A sensitive method for the quantitative determination of the respiratory stimulant dimefline in 5 ml urine using capillary gas chromatography with nitrogen specific detection is presented. After the oral administration of a therapeutical amount of 16 mg dimefline to five subjects only 0.26 +/- 0.16% of the dose is excreted as the conjugated drug in 24 h. The maximum excretion rate occurred 3 h after dosing, the peak concentration being 154 +/- 60 ng ml-1. The influence of diuretics taken 2 h after the administration of dimefline was studied in three subjects. From these results it appeared that the use of acetazolamide and hydrochlorthiazide in order to circumvent a positive dimefline doping case is questionable. Due to the potent diuretic effect of furosemide, the intake of this diuretic could result in a suppression of the dimefline concentration below the detection limit of 10 ng ml-1.

1989-01-01·Archiv der Pharmazie4区 · 医学

Synthesis and Quantitative Structure‐Activity Relationships of Analeptic Agents Related to Dimefline

4区 · 医学

Article

作者: Piero Valenti ; Maurizio Recanatini ; Paolo Da Re ; Pietro Giusti

AbstractSome new dimefline‐type derivatives have been synthesized and their pharmacological activity, as well as their distribution coefficients have been determined. The distribution coefficients of a number of previously published analogue compounds have also been measured and the QSAR analysis of the whole set has been carried out. The results of such analysis allow to point out which factors are influencing the biological activity of this group of compounds.

1985-10-01·Sheng li ke xue jin zhan [Progress in physiology]

[Mechanism of dimefline].

Review

作者: Huang, Q ; Zhang, J R

项与盐酸二甲弗林相关的新闻（医药）

2022-08-02

·蒲公英Ouryao

94个品种新增挂网、公示期截止8月3日！

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100 项与盐酸二甲弗林相关的药物交易

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