Endovenous interventions are keyhole operations for varicose veins that are carried out from within the vein itself. Varicose veins are enlarged veins close to the surface of the skin. They are connected to the bigger deeper veins in the leg (known as deep veins). Because of this, operations to close the varicose veins can increase the chance of a blood clot forming in the deep veins. Blood clots in the deep veins happen in around 1 in 50 people after endovenous operations. A clot in the leg can cause swelling, pain, and other long-term problems. If a clot in the leg breaks off and travels to the lungs, it can cause problems with the lung' ability to move oxygen from the air into the blood and may, in rare cases, be life threatening.
Varicose vein procedures may carry a slightly higher risk of blood clot formation, and we are currently unsure if current clot reducing medicines are beneficial in preventing blood clots in people having varicose vein procedures.
This study will investigate if it is worthwhile prescribing medicines to reduce blood clots after varicose vein procedures.

开始日期2024-01-22

申办/合作机构

Imperial College London

CTIS2022-502426-41-00

/ Recruiting临床3期IIT

Thromboprophylaxis in good and intermediate prognosis advanced germ cell tumors (GIG-T)

开始日期2023-10-17

申办/合作机构

Institut Gustave Roussy EURL

100 项与亭扎肝素钠相关的临床结果

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100 项与亭扎肝素钠相关的转化医学

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100 项与亭扎肝素钠相关的专利（医药）

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451

项与亭扎肝素钠相关的文献（医药）

2026-01-02·Cureus Journal of Medical Science

A Regional Audit on Venous Thromboembolism (VTE) Prophylaxis Compliance and Cultural Considerations in Prescribing Porcine-Derived Low-Molecular-Weight Heparins

Article

作者: Norouzi, Mohsen ; Mujahid, Isra ; Ahmed, Husain ; Ahmad, Shibbir ; Mujahid, Minahil ; Maheshwari, Geeta ; Ur-Rehman, Junaid ; Prudon, Ben

BACKGROUND:

Hospital-acquired venous thromboembolism (VTE) remains a leading cause of preventable mortality in the NHS. NICE guidelines (NG89) mandate timely risk assessment and prophylaxis, yet practice varies widely. Many low-molecular-weight heparins (LMWHs), such as tinzaparin, are porcine-derived, posing ethical challenges for patients with specific dietary or religious beliefs.

OBJECTIVE:

The objective of this study is to evaluate adherence to NICE NG89 guidelines on VTE prophylaxis across two hospitals, with a particular focus on culturally sensitive prescribing. This audit also assessed clinician awareness of LMWH origins and explored patient preferences around dietary compliance. The impact of targeted interventions was measured across two audit cycles.

METHOD:

A prospective two-cycle audit was conducted at two NHS hospitals in North East England, The James Cook University Hospital (JCUH) and University Hospital North Tees (UHNT), between March 2024 and January 2025. Patients with dietary requirements were identified via catering records and surveyed. A doctor questionnaire assessed awareness and counselling practice. Interventions included staff education, posters, prescribing alerts, and community outreach.

RESULTS:

Cycle one included 76 patients. Cycle two included 61 patients. VTE risk assessment improved by 14% at UHNT; JCUH maintained 100% compliance. However, timely prophylaxis fell in UHNT, with 80% receiving it late. Documentation and discussions regarding VTE and dietary compliance improved but remained suboptimal. Leaflet distribution rose by 10% at JCUH but was absent at UHNT. Notably, 98% (n = 137) of patients prioritised medication aligned with their beliefs, and nearly half would decline porcine-derived prophylaxis even if it prevented serious illness. Clinician questionnaire data showed 64% (n = 50) were unaware that LMWHs are animal-derived, and 94% (n = 50) did not inform patients, citing time pressures and limited knowledge.

CONCLUSION:

While guideline compliance improved following intervention, particularly for risk assessments and documentation, major gaps remain in patient communication and dietary-informed prescribing. Most patients expected transparency and alternatives to porcine-based medications. Future efforts must embed dietary screening into routine prescribing and strengthen shared decision-making through structured education and culturally competent communication strategies.

2026-01-01·Research and Practice in Thrombosis and Haemostasis

The Ottawa score for prediction of recurrent venous thromboembolism in cancer patients treated with tinzaparin: an individual patient data meta-analysis

Article

作者: Jara-Palomares, Luis ; Laporte, Silvy ; Mahé, Isabelle ; Poenou, Géraldine ; Girard, Philippe ; Mismetti, Patrick ; Lee, Agnès Y Y ; Sanchez, Olivier ; Meyer, Guy ; Chapelle, Céline

Background:

Risk of venous thromboembolism (VTE) recurrence remains high in patients with cancer-associated thrombosis (CAT), despite therapeutic anticoagulation. Identifying patients at risk of treatment failure is still a challenge.

Objectives:

We aimed to assess the performance of the Ottawa score in predicting VTE recurrence in a large homogeneous population of patients with CAT treated with the same anticoagulant, tinzaparin, for at least 3 months.

Methods:

Individual patient data from 3 prospective cohort studies and 1 randomized controlled trial were pooled (PROSPERO: CRD42019119907). Clinical events of interest were adjudicated by independent central adjudication committees in all 4 studies.

Results:

Among the 1413 patients included, the Ottawa score could be calculated for 1088 of whom 646 (59.4%) were classified at high risk of recurrence (Ottawa score ≥ 1). The 6-month cumulative incidence of recurrent VTE was 5.0% (95% CI, 3.2-7.8) in the Ottawa low-risk group and 8.5% (95% CI, 6.6-10.8) in the high-risk group. The area under the receiver operating characteristic curve was 0.56 (95% CI, 0.51-0.62). The sensitivity of the dichotomized Ottawa score (score ≥ 1) was 72.8% (95% CI, 62.6%-83.0%), the specificity was 41.9% (95% CI, 37.8%-45.9%), the positive predictive value was 8.6% (95% CI, 6.4%-10.8%), and the negative predictive value was 95.3% (95% CI, 93.3%-97.4%). Introducing additional predictive factors failed to significantly improve the score's performance.

Conclusions:

Despite the large number of patients and anticoagulant treatment standardization, the Ottawa score failed to accurately predict recurrent VTE in patients with CAT treated with tinzaparin.

2025-11-01·Research and Practice in Thrombosis and Haemostasis

Comparative safety of enoxaparin versus other low-molecular-weight heparins in cancer-associated venous thromboembolism: a real-world cohort study from RIETE

Article

Background:

Low-molecular-weight heparins (LMWHs) are widely used in the treatment of cancer-associated venous thromboembolism (VTE), yet their long-term safety profiles remain insufficiently compared in clinical practice.

Objectives:

The primary outcome was major bleeding over a 6-month follow-up. Secondary outcomes included VTE recurrence, non-major clinically relevant bleeding, and all-cause mortality.

Methods:

We analyzed 7287 patients with active cancer and acute VTE from the RIETE registry (2009-2022) who were treated with full-dose enoxaparin (n = 5628) or tinzaparin/dalteparin (n = 1659). Analyses were adjusted using multivariable Cox models, Fine-Gray competing risk models, frailty models clustered by center, and propensity score approaches.

Results:

Major bleeding occurred in 3.84% of patients receiving enoxaparin versus 2.53% in the tinzaparin/dalteparin group (adjusted hazard ratio [aHR] 1.56; 95% CI: 1.11-2.19), with consistent findings across all sensitivity analyses. Enoxaparin was also associated with higher all-cause mortality (28.3% vs 25.1%; aHR 1.22; 95% CI: 1.09-1.37). No significant differences were observed in VTE recurrence (3.59% vs 3.07%) or non-major bleeding (3.98% vs 3.25%). Importantly, during the first 10 days of therapy, major bleeding occurred in 1.2% of patients treated with enoxaparin twice-daily, compared to 0.4% with once-daily dosing and 0.1% in the tinzaparin/dalteparin group (P < .001).

Conclusion:

In this large, observational study, enoxaparin, particularly in twice-daily regimens, was associated with significantly increased risks of bleeding and mortality compared to tinzaparin/dalteparin. These findings may help refine LMWH selection and dosing strategies in patients with cancer-associated VTE and warrant further investigation in prospective studies.

项与亭扎肝素钠相关的新闻（医药）

2025-07-17

·FiercePharma

Leo Pharma's slow response to app lapse scolded by UK marketing watchdog

Leo Pharma accepted that “appropriate actions were not taken to rectify the issue immediately” with its Innohep app. Leo Pharma’s inaccurate Innohep app has prompted a slap-down from the PMCPA. The U.K. marketing watchdog ruled Leo brought discredit on the pharma industry by leaving the app live for three months after the errors were discovered. Two healthcare professionals complained to the PMCPA about an app for patients prescribed Innohep, Leo’s tinzaparin sodium product. The app presented information from the patient information leaflet, and users were prompted to select their prescribed dosage and shown information on injection technique.Both complainants flagged inaccuracies in the dosing information presented in the app. A Leo employee identified the errors in August 2024, and Leo’s medical affairs team learned of the inaccuracies the next day, according to the PMCPA report, yet the app was still available when the PMCPA contacted Leo in November. Leo deactivated the app and made an updated version available within two weeks of being contacted by the PMCPA.Responding to the marketing authority, Leo said two senior medical affairs employees concluded that the full volume of the syringe would always be administered, despite any conflicting information in the app, and, as such, the inaccuracies didn’t affect patient safety. The PMCPA panel took a dim view of Leo’s conclusion, stating that inaccurate dosing information is a serious matter regardless of the likelihood of a safety issue. The panel said it “was extremely concerned about Leo Pharma’s lack of urgency” and the company’s “conscious decision to keep the app live with the inaccuracies for approximately three months.” The dosage volume inaccuracies and failure to withdraw the app immediately could “reduce confidence in the industry being able to produce patient material to the required quality standards,” the panel said.Leo accepted that “appropriate actions were not taken to rectify the issue immediately.” The company listed mitigating factors that may have played a role in the failings, including a disruption that affected the company from July, when the app was certified, to October, when Leo was still working through its response to the inaccuracies. “At the time of this issue occurring there was a reorganization of the thrombosis business impacting resource and headcount; many colleagues’ roles were placed at risk of redundancy. There was no dedicated medical support for the U.K. thrombosis business at this time,” Leo said. “Whilst this does not negate the seriousness of the issue and decisions made, we believe this to be a contributing factor.”The PMCPA appeal board opted against imposing additional sanctions on Leo. The board reached the decision after assessing Leo’s work to enhance its governance, train staff and update its processes to add checks and scrutiny. Leo said “it was not experienced with creating and managing apps and had relied on external expertise,” according to the PMCPA, and would act differently if in the same situation today.

专利侵权

2023-11-06

·PRNewswire

Global Antithrombotic/Anticoagulant Drugs Market Set to Reach $46.2 Billion by 2028 with a 7.9% CAGR

DUBLIN, Nov. 6, 2023 /PRNewswire/ -- The "Antithrombotic/Anticoagulant Drugs: Technologies and Global Markets" report has been added to ResearchAndMarkets.com's offering. The global antithrombotic/anticoagulant drugs market is expected to reach $46.2 billion in 2028 from $31.6 billion in 2023 at a CAGR of 7.9%. This report discusses the implications of the trends mentioned above in the context of the current size and growth of the antithrombotic/anticoagulant drugs market, in global terms and by the most important national markets. Companies in the relevant pharmaceutical and medical industries are discussed, with profiles of the leaders and an update on M&A activity. Five-year global sales forecasts are provided for the leading drug categories and the country offers breakdowns of the antithrombotic/anticoagulant drugs market. Major players, competitive intelligence, innovative technologies, market dynamics and regional opportunities are discussed in detail. The report examines recent developments and product portfolios of major players. The patent analysis focuses on technological trends in recent years in regions such as the U.S., Europe, and Japan. The report presents a market analysis and estimates the compound annual growth rate (CAGR) for the antithrombotic/anticoagulant drugs market. This report segments the global market by these geographic regions: North America, Europe, Asia-Pacific, and the Rest of the World. For market estimates, data are provided for 2022 as the base year, forecasted through 2023-2028. Companies Mentioned Bayer AG Boehringer Ingelheim International GmbH Bristol Myers Squibb Daiichi Sankyo Co. Ltd. F. Hoffmann-La Roche Ltd. Johnson & Johnson Services Inc. Merck & Co. Inc. Pfizer Inc. Sanofi Report Includes 59 data tables and 35 additional tables Overview and an up-to-date analysis of the global markets for antithrombotic/anticoagulant drugs for the treatments of thrombotic (cardiovascular) disease Analyses of the global market trends, with historical market revenue data (sales figures) from 2020 to 2022, estimates for 2023, and projections of compound annual growth rates (CAGRs) through 2028 Examination of the market potential for antithrombotic/anticoagulant drugs, and quantification of the global market for these drugs and its market segments and sub-segments over the next five years Estimate of the actual market size and revenue forecast for the market, and corresponding market share analysis based on product type, application and region In-depth information (facts and figures) pertaining to the market drivers, challenges, opportunities and prospects, as well as the technologies, regulatory scenarios and impact of COVID-19 A look at the major vendors in the global market for antithrombotic/anticoagulant drugs, and analysis of the healthcare industry structure, including market shares and recent mergers and acquisitions (M&A) activity Review of key patent grants and a look at breakthrough innovations, novel products, upcoming trends and technologies, and emerging applications for cardiovascular treatments Insight into the importance of ESG in the worldwide market, with a look at consumer attitudes, risks and opportunities assessment, and ESG practices followed by manufacturers and service providers Identification of the major stakeholders, and analysis of the competitive landscape based on recent developments, key financials and segmental revenues, and operational integration Profiles of the leading market players The following are the main conclusions reached in this report regarding antithrombotic and anticoagulant drugs: Recent innovations and the emergence of novel thrombin inhibitors have led to the decrease in revenue of traditional anticoagulants such as heparin and Vitamin K antagonists. Low molecular weight heparins, such as Fragmin (-11.8%) and Innohep (-14.1%), have seen a significant decrease in the market. The anticoagulant drug market will continue to grow at a slow rate compared to antiplatelet and thrombin inhibitors segment due to the lack of new drug launches since the expiration of the patent on Plavix. The anticoagulant segment is expected to decline soon as prices fall and the market for novel thrombin inhibitors grows. The market for thrombin inhibitors is expected to grow at the highest CAGR of 8.1% over the forecast period of 2023 to 2028. Xarelto (rivaroxaban), Eliquis (apixaban), TNKase (tenecteplase) and Savaysa (edoxaban) are the major contributors to the high growth rate of thrombin inhibitors. An aging population and the increased prevalence of cardiovascular disease worldwide fueled by a Westernized diet and lifestyle have created new opportunities for antithrombotic/ anticoagulant drug products. Key Topics Covered: Chapter 1 Introduction Chapter 2 Summary and Highlights Market Outlook Market Summary Chapter 3 Market Overview Overview of Cardiovascular Disease Coronary Artery Disease Atherosclerosis Angina (Angina Pectoris) Acute Myocardial Infarction Medical Management Lifestyle Changes Diet Modification Smoking Cessation Pharmaceuticals Anticoagulants and Antiplatelet Drugs Major Drivers Coagulation Factors Targeted to Reduce Cvd The Global Burden of Cardiovascular Disease 2030 Global Burden of Cardiovascular Disease The Global Economic Burden of Cardiovascular Disease Sales Performance of Major Drugs in 2022 Chapter 4 Global Market for Anticoagulant Drugs Overview Products Low Molecular Weight Heparin Oral Anticoagulants (Vitamin K Antagonists) Global Anticoagulant Drugs Market Forecast Chapter 5 Global Market for Antiplatelet Drugs Overview Products Oral Antiplatelets Global Antiplatelet Drugs Market Forecast Chapter 6 Global Market for Thrombin Inhibitors Overview Products Direct Thrombin Inhibitors Thrombolytic Agents Direct Factor Xa Inhibitors Global Thrombin Inhibitors Market Forecast Chapter 7 Global Market for Antithrombotic/Anticoagulant Drugs by Region Overview North America Europe Asia-Pacific Rest of the World Chapter 8 Sustainability in the Market for Antithrombotic/Anticoagulant Drugs: An ESG Perspective Introduction to ESG Sustainability in Market for Antithrombotic/Anticoagulant Drugs: An ESG Perspective Key ESG Issues Consumer Attitudes Towards ESG Industry ESG Performance Analysis Case Study Concluding Remarks Chapter 9 Clinical Trials and Patent Landscape Clinical Trials Analysis Patent Analysis Patent by Assignee Chapter 10 M&A and Venture Funding Outlook Chapter 11 Competitive Landscape Chapter 12 Company Profiles Chapter 13 Appendix For more information about this report visit About ResearchAndMarkets.com ResearchAndMarkets.com is the world's leading source for international market research reports and market data. We provide you with the latest data on international and regional markets, key industries, the top companies, new products and the latest trends. Media Contact: Research and Markets Laura Wood, Senior Manager [email protected] For E.S.T Office Hours Call +1-917-300-0470 For U.S./CAN Toll Free Call +1-800-526-8630 For GMT Office Hours Call +353-1-416-8900 U.S. Fax: 646-607-1907 Fax (outside U.S.): +353-1-481-1716 Logo: SOURCE Research and Markets

100 项与亭扎肝素钠相关的药物交易

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外链

KEGG	Wiki	ATC	Drug Bank
D06398	亭扎肝素钠	B01AB10	DB06822

研发状态

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适应症	国家/地区	公司	日期
肺栓塞	美国	LEO Pharma A/S	2000-07-14
静脉血栓形成	美国	LEO Pharma A/S	2000-07-14
血栓形成	加拿大	Novo Nordisk Canada, Inc.	1994-12-31

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适应症	最高研发状态	国家/地区	公司	日期
静脉血栓栓塞	临床3期	斯洛伐克	LEO Pharma A/S	2010-06-09
下肢急性深静脉血栓形成	临床3期	捷克	LEO Pharma A/S	2007-06-28

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临床结果

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


NCT05625932 (PROTINCOL, Pubmed \| BMC Cancer)	临床3期	转移性结直肠癌一线	526	Tinzaparin	醖鹹選鏇夢鬱簾餘憲築(鹽獵餘範鑰鹽醖壓鑰繭) = 範範蓋鑰襯構選淵製築膚顧願衊製衊獵襯構遞 (觸膚憲糧簾繭餘遞鹹糧 ) 更多	积极	2025-11-17
ISTH2022	N/A	浅表血栓性静脉炎	147	tinzaparin	積鏇簾鏇簾蓋憲衊鏇窪(願餘獵顧齋廠襯窪襯壓) = 餘獵壓衊觸繭醖齋夢夢齋顧餘淵鹽繭淵顧繭餘 (繭憲選淵顧鑰齋築築築 )	-	2022-07-09
Onco-CAST (ASCO2022)	临床4期	结直肠癌	175	Tinzaparin 8.000 Anti-Xa IU	窪觸積襯製壓獵壓積構(襯願餘窪餘醖積鹹蓋願) = 鑰獵繭鏇製艱獵鏇齋憲繭構築選廠衊繭構願築 (憲膚觸鏇鏇構鏇壓範製, 2.3 ~ 8.8) 更多	-	2022-06-02
NCT01455831 (Periop-01, ASCO_GI2022) 人工标引	临床3期	结直肠癌	602	Tinzaparin Sodium (Extended peri-operative thromboprophylaxis)	選製構醖糧範艱繭築淵(範鏇醖願齋膚壓繭鹽壓) = 繭襯築蓋獵網蓋遞鏇鏇壓遞鏇繭糧齋廠鬱鏇齋 (鹹獵獵夢壓艱襯鏇觸餘 ) 更多	非优	2022-01-19
NCT01455831 (Periop-01, ASCO_GI2022) 人工标引	临床3期	结直肠癌	602	Tinzaparin Sodium (Standard thromboprophylaxis)	選製構醖糧範艱繭築淵(範鏇醖願齋膚壓繭鹽壓) = 願糧膚遞壓鬱憲齋觸簾壓遞鏇繭糧齋廠鬱鏇齋 (鹹獵獵夢壓艱襯鏇觸餘 ) 更多	非优	2022-01-19
iCaLT study (ERS2021)	N/A	肺癌	60	Tinzaparin 0.5 ml, 10.000 Anti-Xa IU	壓繭遞製衊網餘衊蓋糧(糧齋鹹願憲衊觸襯壓繭) = Low in patients with bleeding compared to others 獵遞鹽鹹糧膚積獵夢構 (構鹽願鏇顧觸夢膚鹹積 )	积极	2021-09-05
ISTH2020	N/A	静脉血栓栓塞	287	Weight-adjusted Tinzaparin	齋鏇壓憲選窪艱簾積積(構鏇製憲遞淵願衊襯膚) = 簾窪餘鹹積窪觸鹹蓋繭範積積繭網夢糧遞鏇糧 (製壓廠糧艱餘鑰鑰簾繭 )	-	2020-07-12
ISTH2020	N/A	静脉血栓栓塞	287	No prophylaxis or subcutaneous UFH	齋鏇壓憲選窪艱簾積積(構鏇製憲遞淵願衊襯膚) = 獵選襯衊獵廠鹽鬱遞鹽範積積繭網夢糧遞鏇糧 (製壓廠糧艱餘鑰鑰簾繭 )	-	2020-07-12
PROSPERO CRD42020139413 (ISTH2020)	N/A	慢性肾病	1,831	Tinzaparin	餘鹽範鏇廠夢艱夢衊廠(築夢簾繭構膚築襯餘餘) = 窪醖遞鑰範膚獵糧獵壓壓築夢網餘衊獵願醖夢 (範襯築遞願廠積築淵築, (0.85 ~ 3.61)) 更多	-	2020-07-12
TROPIQUE (ISTH2020)	N/A	血栓形成	-	Long-term tinzaparin treatment	夢醖遞構淵夢夢壓獵淵(範窪構遞夢膚糧築鹽齋) = 襯願遞鹽壓鹽顧糧淵衊憲窪憲淵鏇襯製憲衊廠 (廠獵範鏇顧獵艱壓網衊 ) 更多	积极	2020-07-12
NCT01130025 (CATCH Study \| IN 0901 INT, Pubmed \| Thromb Haemost)	临床3期	出血 \| 肿瘤 \| 肾功能不全 ... 更多	864	tinzaparin	顧鏇膚夢夢鬱願鑰醖繭(繭簾積膚鹹壓醖鹽廠衊) = 壓繭鹽餘醖範觸獵遞襯遞鹽餘壓製顧鏇艱衊鬱 (膚衊齋繭製壓遞繭鏇夢 ) 更多	-	2018-05-01
	临床3期	出血 \| 肿瘤 \| 肾功能不全 ... 更多	864	warfarin	顧鏇膚夢夢鬱願鑰醖繭(繭簾積膚鹹壓醖鹽廠衊) = 簾簾醖築淵夢顧夢淵鏇遞鹽餘壓製顧鏇艱衊鬱 (膚衊齋繭製壓遞繭鏇夢 ) 更多	-	2018-05-01
NCT00186745 (TRIVET, ASH 12016 \| ASH 22016) 人工标引	N/A	慢性肾病	148	Tinzaparin (1st measurement (Day 3-5))	窪獵膚製遞鹽鬱糧廠願(鏇製膚積觸願簾獵憲廠) = 製憲鹽網遞觸獵鹽簾膚選憲廠顧遞窪遞餘憲鹽 (築鹹簾繭鏇遞糧選衊網, 0.22) 更多	积极	2016-12-02
NCT00186745 (TRIVET, ASH 12016 \| ASH 22016) 人工标引	N/A	慢性肾病	148	Tinzaparin (2nd measurement (Day 5-7))	窪獵膚製遞鹽鬱糧廠願(鏇製膚積觸願簾獵憲廠) = 繭淵鬱鹽鬱願醖窪構蓋選憲廠顧遞窪遞餘憲鹽 (築鹹簾繭鏇遞糧選衊網, 0.09) 更多	积极	2016-12-02