曲美孕酮(Trimegestone) - 药物靶点：PR_在研适应症：绝经期综合征_专利_临床

概要

基本信息

药物类型

小分子化药

别名

Ondeva、TMG、Trimegestone (USAN/INN)

+ [2]

靶点

PR

作用方式

激动剂

作用机制

PR激动剂(孕激素受体激动剂)

治疗领域

其他疾病

在研适应症

绝经期综合征

非在研适应症-

原研机构-

在研机构

Aventis Pharma SARL

非在研机构-

权益机构-

最高研发阶段批准上市

首次获批日期

英国 (2001-02-11)

最高研发阶段(中国)-

特殊审评-

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结构/序列

分子式C22H30O3

InChIKeyJUNDJWOLDSCTFK-MTZCLOFQSA-N

CAS号74513-62-5

关联

2

项与曲美孕酮相关的临床试验

EUCTR2017-004664-36-DE

/ Not yet recruiting临床2期

Characterization of ovulation inhibition of a new vaginal delivery system containing trimegestone - an open-label, single-centre study in healthy females of childbearing potential - Ovulation inhibition study with trimegestone

开始日期2018-06-19

申办/合作机构-

NCT00195455

/ Completed临床4期

A Prospective Open Label Study to Evaluate Vasomotor Symptoms Control and Bleeding Patterns With a Continuous Regimen of a New Progestin Trimegestone 0.125 mg and 17 b Estradiol 1 mg (Totelle),as HT on Postmenopausal Women

The purpose of this study is to evaluate vasomotor symptoms (VMS) control of the continuous regimen 17 b estradiol/trimegestone combination.

开始日期2005-02-01

申办/合作机构

Wyeth AB

100 项与曲美孕酮相关的临床结果

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100 项与曲美孕酮相关的转化医学

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100 项与曲美孕酮相关的专利（医药）

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297

项与曲美孕酮相关的文献（医药）

2025-06-01·Clinica Chimica Acta

Quantification of trimethylamine-N-oxide (TMAO) and its main related trimethylammonium-containing compounds in human plasma by LC-MS/MS

Article

作者: Sotgia, Salvatore

BACKGROUNDTrimethylammonium-containing compounds, including choline (CHOL), carnitine (CAR), trimethylglycine (TMG), ergothioneine (ERT), Nε,Nε,Nε-trimethyllysine (TML), γ-butyrobetaine (gBB), and dimethylglycine (DMG) contribute to trimethylamine N-oxide (TMAO) production, a metabolite linked to cardiovascular, renal, and metabolic diseases. An LC-MS/MS method has been established for their simultaneous measurement in human plasma, as an accurate quantification of TMAO and its precursors is crucial for understanding its clinical relevance.METHODSBlood samples from ten healthy male volunteers were processed using acetonitrile protein precipitation. Analysis was performed using a HILIC column and an isocratic methanol-formic acid mobile phase, achieving a total run time of less than 6 min. Linearity was adequate for all analytes (R² > 0.995), with mean intra- and inter-assay variation coefficients of 2.88 % and 4.23 %, respectively. Recoveries ranged from 95 % to 101 %, limits of detection from 0.009 to 0.068 µmol/L, and limits of quantification from 0.031 to 0.187 µmol/L. Plasma mean concentrations were 3.18 ± 0.73 µmol/L for TMAO, 3.99 ± 0.65 µmol/L for DMG, 9.84 ± 2.08 µmol/L for CHOL, 24.22 ± 6.19 µmol/L for TMG, 0.54 ± 0.22 µmol/L for gBB, 57.29 ± 8.89 µmol/L for CAR, 1.10 ± 0.42 µmol/L for ERT, and 0.40 ± 0.11 µmol/L for TML. Significant inter-individual variability (mean RSD% of 26 %) was observed.CONCLUSIONThe developed LC-MS/MS method enables rapid, sensitive, and selective quantification of TMAO and its precursors in human plasma. The analytical performance supports its application in clinical and metabolomic studies, contributing to a better understanding the role of TMAO in disease states.

2025-04-01·Reproduction in Domestic Animals

Serum Ionised Calcium and Ionised Magnesium in Dairy Cows and Their Associations With the Incidence and Severity of Postpartum Metritis

Article

作者: Ríos, José ; Elcoso, Guillermo ; Bach, Alex ; Jose‐Cunilleras, Eduard ; Bassols, Anna ; Robles‐Guirado, José Angel

ABSTRACTPeripartum is a critical period for dairy cows during which they may undergo postpartum diseases such as hypocalcaemia and metritis. Determination of serum total calcium (tCa) is widely used to monitor imbalances in this period, but determination of total magnesium (tMg) and ionised forms of both cations (iCa and iMg) has been less studied. In the present work, 42 healthy cows and 53 cows diagnosed with mild or moderate metritis were included. Serum samples were collected 10 days prepartum and 1, 3 and 10 days postpartum to determine tCa, iCa, tMg and iMg concentrations, as well as their corresponding ratios. Our results show that hypocalcaemia and hypermagnesaemia occur on Day 1 postpartum in cows that stayed healthy and cows undergoing metritis. Cows with moderate metritis showed lower serum concentrations of iCa and iMg throughout the period. Low values of prepartum iCa and iMg at 10 days before calving were associated with later development of metritis and therefore could represent potential prognostic indicators. In conclusion, the determination of iCa, tMg and iMg in serum, in addition to tCa, could offer a more comprehensive view of the ionic status of the periparturient dairy cow and may provide information about the risk of suffering uterine diseases.

2025-01-01·American Journal of Veterinary Research

Calcium and magnesium abnormalities in puppies with parvoviral enteritis

Article

作者: Celliers, Anri ; Thompson, Peter N. ; Mouton, Anneri ; Schoeman, Johan P. ; Mellanby, Richard J.

AbstractOBJECTIVETo determine the association between ionized calcium (iCa) and/or total magnesium (tMg) and the development of sepsis and to investigate whether iCa or tMg is associated with mortality in puppies with canine parvoviral enteritis (CPE).METHODS64 client-owned puppies with CPE were enrolled in this prospective cohort study. Serum iCa and tMg were measured daily from admission until death or discharge. Fifteen healthy client-owned puppies were used as controls.RESULTSMean iCa concentrations of the CPE group on admission were significantly lower compared to the control group (1.35 mmol/L vs 1.52 mmol/L). Ionized calcium concentrations of nonsurvivors were significantly higher compared to survivors on day 2 but not on any other days. Puppies that were hypercalcemic on day 2 were also significantly more likely to die than normocalcemic puppies (OR, 10.7; 95% CI, 1.7 to 71). Ionized calcium was not associated with the development of sepsis on any day. In contrast, mean admission tMg concentrations of the CPE group were significantly higher compared to the control group (0.72 mmol/L vs 0.63 mmol/L). However, tMg concentrations were not significantly different between survivors and nonsurvivors nor were they associated with the development of sepsis on any day.CONCLUSIONSOn admission, puppies with CPE had lower iCa and higher tMg compared to healthy puppies, and higher iCa a day after initiation of treatment was associated with increased odds of mortality.CLINICAL RELEVANCEThe results of this study provide insight into calcium homeostasis in critically ill young dogs with CPE.

100 项与曲美孕酮相关的药物交易

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