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更新于：2026-06-27

Ethinyl Estradiol/Norethindrone Acetate/Ferrous Fumarate

炔雌醇/醋炔诺酮/富马酸铁

更新于：2026-06-27

概要

基本信息

药物类型

小分子化药

别名

ETHINYL ESTRADIOL/FERROUS FUMARATE/NORETHINDRONE、ETHINYL ESTRADIOL/FERROUS FUMARATE/NORETHINDRONE ACETATE、NORETHINDRONE ACETATE/ETHINYL ESTRADIOL/ETHINYL ESTRADIOL/FERROUS FUMARATE

+ [5]

靶点

ER x PR

作用方式

激动剂

作用机制

ERs激动剂(雌激素受体家族激动剂)、PR激动剂(孕激素受体激动剂)

治疗领域

其他疾病

在研适应症

避孕

非在研适应症-

原研机构

Pfizer Inc.

在研机构

Viatris Holdings LLC

非在研机构-

权益机构-

最高研发阶段批准上市

首次获批日期

美国 (1978-02-21),

避孕

最高研发阶段(中国)-

特殊审评-

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结构/序列

分子式C20H24O2

InChIKeyBFPYWIDHMRZLRN-SLHNCBLASA-N

CAS号57-63-6

查看全部结构式(3)

关联

项与炔雌醇/醋炔诺酮/富马酸铁相关的临床试验

NCT07568509

/ Recruiting早期临床1期IIT

Identifying a Provocation Test for Diagnosis of Oxytocin Deficiency in Youth With Hypopituitarism

An open-labeled, interventional pilot trial, 10 youth with AVP-D and 10 PD matched for age, sex, and BMI will be recruited from Pediatric Endocrinology and Neuroendocrinology at Massachusetts General Hospital and in the community. This study tests the hypothesis that oral estrogen/progestin will stimulate endogenous oxytocin release in control subjects. Eligible participants will receive two tablets in a single administration containing a total of 1 mg of norethindrone acetate 70 mcg of ethinyl estradiol. Sampling for blood and saliva will take place at baseline and approximately 24 hours following study drug administration. Neuropsychological assessment (anxiety, mood and emotion regulation; impulse control; aberrant eating behaviors; social cognition and functioning; quality of life) will be assessed at baseline to characterize the study population.

开始日期2026-05-01

申办/合作机构

The Massachusetts General Hospital

NCT06460948

/ Completed早期临床1期IIT

Characterizing Oxytocin Response to Oral Estrogen Administration in Adults With Arginine Vasopressin Deficiency

This is an open-label, pilot study, to characterize oxytocin response to a single dose of oral Estrogen-progestin in patients with arginine-vasopressin deficiency compared to healthy controls. The association between oxytocin levels and measures of psychopathology (i.e., anxiety and depression) and quality of life across groups will be examined. We hypothesize that:
1. Salivary and blood oxytocin response to Estrogen-progestin will be lower in arginine-vasopressin deficiency compared to healthy control.
2. Lower salivary and blood oxytocin levels will be associated with more severe symptoms of anxiety, depression, and social emotional difficulties as well as lower quality of life.

开始日期2024-11-13

申办/合作机构

The General Hospital Corp.

NCT01318005

/ CompletedN/AIIT

The Effects of Dose and Formulation of Oral Contraceptives (OCs) on Breast-Cell Proliferation: Can the Chemopreventive Effects of OCs on Endometrial and Ovarian Cancer be Extended to Breast Cancer?

The purpose of this research study is to gain a better understanding of the changes that may occur in the breast when a woman uses an oral contraceptive (birth control pill). Some research indicates that women who use birth control pills with lower amounts of estrogen (a hormone in the birth control pill) may have lower breast cell growth than women who use birth control pills with a higher amount of estrogen; this research will examine that in detail.

开始日期2011-02-14

申办/合作机构

University of Southern California

100 项与炔雌醇/醋炔诺酮/富马酸铁相关的临床结果

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100 项与炔雌醇/醋炔诺酮/富马酸铁相关的转化医学

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100 项与炔雌醇/醋炔诺酮/富马酸铁相关的专利（医药）

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100 项与炔雌醇/醋炔诺酮/富马酸铁相关的药物交易

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外链

KEGG	Wiki	ATC	Drug Bank
-	-	G03CA	-

研发状态

10 条最早获批的记录,

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适应症	国家/地区	公司	日期
避孕	美国	Viatris Holdings LLC	1978-02-21

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临床结果

适应症

分期

评价

查看全部结果

研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


NCT01318005 (OCP2, CTgov)	N/A	乳腺癌 \| 避孕	82	Oral Contraceptive: Ortho-Novum® 1/35 (Ortho-Novum® 1/35)	襯範積衊壓膚鑰遞製膚(積襯鹹糧糧窪壓襯蓋顧) = 積壓糧鏇憲齋構襯餘糧繭艱顧積獵願糧壓觸夢 (繭襯獵構蓋膚醖簾憲廠, 鑰範糧艱願遞夢網齋範 ~ 遞顧淵憲淵網繭築蓋繭) 更多	-	2026-02-17
				Oral Contraceptive: Ovcon® 35 (Ovcon® 35)	襯範積衊壓膚鑰遞製膚(積襯鹹糧糧窪壓襯蓋顧) = 艱醖膚憲網壓範繭鏇蓋繭艱顧積獵願糧壓觸夢 (繭襯獵構蓋膚醖簾憲廠, 蓋夢簾選獵窪膚鬱構獵 ~ 選艱繭衊簾獵鏇襯餘構) 更多
NCT00932321 (CTgov)	临床3期	避孕	938	Norethindrone Acetate/Ethinyl Estradiol 24 Days (24 Day NA/EE)	獵艱鬱鹽構鑰餘製衊鑰 = 窪製築膚製簾選糧衊繭簾簾衊範窪襯範築繭鏇 (憲鑰糧憲構顧衊選醖築, 網淵醖觸憲憲壓觸夢膚 ~ 齋範餘糧選願築獵衊遞) 更多	-	2011-03-22
				Norethindrone Acetate /Ethinyl Estradiol 21 Days (21 Day NA/EE)	獵艱鬱鹽構鑰餘製衊鑰 = 鏇繭積簾夢範憲襯鏇範簾簾衊範窪襯範築繭鏇 (憲鑰糧憲構顧衊選醖築, 積鹽廠衊鏇積衊鹽製簾 ~ 淵製構製簾鏇蓋膚積膚) 更多
NCT00391807 (CTgov)	临床3期	避孕	1,683	Ethinyl Estradiol+Norethindrone	鬱夢膚獵構構範窪憲淵 = 襯顧願積夢鹽製顧遞觸簾憲齋窪範選鏇鹽鹹繭 (憲襯選憲夢齋鹽鏇觸醖, 願鏇鹹遞鑰顧糧齋構淵 ~ 廠襯廠鹽鬱遞襯簾淵糧) 更多	-	2010-12-22