A 48 hour patch test performed in healthy volunteers to determine the presensitization (pre-existing allergy) of Neo-Synalar (neomycin sulfate 0.5%(0.35% neomycin base), fluocinolone acetonide 0.025%) Cream . Subjects also receive a positive control (Sodium Lauryl Sulfate) and a negative control (Saline).
The primary objective of this study is to determine if any subjects exhibit an allergic reaction which may be indicative of a pre-existing sensitization.

开始日期2014-06-01

申办/合作机构

Medimetriks Pharmaceuticals, Inc.

100 项与氟轻松丙酮酯/硫酸新霉素相关的临床结果

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100 项与氟轻松丙酮酯/硫酸新霉素相关的转化医学

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100 项与氟轻松丙酮酯/硫酸新霉素相关的专利（医药）

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1,115

项与氟轻松丙酮酯/硫酸新霉素相关的文献（医药）

2025-01-01·Talanta

Cyano-functionalized porous hyper-crosslinked cationic polymers for efficient preconcentration and detection of phenolic endocrine disruptors in fresh water and fish

Article

作者: Zhao, Guijiao ; Wang, Qianqian ; Wang, Chenhuan ; Wang, Chun ; Wu, Qiuhua ; Wang, Zhi

Sensitively analyzing phenolic endocrine-disrupting chemicals (EDCs) in environmental substrates and aquatic organisms provides a significant challenge. Here, we developed a novel porous hyper-crosslinked ionic polymer bearing cyano groups (CN-HIP) as adsorbent for the highly efficient solid phase extraction (SPE) of phenolic EDCs in water and fish. The CN-HIP gave an excellent adsorption capability for targeted EDCs over a wide pH range, and the adsorption capacity was superior to that of several common commercial SPE adsorbents. The coexistence of electrostatic forces, hydrogen bond, and π-π interactions was confirmed as the main adsorption mechanism. A sensitive quantitative method was established by coupling CN-HIP based SPE method with high-performance liquid chromatography for the simultaneously determining trace bisphenol A, bisphenol F, bisphenol B and 4-tert-butylphenol in fresh water and fish. The method afforded lower detection limits (S/N = 3) (at 0.03-0.10 ng mL^-1 for water and 0.8-4.0 ng g^-1 for fish), high accuracy (the recovery of spiked sample at 88.0%-112 %) and high precision (the relative standard deviation < 8.5 %). This work provides a feasible method for detecting phenolic EDCs, and also opens a new perspective in developing functionalized cationic adsorbent.

2024-12-01·Environmental Pollution

Neurotoxic effects of perinatal exposure to Bisphenol F on offspring mice

Article

作者: Song, Miao ; Huo, Siming ; Du, Jiayu ; Li, Bo ; Zhang, Xuliang ; Li, Yanfei

Bisphenols constitute a diverse group of endocrine-disrupting chemicals (EDCs) that impact hormone activity. Bisphenol F (BPF) is commonly used as a substitute for Bisphenol A (BPA). The disruption of the immune system by EDCs during embryonic brain development has been suggested as a plausible factor to neurodevelopmental disorders. We investigated the neurotoxic effects of perinatal exposure to BPF on offspring mice. Female mice were exposed to BPF through their drinking water on day 0.5 of pregnancy, and this exposure continued until the offspring mice were weaned, throughout the perinatal period. Our findings revealed that exposure to BPF hindered both growth and neurodevelopment in offspring mice, with a more pronounced effect observed in males. Additionally, transcriptomic analysis was conducted on the brains of male offspring mice exposed to high doses of BPF. In summary, our study indicates that perinatal exposure to BPF results in neurodevelopmental impairments in male offspring mice, linked to oxidative stress, inflammatory responses, and immune dysregulation. These findings underscore that BPF may not be a safe substitute for BPA. Thus, there is a pressing need to reevaluate the current regulation of BPF.

2024-12-01·Food Chemistry

Hydroxyl-functionalized cationic porous organic polymers for efficient enrichment and detection of phenolic endocrine disrupting chemicals in water and snapper

Article

作者: Wang, Qianqian ; Dou, Yiran ; Li, Zhi ; Wu, Qiuhua ; Wang, Zhi ; Wang, Chenhuan ; Wang, Chun

Endocrine-disrupting chemicals (EDCs) can disrupt the normal functioning of the endocrine system in organisms, leading to various health issues. Therefore, monitoring EDCs in the environment and food is of significant importance. In this study, a hydroxyl-functionalized ionic porous organic polymer (OH-IPOP) has been synthesized for the first time using 2-benzimidazolemethanol as a monomer. The OH-IPOP exhibited excellent adsorption performance towards phenolic EDCs. An efficient method for determination of phenolic EDCs (p-tert-butylphenol, bisphenol B, bisphenol A and bisphenol F) in environmental water and snapper samples was successfully established by with OH-IPOP as solid-phase extraction sorbent and determination with high-performance liquid chromatography-ultraviolet detection. The method showed good linearity (r² > 0.998), low detection limits (0.008-0.020 ng mL^-1 for lake water, 1.00-3.00 ng/g for snapper), high recovery rates (82.3-106 %), and good precision (relative standard deviation < 6.6 %), making it a highly efficient adsorbent for the enrichment of EDCs in complex sample matrices.

100 项与氟轻松丙酮酯/硫酸新霉素相关的药物交易

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外链

KEGG	Wiki	ATC	Drug Bank
-	-	D11AX	-

研发状态

10 条最早获批的记录,

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适应症	国家/地区	公司	日期
湿疹	日本	Mitsubishi Tanabe Pharma Corp.	1963-08-26
掌跖角化病	日本	Mitsubishi Tanabe Pharma Corp.	1963-08-26
肛门瘙痒	日本	Mitsubishi Tanabe Pharma Corp.	1963-08-26
银屑病	日本	Mitsubishi Tanabe Pharma Corp.	1963-08-26
脓皮症	日本	Mitsubishi Tanabe Pharma Corp.	1963-08-26
传染性皮肤病	日本	Mitsubishi Tanabe Pharma Corp.	1963-08-26
伤口感染	日本	Mitsubishi Tanabe Pharma Corp.	1963-08-26
嗜皮菌病	美国	Medimetriks Pharmaceuticals, Inc.	1963-06-11

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临床结果

适应症

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


NCT02168478 (CTgov)	临床4期	过敏	206	Sodium Lauryl Sulfate Aqueous Solution (0.40%)+Neo-Synalar Cream+Saline	築壓齋淵餘鹽顧鏇艱餘(夢憲鑰糧遞蓋繭蓋醖願) = 築衊製夢壓積衊顧鹹齋簾繭選鹹鏇廠鏇簾艱窪 (鏇壓齋醖簾襯餘鬱壓願, 淵壓窪觸淵糧壓窪網廠 ~ 醖憲觸憲鹹壓襯淵憲網) 更多	-	2015-12-11
FAME study (ARVO2014)	临床3期	糖尿病性黄斑水肿	-	Fluocinolone Acetonide 0.2 μg/d	(齋廠廠鑰願範選餘艱淵) = 衊觸觸醖構鬱構鹹鹹顧淵醖遞製糧構窪築醖網 (鹽餘繭顧糧築廠築鹽夢 )	-	2014-04-01
FAME study (ARVO2014)	临床3期	糖尿病性黄斑水肿	-	fluocinolone acetonide (FAc)	(齋廠廠鑰願範選餘艱淵) = 鹽淵夢積糧蓋製獵憲蓋淵醖遞製糧構窪築醖網 (鹽餘繭顧糧築廠築鹽夢 )	-	2014-04-01