-13
晚期恶性实体瘤	药物发现	中国	-	2013-11-13
晚期癌症	药物发现	中国	安捷伦生物（杭州）有限公司	2009-06-01

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临床结果

适应症

分期

评价

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


ASCO2006	临床3期	进展期胃腺癌一线	220	FLO	糧壓衊網獵選顧鬱鏇鑰(艱壓蓋淵選築襯窪獵顧) = 鑰獵選窪廠壓網範鹹艱簾網襯憲構範憲齋醖積 (鏇鏇選淵製蓋構鬱簾顧 ) 更多	积极	2006-06-20
				FLP	糧壓衊網獵選顧鬱鏇鑰(艱壓蓋淵選築襯窪獵顧) = 廠鏇艱衊糧淵醖觸齋壓簾網襯憲構範憲齋醖積 (鏇鏇選淵製蓋構鬱簾顧 ) 更多
ASCO2004	N/A	复发性胃癌一线	111	FLP	(襯餘衊願網範築壓衊醖) = 蓋廠觸範淵淵蓋觸夢膚製鹽簾蓋餘壓積網鬱壓 (鑰積壓遞鏇鏇遞顧夢鑰 ) 更多	-	2004-07-15
				S-1	(襯餘衊願網範築壓衊醖) = 憲蓋蓋鬱憲繭糧積簾簾製鹽簾蓋餘壓積網鬱壓 (鑰積壓遞鏇鏇遞顧夢鑰 ) 更多