LNK01004

创新药研发公司凌科药业（杭州）有限公司（以下简称"凌科药业"）今日正式宣布完成C2轮融资。本轮融资由盛世投资管理的绍兴滨海新区生物医药产业股权投资基金、海邦投资、好买母基金共同参与，老股东联新资本和礼来亚洲基金持续加注。这是继5月31日C1轮融资之后公司获得的新一笔融资，截至目前C轮总融资额3.22亿元人民币。浩悦资本担任本轮融资的独家财务顾问。 凌科药业成立于2018年，是一家专注于自身免疫疾病、炎症、肿瘤领域FIC与BIC药物研发的领军企业。依托于核心团队在药物化学、生物学、临床开发和商业开发方面深厚的背景与平均超过20年的新药研发经验，凌科药业的管线布局注重创新性与差异化。核心管线以第二代高选择性和第三代组织特异性JAK抑制剂的开发为核心，同时探索创新靶点成药性的可能。 自成立以来，高效的执行力持续驱动凌科药业加速向前发展。在过去的3个月里，LNK01001在类风湿关节炎、特应性皮炎以及强直性脊柱炎的II期临床试验数据相继公布，结果均显示显著的治疗效果和较高的安全性，充分体现出小分子JAK1抑制剂起效快、药效好的特点。公司近期已提交多个II期临床试验结束/III期临床试验启动前会议申请；多个管线即将进入III期临床试验，力求尽早惠及更多患者。与此同时，LNK01004针对银屑病和特应性皮炎的Ib期临床研究也已经实现首例患者入组；公司的LNK01002和LNK01003等管线的早期临床试验的数据积极，临床前管线研发也在快速推进。 凌科药业的创新研发和临床开发能力持续得到验证和增强，正处于关键的价值快速爆发阶段。据弗若斯特沙利文预测，仅JAK1抑制剂市场在2030年将高达305亿美元，未来市场广阔。公司依托自身免疫疾病和肿瘤领域的巨大市场，未来的商业化潜力可期。 凌科药业董事长兼首席执行官万昭奎博士表示："感谢本轮投资机构绍兴滨海新区生物医药产业股权投资基金、联新资本、海邦投资、好买母基金和礼来亚洲基金的支持和信任，同时感谢C1轮投资机构泰珑投资和联东投资，共同助力我们顺利完成C轮融资。凌科药业是一家聚焦自身免疫疾病、肿瘤治疗领域的企业，开发具有全球竞争力的FIC/BIC创新药，致力于以差异化的创新疗法惠及全球的患者。我们很高兴地看到，即使在当今生物医药资本寒冬的现状下，凌科药业依旧持续获得新老股东的支持，充分展现了资本市场对团队的认可。现在凌科药业正处于高速发展的阶段，我们将进一步整合多方资源，继续加大对临床开发、研发团队和技术平台的投入，力求让更加安全、有效的创新药物尽早惠及更多患者。浩悦资本担任了本次融资的独家财务顾问，我们对他们的专业精神和支持表示感谢。" 浩悦资本创始管理合伙人、首席运营官丁亚猛先生表示："我们很荣幸能持续协助凌科药业完成本轮融资。自身免疫领域的疾病种类多元复杂，适应症拓展空间大，尚存在大量未满足的临床需求和差异化的创新机会。凌科药业具有国际竞争力的创新管线，正在不断获得市场验证与认可。我们期待凌科的多个差异化显著的管线在后续的临床验证中展现出突破性潜力，也相信在一支富有执行力和使命感的团队带领下，凌科药业将继续稳步穿越周期，拥抱广阔的蓝海市场，早日为患者提供更好的选择。" 关于凌科药业 凌科药业成立于2018年，由来自辉瑞 (Pfizer)、默克 (Merck) 和强生 (Johnson & Johnson) 的资深药物研发专家和高管共同创立，是一个临床阶段的新药研发公司。公司致力于发现和开发用于治疗癌症以及免疫和炎症性疾病的创新药物。在更高目标的驱动下，凌科药业旨在成为市场领导者，通过开发创新疗法，满足未被满足的临床需求。至今为止，凌科药业已经开发出多款自主研发的一类临床新药，并独立或携手国际合作伙伴在全球展开了多个临床实验 。如需了解更多关于凌科药业的信息请访问：https:\/\/www.lynkpharma.com0 。 关于盛世投资 盛世投资于2010年在北京成立，是中国母基金行业的先行者、领先者、布道者。基于全国性布局资源优势及专业投资管理能力，盛世投资构建了母基金、S基金、直投基金、项目制基金、并购及定增交易等多元化业务形态，致力于成为中国更懂管理和退出的私募股权投资管理机构。秉承市场化、专业化、产业化之道，盛世投资深度聚焦集成电路、新一代信息技术、医疗健康、先进制造、新能源、新材料等重点产业，投资覆盖天使、VC、PE、并购等全阶段，以创新引领产业转型升级，赋能实体经济高质量发展。多年来，盛世投资不断深入践行ESG投资，以实现经济效益、环境效益和社会效益多赢，打造机构长效竞争优势，携手合作方共赴可持续未来。 绍兴滨海新区管理委员会于2020年8月设立绍兴滨海新区生物医药产业股权投资基金,由盛世投资担任执行事务合伙人。基金按照"政府引导、市场运作、科学决策、防范风险"的原则开展运作管理，充分贯彻落实绍兴及滨海新区经济发展战略。基金总规模100亿元，主要采取"子基金+直投"模式进行投资，围绕建设绍兴生物医药"万亩千亿"新产业平台开展投资活动，支持市、区两级政府生物医药为主的新兴产业做大做强。 关于联新资本 联新资本成立于2008年，是一家专注于私募股权和创业投资的基金管理公司。联新资本的主要投资方向包括科技、媒体和电信（TMT）以及医疗健康领域，涵盖早期、成长期和成熟期各个阶段的企业。至今已完成120多项投资，其中包括近30家国内外上市企业，培育了一批行业领军者。 关于海邦投资 海邦投资于2010年在杭州成立，始终坚持专业化、精细化的投资方向，围绕生命健康、数字经济、新材料和高端制造等重点领域持续深耕布局。在早期项目的投资与引进上不断探索、总结，逐步形成具有自身优势的"科技+人才"的独特投资模式，为促进高端人才集聚、帮扶人才创业创新、推动人才企业进入资本市场等方面做出了重要贡献。 关于好买母基金 好买财富成立于2007年，是领先的第三方财富管理公司，好买母基金是好买财富旗下从事私募股权投资的母基金，管理母基金、行业基金、跟投基金等多支基金，投资管理规模近200亿人民币。以扎实的行业研究为基础，重点布局医疗健康、硬科技、TMT、消费等行业，致力于成为助力创业者、成就卓越基金的合作伙伴。 关于礼来亚洲基金 礼来亚洲基金（LAV）是业界具有领导力的生命科学和医疗健康风险投资基金，在上海、香港和美国硅谷均有设立办公室。作为最早在中国开始耕耘的生物医药专业基金之一，LAV十多年来一直持续投资中国医疗健康产业。建立以突破性产品战胜疾病并改善人类健康的伟大公司和成为杰出创业者寻求智慧资本时的可靠伙伴关于浩悦资本 浩悦资本创立于2014年1月，是中国领先的专注医疗健康行业的产业投行。公司总部位于上海，在北京和深圳设立区域办公室。浩悦资本始终致力于以资本助力，以研究驱动，帮助中国医疗行业优秀企业成功对接资本市场，为客户创造增值价值。浩悦资本的合伙人团队由深耕中国医疗健康领域多年的资深投资银行家组成，专业团队人数超过70名。浩悦资本长期密切追踪医疗健康投资市场动态和投资趋势，研究领域及交易范围覆盖创新医药、创新医疗器械、IVD与生命科学、健康服务和智慧医疗等多个细分赛道。2022年，浩悦资本完成了超过50笔私募融资、并购整合和上市公司分拆复杂交易，交易总额数百亿元人民币，在医疗行业各细分赛道全面领先。 内容来源于网络，如有侵权，请联系删除。

HANGZHOU, China, Sept. 21, 2023 /PRNewswire/ -- Lynk Pharmaceuticals Co., Ltd. (hereinafter referred to as 'Lynk Pharmaceuticals'), an innovative clinical stage company, today announced the successful completion of Series C2 financing. This round of financing was jointly participated by the Shaoxing Binhai New Area Biomedical Industry Equity Investment Fund managed by China Grand Prosperity Investment, Haibang Venture and Howbuy Primary Fund, while original shareholders, New Alliance Capital and Lilly Asia Ventures (LAV), increased their investment. Following Series C1 financing on May 31, this new funding marks another step in the company's continuous growth, bringing the total amount raised in the C-round to 322 million RMB. HaoYue Capital acted as the exclusive financial advisor in this transaction. Founded in 2018, Lynk Pharmaceuticals is a leading company dedicated to the research and development of FIC and BIC drugs targeting autoimmune diseases, inflammation, and oncology. Leveraging the core team's extensive background in medicinal chemistry, biology, clinical development, and commercial development, and with an average of more than 20 years of experience in new drug research and development, Lynk Pharmaceuticals focuses on innovative and differentiated pipeline development. The core of the pipeline is centered around the development of second-generation highly selective and third-generation tissue-specific JAK inhibitors, while also exploring the potential of innovative target-based drug development. Since its establishment, efficient execution has propelled Lynk Pharmaceuticals rapid development. In the past three months, the Phase II clinical trial data for LNK01001 in rheumatoid arthritis, atopic dermatitis, and ankylosing spondylitis have been successively released, with all results demonstrating significant therapeutic effects and a high level of safety. These results highlight the characteristics of small molecule JAK1 inhibitors, that have quick onset action and excellent efficacy. The company has submitted applications for the End of Phase II (EOP2)/Pre-Phase III meeting; several indications are poised to enter Phase III clinical trials, aiming to benefit more patients as soon as possible. Additionally, first patient dosing was achieved in a Phase 1b trial of LNK01004 in both psoriasis and atopic dermatitis in the first half of this year. The early clinical trial data fromLNK01002 and LNK01003 are also promising while the pre-clinical pipeline development is progressing steadily as well. Lynk Pharmaceuticals innovative research and clinical development capabilities have been continuously validated and enhanced, positioning the company for a crucial stage of rapid value growth. According to Frost & Sullivan's projections, the market size for JAK1 inhibitors is expected to reach $30.5 billion by 2030, underscoring the significant potential of the future market. Leveraging the considerable market demand in autoimmune diseases and oncology, the company holds substantial commercialization prospects. Dr. Zhao-Kui (ZK) Wan, Chairman and CEO of Lynk Pharmaceuticals, said, "We are grateful for the support and trust from Shaoxing Binhai New Area Biomedical Industry Equity Investment Fund （managed by China Grand Prosperity Investment）, New Alliance Capital, Fenghua Venture, Howbuy Primary Fund and Lilly Asia Ventures (LAV) for this round of investment. We also thank Tailong Capital and Liando Investment, the series C1 round investment institutions. Together they have helped us successfully complete the C round of financing. As a company focused on the treatment of autoimmune diseases and oncology, Lynk Pharmaceuticals is committed to developing globally competitive FIC/BIC innovative drugs and delivering differentiated and innovative therapeutic solutions to patients worldwide. We are pleased to see that even amidst the current challenges in the biopharmaceutical capital landscape, Lynk Pharmaceuticals continues to gain support from both new and existing shareholders, demonstrating the capital market's recognition of our team. During this rapid growing stage, we will need to consolidate resources from various aspects, further invest in clinical development, R&D teams, and technology platforms, aiming to provide safer and more effective innovative drugs to patients as early as possible. HaoYue Capital acted as the exclusive financial advisor for this financing, and we sincerely appreciate their professionalism and support." Mr. Ding Yameng, Founding and Managing Partner and Chief Operating Officer of HaoYue Capital, said, "We are honored to continue assisting Lynk Pharmaceuticals in completing this round of financing. The field of autoimmune diseases is diverse and complex, with significant room for expanding indications and numerous unmet clinical needs, offering distinct opportunities for innovation. Lynk Pharmaceuticals has an internationally competitive and innovative pipeline that is continuously gaining market validation and recognition. We look forward to seeing breakthrough potentials in subsequent clinical validations of multiple highly differentiated candidates from Lynk. We believe that under the guidance of a highly capable and mission-driven team, Lynk Pharmaceuticals will steadily navigate through cycles, embrace the vast blue ocean markets, and provide better choices for patients soon." About Lynk Pharmaceuticals: Lynk Pharmaceuticals, a clinical stage company, was founded in 2018 by senior drug R&D experts and executives from Pfizer, Merck, and Johnson & Johnson. Lynk Pharmaceuticals is dedicated to the discovery and development of innovative drugs for the treatment of cancer, as well as autoimmune and inflammatory diseases. Driven by a higher goal, Lynk Pharmaceuticals aims to be a market leader to address unmet medical demands by the development of innovative therapies. To date, Lynk Pharmaceuticals has independently developed several innovative new drugs and successfully completed a number of clinical studies. For more information about Lynk Pharmaceuticals, please visit: About China Grand Prosperity Investment: Founded in Beijing in 2010, China Grand Prosperity Investment (Prosperity Investment) plays an important role as a pioneer, leader and advocate of China's FOFs. Based on the advantages of national layout resources and professional asset management capabilities, Prosperity Investment has developed diversified business models such as FOF, secondary fund, direct investment fund, case fund, M&A and PIPE. Prosperity Investment is committed to growing into a local private equity asset management institution which has a better understanding of management and exit strategies in China. Adhering to a market-oriented, professional and industrialized approach, Prosperity Investment has a core focus on strategic emerging industries such as semiconductors, next generation information technology, healthcare, advanced manufacturing, new energy, and new materials. Their investments cover all stages ranging from angel, VC, PE, to M&A, and aim to promote industrial transformation and improvement through innovation and empowerment of high-quality development for a better economy. Over the years, Prosperity Investment has always adhered to the ESG investment philosophy, aiming to achieve win-win economic, environmental and social benefits, including building long-term competitive advantages and working alongside their partners for a sustainable future. Shaoxing Binhai New Area Management Committee established the Shaoxing Binhai New Area Biopharmaceutical Industry Equity Investment Fund in August 2020. Prosperity Investment acted as the executive affairs partner. The fund operates and manages according to the principles of "guidance from government, market operation, scientific decision-making, and risk prevention", fully implementing the economic development strategy of the Shaoxing and Binhai New Area. The total size of the fund is 10 billion yuan. It mainly uses the "sub-fund + direct investment" model for investment and invests in the construction of Shaoxing's new industrial platform of "10,000 acres of land, 100 billion yuan" in the biopharmaceutical industry, to support the development and growth of emerging industries led by the biopharmaceutical industry at the municipal and district levels. About New Alliance Capital: New Alliance Capital was established in 2008 and is a fund management company specializing in private equity and venture capital. The main investment directions of New Alliance Capital include TMT and healthcare, covering early, growth, and maturity stages. So far, more than 120 investments have been completed, including nearly 30 IPOs/listed enterprises both domestically and internationally, cultivating a group of industry leaders. About Haibang Venture: Haibang Venture was established in Hangzhou in 2010. Haibang has always adhered to a professional and refined investment direction, continuously deepening its presence in critical areas such as life and health, the digital economy, new materials, and high-end manufacturing. For early-stage projects, the fund has explored and summarized a unique investment model characterized by "technology + talent" based on solid industry research. This model has significantly contributed to attracting high-end talents, supporting talent entrepreneurship and innovation, and promoting talent enterprises to enter the capital market. About Howbuy Primary Fund: Howbuy, founded in 2007, is a leading independent third-party wealth management company. Howbuy Primary Fund is an affiliated department engaged in VC/PE investment under Howbuy with nearly 20 billion RMB in FOF, industry funds, and co-investment funds under management. Howbuy Primary Fund focus on outstanding funds and companies in healthcare, deep technology, TMT, industrial digitalization and consumer industry. About Lilly Asia Ventures(LAV): Lilly Asia Ventures (LAV) is a leading biomedical venture capital firm founded in 2008, with offices in Shanghai, Hong Kong, and Palo Alto. Our vision is to become the trusted partner for exceptional entrepreneurs seeking smart capital and to build great companies developing breakthrough products that treat diseases and improve human health. About HaoYue Capital HaoYue China Healthcare Fund is a private equity investment fund specializing in China healthcare. With the help of HaoYue Capital's investment banking business, HaoYue China Healthcare Fund invests in healthcare companies with extraordinary growth potential. They empower the success of their portfolio companies and serve investors with returns above market average. They invest in leading companies in key areas across biopharma, medical devices, healthcare services & digital health, and IVD & precision medicine. HaoYue China Healthcare Fund is a private equity investment fund, specializing in China healthcare. SOURCE Lynk Pharmaceuticals Co., Ltd.