A Prospective, Randomised Controlled Trial Comparing Weight-based Tinzaparin Versus Weight-based Enoxaparin for Peri-operative Thromboprophylaxis in Patients Undergoing Bariatric Surgery: Evaluation of Anti-Xa Levels and Clinical Outcomes.

Blood clots in the legs or lungs (called venous thromboembolism or VTE) are one of the most serious complications after weight loss surgery. Most blood clots occur after patients go home from hospital, within the first 30 days after surgery. To prevent blood clots, all patients having weight loss surgery receive a daily blood-thinning injection for 21 days after their operation.
Two blood-thinning injections are currently used at St Vincent's University Hospital for this purpose: enoxaparin (Clexane®) and tinzaparin (Innohep®). Both belong to a group of medicines called low molecular weight heparins (LMWHs). Patients with obesity process these medicines differently to the general population, and previous studies from our hospital have shown that fewer than 53% of patients achieve adequate blood-thinning levels with either injection when measured by a blood test called an anti-Xa level.
Patients will be randomly assigned (like a coin toss) to receive either tinzaparin or enoxaparin for 21 days after their surgery. Both injections are already in routine use at this hospital. A single extra blood sample will be taken on the second day after surgery to measure the anti-Xa level, which tells us whether the injection is providing adequate protection against blood clots. This blood sample will be taken at the same time as routine post-operative blood tests so that no additional blood draws are required.
The study will also look at rates of blood clots and bleeding events within 30 days of surgery, and will ask patients to complete a short questionnaire at their six-week follow-up appointment about their experience with the injection.

开始日期2026-05-01

申办/合作机构

University College Dublin

CTIS2024-512475-12-01

/ Recruiting临床4期IIT

Thrombosis prophylaxis and coagulation activation during neoadjuvant treatment in pancreatic cancer - Association to prognosis and recurrence.

开始日期2024-11-27

申办/合作机构

University of Helsinki

NCT05735639

/ Recruiting临床4期IIT

THRomboprophylaxis in Individuals Undergoing Superficial endoVEnous Treatment (THRIVE) - a Multi-centre Assessor-blind Randomised-controlled Trial

Endovenous interventions are keyhole operations for varicose veins that are carried out from within the vein itself. Varicose veins are enlarged veins close to the surface of the skin. They are connected to the bigger deeper veins in the leg (known as deep veins). Because of this, operations to close the varicose veins can increase the chance of a blood clot forming in the deep veins. Blood clots in the deep veins happen in around 1 in 50 people after endovenous operations. A clot in the leg can cause swelling, pain, and other long-term problems. If a clot in the leg breaks off and travels to the lungs, it can cause problems with the lung' ability to move oxygen from the air into the blood and may, in rare cases, be life threatening.
Varicose vein procedures may carry a slightly higher risk of blood clot formation, and we are currently unsure if current clot reducing medicines are beneficial in preventing blood clots in people having varicose vein procedures.
This study will investigate if it is worthwhile prescribing medicines to reduce blood clots after varicose vein procedures.

开始日期2024-01-22

申办/合作机构

Imperial College London

100 项与亭扎肝素钠相关的临床结果

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100 项与亭扎肝素钠相关的转化医学

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100 项与亭扎肝素钠相关的专利（医药）

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项与亭扎肝素钠相关的文献（医药）

2026-01-02·Cureus Journal of Medical Science

A Regional Audit on Venous Thromboembolism (VTE) Prophylaxis Compliance and Cultural Considerations in Prescribing Porcine-Derived Low-Molecular-Weight Heparins

Article

作者: Norouzi, Mohsen ; Mujahid, Isra ; Ahmed, Husain ; Ahmad, Shibbir ; Mujahid, Minahil ; Maheshwari, Geeta ; Ur-Rehman, Junaid ; Prudon, Ben

BACKGROUND:

Hospital-acquired venous thromboembolism (VTE) remains a leading cause of preventable mortality in the NHS. NICE guidelines (NG89) mandate timely risk assessment and prophylaxis, yet practice varies widely. Many low-molecular-weight heparins (LMWHs), such as tinzaparin, are porcine-derived, posing ethical challenges for patients with specific dietary or religious beliefs.

OBJECTIVE:

The objective of this study is to evaluate adherence to NICE NG89 guidelines on VTE prophylaxis across two hospitals, with a particular focus on culturally sensitive prescribing. This audit also assessed clinician awareness of LMWH origins and explored patient preferences around dietary compliance. The impact of targeted interventions was measured across two audit cycles.

METHOD:

A prospective two-cycle audit was conducted at two NHS hospitals in North East England, The James Cook University Hospital (JCUH) and University Hospital North Tees (UHNT), between March 2024 and January 2025. Patients with dietary requirements were identified via catering records and surveyed. A doctor questionnaire assessed awareness and counselling practice. Interventions included staff education, posters, prescribing alerts, and community outreach.

RESULTS:

Cycle one included 76 patients. Cycle two included 61 patients. VTE risk assessment improved by 14% at UHNT; JCUH maintained 100% compliance. However, timely prophylaxis fell in UHNT, with 80% receiving it late. Documentation and discussions regarding VTE and dietary compliance improved but remained suboptimal. Leaflet distribution rose by 10% at JCUH but was absent at UHNT. Notably, 98% (n = 137) of patients prioritised medication aligned with their beliefs, and nearly half would decline porcine-derived prophylaxis even if it prevented serious illness. Clinician questionnaire data showed 64% (n = 50) were unaware that LMWHs are animal-derived, and 94% (n = 50) did not inform patients, citing time pressures and limited knowledge.

CONCLUSION:

While guideline compliance improved following intervention, particularly for risk assessments and documentation, major gaps remain in patient communication and dietary-informed prescribing. Most patients expected transparency and alternatives to porcine-based medications. Future efforts must embed dietary screening into routine prescribing and strengthen shared decision-making through structured education and culturally competent communication strategies.

2026-01-01·Research and Practice in Thrombosis and Haemostasis

The Ottawa score for prediction of recurrent venous thromboembolism in cancer patients treated with tinzaparin: an individual patient data meta-analysis

Article

作者: Jara-Palomares, Luis ; Laporte, Silvy ; Mahé, Isabelle ; Poenou, Géraldine ; Girard, Philippe ; Mismetti, Patrick ; Lee, Agnès Y Y ; Sanchez, Olivier ; Meyer, Guy ; Chapelle, Céline

Background:

Risk of venous thromboembolism (VTE) recurrence remains high in patients with cancer-associated thrombosis (CAT), despite therapeutic anticoagulation. Identifying patients at risk of treatment failure is still a challenge.

Objectives:

We aimed to assess the performance of the Ottawa score in predicting VTE recurrence in a large homogeneous population of patients with CAT treated with the same anticoagulant, tinzaparin, for at least 3 months.

Methods:

Individual patient data from 3 prospective cohort studies and 1 randomized controlled trial were pooled (PROSPERO: CRD42019119907). Clinical events of interest were adjudicated by independent central adjudication committees in all 4 studies.

Results:

Among the 1413 patients included, the Ottawa score could be calculated for 1088 of whom 646 (59.4%) were classified at high risk of recurrence (Ottawa score ≥ 1). The 6-month cumulative incidence of recurrent VTE was 5.0% (95% CI, 3.2-7.8) in the Ottawa low-risk group and 8.5% (95% CI, 6.6-10.8) in the high-risk group. The area under the receiver operating characteristic curve was 0.56 (95% CI, 0.51-0.62). The sensitivity of the dichotomized Ottawa score (score ≥ 1) was 72.8% (95% CI, 62.6%-83.0%), the specificity was 41.9% (95% CI, 37.8%-45.9%), the positive predictive value was 8.6% (95% CI, 6.4%-10.8%), and the negative predictive value was 95.3% (95% CI, 93.3%-97.4%). Introducing additional predictive factors failed to significantly improve the score's performance.

Conclusions:

Despite the large number of patients and anticoagulant treatment standardization, the Ottawa score failed to accurately predict recurrent VTE in patients with CAT treated with tinzaparin.

2025-11-01·Research and Practice in Thrombosis and Haemostasis

Comparative safety of enoxaparin versus other low-molecular-weight heparins in cancer-associated venous thromboembolism: a real-world cohort study from RIETE

Article

Background:

Low-molecular-weight heparins (LMWHs) are widely used in the treatment of cancer-associated venous thromboembolism (VTE), yet their long-term safety profiles remain insufficiently compared in clinical practice.

Objectives:

The primary outcome was major bleeding over a 6-month follow-up. Secondary outcomes included VTE recurrence, non-major clinically relevant bleeding, and all-cause mortality.

Methods:

We analyzed 7287 patients with active cancer and acute VTE from the RIETE registry (2009-2022) who were treated with full-dose enoxaparin (n = 5628) or tinzaparin/dalteparin (n = 1659). Analyses were adjusted using multivariable Cox models, Fine-Gray competing risk models, frailty models clustered by center, and propensity score approaches.

Results:

Major bleeding occurred in 3.84% of patients receiving enoxaparin versus 2.53% in the tinzaparin/dalteparin group (adjusted hazard ratio [aHR] 1.56; 95% CI: 1.11-2.19), with consistent findings across all sensitivity analyses. Enoxaparin was also associated with higher all-cause mortality (28.3% vs 25.1%; aHR 1.22; 95% CI: 1.09-1.37). No significant differences were observed in VTE recurrence (3.59% vs 3.07%) or non-major bleeding (3.98% vs 3.25%). Importantly, during the first 10 days of therapy, major bleeding occurred in 1.2% of patients treated with enoxaparin twice-daily, compared to 0.4% with once-daily dosing and 0.1% in the tinzaparin/dalteparin group (P < .001).

Conclusion:

In this large, observational study, enoxaparin, particularly in twice-daily regimens, was associated with significantly increased risks of bleeding and mortality compared to tinzaparin/dalteparin. These findings may help refine LMWH selection and dosing strategies in patients with cancer-associated VTE and warrant further investigation in prospective studies.

项与亭扎肝素钠相关的新闻（医药）

2026-04-14

·GlobeNewswire-Health Care

Er-Kim Signs Exclusive Distribution Agreement with LEO Pharma A/S to Commercialize LOQTORZI® (toripalimab) for Nasopharyngeal and Oesophageal Cancers

Er-Kim announces exclusive partnership with LEO Pharma A/S to launch LOQTORZI® across Central and Eastern Europe, expanding access to innovative cancer treatment for Nasopharyngeal and Oesophageal CancersISTANBUL and BALLERUP, Denmark, April 14, 2026 (GLOBE NEWSWIRE) -- Er-Kim, an international pharmaceutical company specializing in the commercialization of novel therapies in the EMEA region, today announced that it has signed an exclusive agreement with LEO Pharma A/S to commercialize LOQTORZI® (toripalimab) in select regions in Central and Eastern Europe (CEE). Under the terms of the agreement, Er-Kim will serve as the exclusive commercial partner for LOQTORZI® in the following markets: Bulgaria, Croatia, Czechia, Estonia, Hungary, Latvia, Lithuania, Poland, Romania, Slovakia, and Slovenia. This PD-1 inhibitor is an intravenous immunotherapy that harnesses the body’s immune system to identify and attack cancer cells. In the European Union, the treatment is indicated for two distinct, hard-to-treat malignancies: Nasopharyngeal Carcinoma (NPC): A rare and aggressive cancer of the head and neck. The therapy is used in combination with cisplatin and gemcitabine for adults with recurrent (non-resectable) or metastatic NPC as a first-line option, or as a monotherapy for those who have previously undergone chemotherapy.Oesophageal Squamous Cell Carcinoma (OSCC): For patients with advanced, recurrent, or metastatic OSCC that cannot be removed by surgery. In these cases, it is used in combination with cisplatin and paclitaxel. Cem Zorlular, Chief Executive Officer of Er-Kim, said, “Advancements in immunotherapy are fundamentally changing the outlook for patients with nasopharyngeal carcinoma and oesophageal squamous cell carcinoma, but innovation only matters when it reaches the people who need it. By leveraging our deep infrastructure and relationships in Central and Eastern Europe, we are pleased to partner with LEO Pharma to bridge this access gap and bring LOQTORZI® to oncology patients throughout the CEE region.” “We are committed to advancing cancer care by making innovative treatments available to this vulnerable group of patients who face limited options. Er‑Kim’s regional knowledge makes them a strong partner to bring LOQTORZI® to new markets in Central and Eastern Europe,” said Jean Monin, Executive Vice President of the Critical Care Business Unit at LEO Pharma A/S. “Together, we can make a difference for the patients and healthcare professionals we serve.” In 2025, LEO Pharma A/S was granted exclusive distribution and sales rights for LOQTORZI® in the European Union (EU), the European Economic Area (EEA), as well as Switzerland and the United Kingdom, while TopAlliance Biosciences remains the Marketing Authorisation Holder (MAH). About Er-Kim Established in 1981, Er-Kim stands at the forefront of biopharmaceutical innovation, setting new commercialization and patient access standards. Through strategic partnerships with over 40 global leaders, Er-Kim distributes more than 68 products to 50+ countries, revolutionizing patient care in international markets by solving complex distribution challenges. Er-Kim has a dedicated team of over 400 professionals worldwide and revenues exceeding EUR 390M. For more information, please visit www.er-kim.com. About LEO Pharma's Critical Care business unitWith over 80 years of expertise in heparin production, LEO Pharma’s Critical Care unit is a global player in thrombosis. Anchored by innohep® and other established products, we leverage a specialty hospital commercial platform to drive growth through expansion into cancer-associated thrombosis and broader critical care. In 2024, the Critical Care business unit contributed 18% of total revenue of LEO Pharma. About LEO Pharma LEO Pharma is a global leader in medical dermatology. We deliver innovative solutions for skin health, building on a century of experience with breakthrough medicines in healthcare. We are committed to making a fundamental difference in people’s lives, and our broad portfolio of treatments serves close to 100 million patients in over 70 countries annually. LEO Pharma is co-owned by majority shareholder the LEO Foundation and, since 2021, Nordic Capital. Headquartered in Denmark, LEO Pharma has a team of 4,000 people worldwide. Together, we reach far beyond the skin. For more information, visit www.leo-pharma.com. Media contact: Rosalia ScampoliMarketcom PRTel: (914) 815-1465rscampoli@marketcompr.com

2025-07-17

·FiercePharma

Leo Pharma's slow response to app lapse scolded by UK marketing watchdog

Leo Pharma accepted that “appropriate actions were not taken to rectify the issue immediately” with its Innohep app. Leo Pharma’s inaccurate Innohep app has prompted a slap-down from the PMCPA. The U.K. marketing watchdog ruled Leo brought discredit on the pharma industry by leaving the app live for three months after the errors were discovered. Two healthcare professionals complained to the PMCPA about an app for patients prescribed Innohep, Leo’s tinzaparin sodium product. The app presented information from the patient information leaflet, and users were prompted to select their prescribed dosage and shown information on injection technique.Both complainants flagged inaccuracies in the dosing information presented in the app. A Leo employee identified the errors in August 2024, and Leo’s medical affairs team learned of the inaccuracies the next day, according to the PMCPA report, yet the app was still available when the PMCPA contacted Leo in November. Leo deactivated the app and made an updated version available within two weeks of being contacted by the PMCPA.Responding to the marketing authority, Leo said two senior medical affairs employees concluded that the full volume of the syringe would always be administered, despite any conflicting information in the app, and, as such, the inaccuracies didn’t affect patient safety. The PMCPA panel took a dim view of Leo’s conclusion, stating that inaccurate dosing information is a serious matter regardless of the likelihood of a safety issue. The panel said it “was extremely concerned about Leo Pharma’s lack of urgency” and the company’s “conscious decision to keep the app live with the inaccuracies for approximately three months.” The dosage volume inaccuracies and failure to withdraw the app immediately could “reduce confidence in the industry being able to produce patient material to the required quality standards,” the panel said.Leo accepted that “appropriate actions were not taken to rectify the issue immediately.” The company listed mitigating factors that may have played a role in the failings, including a disruption that affected the company from July, when the app was certified, to October, when Leo was still working through its response to the inaccuracies. “At the time of this issue occurring there was a reorganization of the thrombosis business impacting resource and headcount; many colleagues’ roles were placed at risk of redundancy. There was no dedicated medical support for the U.K. thrombosis business at this time,” Leo said. “Whilst this does not negate the seriousness of the issue and decisions made, we believe this to be a contributing factor.”The PMCPA appeal board opted against imposing additional sanctions on Leo. The board reached the decision after assessing Leo’s work to enhance its governance, train staff and update its processes to add checks and scrutiny. Leo said “it was not experienced with creating and managing apps and had relied on external expertise,” according to the PMCPA, and would act differently if in the same situation today.

专利侵权

2023-11-06

·PRNewswire

Global Antithrombotic/Anticoagulant Drugs Market Set to Reach $46.2 Billion by 2028 with a 7.9% CAGR

DUBLIN, Nov. 6, 2023 /PRNewswire/ -- The "Antithrombotic/Anticoagulant Drugs: Technologies and Global Markets" report has been added to ResearchAndMarkets.com's offering. The global antithrombotic/anticoagulant drugs market is expected to reach $46.2 billion in 2028 from $31.6 billion in 2023 at a CAGR of 7.9%. This report discusses the implications of the trends mentioned above in the context of the current size and growth of the antithrombotic/anticoagulant drugs market, in global terms and by the most important national markets. Companies in the relevant pharmaceutical and medical industries are discussed, with profiles of the leaders and an update on M&A activity. Five-year global sales forecasts are provided for the leading drug categories and the country offers breakdowns of the antithrombotic/anticoagulant drugs market. Major players, competitive intelligence, innovative technologies, market dynamics and regional opportunities are discussed in detail. The report examines recent developments and product portfolios of major players. The patent analysis focuses on technological trends in recent years in regions such as the U.S., Europe, and Japan. The report presents a market analysis and estimates the compound annual growth rate (CAGR) for the antithrombotic/anticoagulant drugs market. This report segments the global market by these geographic regions: North America, Europe, Asia-Pacific, and the Rest of the World. For market estimates, data are provided for 2022 as the base year, forecasted through 2023-2028. Companies Mentioned Bayer AG Boehringer Ingelheim International GmbH Bristol Myers Squibb Daiichi Sankyo Co. Ltd. F. Hoffmann-La Roche Ltd. Johnson & Johnson Services Inc. Merck & Co. Inc. Pfizer Inc. Sanofi Report Includes 59 data tables and 35 additional tables Overview and an up-to-date analysis of the global markets for antithrombotic/anticoagulant drugs for the treatments of thrombotic (cardiovascular) disease Analyses of the global market trends, with historical market revenue data (sales figures) from 2020 to 2022, estimates for 2023, and projections of compound annual growth rates (CAGRs) through 2028 Examination of the market potential for antithrombotic/anticoagulant drugs, and quantification of the global market for these drugs and its market segments and sub-segments over the next five years Estimate of the actual market size and revenue forecast for the market, and corresponding market share analysis based on product type, application and region In-depth information (facts and figures) pertaining to the market drivers, challenges, opportunities and prospects, as well as the technologies, regulatory scenarios and impact of COVID-19 A look at the major vendors in the global market for antithrombotic/anticoagulant drugs, and analysis of the healthcare industry structure, including market shares and recent mergers and acquisitions (M&A) activity Review of key patent grants and a look at breakthrough innovations, novel products, upcoming trends and technologies, and emerging applications for cardiovascular treatments Insight into the importance of ESG in the worldwide market, with a look at consumer attitudes, risks and opportunities assessment, and ESG practices followed by manufacturers and service providers Identification of the major stakeholders, and analysis of the competitive landscape based on recent developments, key financials and segmental revenues, and operational integration Profiles of the leading market players The following are the main conclusions reached in this report regarding antithrombotic and anticoagulant drugs: Recent innovations and the emergence of novel thrombin inhibitors have led to the decrease in revenue of traditional anticoagulants such as heparin and Vitamin K antagonists. Low molecular weight heparins, such as Fragmin (-11.8%) and Innohep (-14.1%), have seen a significant decrease in the market. The anticoagulant drug market will continue to grow at a slow rate compared to antiplatelet and thrombin inhibitors segment due to the lack of new drug launches since the expiration of the patent on Plavix. The anticoagulant segment is expected to decline soon as prices fall and the market for novel thrombin inhibitors grows. The market for thrombin inhibitors is expected to grow at the highest CAGR of 8.1% over the forecast period of 2023 to 2028. Xarelto (rivaroxaban), Eliquis (apixaban), TNKase (tenecteplase) and Savaysa (edoxaban) are the major contributors to the high growth rate of thrombin inhibitors. An aging population and the increased prevalence of cardiovascular disease worldwide fueled by a Westernized diet and lifestyle have created new opportunities for antithrombotic/ anticoagulant drug products. Key Topics Covered: Chapter 1 Introduction Chapter 2 Summary and Highlights Market Outlook Market Summary Chapter 3 Market Overview Overview of Cardiovascular Disease Coronary Artery Disease Atherosclerosis Angina (Angina Pectoris) Acute Myocardial Infarction Medical Management Lifestyle Changes Diet Modification Smoking Cessation Pharmaceuticals Anticoagulants and Antiplatelet Drugs Major Drivers Coagulation Factors Targeted to Reduce Cvd The Global Burden of Cardiovascular Disease 2030 Global Burden of Cardiovascular Disease The Global Economic Burden of Cardiovascular Disease Sales Performance of Major Drugs in 2022 Chapter 4 Global Market for Anticoagulant Drugs Overview Products Low Molecular Weight Heparin Oral Anticoagulants (Vitamin K Antagonists) Global Anticoagulant Drugs Market Forecast Chapter 5 Global Market for Antiplatelet Drugs Overview Products Oral Antiplatelets Global Antiplatelet Drugs Market Forecast Chapter 6 Global Market for Thrombin Inhibitors Overview Products Direct Thrombin Inhibitors Thrombolytic Agents Direct Factor Xa Inhibitors Global Thrombin Inhibitors Market Forecast Chapter 7 Global Market for Antithrombotic/Anticoagulant Drugs by Region Overview North America Europe Asia-Pacific Rest of the World Chapter 8 Sustainability in the Market for Antithrombotic/Anticoagulant Drugs: An ESG Perspective Introduction to ESG Sustainability in Market for Antithrombotic/Anticoagulant Drugs: An ESG Perspective Key ESG Issues Consumer Attitudes Towards ESG Industry ESG Performance Analysis Case Study Concluding Remarks Chapter 9 Clinical Trials and Patent Landscape Clinical Trials Analysis Patent Analysis Patent by Assignee Chapter 10 M&A and Venture Funding Outlook Chapter 11 Competitive Landscape Chapter 12 Company Profiles Chapter 13 Appendix For more information about this report visit About ResearchAndMarkets.com ResearchAndMarkets.com is the world's leading source for international market research reports and market data. We provide you with the latest data on international and regional markets, key industries, the top companies, new products and the latest trends. Media Contact: Research and Markets Laura Wood, Senior Manager [email protected] For E.S.T Office Hours Call +1-917-300-0470 For U.S./CAN Toll Free Call +1-800-526-8630 For GMT Office Hours Call +353-1-416-8900 U.S. Fax: 646-607-1907 Fax (outside U.S.): +353-1-481-1716 Logo: SOURCE Research and Markets

100 项与亭扎肝素钠相关的药物交易

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KEGG	Wiki	ATC	Drug Bank
D06398	亭扎肝素钠	B01AB10	DB06822

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适应症	国家/地区	公司	日期
肺栓塞	美国	LEO Pharma A/S	2000-07-14
静脉血栓形成	美国	LEO Pharma A/S	2000-07-14
血栓形成	加拿大	Novo Nordisk Canada, Inc.	1994-12-31

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适应症	最高研发状态	国家/地区	公司	日期
静脉血栓栓塞	临床3期	希腊	LEO Pharma A/S	2019-01-30

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


NCT05625932 (PROTINCOL, Pubmed \| BMC Cancer)	临床3期	转移性结直肠癌一线	526	Tinzaparin	糧範製壓廠襯繭廠鏇範(廠餘鏇構衊鬱顧網簾淵) = 艱範範膚齋顧選製窪觸齋繭製齋簾窪選鏇鏇衊 (繭簾醖廠廠鹹繭鹹艱糧 ) 更多	积极	2025-11-17
ERS2024	N/A	血栓形成	511	Tinzaparin	築獵蓋壓鹹憲構築鹽鑰(襯襯窪顧遞願鏇壓積糧) = 餘糧構積獵願網衊築蓋鑰廠淵糧構衊鹹餘築齋 (築選憲顧構鑰蓋網簾鏇 )	积极	2024-09-07
ISTH2022	N/A	浅表血栓性静脉炎	147	tinzaparin	糧鬱鹽餘窪觸繭築壓願(顧醖醖繭醖選鬱鹹鏇繭) = 簾糧獵廠簾築淵鹹夢艱鏇觸鬱膚壓淵獵憲選獵 (積衊醖繭遞壓齋廠膚醖 )	-	2022-07-09
Onco-CAST (ASCO2022)	临床4期	结直肠癌	175	Tinzaparin 8.000 Anti-Xa IU	鬱襯衊範範憲遞鬱選膚(襯醖願鬱淵夢壓夢衊範) = 醖廠襯遞鹹築構鹹觸範鏇願願鹹鹽壓觸願糧鹽 (鬱窪憲鬱繭窪鑰窪廠糧, 2.3 ~ 8.8) 更多	-	2022-06-02
NCT01455831 (Periop-01, ASCO_GI2022) 人工标引	临床3期	结直肠癌	602	Tinzaparin Sodium (Extended peri-operative thromboprophylaxis)	製築艱餘鹽積齋淵齋網(獵顧夢餘簾廠遞鏇壓觸) = 壓範醖糧鬱襯鏇鬱窪鬱蓋築顧蓋選鏇衊齋網夢 (選壓築醖構膚壓遞憲窪 ) 更多	非优	2022-01-19
NCT01455831 (Periop-01, ASCO_GI2022) 人工标引	临床3期	结直肠癌	602	Tinzaparin Sodium (Standard thromboprophylaxis)	製築艱餘鹽積齋淵齋網(獵顧夢餘簾廠遞鏇壓觸) = 淵範觸廠廠遞窪蓋窪製蓋築顧蓋選鏇衊齋網夢 (選壓築醖構膚壓遞憲窪 ) 更多	非优	2022-01-19
iCaLT study (ERS2021)	N/A	肺癌	60	Tinzaparin 0.5 ml, 10.000 Anti-Xa IU	構齋醖製積憲夢糧觸願(憲膚鬱壓鹹淵壓齋糧窪) = Low in patients with bleeding compared to others 壓鏇醖鹹顧憲淵齋衊顧 (鑰膚顧獵選糧廠蓋膚構 )	积极	2021-09-05
PROSPERO CRD42020139413 (ISTH2020)	N/A	慢性肾病	1,831	Tinzaparin	艱鹽範繭衊構壓獵憲鹽(鹽構糧憲襯齋遞襯醖鑰) = 壓餘蓋網製選範醖鹹繭網廠網顧選艱鹽鹹淵餘 (獵鹹膚獵廠夢顧艱醖鹹, (0.85 ~ 3.61)) 更多	-	2020-07-12
ISTH2020	N/A	静脉血栓栓塞	287	Weight-adjusted Tinzaparin	範齋範構鬱廠糧窪膚餘(獵餘積築憲醖壓齋繭糧) = 鹹遞襯衊餘築簾淵製艱鹹齋遞鏇糧膚遞積鹽壓 (網鹹網構夢鑰網鹹襯鏇 )	-	2020-07-12
ISTH2020	N/A	静脉血栓栓塞	287	No prophylaxis or subcutaneous UFH	範齋範構鬱廠糧窪膚餘(獵餘積築憲醖壓齋繭糧) = 願衊獵繭願膚構鬱願網鹹齋遞鏇糧膚遞積鹽壓 (網鹹網構夢鑰網鹹襯鏇 )	-	2020-07-12
TROPIQUE (ISTH2020)	N/A	血栓形成	-	Long-term tinzaparin treatment	遞廠窪鹽醖廠鹹衊憲窪(顧窪淵鬱鑰製襯鹹夢願) = 壓製遞廠壓艱醖衊膚製膚鏇醖淵窪繭醖範觸選 (蓋鑰鏇憲積願願簾餘簾 ) 更多	积极	2020-07-12
NCT01130025 (CATCH Study \| IN 0901 INT, Pubmed \| Thromb Haemost)	临床3期	出血 \| 肿瘤 \| 肾功能不全 ... 更多	864	tinzaparin	廠蓋繭願淵壓憲鬱顧網(觸築壓窪鏇獵積憲範廠) = 積窪網醖齋壓蓋衊簾壓壓網壓獵築遞顧齋構簾 (築餘觸網蓋鏇艱網壓醖 ) 更多	-	2018-05-01
	临床3期	出血 \| 肿瘤 \| 肾功能不全 ... 更多	864	warfarin	廠蓋繭願淵壓憲鬱顧網(觸築壓窪鏇獵積憲範廠) = 積壓夢糧鬱顧醖憲築鑰壓網壓獵築遞顧齋構簾 (築餘觸網蓋鏇艱網壓醖 ) 更多	-	2018-05-01