延藜胶囊(Yanli Capsule) - 在研适应症：勃起功能障碍_专利_临床

概要

基本信息

药物类型

中药

别名-

靶点-

作用机制-

治疗领域

泌尿生殖系统疾病

在研适应症

勃起功能障碍

非在研适应症-

原研机构-

在研机构

江西桔王药业有限公司江西省中医药研究院

非在研机构-

最高研发阶段临床2期

首次获批日期-

最高研发阶段(中国)临床2期

特殊审评-

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关联

2

项与延藜胶囊相关的临床试验

CTR20190133 / Not yet recruiting临床2期

延藜胶囊治疗功能性勃起功能障碍-肾阳虚证的随机、双盲、安慰剂平行对照、多中心Ⅱ期（补充）临床试验

① 以安慰剂为对照，初步评价延藜胶囊治疗功能性勃起功能障碍-肾阳虚证的有效性。 ② 初步评价延藜胶囊在功能性勃起功能障碍-肾阳虚证患者中使用的安全性。

开始日期-

申办/合作机构

江西桔王药业有限公司

[+1]

CTR20150212 / Completed临床2期

延藜胶囊治疗功能性勃起功能障碍（肾阳虚证）随机、双盲、安慰剂平行对照、多中心Ⅱ期临床试验

初步评价延藜胶囊治疗功能性勃起功能障碍（肾阳虚证）有效性与安全性。

开始日期2010-10-24

申办/合作机构

江西桔王药业有限公司

[+1]

100 项与延藜胶囊相关的临床结果

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100 项与延藜胶囊相关的转化医学

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100 项与延藜胶囊相关的专利（医药）

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4

项与延藜胶囊相关的文献（医药）

2021-06-01·Journal of Cellular and Molecular Medicine2区 · 医学

Qianliexin capsule exerts anti‐inflammatory activity in chronic non‐bacterial prostatitis and benign prostatic hyperplasia via NF‐κB and inflammasome

2区 · 医学

ArticleOA

作者: Fan, Shengci ; Meng, Zhaoqing ; Lu, Jincai ; Zang, Linghe ; Tian, Fangyuan ; Zhang, Xinyi ; Chen, Yiran ; Han, Mingyu ; Yao, Yuancheng ; Shen, Yuan ; Gao, Qi ; Zhang, Yuwei ; Cai, Tian

AbstractQianliexin capsule (QLX) is a standardized traditional Chinese herbal preparation that has long been used to treat chronic non‐bacterial prostatitis (CNP) and benign prostatic hyperplasia (BPH). This study investigated the anti‐inflammatory activity of QLX in improving lower urinary tract symptoms (LUTS) associated with CNP and BPH. Rat models of CNP and BPH were induced by oestradiol or testosterone (hormonal imbalance) or chemical inflammation (carrageenan). QLX significantly relieved LUTS in CNP and BPH rat model by reducing prostate enlargement, epithelial thickness, pain response time, urine volume and bleeding time, and by improving prostatic blood flow. The expression of the pro‐inflammatory cytokines interleukin (IL)‐1β and tumour necrosis factor (TNF)‐α, the pro‐inflammatory transcription factor nuclear factor kappa‐light‐chain‐enhancer of activated B cells (NF‐κB), and inflammasome components (NLRP3, caspase‐1 and ASC) in CNP and BPH tissues was reduced by QLX addition. QLX treatment was followed by reduced cellular malondialdehyde and increased superoxide dismutase, catalase and glutathione peroxidase activity, consistent with antioxidant activity. Increases in Beclin‐1 expression and the LC3II/I ratio following QLX treatment indicated that autophagy had been induced. QLX relieved LUTS in CNP and BPH rat models by inhibiting inflammation. The underlying mechanisms included inhibition of inflammasome activation, NF‐κB activation, oxidant stress and autophagy.

2006-06-01·Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine

[Changes of serum nitric oxide level after acute hepatic injury in mice and the effect of yugan capsule on it].

Article

作者: Cheng, Xin ; Wang, Jing ; Xie, Chao-liang

OBJECTIVETo observe the changes of serum nitric oxide (NO) level after acute hepatic injury (AHI) in mice and the effect of Yugan capsule (YC) on it.METHODSThe mouse AHI model was induced by carbon tetrachloride ( CC14 ) at different time points. After treatment with or without YC, serum nitric oxide ( NO) , anlanine aminotransferase (ALT) and aspartate aminotransferase (AST) were detected, and liver histopathologic injury was observed at different time points after AHI, respectively.RESULTSSerum NO, ALT and AST in the model group escalated significantly with time going, while they decreased and liver histopathologic injury was improved in the YC groups.CONCLUSIONThe serum levels of NO, ALT and AST increased,and liver histopathologic injury gradually aggravated with time going after CCl4 injection. Yugan capsule could decrease the levels of ALT, AST and NO.

2005-06-01·Current Medical Science

Prevention and treatment of vaginal bleeding after drug-induced abortion by yaoliuan capsule and its effects on menses recovery

Article

作者: Zhichun Jin ; Guangying Huang

In order to explore the effect of Yaoliuan capsule in the prevention and treatment of vaginal bleeding after drug-induced abortion and menses recovery after drug-induced abortion, 323 cases of gestation period < or = 49 days and without contraindication, were divided randomly into study group (168 cases, taking Yaoliuan capsule) and control group (155 cases, taking placebo capsule). The results showed that in the study group, there were 161 cases (95.8%) of complete abortion, 7 cases (4.2%) of incomplete abortion; In the control group, there were 146 cases (94.2%) of complete abortion, 6 cases (3.9%) of incomplete abortion, 3 cases (1.9%) of abortion failure. The vaginal bleeding time was 5-25 days (mean 10.8 days) in study group, while that was 6-62 days (mean 19.1 days) in control group. The menstrual cycle was 30.5+/-5. 2 days and 33.8 d+/-8.6 days respectively in study and control groups. The menstrual period was 6.1+/-3. 5 days and 9.9+/-5.1 days respectively in study and control groups. Yaoliuan capsule is an effective drug to prevent and treat vaginal bleeding following drug-induced abortion, promote menstruation recovery and prevent pelvic infection.

100 项与延藜胶囊相关的药物交易

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