Durlobactam

Clinical Microbiology and Infection[Jour] AND 32[volume] AND 7[issue] 临床微生物学与感染 32卷 7期 https://www.sciencedirect.com/journal/clinical-microbiology-and-infection/vol/32/issue/7 Editorial Note（编者注） 1 Call for editor in virology 病毒学编辑征稿启事 J. Rodríguez-Baño Page 1035 Commentaries（述评） 2 US WHO withdrawal and clinical readiness 美国退出世卫组织与临床应对准备 Lukasz Szarpak, Michal Pruc, Beata Piskorska, Maciej Maslyk Pages 1036-1038 3 Reunion's bold bet against leptospirosis 留尼汪岛抗击钩端螺旋体病的大胆举措 Anissa Desmoulin, Xavier Deparis, Barbara Kuli, Loïc Raffray, Emilie Mosnier Pages 1039-1041 4 Reviving β-lactams for Mycobacterium abscessus: the emerging role of durlobactam β-内酰胺类抗生素重振活力治疗脓肿分枝杆菌：杜洛巴坦的新兴作用 Chengcheng Wang, Zhiyong Zong Pages 1042-1044 Editorials（社论） 5 A cutting-edge vaccine could address a gap in protection against Ebola virus disease 一种前沿疫苗有望填补埃博拉病毒病免疫保护的空白 Armand Sprecher, Sylvie Jonckheere, Michel Van Herp Pages 1045-1046 6 Widespread extended-spectrum β-lactamase–producing Enterobacterales colonization in healthy individuals in Burkina Faso: a hidden community reservoir 布基纳法索健康人群中广泛存在产超广谱β-内酰胺酶肠杆菌目细菌定植：一个隐匿的社区储库 Caroline Theunissen, Olivier Denis Pages 1047-1049 Theme Issue（主题专刊） Theme Issue Editorial（专题社论） 7 Microbiome science at a turning point: from descriptive ecology to clinical decision making in infectious diseases 微生物组学正处于转折点：从描述性生态学走向感染性疾病的临床决策 Silvia Corcione, Nicolas Benech, Ed Kuijper Pages 1050-1051 Theme Issue Reviews（专题综述） 8 Role of the gut microbiome in shaping drug response in immunocompromised hosts 肠道微生物组在免疫功能低下宿主药物应答中的作用 Semeh Bejaoui, Federica D'Amico, Silvia Turroni Pages 1052-1059 9 The role of the gut microbiome in multidrug-resistant organism colonization and infection 肠道微生物组在多重耐药菌定植与感染中的作用 Blair Merrick, Rebecca Cooper, Benjamin Davido, Simon D. Goldenberg Pages 1060-1066 10 Dynamics of the gut and lung microbiota in severe infections: from observational studies to therapeutic strategies 严重感染中肠道与肺部微生物群的动态变化：从观察性研究到治疗策略 Duveke P.E. de Gaay Fortman, Robert F.J. Kullberg, W. Joost Wiersinga, Bastiaan W. Haak Pages 1067-1074 11 Advanced computational analysis in metagenomic studies to support precision medicine 宏基因组研究中支持精准医学的高级计算分析 Gianmarco Piccinno, Francesco Asnicar Pages 1075-1080 12 How to set up and manage a microbiome research facility 如何建立和管理微生物组研究设施 Jannie G.E. Henderickx, Wiep Klaas Smits, Georg Zeller, Ed J. Kuijper Pages 1081-1086 Systematic Reviews（系统综述） 13 The impact of toll-like receptor polymorphisms on susceptibility to fungal infections: a systematic review of genetic and clinical data Toll样受体多态性对真菌感染易感性的影响：遗传与临床数据的系统综述 Martha Fabielle Pereira Staiger, Gleyce Hellen de Almeida Souza, James Venturini, Nalu Teixeira de Aguiar Peres, ... Luana Rossato Pages 1087-1095 14 Host blood biomarkers for the diagnosis of childhood tuberculosis disease: a systematic review and meta-analysis 用于儿童结核病诊断的宿主血液生物标志物：系统综述与荟萃分析 Michael Prodanuk, James W. King, Jessie Cunningham, Ian Kitai, ... Melissa Richard-Greenblatt Pages 1096-1106 Guidelines（指南） 15 Guiding principles for implementing ESCMID clinical practice guidelines 实施ESCMID临床实践指南的指导原则 Bianca Albers, Blin Nagavci, Oana Joean, Sarah Tschudin Sutter, ... Marcus Zervos Pages 1107-1114 Picture of a Microorganism（微生物图鉴） 16 A hard tick on the scalp visualized by polarized and ultraviolet dermoscopy 偏振光与紫外线皮肤镜下头皮上的硬蜱 Jia-Xu Li, Dan-Qiong Zheng, Yi-Ming Fan Pages 1115-1116 Original Articles（论著） 17 Genomic determinants of Bacillus cereus and outcomes of infection in preterm neonates: a multicentre retrospective study 蜡样芽孢杆菌的基因组决定因素及早产儿感染预后：一项多中心回顾性研究 Alicia Chevalier, Mariem Ben Khedher, Antoine Tran, Matilde Coin, ... Raymond Ruimy Pages 1117-1124 18 Faecal colonization with extended-spectrum β-lactamase–producing Escherichia coli and Klebsiella pneumoniae in rural Burkina Faso 布基纳法索农村地区产超广谱β-内酰胺酶大肠埃希菌和肺炎克雷伯菌的粪便定植 Daniel Valia, Ibrahima Karama, Brecht Ingelbeen, Zakaria Garba, ... Hector Rodriguez-Villalobos Pages 1125-1134 19 Changes in nasal and throat microbiota composition during and after mupirocin and chlorhexidine decolonization treatment in asymptomatic methicillin-resistant Staphylococcus aureus carriers: a longitudinal observational study 无症状耐甲氧西林金黄色葡萄球菌携带者接受莫匹罗星与氯己定去定植治疗期间及之后鼻咽部微生物群组成的变化：一项纵向观察研究 Sofie Marie Edslev, Cindy M. Liu, Bobby Zhao Sheng Lo, Heidi Meiniche, ... Marc Stegger Pages 1135-1143 20 Clinical utility of the DENOVA score for predicting infective endocarditis in Enterococcus faecalis bacteraemia: external validation with decision curve analysis DENOVA评分预测粪肠球菌菌血症感染性心内膜炎的临床效用：基于决策曲线分析的外部验证 Benedetta Varisco, Daniele Piovani, Elena Rosselli Del Turco, Linda Bussini, ... Martina Spaziante Pages 1144-1151 21 Clinical validation of a new multi-Aspergillus species reverse transcriptase quantitative PCR: a diagnostic case-control study 新型多曲霉属逆转录酶定量PCR的临床验证：一项诊断性病例对照研究 Marion Benazra, Wicem Mallek, Théo Ghelfenstein-Ferreira, Aude Sturny-Leclère, ... Alexandre Alanio Pages 1152-1157 22 A phase Ib, placebo-controlled randomized clinical trial of the Ebolavirus DNA vaccine candidate INO-4201 followed by electroporation as booster vaccination in healthy, rVSVΔG-ZEBOV-GP-primed volunteers (Boost-EBOV) 一项关于埃博拉病毒DNA疫苗候选物INO-4201的Ib期、安慰剂对照、随机临床试验，该试验在健康、已接种rVSVΔG-ZEBOV-GP的初免志愿者中，以电穿孔作为加强接种（Boost-EBOV） Angela Huttner, Marc-Antoine de La Vega, Cristina Boehm-Bosmani, Jean Boyer, ... Gary P. Kobinger Pages 1158-1164 23 Burden of HIV and hepatitis B and C viruses in incoming Venezuelan migrants at the Colombian border: a laboratory-based cross-sectional study, 2021–2023 2021–2023年哥伦比亚边境入境委内瑞拉移民中HIV及乙型和丙型肝炎病毒的负担：一项基于实验室的横断面研究 Felix Lehmann, Ruth Aralí Martínez-Vega, Andres Moreira-Soto, Carlos Hernán Becerra-Mojica, ... Jan Felix Drexler Pages 1165-1170 24 Association between early SARS-CoV-2 viral rebound and post-COVID conditions among immunocompromised patients: cohort study 免疫功能低下患者中早期SARS-CoV-2病毒反弹与新冠后遗症的关联：队列研究 Guozhang Lin, Yuchen Wei, Carlos King Ho Wong, Xi Xiong, ... Ka Chun Chong Pages 1171-1178 Research Note（研究简讯） 25 From compliance to complexity: the impact of in vitro diagnostic regulation for clinical microbiology laboratories 从合规到复杂：体外诊断法规对临床微生物学实验室的影响 Sangeeta Gaja-Lachman, Mariëlle De Visser-Timmermans, Diana Langerak, Amber Jansma, Erlangga Yusuf Pages 1179-1182 Letters（读者来信） 26 Emerging extraintestinal Vibrio infections in Ireland from clinical and marine sources, 2020–2022 2020–2022年爱尔兰来自临床与海洋来源的新兴肠道外弧菌感染 Brigid Hooban, Seán Olann Whelan, Amy Burke, Mary Lucey, ... Georgios Miliotis Pages 1183-1186 27 Neisseria meningitidis MenY ST-1466 harbouring Neisseria gonorrhoeae 16S rRNA allele causing false-positive Aptima® gonococcal nucleic acid amplification test results 携带淋病奈瑟菌16S rRNA等位基因的脑膜炎奈瑟菌MenY ST-1466导致Aptima®淋球菌核酸扩增检测假阳性 Sebastiaan J. van Hal, Emma Goeman, Yvette Davidson, Frances Jenkins, ... Monica Lahra Pages 1187-1189 28 Nationwide emergence of cefotaxime-resistant Neisseria meningitidis via interspecies gene transfer from penA795-bearing Neisseria commensals in China 中国境内通过种间基因转移自携带penA795的奈瑟菌属共生菌而出现的全国性头孢噻肟耐药脑膜炎奈瑟菌 Youxing Shao, Xin Lan, Mingliang Chen, Minggui Wang, Qinglan Guo Pages 1190-1192 29 Carbapenemase-producing Klebsiella pneumoniae harbouring virulence-associated genes among war-affected children from the Gaza Strip 加沙地带受战争影响儿童中携带毒力相关基因的产碳青霉烯酶肺炎克雷伯菌 Andrés Pérez-López, Anju Sharma, Ruwa Mohamed, Clement K.M. Tsui, ... Mohammed Suleiman Pages 1193-1195 Corrigendum（勘误） 30 Corrigendum to “A new SARS-CoV-2 variant with high lethality poorly detected by RT-PCR on nasopharyngeal samples: an observational study” [Clin Microbiol Infect 28 (2) (2022) 298.e9–e15] 勘误："一种高致死率且鼻咽拭子RT-PCR检测灵敏度低的新型SARS-CoV-2变异株：一项观察性研究" [Clin Microbiol Infect 28 (2) (2022) 298.e9–e15] Pierre Fillâtre, Marie-José Dufour, Sylvie Behillil, Rémi Vatan, ... Nicolas Massart Page 1196 Clinical Microbiology and Infection[Jour] AND 32[volume] AND 7S[issue] 临床微生物学与感染 32卷 7期增刊 https://www.sciencedirect.com/journal/clinical-microbiology-and-infection/vol/32/issue/7/suppl/S The role of whole genome sequencing in antimicrobial susceptibility prediction of bacteria: 2025 update from the EUCAST Subcommittee 全基因组测序在细菌抗菌药物敏感性预测中的应用 —— 欧洲抗微生物药物敏感性试验委员会分委会 2025 年更新报告 The publication of this supplement has been sponsored by the Antibiotic Resistance and Pathogenicity of Bacterial Infections Research Group, Instituto de Investigaci\xF3n Sanitaria Illes Balears (IdISBa) 本增刊出版由巴利阿里群岛卫生研究所（IdISBa）细菌感染耐药与致病性研究组资助 The role of whole genome sequencing in antimicrobial susceptibility prediction of bacteria: 2025 update from the European Committee on Antimicrobial Susceptibility Testing Subcommittee 全基因组测序在细菌抗菌药物敏感性预测中的应用 —— 欧洲抗微生物药物敏感性试验委员会分委会 2025 年更新报告 Ørjan Samuelsen, Carla López-Causapé, Frank Møller Aarestrup, Valeria Bortolaia, ... Antonio Oliver Pages S1-S34 【abstract】（摘要） Scope: The 2017 European Committee on Antimicrobial Susceptibility Testing (EUCAST) subcommittee report on the role of whole genome sequencing (WGS) in antimicrobial susceptibility testing (AST) concluded that WGS antimicrobial susceptibility prediction (WGS-ASP) was not a sufffciently robust alternative to AST to guide clinical decision making at that stage and that more evidence was required [1]. Since then, the use of WGS, bioinformatic tools, machine learning (ML)/artiffcial intelligence (AI), databases, and prediction approaches has greatly expanded, along with an increased knowledge of resistance mechanisms and their contribution to antimicrobial susceptibility. In response, a new EUCAST ad hoc subcommittee was established in 2024 to review the literature, with the aim of assessing the current potential and limitations of WGS-ASP. 研究范围：2017年欧洲抗微生物药物敏感性试验委员会（EUCAST）分委会发布的全基因组测序（WGS）用于抗菌药物敏感性试验（AST）专项报告指出，彼时全基因组测序抗菌药物敏感性预测技术（WGS-ASP）稳定性不足，尚无法替代表型药敏试验指导临床诊疗决策，仍需积累更多研究证据[1]。此后，全基因组测序技术、生物信息学分析工具、机器学习/人工智能算法、耐药数据库及基因型预测模型得到广泛应用；同时，学界对抗菌药物耐药机制及其对药敏表型的影响认知持续深化。为此，EUCAST于2024年成立专项临时分委会，系统梳理现有文献，评估当前WGS-ASP技术的应用潜力与现存局限。 Methods: As in the previous report, the subcommittee reviewed the literature on a ‘by organism’ basis but expanded the list to also include enterococci, Haemophilus inffuenzae, and Bacteroides fragilis in addition to those already included in the ffrst version: Enterobacterales, Pseudomonas aeruginosa, Acinetobacter baumannii, Neisseria gonorrhoeae, Staphylococcus aureus, Streptococcus pneumoniae, Clostridioides difffcile, and Mycobacterium tuberculosis. Additional sections were included to cover advances in metagenomics, other omics technologies and ML/AI. The full report was compiled and reviewed by all subcommittee members before public consultation in November 2025. 研究方法：与上一版报告一致，本分委会按照菌种分类开展文献综述；相较于初版，本次扩充菌种覆盖范围，除原有肠杆菌目、铜绿假单胞菌、鲍曼不动杆菌、淋病奈瑟菌、金黄色葡萄球菌、肺炎链球菌、艰难梭菌、结核分枝杆菌外，新增肠球菌、流感嗜血杆菌、脆弱拟杆菌。报告增设独立章节，系统阐述宏基因组学、其他组学技术及机器学习/人工智能领域的研究进展。完整报告经全体分委会成员编撰、内审后，于2025年11月面向公众征求意见。 Conclusions and Recommendations: Signiffcant progress has been achieved in WGS-ASP, with growing evidence supporting its ability to distinguish wild-type from non—wild-type isolates and, consequently, susceptible from resistant strains, particularly for M. tuberculosis and when clinical breakpoints align with the epidemiological cut-off (ECOFF). Despite these advances, important challenges remain before WGS-ASP can be adopted as a clinical decision-making tool. Addressing these gaps will require integrated phenotypic and genotypic surveillance to strengthen the evidence base for complex resistance mechanisms and newer antimicrobial agents, alongside comparative assessments that consider both ECOFF and clinical breakpoints. The analyses will require reference method phenotypic AST and highquality genomic data. It is critical to ensure that datasets reffect the target populations and encompass the full spectrum of antimicrobial susceptibility, while developing uniffed interpretation frameworks and harmonized bioinformatics tools to standardize outputs. Robust external quality assessment schemes will be essential for clinical validation, and emerging technologies such as AI and ML offer promising avenues to enhance predictive accuracy. Finally, improvements in cost and turnaround time, coupled with evaluations of setting-speciffc cost-effectiveness, will be key to enabling practical implementation of WGS-ASP.  结论与建议：WGS-ASP技术已取得长足进展，现有大量证据证实该技术可区分野生型菌株与非野生型菌株，进而判别敏感株与耐药株；针对结核分枝杆菌的检测优势尤为突出，且当临床折点与流行病学临界值（ECOFF）一致时检测效果更佳。尽管技术进步显著，若要将WGS-ASP作为临床常规决策工具，仍存在诸多亟待解决的难题。需联合开展表型-基因型一体化耐药监测，完善复杂耐药机制与新型抗菌药物相关研究证据；同时同步结合流行病学临界值与临床折点开展对比验证。相关研究需配套参比标准表型药敏试验与高质量基因组测序数据。数据集需贴合目标人群特征，覆盖全部药敏表型谱系；同时搭建统一判读体系、标准化生物信息学工具，实现检测结果规范化输出。完善、可靠的室间质评体系是该技术完成临床验证的核心保障；人工智能、机器学习等新兴技术可有效提升药敏预测准确度，具备良好应用前景。最后，降低检测成本、缩短报告周转时长，并结合不同医疗场景开展卫生经济学效益评估，是推动WGS-ASP落地临床实际应用的关键。 Ørjan Samuelsen, Clin Microbiol Infect 2026;32:S3 作者：厄尔扬·萨缪尔森 发表期刊：《临床微生物学与感染》2026年；32卷：增刊3 Clinical Microbiology and Infection[Jour] AND 32[volume] AND 8[issue] 临床微生物学与感染 32卷 8期 https://www.sciencedirect.com/journal/clinical-microbiology-and-infection/vol/32/issue/8 Commentaries（述评） 1 Andes hantavirus outbreak on a cruise ship—an European Society of Clinical Microbiology and Infectious Disease Emerging Infections Subcommittee rapid assessment 邮轮安第斯汉坦病毒暴发——欧洲临床微生物与感染病学会新发感染分委会快速评估 Marta Mora-Rillo, Nitin Gupta, Effrossyni Gkrania-Klotsas, Jan Felix Drexler, ... Martin P. Grobusch Pages 1197-1201 2 Bundibugyo Ebolavirus outbreak in the Democratic Republic of the Congo and Uganda: rapid assessment from the European Society of Clinical Microbiology and Infectious Diseases Emerging Infections Subcommittee 刚果民主共和国与乌干达本迪布焦埃博拉病毒暴发：欧洲临床微生物与感染病学会新发感染分委会快速评估 Nitin Gupta, Marta Mora-Rillo, Effrossyni Gkrania-Klotsas, Jan Felix Drexler, ... Sotirios Tsiodras Pages 1202-1207 3 Beyond sensitivity and specificity: designing outcome-driven evidence for infectious disease in vitro diagnostics 超越灵敏度与特异度：构建以临床结局为导向的感染病体外诊断循证依据 Benjamin Hommel Pages 1208-1210 4 Rethinking informed consent in phage therapy: why location and approach matter 重新审视噬菌体疗法知情同意：实施场景与沟通方式的关键价值 Ran Nir-Paz, Jean-Paul Pirnay, Tristan Ferry, Zuzanna Drulis-Kawa, ... Gina A. Suh Pages 1211-1215 5 Which trial do we need? The Selective Digestive Decontamination Herd Effects Estimation Trial (SHEET) study 我们需要何种临床试验？选择性消化道去污群体效应评估（SHEET）研究 James C. Hurley Pages 1216-1220 Editorial（社论） 6 Inputs of robust observational studies on encephalitis: the game will never be over 高质量观察性研究对脑炎诊疗的价值：探索永无止境 Pierre Fillâtre, Alexandra Mailles, Jean-Paul Stahl, Sylviane Defres, Pierre Tattevin Pages 1221-1223 Theme Issue（专刊） Theme Issue Editorial（专刊社论） 7 On silence and modesty 论医学研究中的审慎与谦逊 Katharina Last Page 1224 Theme Issue Reviews（专题综述） 8 Hybrid effectiveness-implementation studies in infection prevention and infectious diseases: a narrative review 感染防控领域效果-实施混合研究：叙述性综述 Lauren Clack, Marie-Therese Schultes, Bianca Albers, Aline Wolfensberger Pages 1225-1237 9 Anthropology of infectious disease emergence and epidemic control: a review 新发传染病与疫情防控的人类学视角：综述 Tamara Giles-Vernick, Jules Villa Pages 1238-1243 10 The human cost of resistance: ethical implications of coping with isolation for multidrug resistant organisms 耐药带来的人文代价：多重耐药菌隔离管理的伦理考量 Sibylle C. Mellinghoff, Alessandra A. Grossi, Claudia Recanatini, Leonie Breull-Wierschem, ... Norma Jung Pages 1244-1249 Narrative Reviews（叙述性综述） 11 Blood vessels at the crossroads: angiogenesis in the intersection of HIV and atherosclerosis 血管的交叉病理：HIV合并动脉粥样硬化中的血管新生机制 Pere Domingo, Paula Prieto, Marta Giralt, Didac Mauricio, Elvira Fernández Pages 1250-1259 12 Antifungal susceptibility testing across fungi: why MICs vary and methods diverge and what MIC can miss 广谱真菌药敏检测：最低抑菌浓度差异、检测方法分歧及检测盲区 Cornelia Lass-Flörl, Maximilian Lass, Jan Marco Kern, Silke Huber Pages 1260-1264 13 Antimicrobial stewardship during extracorporeal membrane oxygenation: challenges and new perspectives 体外膜肺氧合（ECMO）期间抗菌药物精细化管理：挑战与新进展 Salman Abdulaziz, Hanan Salah Alhajri, Miranda So, Salman Butt, ... Daniel Brodie Pages 1265-1272 Systematic Reviews（系统综述） 14 Nudging in MicroBiology laboratory Evaluation (NiMBLE): a systematic review and meta-analysis 微生物实验室干预引导策略（NiMBLE）：系统综述与荟萃分析 Bradley J. Langford, Elizabeth Leung, Esther Jeong, Kevin A. Brown, ... Larissa M. Matukas Pages 1273-1285 Position Paper（立场声明） 15 Language, trust, and the polio endgame: words matter in vaccine communication 语言、公众信任与脊髓灰质炎消除攻坚：疫苗科普沟通的措辞策略 Sotirios Tsiodras, Nitin Gupta, Thomas Hanscheid, Pikka Jokelainen, ... Martin P. Grobusch Pages 1286-1292 Picture of a Microorganism（微生物图鉴） 16 Plectosphaerella cucumerina fungal keratitis in an uncommon presentation 黄瓜隔孢菌所致非典型真菌性角膜炎 Lipeng Wang, Lihua Jiang, Shujun Liu, Maoli Yi Pages 1293-1294 Original Articles（论著） 17 Performance of an antigen test for detection of SARS-CoV-2, influenza, and respiratory syncytial virus—a prospective study 新冠病毒、流感病毒、呼吸道合胞病毒三联抗原检测效能：前瞻性研究 Karoline Berger, Siv-Hege Vang, Roy H.O. Bekkeseth, Anders Bredberg Pages 1295-1301 18 Risk of major structural birth defects following repeat mRNA COVID-19 vaccination in the first trimester: a population-based cohort study 孕早期重复接种mRNA新冠疫苗后重大结构性出生缺陷风险：基于人群的队列研究 Liang En Wee, Muhammad Ismail Bin Abdul Malek, Reen WL Ho, Jue Tao Lim, ... Kelvin B. Tan Pages 1302-1310 19 Persistence of late HIV diagnosis and poorer response to antiretrovirals: a comparison between migrants and native-born people with HIV in Spain HIV晚诊持续现状及抗逆转录病毒治疗应答不佳：西班牙移民与本土HIV感染者对比研究 Jose A. Perez-Molina, Miguel Suárez-Robles, María Belén Sánchez-López, Francisco Tejerina, ... M Ángeles Muñoz-Fernández Pages 1311-1321 20 Emergence of novel zoonotic and multidrug-resistant Streptococcus suis lineages 新型人兽共患病多重耐药猪链球菌谱系的出现 Jaime Brizuela, Gemma G.R. Murray, Parichart Boueroy, Andrew J. Balmer, ... Constance Schultsz Pages 1322-1330 21 Pharmacokinetic and pharmacodynamic evaluations of oral moxifloxacin for Enterococcus faecalis endocarditis 口服莫西沙星治疗粪肠球菌心内膜炎的药代动力学/药效学评价 Magnus Bock, Johan G.C. Van Hasselt, Kurt Fuursted, Nikolaj Ihlemann, ... Claus Moser Pages 1331-1337 22 Infectious encephalitis among adults: a prospective and population-based cohort study 成人感染性脑炎：前瞻性人群队列研究 Lærke Storgaard Duerlund, Lykke Larsen, Merete Storgaard, Helene Mens, ... Jacob Bodilsen Pages 1338-1346 23 Doxycycline in the treatment of outpatient mild community-acquired pneumonia: a propensity-matched retrospective cohort study 多西环素治疗门诊轻型社区获得性肺炎：倾向得分匹配回顾性队列研究 Genady Drozdinsky, Asaf Ness, Melanie Shahar, Shiri Kushnir, ... Noa Eliakim-Raz Pages 1347-1351 24 Rifapentine dosing for drug-susceptible tuberculosis: stage 1 of a seamless phase 2/3 randomized clinical trial 利福喷丁治疗药物敏感肺结核给药方案：无缝Ⅱ/Ⅲ期随机临床试验第一阶段研究 Yang Li, Lingyun Song, Zhen Feng, Xiaoqiang Zhang, ... Wenhong Zhang Pages 1352-1359 Research Notes（研究简报） 25 First reported case of Andes hantavirus cardiopulmonary syndrome treated with a combination of favipiravir, ribavirin, icatibant and baricitinib 法匹拉韦、利巴韦林、艾替班特联合巴瑞替尼救治安第斯汉坦病毒心肺综合征首例报道 Miriam Estébanez, María Simón Sacristán, Tatiana Mata Forte, Anabel Negredo, ... Francisco Javier Areta Jimenez Pages 1360-1366 Letters（读者来信） 26 Re: ‘ESCMID clinical guidelines on the evaluation and management of a reported antibiotic allergy’ by Joean et al. 回应：Joean等人《ESCMID抗生素过敏评估与临床治疗指南》 Ignacio Martin-Loeches, Sean Keane Pages 1367-1368 27 ‘ESCMID clinical guidelines on the evaluation and management of a reported antibiotic allergy’—author’s reply 《ESCMID抗生素过敏评估与临床治疗指南》——作者回复 Oana Joean, Kevin Sermet, Blin Nagavci, Jonathan Sandoe, Mark de Boer Pages 1369-1370 28 Antibiotic allergy delabeling requires more than guidelines: the role of patient perspective 抗生素过敏去标签管理不能仅依靠指南：患者主观视角的重要作用 Neda Milevska-Kostova, Teske Schoffelen, Tessa Langeveld, Jeroen Schouten, Marlies E.J.L. Hulscher Pages 1371-1372 29 Re: ‘Clinical utility of the DENOVA score for predicting infective endocarditis in Enterococcus faecalis bacteraemia: external validation with decision curve analysis’ by Varisco et al. 回应：Varisco等人《DENOVA评分预测粪肠球菌菌血症并发感染性心内膜炎的临床价值：决策曲线分析外部验证》 Pierre Danneels, Floris Chabrun, Baptiste Clément, Xavier Duval, Vincent Dubée Pages 1373-1374 30 Clinical utility of the DENOVA score for predicting infective endocarditis in Enterococcus faecalis bacteraemia—Author's reply DENOVA评分预测粪肠球菌菌血症并发感染性心内膜炎的临床价值——作者回复 Benedetta Varisco, Linda Bussini, Davide Fiore Bavaro, Michele Bartoletti Pages 1375-1376 Clinical Microbiology and Infection[Jour] AND 32[volume] AND 9[issue] 临床微生物学与感染 32卷 9期 https://www.sciencedirect.com/journal/clinical-microbiology-and-infection/vol/32/issue/9 Commentaries（述评） 1 Advancing medicine, undermining life: a global health contradiction 推动医学进步却损害生命：一项全球卫生领域的矛盾 Edmond Puca, Francesca Rossi, Rima Moghnieh, Lukas Tometten, ... Ricardo Strauss Pages 1377‑1379 2 A European perspective on antibiotic use in viral respiratory infections: new paradigm integrating pathogens with host factors 病毒性呼吸道感染抗生素应用的欧洲观点：整合病原体与宿主因素的新模式 Şiran Keske, Virginie Prendki, Paraskevi C. Fragkou, Jordi Rello, the ESGREV and ESGIE Pages 1380‑1383 3 Antibiotic prophylaxis: a sharp tool that could be blunted easily 抗生素预防：一把易被钝化的利器 Marek Stefan, Marcela Krutova Pages 1384‑1387 3 Beyond the ward: the evolving roles of infectious disease specialists 走出病房：感染病专科医师角色的演变 Konstantinos Alexakis, Angela Ishak, Nikolaos Mazonakis, Constantinos Tsioutis, Nikolaos Spernovasilis Pages 1388‑1392 Editorial（社论） 4 From surveillance to participation: redefining respiratory virus epidemiology in the era of self‑testing 从监测到参与：自检时代下呼吸道病毒流行病学的重新定义 Markus Fally, Alexander G. Mathioudakis Pages 1393‑1395 5 Time to tap early: do not delay lumbar puncture in older adults 宜尽早实施：老年患者不应延迟腰椎穿刺 Marion Le Maréchal, Mathieu Vaillant Pages 1396‑1397 6 Can we improve on standard cefoxitin dosing for surgical prophylaxis? 外科预防用药中，我们能否优化头孢西丁标准给药方案？ Sheryl A. Zelenitsky Pages 1398‑1400 7 Diagnosing and managing unexpected donor bloodstream infection in organ transplantation 器官移植中供体不明原因血流感染的诊断与处理 Maddalena Giannella, Matteo Rinaldi Pages 1401‑1403 Narrative Reviews（叙述性综述） 8 Nipah virus in South Asia: from emergence to enduring preparedness' challenges 南亚尼帕病毒：从病毒出现到持续防控准备面临的挑战 Nitin Gupta, Effrossyni Gkrania‑Klotsas, Jan Felix Drexler, Sayantan Banerjee, ... Sotirios Tsiodras Pages 1404‑1411 9 Emerging mycoses: a neglected area of concern for global health 新发真菌病：全球卫生被忽视的关注点 Aleksandra Barac, Oliver A. Cornely, José Ramón Paño‑Pardo, Nitin Gupta, ... Martin P. Grobusch Pages 1412‑1417 10 New antifungals for the treatment of invasive mould disease 用于侵袭性霉菌病治疗的新型抗真菌药物 Nancy N. Vuong, David R. McClung, Samuel L. Aitken, Caitlin R. Rausch Pages 1418‑1424 11 Questions and issues of nonventilated hospital‑acquired pneumonia: an opinion document 非机械通气医院获得性肺炎的若干问题：一份专家意见文件 Marina Fayos, Almudena Burillo, Alicia Galar, Ana Álvarez Uría, ... Emilio Bouza Pages 1425‑1434 Systematic Reviews（系统综述） 12 Andes virus–associated cardiopulmonary syndrome: diagnostic approaches, clinical management, and evidence gaps—a scoping review 安第斯病毒相关心肺综合征：诊断手段、临床处置与证据缺口——范围综述 Federico Fama, Francesco Molà, Alberto Rizzo, Lucia Galli, ... Marta Colaneri Pages 1435‑1447 Position Paper（立场文件） 13 Position statement: integrating planetary health into infection prevention and control in healthcare settings—towards a balanced and evidence‑based approach 立场声明：将地球健康理念融入医疗机构感染预防与控制——构建均衡的循证实践路径 Ermira Tartari, Emine Alp Meşe, Andre N.H. Bulabula, Stephanie J. Dancer, ... Walter Zingg Pages 1448‑1462 Picture of a Microorganism（微生物图鉴） 14 Lumbar‑sacral giant sparganosis presenting as an intradural mass 表现为硬脊膜内占位的腰骶部巨大裂头蚴病 Jiarui Chen, Xinli Zhan, Chengqian Huang, Mingbo Wang, ... Chong Liu Pages 1463‑1464 Original Articles（原创论著） 15 Performance of a rapid, visual fingerstick serology self‑test for Helicobacter pylori detection and typing: a prospective multicentre diagnostic accuracy study 幽门螺杆菌检测及分型的指尖采血可视化血清学快速自检试剂盒效能：一项前瞻性多中心诊断准确性研究 Jing Chen, Tingting Wang, Song Liu, Jing Xiang, ... Changjiang Hu Pages 1465‑1471 16 Diagnostic accuracy and potential resource savings of pooled sputum testing with Xpert MTB/RIF Ultra for tuberculosis among adults in Vietnam: a cross‑sectional study 越南成人肺结核采用Xpert MTB/RIF Ultra混合痰液检测的诊断效能与潜在医疗资源节约：一项横断面研究 Han Thi Nguyen, Andrew James Codlin, Luan Nguyen Quang Vo, Nga Thi Thuy Nguyen, ... Tom Wingfield Pages 1472‑1479 17 Self‑testing for five respiratory viruses in adults ≥50 years of age in Germany for longitudinal monitoring of community‑acquired acute respiratory infections 德国≥50岁成人5种呼吸道病毒自检用于社区获得性急性呼吸道感染的纵向监测 Julia A. Nacov, Jon Salmanton‑García, Julia Jakobs, Miranda Anggitakirana, ... Oliver A. Cornely Pages 1480‑1486 18 Blinded two‑year longitudinal evaluation of SARS‑CoV‑2 antigenemia in long COVID 长新冠患者新冠病毒抗原血症为期两年的盲法纵向评估 Lourdes Mateu, Louise L. Hansen, Joao Pedro Carmezim, Cora Loste, ... Marta Massanella Pages 1487‑1494 19 Early vs late diagnosis in infectious encephalitis: a population‑based cohort study 感染性脑炎早期与晚期诊断对比：一项基于人群的队列研究 Lærke Storgaard Duerlund, Lykke Larsen, Merete Storgaard, Helene Mens, ... Jacob Bodilsen Pages 1495‑1502 20 Target‑controlled infusion vs. standard dosing of cefoxitin for surgical prophylaxis in colorectal surgery: a randomized clinical trial 结直肠外科手术预防感染：头孢西丁靶控输注与标准给药方案对比的随机临床试验 Jong Lyul Lee, Ha‑Jung Kim, Kyung Mi Kim, Jung‑Min Yi, ... In Ja Park Pages 1503‑1509 21 Impact of generic market entry on the consumption of last‑resort antibiotics in six European countries 仿制药上市对6个欧洲国家终极抗生素使用量的影响 Caroline Schweizer, Sebastian Weis, Evelina Tacconelli, Stephan Harbarth, ... Miriam Kesselmeier Pages 1510‑1516 22 Association between unrecognized donor bloodstream infection and outcomes in solid organ transplant recipients: a prospective observational cohort study 未被发现的供体血流感染与实体器官移植受者预后的关联：一项前瞻性观察队列研究 Andrea Cona, Caterina Curatolo, Paola Giordani, Flavia D'Andrea, ... Alessandra Mularoni Pages 1517‑1525 Research Note（研究简报） 23 Multicentre validation of EUCAST disk diffusion for frequently encountered anaerobic bacteria (excluding Cutibacterium acnes) in clinical microbiology laboratories in the Netherlands 荷兰临床微生物实验室针对常见厌氧菌（痤疮棒状杆菌除外）EUCAST纸片扩散法的多中心验证 Erlangga Yusuf, Wouter van den Bijlaardt, Helke van Dessel, Thomas Dierikx, ... Alida CM. Veloo Pages 1526‑1530 24 Ceftazidime‑avibactam‑resistant Klebsiella pneumoniae driven by multiple β‑lactamase mutations: a hospital outbreak report 多种β‑内酰胺酶突变介导的耐头孢他啶‑阿维巴坦肺炎克雷伯菌：一起医院暴发报告 Weiwei Yang, Chengkang Tang, Qingyu Shi, Hongjian Ou, ... Fupin Hu Pages 1531‑1535 Letters（读者来信） 25 Re: ‘Meropenem and fosfomycin against Klebsiella pneumoniae’ by Wicha et al. 对Wicha等人《美罗培南联合磷霉素抗肺炎克雷伯菌》一文的回复 Guofu Mao, Haizhen Lan Pages 1536‑1537 26 Meropenem and fosfomycin against Klebsiella pneumoniae: author‘s response 《美罗培南联合磷霉素抗肺炎克雷伯菌》：作者回复 Aneeq Farooq, Miklas Martens, Marie L.G. Attwood, Patrice Nordmann, ... Sebastian G. Wicha Pages 1538‑1539 27 Re: ‘Invasive fungal infections after CD19 chimeric antigen receptor‑T‑cell therapy for B‑cell lymphoma: a lymphoma study association study from the DESCAR‑T registry’ by Bouvier et al. 对Bouvier等人《B细胞淋巴瘤CD19嵌合抗原受体T细胞治疗后侵袭性真菌感染：DESCAR‑T登记库淋巴瘤研究联盟研究》一文的回复 Jice Wang Pages 1540‑1541 28 Invasive fungal infections after cluster of differentiation (CD19) chimeric antigen receptor (CAR) T‑cell therapy for B‑cell lymphoma: author’s response B细胞淋巴瘤CD19嵌合抗原受体T细胞治疗后侵袭性真菌感染：作者回复 Amélie Bouvier, François Lemonnier, Giovanna Melica Pages 1542‑1543 29 Tackling clinical research fragmentation in public health emergencies in Europe 应对欧洲突发公共卫生事件下临床研究碎片化问题 Evelyn Depoortere, Corinna Hartung, Teresa Chavarria Gimenez, Patricia Urbán, Cornelius Schmaltz Pages 1544‑1545 30 Delayed intestinal adenovirus response to intravenous brincidofovir in paediatric allogeneic stem cell transplant recipients displaying rapid clearance of the virus from peripheral blood 儿童异基因干细胞移植受者外周血腺病毒快速清除，但肠道腺病毒对静脉布林西多福韦应答延迟 Chantal Lucini, Sandra Preuner, Lisa Grösslinger, Nkechi Azie, Thomas Lion Pages 1546‑1548