An Exploratory, Multi-Centre, Interventional, Prospective, Randomised, Double-Blind, Placebo-Controlled Clinical Trial to Assess the Safety and Efficacy of AON-D21 in Patients With Severe Community-Acquired Pneumonia.

The goal of this clinical trial is to compare the safety and efficacy of AON-D21 versus placebo, both on top of standard of care, in patients with severe community acquired pneumonia admitted to ICU (or similar unit). The main questions to answer are:
* The safety and tolerability of AON-D21 vs placebo.
* The efficacy of AON-D21vs placebo.
* The pharmacokinetics of AON-D21.
* The pharmacodynamics of AON D21.
* To identify biomarkers for patient stratification and analyses in future trials.

开始日期2024-02-02

申办/合作机构

Aptarion Biotech Ag初创企业

NCT05343819 / Completed临床1期

A Randomized, Single-center, Double-blind, Placebo Controlled Trial With Ascending Multiple Intravenous Doses to Determine Safety, Tolerability and Pharmacokinetics of AON-D21 in Healthy Male Subjects.

The main purpose of this study is to evaluate safety, tolerability, pharmacokinetics and pharmacodynamic parameters after multiple ascending intravenous doses of AON-D21 in healthy male subjects.

开始日期2022-04-12

申办/合作机构

Aptarion Biotech Ag初创企业

NCT05018403 / Completed临床1期

A Randomized, Single-center, Double-blind, Placebo Controlled, First-in-human Trial With Single Ascending Intravenous Doses to Determine Safety, Tolerability and Pharmacokinetics of AON-D21 in Healthy Male Subjects

The main purpose of this study is to evaluate safety, tolerability, pharmacokinetics and pharmacodynamic parameters after single ascending intravenous doses of AON-D21 in healthy male subjects.

开始日期2021-08-03

申办/合作机构

Aptarion Biotech Ag初创企业

100 项与 AON-D21 相关的临床结果

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100 项与 AON-D21 相关的转化医学

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100 项与 AON-D21 相关的专利（医药）

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项与 AON-D21 相关的文献（医药）

2017-12-01·Stem Cell Reviews and Reports3区 · 医学

Signaling of the Complement Cleavage Product Anaphylatoxin C5a Through C5aR (CD88) Contributes to Pharmacological Hematopoietic Stem Cell Mobilization

3区 · 医学

Article

作者: Ratajczak, Mariusz Z ; Yan, Jun ; Vater, Axel ; Bujko, Kamila ; Hoehlig, Kai ; Rzeszotek, Sylwia

Several mechanisms have been postulated for orchestrating the mobilization of hematopoietic stem/progenitor cells (HSPCs), and we previously proposed that activation of the complement cascade plays a crucial role in the initiation and execution of the egress of HSPCs from bone marrow (BM) into peripheral blood (PB). In support of this notion, we demonstrated that mice deficient in the mannan-binding lectin (MBL) pathway, which activates the proximal part of the complement cascade, as well as mice deficient in the fifth component of the complement cascade (C5), which is part of the distal part of the complement cascade, are poor mobilizers. To further narrow down on the exact mechanisms and the molecules involved, we performed studies in mice that do not express the receptor C5aR, which binds the C5 cleavage fragments, C5a and C5a_desArg. We also employed the plasma stable nucleic acid aptamer AON-D21 that binds and neutralizes C5a and C5a_desArg. We present evidence that mice deficient in C5aR or treated with AON-D21 are poor HSPC mobilizers, thereby establishing a critical role for the C5a/C5a_desArg-C5aR axis in the mobilization process. While enhancing mobilization is of clinical importance for poor mobilizers, inhibition of the complement cascade could be of therapeutic importance in patients suffering from paroxysmal nocturnal hemoglobinuria (PNH) or acquired hemolytic syndrome (aHUS).

100 项与 AON-D21 相关的药物交易

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研发状态

10 条进展最快的记录,

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适应症	最高研发状态	国家/地区	公司	日期
社区获得性肺炎	临床2期	英国	Aptarion Biotech Ag初创企业	2024-02-02
社区获得性肺炎	临床2期	德国	Aptarion Biotech Ag初创企业	2024-02-02
社区获得性肺炎	临床2期	比利时	Aptarion Biotech Ag初创企业	2024-02-02
社区获得性肺炎	临床2期	西班牙	Aptarion Biotech Ag初创企业	2024-02-02
社区获得性肺炎	临床2期	法国	Aptarion Biotech Ag初创企业	2024-02-02
肺癌	临床1期	德国	Aptarion Biotech Ag初创企业	2022-08-25
阵发性睡眠性血红蛋白尿症	临床前	德国	Aptarion Biotech Ag初创企业	2017-12-07
阵发性睡眠性血红蛋白尿症	临床前	美国	University of Louisville	2017-12-07