Endovenous interventions are keyhole operations for varicose veins that are carried out from within the vein itself. Varicose veins are enlarged veins close to the surface of the skin. They are connected to the bigger deeper veins in the leg (known as deep veins). Because of this, operations to close the varicose veins can increase the chance of a blood clot forming in the deep veins. Blood clots in the deep veins happen in around 1 in 50 people after endovenous operations. A clot in the leg can cause swelling, pain, and other long-term problems. If a clot in the leg breaks off and travels to the lungs, it can cause problems with the lung' ability to move oxygen from the air into the blood and may, in rare cases, be life threatening.
Varicose vein procedures may carry a slightly higher risk of blood clot formation, and we are currently unsure if current clot reducing medicines are beneficial in preventing blood clots in people having varicose vein procedures.
This study will investigate if it is worthwhile prescribing medicines to reduce blood clots after varicose vein procedures.

开始日期2024-01-22

申办/合作机构

Imperial College London

NCT05625932

/ Recruiting临床3期IIT

Prophylaxis of Venous Thromboembolic Disease With Low Molecular Weight (LMWH) (TINzaparin) in Patients With Metastatic Colorectal Cancer Who Start the First Line of Treatment.

Patients with metastatic colorectal cancer (mCRC) who are scheduled to receive systemic cancer therapy have an increased risk for venous thromboembolic (VTE) events compared with the general population.
PROTINCOL is a randomized, open label, non placebo-controlled, low intervention, and phase III clinical trial that will recruit patients with mCRC. The study hypothesizes that prophylaxis with Tinzaparin could prevent the appearance of symptomatic and incidental VTE.
All patients will receive the first-line anticancer treatment deemed more appropriate according to the physician criteria. Enrolled patients are randomized in a 1:1 ratio (stratifying by BRAF/RAS, resection of primary tumor, and anti-angiogenic first-line treatment) to: control arm (no interventions related to VTE risk and no placebo) or experimental arm (prophylactic Tinzaparin at a fixed dose of 4500 IU/day in patients with up to 80kg, 6000 IU/day for those between 80-100 kg, or 8000 IU/day for those >100kg). Treatment is scheduled for a maximum period of 4 months. Treatment could be stopped earlier in case of unacceptable toxicity, patient consent withdrawal, physician criteria or end of study. Patients will undergo tumor and VTE assessments according to standard clinical practice.
The main objective of the study is to evaluate the efficacy of tinzaparin for the prevention of symptomatic or incidental VTE events. Secondary objectives include the associations between VTE events and tumor characteristics (i.e. laterality, RAS/BRAF mutations) or management (i.e. surgery or treatment with anti-angiogenic or anti-EGFR agents), cancer-specific survival outcomes, safety, the incidence of bleeding events, and patient-reported quality of life. The trial includes also a translational exploratory analysis to assess the predictive value of risk assessment models and genetic risk scores, their evolution through the study and microsatellite instability or other biomarkers.

开始日期2023-03-02

申办/合作机构

Leo Pharma, Inc.

NCT05255003

/ Recruiting临床4期IIT

STrategies for Anticoagulation in Patients With thRombocytopenia and Cancer-associated Thrombosis

Patients with cancer are prone to have blood clots, which are usually treated with blood thinners. The main complication of blood thinners is bleeding. This is especially a concern when the number of platelets in the blood is lower than 50,000 per microliter. The role of platelets is to stop bleeding, so when the number of platelets is low, patients are at a higher risk of bleeding. Cancer patients are prone to have lower platelet numbers due to cancer therapies and/or cancer itself. It is not clear what the best treatment is for cancer patients who need blood thinners for a blood clot but have low platelet counts.
The investigators plan to do a small study called a pilot study to help plan for a larger study in such patients. In the pilot study, investigators will include 50 patients with cancer, low platelet counts, and a blood clot diagnosed within 4 weeks. Patients will be randomly assigned to one of the two treatment strategies: the full dose of blood thinners along with platelet transfusion or a reduced dose of blood thinners without platelet transfusion. The investigators will follow all patients for 90 days. If this pilot study is successful, it will help lead to a much larger trial, which will provide important information on the best treatment strategy in these patients.

开始日期2022-08-29

申办/合作机构

Ottawa Hospital Research Institute

100 项与亭扎肝素钠相关的临床结果

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100 项与亭扎肝素钠相关的专利（医药）

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521

项与亭扎肝素钠相关的文献（医药）

2025-04-01·ACTA ANAESTHESIOLOGICA SCANDINAVICA

Preferences for thromboprophylaxis in the intensive care unit: An international survey

Article

作者: Nassef, Mohamed ; Orde, Sam ; Krag, Mette ; Ananthan, Prakkash Parangi ; Meijer, Karina ; Mallat, Jihad ; Pilcher, David ; Meyhoff, Tine Sylvest ; Omar, Rania ; Ergan, Begum ; Bestle, Morten H. ; Heijkoop, Èmese Robin Hélène ; Alshamsi, Fayez ; Bhadange, Neeraj ; Troelsen, Thomas Tværmose ; Aslam, Tayyba Naz ; Poulsen, Lone Musaeus ; Ferrer, Ricard ; Al‐Fares, Abdulrahman A. ; Marella, Prashanti ; Anstey, Matthew H. ; Hjortrup, Peter Buhl ; Sigurdsson, Martin Ingi ; Eck, Ruben Julius ; Siegemund, Martin ; Blaser, Annika Reintam ; Nalos, Marek ; Mer, Mervyn ; Ostermann, Marlies ; Greco, Massimiliano ; van Haren, Frank M. P. ; Arabi, Yaseen M. ; Attokaran, Antony George ; Ho, Kwok M. ; Freebairn, Ross ; Jonmarker, Sandra ; Rai, Sumeet ; Brøchner, Anne Craveiro ; Kruger, Peter ; Young, Paul ; Elhoufi, Ashraf ; Morgan, Matthew ; Rasmussen, Bodil Steen ; Perner, Anders ; Abdelhadi, Adel ; Keus, Frederik ; Dąbrowski, Wojciech ; Shekar, Kiran ; al Shirawi, Nehad Nabeel Mohamed ; Fujii, Tomoko ; Andreasen, Anne Sofie ; Malbrain, Manu L. N. G. ; Hildebrandt, Thomas ; Møller, Morten Hylander ; Cronhjort, Maria

Abstract:

Background:

Venous thromboembolism (VTE) is a frequent complication in critically ill patients, who often have multiple risk factors. Pharmacological thromboprophylaxis is widely applied to lower this risk, but guidelines lack dosing recommendations.

Objective:

This survey aims to assess current thromboprophylaxis preferences and willingness to participate in future randomized clinical trials (RCTs) on this topic.

Method:

We conducted an international online survey between February and May 2023 among intensive care unit (ICU) physicians, including 16 questions about preferences in relation to thromboprophylaxis and preferences on topics for a future RCT. The survey was distributed through the network of the Collaboration for Research in Intensive Care.

Results:

A total of 715 physicians from 170 ICUs in 23 countries contributed information, with a mean response rate of 36%. In most ICUs, both pharmacological (n = 166, 98%) and mechanical thromboprophylaxis (n = 143, 84%) were applied. A total of 36 pharmacological thromboprophylaxis regimens were reported. Use of low‐molecular‐weight heparin (LMWH) was most common (n = 149 ICUs, 87%), followed by subcutaneous unfractionated heparin (n = 44 ICUs, 26%). Seventy‐five percent of physicians indicated that they used enoxaparin 40 mg (4000 IU), dalteparin 5000 IU, or tinzaparin 4500 IU once daily, whereas 25% reported the use of 16 other LMWH type and dose combinations. Dose adjustment according to weight was common (78 ICUs, 46%). Participants perceived high variation in the application of thromboprophylaxis and were willing to consider an alternative LMWH type (n = 542, 76%) or dose (n = 538, 75%) in the context of an RCT.

Conclusion:

LMWH was the preferred agent for thromboprophylaxis in critically ill patients. There was considerable variation in the application of LMWH for prophylaxis, reflected by the use of different types, doses, and dosing strategies. Most physicians would be willing to participate in an RCT on thromboprophylaxis.

Editorial comment:

This survey demonstrates current patterns in implementation preferences for critically ill patients. While there is one approach and drug that is commonly preferred, these findings show that there is some variation in practice.

2025-02-01·Hellenic Journal of Cardiology

Treatment of radial artery occlusion after transradial coronary catheterization: a review of the literature and proposed treatment algorithm

Review

作者: Theodoropoulos, Konstantinos C ; Afendoulis, Dimitrios ; Moysidis, Dimitrios ; Papazoglou, Andreas ; Pagiantza, Areti ; Didagelos, Matthaios ; Ziakas, Antonios ; Kouparanis, Antonios ; Kartalis, Athanasios ; Anastasiou, Vasileios ; Daios, Stylianos ; Kassimis, George ; Kamperidis, Vasileios ; Kakderis, Charalambos

The transradial artery has been established as the default access site for most coronary catheterization procedures with fewer access-related and bleeding complications, rapid hemostasis, early ambulation of the patient, and reduction in all-cause mortality compared with transfemoral access. However, radial artery occlusion (RAO) remains the most frequent complication of coronary catheterization procedures performed via transradial artery access. The purpose of our review was to conduct detailed literature research and summarize all the available treatment strategies for RAO, given the lack of a standardized treatment protocol in the literature. Pharmacological treatment with low-molecular-weight heparin (LMWH) or other anticoagulants, invasive strategies, and pharmaco-invasive methods available in the literature were included in our review. Data were derived from case series, case reports, clinical trials, and observational studies. Eight studies regarding pharmacological treatment with LMWH or any other anticoagulant and seven studies of invasive treatment were included in our review. There were only two randomized studies: one with LMWH (tinzaparin) and one with apixaban. Furthermore, taking into consideration data derived from the above-mentioned studies, a treatment algorithm for RAO was proposed. RAO remains the most frequent complication of coronary procedures with transradial access. Application of preventive strategies and comprehensive knowledge of the risk factors remain the key factors for the reduction of the incidence of this clinical entity. Therapeutic options include anticoagulation regimens and interventional techniques through the distal radial artery. Large, randomized, multicenter studies should be conducted to evaluate the efficacy of the available treatment methods and define a standardized treatment protocol for RAO.

2024-11-01·European journal of hospital pharmacy : science and practice

Questions around a case ofin uterothrombosis in a premature child, concerning the management of anticoagulant treatments

Article

作者: Gerard, Delphine ; Prot-Labarthe, Sonia ; Simon, Laure ; Ternisien, Catherine ; Callies, Arnaud

We report the case of a preterm infant presenting a thrombosis, discovered on ultrasound at 22 weeks of gestational age and confirmed at birth following additional examinations. We describe the anticoagulant treatment of this patient by intravenous enoxaparin, tinzaparin and rivaroxaban, from questioning to practice.

项与亭扎肝素钠相关的新闻（医药）

2023-11-06

·PRNewswire

Global Antithrombotic/Anticoagulant Drugs Market Set to Reach $46.2 Billion by 2028 with a 7.9% CAGR

DUBLIN, Nov. 6, 2023 /PRNewswire/ -- The "Antithrombotic/Anticoagulant Drugs: Technologies and Global Markets" report has been added to ResearchAndMarkets.com's offering. The global antithrombotic/anticoagulant drugs market is expected to reach $46.2 billion in 2028 from $31.6 billion in 2023 at a CAGR of 7.9%. This report discusses the implications of the trends mentioned above in the context of the current size and growth of the antithrombotic/anticoagulant drugs market, in global terms and by the most important national markets. Companies in the relevant pharmaceutical and medical industries are discussed, with profiles of the leaders and an update on M&A activity. Five-year global sales forecasts are provided for the leading drug categories and the country offers breakdowns of the antithrombotic/anticoagulant drugs market. Major players, competitive intelligence, innovative technologies, market dynamics and regional opportunities are discussed in detail. The report examines recent developments and product portfolios of major players. The patent analysis focuses on technological trends in recent years in regions such as the U.S., Europe, and Japan. The report presents a market analysis and estimates the compound annual growth rate (CAGR) for the antithrombotic/anticoagulant drugs market. This report segments the global market by these geographic regions: North America, Europe, Asia-Pacific, and the Rest of the World. For market estimates, data are provided for 2022 as the base year, forecasted through 2023-2028. Companies Mentioned Bayer AG Boehringer Ingelheim International GmbH Bristol Myers Squibb Daiichi Sankyo Co. Ltd. F. Hoffmann-La Roche Ltd. Johnson & Johnson Services Inc. Merck & Co. Inc. Pfizer Inc. Sanofi Report Includes 59 data tables and 35 additional tables Overview and an up-to-date analysis of the global markets for antithrombotic/anticoagulant drugs for the treatments of thrombotic (cardiovascular) disease Analyses of the global market trends, with historical market revenue data (sales figures) from 2020 to 2022, estimates for 2023, and projections of compound annual growth rates (CAGRs) through 2028 Examination of the market potential for antithrombotic/anticoagulant drugs, and quantification of the global market for these drugs and its market segments and sub-segments over the next five years Estimate of the actual market size and revenue forecast for the market, and corresponding market share analysis based on product type, application and region In-depth information (facts and figures) pertaining to the market drivers, challenges, opportunities and prospects, as well as the technologies, regulatory scenarios and impact of COVID-19 A look at the major vendors in the global market for antithrombotic/anticoagulant drugs, and analysis of the healthcare industry structure, including market shares and recent mergers and acquisitions (M&A) activity Review of key patent grants and a look at breakthrough innovations, novel products, upcoming trends and technologies, and emerging applications for cardiovascular treatments Insight into the importance of ESG in the worldwide market, with a look at consumer attitudes, risks and opportunities assessment, and ESG practices followed by manufacturers and service providers Identification of the major stakeholders, and analysis of the competitive landscape based on recent developments, key financials and segmental revenues, and operational integration Profiles of the leading market players The following are the main conclusions reached in this report regarding antithrombotic and anticoagulant drugs: Recent innovations and the emergence of novel thrombin inhibitors have led to the decrease in revenue of traditional anticoagulants such as heparin and Vitamin K antagonists. Low molecular weight heparins, such as Fragmin (-11.8%) and Innohep (-14.1%), have seen a significant decrease in the market. The anticoagulant drug market will continue to grow at a slow rate compared to antiplatelet and thrombin inhibitors segment due to the lack of new drug launches since the expiration of the patent on Plavix. The anticoagulant segment is expected to decline soon as prices fall and the market for novel thrombin inhibitors grows. The market for thrombin inhibitors is expected to grow at the highest CAGR of 8.1% over the forecast period of 2023 to 2028. Xarelto (rivaroxaban), Eliquis (apixaban), TNKase (tenecteplase) and Savaysa (edoxaban) are the major contributors to the high growth rate of thrombin inhibitors. An aging population and the increased prevalence of cardiovascular disease worldwide fueled by a Westernized diet and lifestyle have created new opportunities for antithrombotic/ anticoagulant drug products. Key Topics Covered: Chapter 1 Introduction Chapter 2 Summary and Highlights Market Outlook Market Summary Chapter 3 Market Overview Overview of Cardiovascular Disease Coronary Artery Disease Atherosclerosis Angina (Angina Pectoris) Acute Myocardial Infarction Medical Management Lifestyle Changes Diet Modification Smoking Cessation Pharmaceuticals Anticoagulants and Antiplatelet Drugs Major Drivers Coagulation Factors Targeted to Reduce Cvd The Global Burden of Cardiovascular Disease 2030 Global Burden of Cardiovascular Disease The Global Economic Burden of Cardiovascular Disease Sales Performance of Major Drugs in 2022 Chapter 4 Global Market for Anticoagulant Drugs Overview Products Low Molecular Weight Heparin Oral Anticoagulants (Vitamin K Antagonists) Global Anticoagulant Drugs Market Forecast Chapter 5 Global Market for Antiplatelet Drugs Overview Products Oral Antiplatelets Global Antiplatelet Drugs Market Forecast Chapter 6 Global Market for Thrombin Inhibitors Overview Products Direct Thrombin Inhibitors Thrombolytic Agents Direct Factor Xa Inhibitors Global Thrombin Inhibitors Market Forecast Chapter 7 Global Market for Antithrombotic/Anticoagulant Drugs by Region Overview North America Europe Asia-Pacific Rest of the World Chapter 8 Sustainability in the Market for Antithrombotic/Anticoagulant Drugs: An ESG Perspective Introduction to ESG Sustainability in Market for Antithrombotic/Anticoagulant Drugs: An ESG Perspective Key ESG Issues Consumer Attitudes Towards ESG Industry ESG Performance Analysis Case Study Concluding Remarks Chapter 9 Clinical Trials and Patent Landscape Clinical Trials Analysis Patent Analysis Patent by Assignee Chapter 10 M&A and Venture Funding Outlook Chapter 11 Competitive Landscape Chapter 12 Company Profiles Chapter 13 Appendix For more information about this report visit About ResearchAndMarkets.com ResearchAndMarkets.com is the world's leading source for international market research reports and market data. We provide you with the latest data on international and regional markets, key industries, the top companies, new products and the latest trends. Media Contact: Research and Markets Laura Wood, Senior Manager [email protected] For E.S.T Office Hours Call +1-917-300-0470 For U.S./CAN Toll Free Call +1-800-526-8630 For GMT Office Hours Call +353-1-416-8900 U.S. Fax: 646-607-1907 Fax (outside U.S.): +353-1-481-1716 Logo: SOURCE Research and Markets

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外链

KEGG	Wiki	ATC	Drug Bank
D06398	亭扎肝素钠	B01AB10	DB06822

研发状态

10 条最早获批的记录,

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适应症	国家/地区	公司	日期
肺栓塞	美国	LEO Pharma A/S	2000-07-14
静脉血栓形成	美国	LEO Pharma A/S	2000-07-14
血栓形成	加拿大	Novo Nordisk Canada, Inc.	1994-12-31

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临床结果

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分期

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


ISTH2023	N/A	肾功能不全	623	Tinzaparin prophylactic dosage	鏇艱積憲憲齋繭蓋蓋壓(憲壓鏇夢衊築鏇艱淵齋) = 衊鑰襯窪構鑰範觸淵構餘網製衊蓋糧糧鬱蓋鑰 (蓋鹽淵壓齋遞鬱鏇網願 )	-	2023-06-24
ISTH2023	N/A	肾功能不全	623	Tinzaparin therapeutic dosage	鏇艱積憲憲齋繭蓋蓋壓(憲壓鏇夢衊築鏇艱淵齋) = 廠觸範窪願襯鹹鑰簾醖餘網製衊蓋糧糧鬱蓋鑰 (蓋鹽淵壓齋遞鬱鏇網願 )	-	2023-06-24
ISTH2022	N/A	浅表血栓性静脉炎	147	tinzaparin	觸糧餘艱獵築齋製衊壓(窪醖鹽鑰衊遞襯廠憲顧) = 醖網壓範繭觸夢鑰簾鹽積鏇製簾餘餘觸鑰廠壓 (選簾製艱鹽壓夢憲觸願 )	-	2022-07-09
ISTH2022	N/A	肥胖	-	Tinzaparin adjusted for actual body weight	鬱簾窪憲膚遞簾膚齋齋(選鹽願選繭膚鹽膚壓獵) = 餘簾觸蓋廠齋鹹範築遞膚鹽餘膚範鏇廠膚顧鹹 (襯鬱衊選鹽簾鹽願顧鹽, 0.20 ~ 0.31)	-	2022-07-09
Onco-CAST (ASCO2022)	临床4期	结直肠癌	175	Tinzaparin 8.000 Anti-Xa IU	網觸繭網鏇醖餘窪壓衊(簾積齋襯鹹簾鑰糧夢壓) = 餘獵鏇網鹽糧襯壓襯膚製鬱齋簾糧艱願廠齋蓋 (蓋構選廠糧糧鏇積鬱憲, 2.3 ~ 8.8) 更多	-	2022-06-02
NCT01455831 (Periop-01, ASCO_GI2022) 人工标引	临床3期	结直肠癌	602	Tinzaparin Sodium (Extended peri-operative thromboprophylaxis)	構齋選構鬱蓋蓋鹽壓襯(鹽壓鬱蓋夢憲構鹽糧憲) = 製鹹憲築蓋製觸顧製願糧構鹽獵膚顧壓夢鬱網 (齋選蓋遞簾範範鹽鹽鬱 ) 更多	非优	2022-01-19
NCT01455831 (Periop-01, ASCO_GI2022) 人工标引	临床3期	结直肠癌	602	Tinzaparin Sodium (Standard thromboprophylaxis)	構齋選構鬱蓋蓋鹽壓襯(鹽壓鬱蓋夢憲構鹽糧憲) = 艱壓築齋顧廠餘製築夢糧構鹽獵膚顧壓夢鬱網 (齋選蓋遞簾範範鹽鹽鬱 ) 更多	非优	2022-01-19
ASN2021	N/A	-	-	Tinzaparin	鏇艱構願蓋憲齋憲鹽廠(壓廠願繭觸網夢壓網廠) = 願鑰簾鹽鑰築鏇糧膚繭蓋選衊壓鬱壓遞廠齋餘 (壓構糧餘構窪積餘製糧 )	积极	2021-10-27
iCaLT study (ERS2021)	N/A	肺癌	60	Tinzaparin 0.5 ml, 10.000 Anti-Xa IU	窪廠築獵襯窪鏇淵簾觸(鏇鬱壓願鏇鏇艱觸獵鏇) = Low in patients with bleeding compared to others 蓋網網顧遞選積齋築膚 (壓艱選範艱繭鹹廠衊衊 )	积极	2021-09-05
PROSPERO CRD42020139413 (ISTH2020)	N/A	慢性肾病	1,831	Tinzaparin	壓餘壓餘鹽簾鬱獵鏇繭(簾鏇範繭窪簾選觸構顧) = 壓壓範範窪繭齋鏇鬱淵簾繭窪繭網製繭廠鏇醖 (壓築壓膚鬱糧壓衊艱鬱, (0.85 ~ 3.61)) 更多	-	2020-07-12
ISTH2020	N/A	静脉血栓栓塞	287	Weight-adjusted Tinzaparin	積顧鹹醖獵願憲觸觸壓(襯衊廠選願鹽齋窪鏇選) = 糧繭壓範製獵廠獵觸艱廠鬱製製襯鑰襯廠鏇膚 (願憲製顧餘夢鹽艱鏇顧 )	-	2020-07-12
ISTH2020	N/A	静脉血栓栓塞	287	No prophylaxis or subcutaneous UFH	積顧鹹醖獵願憲觸觸壓(襯衊廠選願鹽齋窪鏇選) = 鬱夢繭網醖糧窪鑰糧壓廠鬱製製襯鑰襯廠鏇膚 (願憲製顧餘夢鹽艱鏇顧 )	-	2020-07-12
TROPIQUE (ISTH2020)	N/A	血栓形成	-	Long-term tinzaparin treatment	膚鑰壓觸顧餘襯廠鹽壓(艱獵獵遞鬱築鹽鏇顧選) = 築顧觸襯憲醖築餘顧夢憲襯鬱齋鹹範壓網壓淵 (鏇選遞襯網艱顧衊膚齋 ) 更多	积极	2020-07-12