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概览

排名前五的药物类型	数量

中药	1

关联

1

项与江西省中医药研究院相关的药物

Yanli Capsule

延藜胶囊

靶点-

作用机制-

在研机构

江西桔王药业有限公司 [+1]

原研机构-

在研适应症

勃起功能障碍

非在研适应症-

最高研发阶段临床2期

首次获批国家/地区-

首次获批日期-

2

项与江西省中医药研究院相关的临床试验

CTR20190133 / Not yet recruiting临床2期

延藜胶囊治疗功能性勃起功能障碍-肾阳虚证的随机、双盲、安慰剂平行对照、多中心Ⅱ期（补充）临床试验

① 以安慰剂为对照，初步评价延藜胶囊治疗功能性勃起功能障碍-肾阳虚证的有效性。 ② 初步评价延藜胶囊在功能性勃起功能障碍-肾阳虚证患者中使用的安全性。

开始日期-

申办/合作机构

江西桔王药业有限公司

[+1]

CTR20150212 / Completed临床2期

延藜胶囊治疗功能性勃起功能障碍（肾阳虚证）随机、双盲、安慰剂平行对照、多中心Ⅱ期临床试验

初步评价延藜胶囊治疗功能性勃起功能障碍（肾阳虚证）有效性与安全性。

开始日期2010-10-24

申办/合作机构

江西桔王药业有限公司

[+1]

100 项与江西省中医药研究院相关的临床结果

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0 项与江西省中医药研究院相关的专利（医药）

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56

项与江西省中医药研究院相关的文献（医药）

2024-01-01·Srpski arhiv za celokupno lekarstvo

Efficacy observation of acupoint application combined with psychological intervention in elderly patients with mild liver-qi stagnation depression

作者: Wang, Zhaoling ; Yu, Liangzhong

Introduction/Objective. The objective was to propose a safer and more effective treatment method for mild liver-qi stagnation syndrome depression in elderly patients. Methods. A total of 70 elderly patients were recruited from the outpatient or inpatient departments of our hospital between July and December 2022 and were randomly divided into two groups, with 35 in each. The control group received sertraline, and the observation group received acupuncture point application combined with psychological intervention. The course of treatment was 10 days for 4 consecutive courses of treatment. Follow-ing courses 1, 2 and 4, the patients? Hamilton Depression Scale (HAMD-24) scores were compared. Statistical analysis was performed using the paired t-test and the chi-square test. Results. After the end of courses 1, 2 and 4, the traditional Chinese medicine syndrome scale and total HAMD-24 scores were lower in the observation group than in the control group (p < 0.01, p < 0.05). Conclusion. The acupoint application combined with psychological intervention has a rapid and significant effect and fewer adverse effects in liver-qi depression.

2023-05-19·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik

The mechanism of white flower formation in Brassica rapa is distinct from that in other Brassica species.

Article

作者: Zhao, Junwei ; Yang, Jianshun ; Liu, Kede ; Zhang, Bao ; Hu, Jianlin ; Li, Xuewei ; Wang, Kaiyue ; Guan, Zhilin

KEY MESSAGEA single nucleotide (G) deletion in the third exon of BraA02.PES2-2 (Bra032957) leads to the conversion of flower color from yellow to white in B. rapa, and knockout mutants of its orthologous genes in B. napus showed white or pale yellow flowers. Brassica rapa (2n = 20, AA) is grown worldwide as an important crop for edible oil and vegetables. The bright yellow flower color and long-lasting flowering period give it aesthetic qualities appealing to countryside tourists. However, the mechanism controlling the accumulation of yellow pigments in B. rapa has not yet been completely revealed. In this study, we characterized the mechanism of white flower formation using a white-flowered natural B. rapa mutant W01. Compared to the petals of yellow-flowered P3246, the petals of W01 have significantly reduced content of yellowish carotenoids. Furthermore, the chromoplasts in white petals of W01 are abnormal with irregularly structured plastoglobules. Genetic analysis indicated that the white flower was controlled by a single recessive gene. By combining BSA-seq with fine mapping, we identified the target gene BraA02.PES2-2 (Bra032957) homologous to AtPES2, which has a single nucleotide (G) deletion in the third exon. Seven homologous PES2 genes including BnaA02.PES2-2 (BnaA02g28340D) and BnaC02.PES2-2 (BnaC02g36410D) were identified in B. napus (2n = 38, AACC), an allotetraploid derived from B. rapa and B. oleracea (2n = 18, CC). Knockout mutants of either one or two of BnaA02.PES2-2 and BnaC02.PES2-2 in the yellow-flowered B. napus cv. Westar by the CRISPR/Cas9 system showed pale-yellow or white flowers. The knock-out mutants of BnaA02.PES2-2 and BnaC02.PES2-2 had fewer esterified carotenoids. These results demonstrated that BraA02.PES2-2 in B. rapa, and BnaA02.PES2-2 and BnaC02.PES2-2 in B. napus play important roles in carotenoids esterification in chromoplasts that contributes to the accumulation of carotenoids in flower petals.

2022-12-14·Journal of Liquid Chromatography & Related Technologies

Determination of clobetasol propionate in cosmetics by high performance liquid chromatography with pre-column fluorescence derivatization of 4-hydrazino-7-nitrobenzo [C] [1,2,5] oxadiazole

作者: Chen, Jin-Zhu ; Guo, Chun-Mei ; Qin, Xin ; Tu, Qi-Dong ; Zhang, Hai-Wen ; Peng, Da-Yong ; Wang, Chang-Zhao ; Xiong, Xue-Min ; Wang, Jie

In this study, a fluorescent labeling reagent 4-hydrazino-7-nitrobenzo [c] [1,2,5] oxadiazole (NBD-NHNH₂) was synthesized and used for fluorescence detection of clobetasol propionate in cosmetics by high performance liquid chromatog.In the presence of acidic catalyst (pH = 6.0), NBD-NHNH₂ reacted at 45 °C for 30 min, and clobetasol propionate can be labeled quickly and efficiently.These derivatives have excellent stability and fluorescent properties.The maximum excitation wavelength was 450 nm, and the emission wavelength was 550 nm.The four cosmetic formulations were completely separated on a Waters e2695 HPLC C18 column by gradient elution.Under the optimal conditions, the standard curve showed a good linear response, and the correlation coefficient of r² = 0.9999.The LOD and LOQ were 0.01 ng/mL and 0.03 ng/mL, resp.Therefore, NBD-NHNH₂ was successfully applied in the detection of clobetasol propionate illegal added in cosmetics.

100 项与江西省中医药研究院相关的药物交易

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100 项与江西省中医药研究院相关的转化医学

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