STING agonist(Sutro Biopharma)

2025年10月份即将结束，10月份Science期刊又有哪些亮点研究值得学习呢？小编对此进行了整理，与各位分享。 1.冬天更不适合吃零食？Science：氢化脂肪会干扰生物钟，让身体错把寒冬当盛夏囤能量 DOI: 10.1126/science.adp3065 下次冬季想拆开一包含氢化脂肪的加工零食时，或许得先想想：这口脂肪可能正在给身体的 “季节时钟” 发错误信号——让它误以为现在是食物丰饶的夏天，进而催生对高热量食物的持续渴望。过去科学家认为，哺乳动物全靠日照长短感知季节，比如黑熊靠日照变长知道春夏该囤积脂肪、日照变短就准备冬眠。 但加州大学旧金山分校团队发表在《科学》杂志的新研究发现，饮食中多不饱和脂肪酸（PUFA）与单不饱和脂肪酸（MUFA）的比例，和日照一样关键，甚至能通过调控一种叫 PER2 的生物钟蛋白，直接决定身体是否能正确适应季节变化。 PER2 蛋白是人体昼夜节律的 “核心齿轮”，之前研究已发现它能协调睡眠 - 觉醒周期和脂肪代谢，而这次研究找到了它的 “季节调节开关”——第 662 位丝氨酸（PER2-S662）的磷酸化状态。当小鼠吃高脂饮食（HFD，尤其是 PUFA:MUFA 比例低的）时，下丘脑中 PER2-S662 的磷酸化水平会升高，这会让它们适应冬季的速度变慢：在模拟冬季的 “4 小时光照、20 小时黑暗” 环境中，吃普通饲料的小鼠每天能提前 0.25 小时开始活动，而吃 HFD 的小鼠仅能提前 0.12 小时，30 天后累计差出 2 小时 “时差”；相反，HFD 却让小鼠适应夏季（20 小时光照、4 小时黑暗）更快，2 天就比普通饲料组多延迟 1 小时活动。 更关键的是 “脂肪类型的影响”。研究团队专门制作了两种等热量高脂饲料：一种用玉米油（高 PUFA，PUFA:MUFA 高），另一种用部分氢化玉米油（PHCO，PUFA 被转化为 MUFA，PUFA:MUFA 低）。结果发现，吃 PHCO 的野生型小鼠，下丘脑 PER2-S662 磷酸化水平更高，适应冬季更慢（每天仅提前 0.15 小时，比玉米油组慢 40%），适应夏季更快；但如果是 PER2-S662G 突变小鼠（这个位点无法磷酸化），不管吃玉米油还是 PHCO，季节适应速度都没差别，这直接证明，脂肪是通过调控 PER2-S662 磷酸化来影响生物钟的。 2.Science：利用转录组学的主动学习框架识别疾病表型的调节因子 DOI: 10.1126/science.adi8577 生物技术公司Cellarity宣布，其一篇阐述如何整合先进转录组数据集与AI模型以改进药物发现框架的论文已在《科学》杂志正式发表。该公司致力于通过整合多组学与AI建模开发细胞状态校正疗法。 Cellarity通过聚焦于定义和调控细胞状态的通路连接与相互作用网络，针对复杂疾病设计新型疗法。公司构建了一个强大的发现平台，利用高维转录组学以单细胞分辨率绘制这些相互作用图谱。 为该平台开发的通用AI模型将化学与疾病生物学联系起来，从而高效生产能够恢复病变组织细胞功能的药物。从该平台诞生的首个候选药物CLY-124，目前正处于治疗镰状细胞病的I期临床试验评估阶段。 Cellarity首席数据官Parul Doshi表示："我们相信，对细胞状态的全面审视将帮助我们创造能够纠正疾病根本机制的更好疗法。我们先进的平台使我们能够有效可视化这一动态过程，并识别最适合纠正疾病状态的新型干预措施。这篇发表在《科学》杂志上的论文描述了为我们平台提供依据的评估工作，强调了成功整合先进转录组学和计算工具所需的严谨性与独创性，以实现新型候选疗法的高效发现。" 该论文提出了一个可重复且通用的蓝图，用于将机器学习方法整合到药物研发项目中，以最大化发现潜力。该蓝图通过采用由高通量转录组学驱动的、主动的"实验室在环"深度学习框架，解决了传统表型药物筛选的诸多局限性。通过根据实验结果持续优化预测，该框架证明其表型活性化合物的回收率比行业标准方法提高了13至17倍。 3.线虫端粒酶 RNA 玩“隐身”！20 年遗传谜题破解：藏进生殖基因内含子“搭车”传后代，抗衰老有新靶点 DOI: 10.1126/science.ads7778 端粒是染色体末端的 “保护帽”，就像鞋带末端的塑料头，每次细胞分裂都会缩短一点——体细胞端粒变短会引发皱纹、细胞衰老，而生殖细胞靠端粒酶 “修复” 端粒，才能让后代拥有完整的染色体。人类和哺乳动物的端粒酶里，有个关键的 RNA 模板（由 TERC 基因编码），可在线虫身上，科学家找了 20 年都没发现独立的 TERC 基因，却偏偏能检测到端粒酶活性。 这个 “矛盾” 成了遗传学界的未解之谜，直到日本理化学研究所（RIKEN）生物系统动力学研究中心 Hiroki Shibuya 团队在《科学》杂志发表新研究，才揭开真相：线虫的端粒酶 RNA 根本没 “独立门户”，而是躲在另一个基因的 “废弃片段” 里，靠 “搭便车” 精准定位到生殖细胞，确保物种代代相传。 为了找到这个 “隐身的 RNA”，研究团队先给秀丽隐杆线虫（C. elegans）做了基因改造——让端粒酶的催化亚基（FLAG-TRT-1）过量表达，这样就能通过增强交联免疫沉淀（eCLIP）技术，捕捉到和它结合的 RNA。 结果在一堆数据里，他们发现所有信号都集中在一个叫 nmy-2 的基因的第 2 个内含子里——这个基因本身编码非肌肉肌球蛋白 II，在生殖细胞中高度活跃。团队把这个隐藏的 RNA 命名为 terc-1，它不仅有和线虫端粒 DNA（5′-(TTAGGC) n-3′）互补的模板序列（5′-UAAGCCUAAG-3′），还能和 TRT-1 紧密结合，完美扮演端粒酶 RNA 的角色。 4.改写遗传学规则！Science：基因的起点和终点并非孤立运作，起点决定终点 DOI: 10.1126/science.ado8279 分子生物学家长期认为，基因的起点仅仅是转录过程的“启动开关”——DNA被复制为RNA，进而指导蛋白质合成。然而，波士顿大学与马萨诸塞大学陈医学院联合在《Science》上发表的最新研究，彻底颠覆了这一传统认知。研究发现，基因的起点和终点并非孤立运作，而是像一对默契的舞伴，在基因组中协同移动。这一机制重塑了细胞构建蛋白质的方式，也揭示了生物在进化中灵活适应的新路径。 “我们的工作改写了教科书，”该研究的共同通讯作者、波士顿大学生物学助理教授 Ana Fiszbein 强调，“基因的起点不仅决定转录从哪里开始，它还直接影响了转录在哪里结束，甚至决定了最终合成的蛋白质种类。”她进一步解释道：“我们过去教导学生，起点只负责‘鸣枪起跑’。而现在我们证实，它同样参与设定‘终点线’——基因的起点在暗中控制着它的终点。” 为了揭开这一规律，团队分析了来自 GTEx 项目的 17350 个人体组织样本（覆盖 54 种组织）和 ENCODE 项目的长读长 RNA 测序数据，发现超过 70% 的哺乳动物基因存在多个 TSS 和 PAS，但这些 “备选起点” 和 “备选终点” 并非随机搭配：比如 MYO10 基因在 H9 细胞中，从上游 TSS 启动的 mRNA，94% 会在 upstream PAS 终止；而从下游 TSS 启动的 mRNA，59% 会选择下游 PAS。这种 “序数匹配” 在不同组织中都稳定存在，哪怕某些基因在不同组织只表达一种 isoform（mRNA 变体），跨组织分析仍能发现 PITA 协同的痕迹。 为了证明这种关联是 “因果” 而非 “巧合”，团队用 dCas9-CRISPR 技术做了精准实验：激活 ZNF638 基因的上游 TSS 后，该基因的上游 PAS 使用量显著增加，下游 PAS 则减少；反之，激活下游 TSS 时，下游 PAS 的使用率也跟着上升。更关键的是，若删除下游 PAS，TSS 的选择虽会变化，却不会触发 PITA 协同。这说明 PITA 是 “单向调控”：起点决定终点，而非反之。 5.Science：我国科学家揭示人类跳跃基因LINE-1靶向结构化DNA来重塑基因组 DOI: 10.1126/science.adu3433 长散布核元件-1（Long interspersed nuclear element-1, LINE-1, L1）是人类基因组中唯一活跃的、能够自我复制的遗传元件，约占基因组的17%。它通常被称为"跳跃基因"或"逆转录转座子"，因为它能够从一个基因组位置"逆转录转座"（移动）到另一个位置。 中国科学院生物物理研究所的研究人员现已揭示了L1逆转录转座并整合进基因组DNA的分子机制。他们的研究于10月9日发表在《科学》杂志上。 转座过程由逆转录酶ORF2p通过一种称为"靶向引发逆转录"的机制介导。在此之前，ORF2p如何识别DNA靶标并介导整合的机制一直不清楚。 在徐瑞明教授、朱冰教授和薛愿超教授的领导下，研究人员纯化了一个具有活性的ORF2p-内源核酸复合物，并利用单颗粒冷冻电子显微镜解析了其高分辨率三维结构。结构分析显示，ORF2p通过强烈的表面静电相互作用与基因组DNA结合。分析还表明，cDNA（互补DNA）的合成发生在逆转录酶活性中心，这是通过对多个氨基酸残基进行变构调节实现的。 重要的是，研究人员建立了首个高效的ORF2p体外DNA切割系统，证明其作为一种结构依赖性的内切核酸酶发挥作用。他们发现ORF2p对特定的叉状DNA底物（尤其是DNA复制过程中滞后链特征的瓣状结构）表现出高催化活性。 6.Science：裸鼹鼠体内cGAS介导的机制增强DNA修复并延缓衰老 DOI: 10.1126/science.adp5056 裸鼹鼠是自然界最非凡的生物之一。这些穴居啮齿类动物的寿命可达37年，大约是体型相近的近亲物种的十倍。但它们极端长寿的秘诀是什么？它们是如何延缓其他啮齿动物所经历的衰老和机能衰退的？根据发表在《科学》杂志上的一项新研究，答案至少部分在于一种常见蛋白质的功能转换，这种转换增强了DNA修复能力。 包括人类在内的所有动物，其衰老的主要原因之一是受损DNA的积累。当这种损伤得不到修复时，就会导致细胞缺陷、蛋白质受损，并最终导致身体功能崩溃。 为了解裸鼹鼠为何如此抵抗DNA损伤，一项由中国同济大学研究人员领导的研究聚焦于一种名为cGAS的常见蛋白质。在大多数哺乳动物中，cGAS会干扰DNA修复，但研究人员怀疑它在长寿的裸鼹鼠体内可能进化出了不同的功能。 研究团队将裸鼹鼠的cGAS蛋白与人类和小鼠的进行了比较，发现了四个氨基酸的改变，这些改变翻转了该蛋白质的功能，使其能够增强细胞修复受损DNA的能力。 7.Science：新研究揭示MTAP缺乏赋予癌细胞对细胞质核酸感应和STING激动剂的抵抗性 DOI: 10.1126/science.adl4089 细胞质核酸感知通路已成为增强免疫检查点阻断疗效的有前景的治疗靶点，尤其是在免疫学上的"冷"肿瘤中。这些通路的激活会刺激I型干扰素（IFN-I）信号传导和干扰素刺激基因（ISG）的表达，促进免疫细胞募集，并可能将冷肿瘤转化为免疫活跃的"热"肿瘤。干扰素基因刺激物（STING）激动剂可激活这种先天免疫通路，在临床前模型中已显示出强大的抗肿瘤活性。然而，临床试验并未在患者身上复现这些效果，这凸显了转化差距，以及需要更好地理解影响人类癌症中STING通路激活的调控机制和耐药因素。 9号染色体短臂21.3区（9p21.3）在多种癌症类型中经常发生纯合性缺失，该区域包含甲基硫腺苷磷酸化酶（MTAP）基因以及邻近的基因位点，如细胞周期蛋白依赖性激酶抑制剂2A（CDKN2A）、CDKN2B，在某些情况下还包括IFN-I基因簇。尽管IFN基因簇的共缺失与9p21.3缺失相关的免疫冷表型有关，但是在一项新的研究中，中国研究人员发现，MTAP缺失本身会损害细胞质核酸感知。对癌症基因组图谱（TCGA）的分析（排除了IFN基因簇纯合缺失的病例）显示，MTAP与IFN-I表达呈正相关。他们还发现MTAP缺失是人类肿瘤的一个常见特征，而在标准小鼠模型中基本不存在。这些观察结果共同使我们提出假设：MTAP缺陷会从内部抑制核酸感知，并导致对STING激动剂的耐药性。 通过使用多个同基因细胞系模型，他们发现MTAP缺失通过下调核酸感知中的关键转录因子——干扰素调节因子3（IRF3）——来抑制IFNβ及其下游ISG的诱导。从机制上讲，MTAP缺失导致其底物甲基硫腺苷（MTA）积累，MTA会抑制甲基转移酶蛋白精氨酸甲基转移酶5（PRMT5）的活性。在MTAP完整的细胞中，抑制或敲低PRMT5同样会降低IRF3表达并损害核酸感知，这确立了PRMT5作为IRF3的正向调节因子。MTA也会被分泌出来，并可以抑制邻近MTAP正常细胞中的PRMT5活性和IRF3，从而形成一种旁分泌免疫抑制环境。他们进一步鉴定出E3泛素连接酶Midline-1（MID1）在MTAP缺陷、PRMT5被抑制或PRMT5耗竭的细胞中表达上调，而MID1会靶向IRF3使其降解。PRMT5通过在其启动子区沉积组蛋白H4第3位精氨酸对称二甲基化（H4R3me2s）这一抑制性组蛋白标记来抑制MID1；MTAP缺陷则废除了这种调控，导致MID1增加和IRF3去稳定化。使用美国FDA批准的鸟氨酸脱羧酶抑制剂DL-α-二氟甲基鸟氨酸（DFMO）进行治疗，可降低MTA水平，恢复PRMT5活性，抑制MID1，并在MTAP缺陷细胞中挽救IRF3水平和核酸感知能力。在同系小鼠肿瘤模型中，MTAP缺陷的肿瘤对STING激动剂耐药。然而，STING激动剂与DFMO的联合治疗克服了这种耐药性，引发了强劲的抗肿瘤反应并增加了免疫细胞浸润。 8.亲完它就缩着跑？！Science：我国科学家破解百年神经通信争论 DOI: 10.1126/science.ads7954 我们的每一次思考、感知和动作，都离不开大脑中神经元之间的 “悄悄话”，而传递这些 “悄悄话” 的关键，就是突触囊泡（SV）。这些微小的 “神经快递员” 会装载神经递质，在动作电位触发下与突触前膜融合、释放内容物，完成神经元间的信号传递。 可几十年来，科学家们一直争论一个关键问题：这些 “快递员” 完成投递后，是短暂 “亲吻” 膜就离开（“即吻即离” 模型），还是彻底融入膜中（“完全坍塌” 模型）？ 如今，中国科学技术大学陶昌路、毕国强团队联合深圳先进技术研究院、美国加州大学洛杉矶分校周正洪团队，用一项 “时空双精” 的技术破解了这个难题。他们开发出时间分辨细胞冷冻电子断层扫描（cryo-ET）技术——既能在纳米尺度看清囊泡的 3D 结构，又能以毫秒级精度捕捉动态过程。实验中，研究人员给培养的大鼠海马神经元装上 “光控开关”（转染 ChIEF 通道视紫红质蛋白），用激光触发动作电位后，在 0 到 300 毫秒内精准冷冻突触，最终拍下了 1000 多张完整兴奋性突触的 “高清动态图”。 在突触前的 “活跃区”（神经递质释放的关键区域），研究团队首先发现了两类 “快递员”：直径约 29 纳米的 “小囊泡” 和 41 纳米的 “大囊泡”，它们还能分成七种状态——锚定（大 / 小）、半融合（大 / 小）、孔开放（大 / 小）和 Ω 形（仅小囊泡）。更关键的是，当用药物（CNQX）让神经网络 “休眠” 后，小囊泡数量明显减少；而用破伤风毒素（TeNT）切断 SNARE 蛋白（帮助囊泡与膜融合的 “分子胶水”）后，小囊泡直接消失了，这说明小囊泡的形成离不开正常的神经活动和融合机制。 接下来的 “动态电影” 更令人惊叹：静息时，大囊泡像 “待命快递员” 一样锚在突触前膜上（对接状态）；动作电位触发后 4 毫秒内，它们就变成 “半融合状态”——像轻轻 “亲吻” 了一下膜（预置步骤）；很快，这些 “亲吻” 的地方会形成一个约 4 纳米的 “小通道”（脂质融合孔），孔的两侧还能看到 SNARE 复合物的痕迹，神经递质就是从这个 “通道” 里释放出去的。更神奇的是，释放完的大囊泡会迅速 “瘦身”，表面积缩到原来的一半，变成小囊泡；到 70 毫秒时，大部分 “瘦身” 后的小囊泡会从膜上脱离（“跑离” 步骤），只有少数会彻底融入膜中；100 毫秒后，“跑离” 的小囊泡会移到囊泡簇的外围，而之前被撑开的突触前膜，则通过 “超速内吞作用” 快速回收。整个过程像一套精密的 “纳米级流水线”。 9.生育力下降别只怪卵子！Science：卵巢里的神经、胶质细胞才是“隐形操控者” DOI: 10.1126/science.adx0659 35 岁后怀孕难” 几乎成了当代女性的生育焦虑标签——从 25 岁到 40 岁，女性每月成功受孕的几率会急剧下滑。几十年来，科学家们都默认 “卵子老了、坏了” 是罪魁祸首，但加州大学旧金山分校（UCSF）和陈・扎克伯格生物中心旧金山分校的新研究，却给这场 “生育困局” 提供了全新答案：卵巢衰老不只是卵子的 “独角戏”，周围的 “生态系统”，包括支持细胞、神经甚至结缔组织，都在悄悄影响卵子成熟，加速生育力衰退。 该研究的通讯作者、UCSF 妇产科与生殖科学系教授 Diana Laird 博士直言：“我们以前总把卵巢衰老简化成‘卵子数量少了、质量差了’，但这次研究清楚地看到，卵子周围的每一寸环境都在变——包裹卵子的颗粒细胞、调节生长的神经、维持结构的结缔组织，都会随年龄发生改变。” 而理解这些变化，不止关乎 “能不能生”，更关乎 “老得健不健康”：要知道，女性绝经或切除卵巢后，心血管疾病、骨质疏松等老年病风险会飙升，若能减缓卵巢衰老，或许能帮我们延缓这些疾病的到来。 为了摸清卵巢衰老的 “全貌”，研究团队先从 “可视化” 入手。他们开发了一种全新的三维（3D）成像技术：给完整的小鼠卵巢做 “整体免疫染色” 并透明化处理，不用像过去那样把卵巢切成薄片，就能清晰看到卵子的分布和状态。 结果发现，2-4 月龄的小鼠（对应人类 20 岁出头）卵巢里，卵子还能均匀分布；可到了 9-12 月龄（对应人类 35-45 岁，即医学上的 “高龄生育期”），不仅储备的原始卵泡（未成熟的 “卵子后备军”）在 6 月龄前缓慢减少、12 月龄时急剧下降，就连正在生长的卵泡，也从 4 月龄开始悄悄减少。更关键的是，这些 “高龄小鼠” 做体外受精（IVF）时，排卵数量会减少，卵子能发育成囊胚的概率也显著降低——这和 35 岁后女性的生育困境几乎一模一样。 当团队把这种 3D 技术用到人类卵巢上时，还发现了一个意外现象：人类的卵子并非均匀散布在卵巢里，而是像 “小社区” 一样，聚集在皮质区的 “卵泡口袋” 里，周围全是没有卵子的 “空白区”。而且年龄越大，这些 “口袋” 里的卵子密度越低，口袋本身的体积也越小。“这完全超出了我们的预期，”Laird 说，“我们原本以为卵子会像‘撒种子’一样分布，可‘口袋’的存在说明，就算在同一个卵巢里，环境不同，卵子的存活和成熟能力也会不一样。” 10.Science：在大脑中发现了一种新的树突纳米管网络 DOI: 10.1126/science.adr7403 大脑中的神经元通过突触相互交流——这些连接点允许电信号和化学信号传递。在非神经元细胞中，已发现细胞间的直接连接是在纳米管结构的辅助下完成的。特别是，隧道纳米管（tunneling nanotubes, TNTs）在某些细胞类型中展现了物质交换功能。这些TNTs在大脑的分离神经元中已有记载，但它们在成熟脑神经元中的存在和功能尚不明确。 如今，一组科学家发现了一种新型纳米管，它似乎扮演着一种桥梁的角色，在树突——神经元上分支状的突起之间运输物质。这项发表在《科学》杂志上的研究，描述了该团队所谓的"树突纳米管(dendritic nanotubes, DNTs)"及其与阿尔茨海默病中常见的β-淀粉样肽积累的可能关联。 研究人员首先使用超分辨率显微镜和电子显微镜，在小鼠和人类脑组织中识别出了DNTs。这些富含肌动蛋白的DNTs被发现连接着小鼠和人类大脑皮层的树突。为了将DNTs与其他树突结构区分开来，该团队采用了专门的成像技术和基于机器学习的分析方法。 研究作者写道："基于机器学习的分类证实，它们的形状与突触结构不同。在培养的神经元中，我们观察到这些纳米管是动态形成的，并确认它们具有独特的内部结构，这使其有别于其他神经元突起。" 这些纳米管的行为也不同于更为人熟知的TNTs。DNTs没有表现出TNTs用于运输物质的隧道行为。相反，它们的末端是封闭的，因此得名略有不同。尽管如此，DNTs确实能够运输物质，如钙离子和小分子。（生物谷Bioon.com）

Cancer Res[Jour] AND 85[volume] AND 1 [issue] 癌症研究 85卷 1期 https://aacrjournals.org/cancerres/issue/ In the Spotlight（焦点） 1 Persistence and/or Senescence: Not So Lasting at Last? 坚持和/或衰老：终于不那么持久了？ Clemens A. Schmitt Cancer Res (2025) 85 (1): 7–9. 2 Peritumoral Venous Vessels: Autobahn and Portal for T Cells to Melanoma Brain Metastasis 瘤周静脉血管：T细胞通向黑色素瘤脑转移的高速公路和门户 Benjamin Izar; Minah Kim Cancer Res (2025) 85 (1): 10–11. 3 Tumor Heterogeneity and Cooperating Cancer Hallmarks Driven by Divergent EMT Programs 不同EMT程序驱动的肿瘤异质性与癌症协同效应特征 Phoebe Carter; Yibin Kang Cancer Res (2025) 85 (1): 12–14. Resource Report（资源报告） 4 Distant Metastases of Breast Cancer Resemble Primary Tumors in Cancer Cell Composition but Differ in Immune Cell Phenotypes 乳腺癌远端转移与原发肿瘤癌细胞的组成相似但免疫细胞的表型不同 Laura Kuett; Alina Bollhagen; Sandra Tietscher; Bettina Sobottka; Nils Eling; Zsuzsanna Varga; Holger Moch; Natalie de Souza; Bernd Bodenmiller Cancer Res (2025) 85 (1): 15–31. Cancer Biology（癌症生物学） 5 H4K20me3-Mediated Repression of Inflammatory Genes Is a Characteristic and Targetable Vulnerability of Persister Cancer Cells H4K20me3-介导的炎症基因抑制是持久性癌症细胞的特征和脆弱性靶标 Valentina Ramponi; Laia Richart; Marta Kovatcheva; Camille Stephan-Otto Attolini; Jordi Capellades; Alice E. Lord; Oscar Yanes; Gabriella Ficz; Manuel Serrano Cancer Res (2025) 85 (1): 32–51. 6 LSD1 and CoREST2 Potentiate STAT3 Activity to Promote Enteroendocrine Cell Differentiation in Mucinous Colorectal Cancer LSD1和CoREST2增强STAT3活性促进粘液性大肠癌肠内分泌细胞分化 Christopher A. Ladaika; Ahmed H. Ghobashi; William C. Boulton; Samuel A. Miller; Heather M. O’Hagan Cancer Res (2025) 85 (1): 52–68. 7 HIF1α Counteracts TGFβ1-Driven TSP1 Expression in Endothelial Cells to Stimulate Angiogenesis in the Hypoxic Tumor Microenvironment HIF1α拮抗TGFβ1驱动的内皮细胞TSP1表达，以刺激缺氧肿瘤微环境中的血管生成 Yu-Wei Luo; Yang Fang; Hui-Xian Zeng; Yu-Chen Ji; Meng-Zhi Wu; Hui Li; Jie-Ying Chen; Li-Min Zheng; Jian-Hong Fang; Shi-Mei Zhuang Cancer Res (2025) 85 (1): 69–83. Cancer Metabolism and Molecular Mechanisms（癌症代谢与分子机制） 8 TCTN1 Induces Fatty Acid Oxidation to Promote Melanoma Metastasis TCTN1诱导脂肪酸氧化促进黑色素瘤转移 Yinlam Li; Ren Ming; Tianyi Zhang; Zixu Gao; Lu Wang; Yang Yang; Kangjie Shen; Chenlu Wei; Yu Zhu; Jianrui Li; Shaoluan Zheng; Zucheng Luo; Yiteng Ding; Jiangying Xuan; Qianrong Hu; Yanwen Yang; Jianying Gu; Chuanyuan Wei Cancer Res (2025) 85 (1): 84–100. Therapeutic Development and Chemical Biology（治疗进展与生物化学） 9 Targeted Degradation of SOS1 Exhibits Potent Anticancer Activity and Overcomes Resistance in KRAS-Mutant Tumors and BCR–ABL–Positive Leukemia SOS1的靶向降解在KRAS突变肿瘤和BCR-ABL阳性白血病中显示出强大的抗癌活性且可抗耐药 Ziwei Luo; Chencen Lin; Chuwei Yu; Changxian Yuan; Wenyong Wu; Xiaowei Xu; Renhong Sun; Yan Jia; Yafang Wang; Jie Shen; Dingyan Wang; Sinan Wang; Hualiang Jiang; Biao Jiang; Xiaobao Yang; Chengying Xie Cancer Res (2025) 85 (1): 101–117. Translational Cancer Biology（癌症转化生物学） 10 SOS1 Inhibition Enhances the Efficacy of KRASG12C Inhibitors and Delays Resistance in Lung Adenocarcinoma SOS1抑制增强KRASG12C抑制剂的疗效并延缓肺腺癌的耐药性 Brianna R. Daley; Nancy E. Sealover; Bridget A. Finniff; Jacob M. Hughes; Erin Sheffels; Daniel Gerlach; Marco H. Hofmann; Kaja Kostyrko; Joseph P. LaMorte; Amanda J. Linke; Zaria Beckley; Andrew M. Frank; Robert E. Lewis; Matthew D. Wilkerson; Clifton L. Dalgard; Robert L. Kortum Cancer Res (2025) 85 (1): 118–133. 11 Stimulating Soluble Guanylyl Cyclase with the Clinical Agonist Riociguat Restrains the Development and Progression of Castration-Resistant Prostate Cancer 临床激动剂利奥雪卡刺激可溶性鸟苷酸环化酶抑制去势抵抗的前列腺癌的发生发展 Ling Zhang; Clara I. Troccoli; Beatriz Mateo-Victoriano; Laura Misiara Lincheta; Erin Jackson; Ping Shu; Trisha Plastini; Wensi Tao; Deukwoo Kwon; Xi Steven Chen; Janaki Sharma; Merce Jorda; Surinder Kumar; David B. Lombard; James L. Gulley; Marijo Bilusic; Albert C. Lockhart; Annie Beuve; Priyamvada Rai Cancer Res (2025) 85 (1): 134–153. 12 Replication Stress Is an Actionable Genetic Vulnerability in Desmoplastic Small Round Cell Tumors 复制应激是促纤维增生性小圆细胞肿瘤中一种可操作的遗传易感性 Asuka Kawai-Kawachi; Madison M. Lenormand; Clémence Astier; Noé Herbel; Meritxell B. Cutrona; Carine Ngo; Marlène Garrido; Thomas Eychenne; Nicolas Dorvault; Laetitia Bordelet; Feifei Song; Ryme Bouyakoub; Anastasia Loktev; Antonio Romo-Morales; Clémence Henon; Léo Colmet-Daage; Julien Vibert; Marjorie Drac; Rachel Brough; Etienne Schwob; Oliviano Martella; Guillaume Pinna; Janet M. Shipley; Sibylle Mittnacht; Astrid Zimmermann; Aditi Gulati; Olivier Mir; Axel Le Cesne; Matthieu Faron; Charles Honoré; Christopher J. Lord; Roman M. Chabanon; Sophie Postel-Vinay Cancer Res (2025) 85 (1): 154–170. Computational Cancer Biology and Technology（计算癌症生物学与技术） 13 SpatialDeX Is a Reference-Free Method for Cell-Type Deconvolution of Spatial Transcriptomics Data in Solid Tumors SpatialDeX是实体瘤中空间转录组学数据细胞类型反卷积的无参考方法 Xinyi Liu; Gongyu Tang; Yuhao Chen; Yuanxiang Li; Hua Li; Xiaowei Wang Cancer Res (2025) 85 (1): 171–182. Acknowledgment to Reviewers（鸣谢编委会） 14 Acknowledgment to Reviewers 鸣谢编委会 Cancer Res (2025) 85 (1): 183–188. Cancer Res[Jour] AND 85[volume] AND 2[issue] 癌症研究85卷 2期 https://aacrjournals.org/cancerres/issue/ In the Spotlight（焦点） 1 Transcription Factor Fingerprint Provides Clues for Brain Tumor Cell of Origin 转录因子指纹图谱为脑肿瘤细胞起源提供线索 Brent A. Orr Cancer Res (2025) 85 (2): 195–196. 2 Midkine at the Crossroads of Aging and Cancer 处于衰老与癌症十字路口的Midkine（一种与肝素结合的生长因子） Huiru Bai; Shang Cai Cancer Res (2025) 85 (2): 197–199. 3 Stayin' Alive: Targeting Chromatin Regulators of Clonal Hematopoiesis Promotes CD8 T-cell Stemness 持续存活：靶向克隆性造血染色质调节因子促进CD8 T细胞之干细胞 Xingjian Qiu; Aaron Yang; Amanda C. Poholek Cancer Res (2025) 85 (2): 200–202. Review（综述） 4 Cancer-Related Cognitive Impairment and the Potential of Dietary Interventions for the Prevention and Mitigation of Neurodegeneration 癌症相关认知障碍与饮食干预用以预防和减轻神经元变性的潜力 Sylvia L. Crowder; Lisa M. Gudenkauf; Aasha I. Hoogland; Hyo S. Han; Brent J. Small; Tiffany L. Carson; Nathan H. Parker; Margaret Booth-Jones; Heather S.L. Jim Cancer Res (2025) 85 (2): 203–217. Resource Report（资源报告） 5 BEEx Is an Open-Source Tool That Evaluates Batch Effects in Medical Images to Enable Multicenter Studies BEEx是一个开源工具，用于评估医学图像中的批处理效应，以实现多中心研究 Yuxin Wu; Xiongjun Xu; Yuan Cheng; Xiuming Zhang; Fanxi Liu; Zhenhui Li; Lei Hu; Anant Madabhushi; Peng Gao; Zaiyi Liu; Cheng Lu Cancer Res (2025) 85 (2): 218–230. Cancer Biology（癌症生物学） 6 FOXR2 Targets LHX6+/DLX+ Neural Lineages to Drive Central Nervous System Neuroblastoma FOXR2靶向LHX6+/DLX+神经谱系以驱动中枢神经系统神经母细胞瘤 Selin Jessa; Antonella De Cola; Bhavyaa Chandarana; Michael McNicholas; Steven Hébert; Adam Ptack; Damien Faury; Jessica W. Tsai; Andrey Korshunov; Timothy N. Phoenix; Benjamin Ellezam; David T.W. Jones; Michael D. Taylor; Pratiti Bandopadhayay; Manav Pathania; Nada Jabado; Claudia L. Kleinman Cancer Res (2025) 85 (2): 231–250. 7 KRAS Loss of Heterozygosity Promotes MAPK-Dependent Pancreatic Ductal Adenocarcinoma Initiation and Induces Therapeutic Sensitivity to MEK Inhibition KRAS杂合子缺失促进MAPK依赖性胰腺导管腺癌的发生，并诱导对MEK抑制的治疗敏感性 Sigrid K. Fey; Arafath K. Najumudeen; Dale M. Watt; Laura M. Millett; Catriona A. Ford; Kathryn Gilroy; Rosalin J. Simpson; Kathy McLay; Rosanna Upstill-Goddard; David Chang; William Clark; Colin Nixon; Joanna L. Birch; Simon T. Barry; Jennifer P. Morton; Andrew D. Campbell; Owen J. Sansom Cancer Res (2025) 85 (2): 251–262. 8 Ephrin A1 Stimulates CCL2 Secretion to Facilitate Premetastatic Niche Formation and Promote Gastric Cancer Liver Metastasis Ephrin A1刺激CCL2分泌促进转移前微环境形成并促进胃癌肝转移 Yun Cui; Yongxia Chang; Xixi Ma; Meng Sun; Yuliang Huang; Feng Yang; Shuang Li; Wei Zhuo; Wei Liu; Bo Yang; Aifu Lin; Guangshuo Ou; Yuehong Yang; Shanshan Xie; Tianhua Zhou Cancer Res (2025) 85 (2): 263–276. Cancer Immunology（癌症免疫学） 9 Spatial and Single-Cell Analyses Reveal Heterogeneity of DNAM-1 Receptor–Ligand Interactions That Instructs Intratumoral γδT-cell Activity 空间和单细胞分析揭示指示肿瘤内γδ t细胞活性的DNAM-1受体-配体相互作用的异质性 Xiaolin Wang; Hui Wang; Zhengjing Lu; Xiangjun Liu; Wenjia Chai; Wei Wang; Jun Feng; Shen Yang; Wei Yang; Haiyan Cheng; Chenghao Chen; Shihan Zhang; Nian Sun; Qiaoyin Liu; Qiliang Li; Wenqi Song; Fang Jin; Qi Zeng; Shengcai Wang; Yan Su; Huanmin Wang; Xin Ni; Jingang Gui Cancer Res (2025) 85 (2): 277–298. 10 ACE2 Enhances Sensitivity to PD-L1 Blockade by Inhibiting Macrophage-Induced Immunosuppression and Angiogenesis ACE2通过抑制巨噬细胞诱导的免疫抑制和血管生成增强对PD-L1阻断的敏感性 Peiyi Xie; Lei Guo; Qiang Yu; Yufei Zhao; Mincheng Yu; Hui Wang; Mengyuan Wu; Wenxin Xu; Min Xu; Xiao-Dong Zhu; Yongfeng Xu; Yong-Sheng Xiao; Cheng Huang; Jian Zhou; Jia Fan; Mien-Chie Hung; Huichuan Sun; Qing-Hai Ye; Bo Zhang; Hui Li Cancer Res (2025) 85 (2): 299–313. Cancer Metabolism and Molecular Mechanisms（癌症代谢与分子机制） 11 PHGDH Induction by MAPK Is Essential for Melanoma Formation and Creates an Actionable Metabolic Vulnerability MAPK诱导的PHGDH对黑色素瘤形成是必需的，并产生可操作的代谢脆弱性 Neel Jasani; Xiaonan Xu; Benjamin Posorske; Yumi Kim; Kaizhen Wang; Olga Vera; Kenneth Y. Tsai; Gina M. DeNicola; Florian A. Karreth Cancer Res (2025) 85 (2): 314–328. Therapeutic Development and Chemical Biology（治疗进展与生化学） 12 Therapeutic Targeting and Structural Characterization of a Sotorasib-Modified KRAS G12C–MHC I Complex Demonstrate the Antitumor Efficacy of Hapten-Based Strategies sotorasib修饰的KRAS G12C-MHC I复合物的靶向治疗和结构表征证明了基于半抗原方法的抗肿瘤疗效 Apurva Pandey; Peter J. Rohweder; Lieza M. Chan; Chayanid Ongpipattanakul; Dong hee Chung; Bryce Paolella; Fiona M. Quimby; Ngoc Nguyen; Kliment A. Verba; Michael J. Evans; Charles S. Craik Cancer Res (2025) 85 (2): 329–341. 13 An Autophagy-Targeting Chimera Induces Degradation of Androgen Receptor Mutants and AR-v7 in Castration-Resistant Prostate Cancer 在去势抵抗性前列腺癌中，靶向自噬的嵌合体诱导雄激素受体突变体和AR-v7的降解 Tae Hyun Bae; Ki Woon Sung; Tri M. Pham; Abdo J. Najy; Alaleh Zamiri; Hyejeong Jang; Su Ran Mun; Seongho Kim; Ha Kyoung Kwon; Yeon Sung Son; Dongping Shi; Steven Kregel; Elisabeth I. Heath; Michael L. Cher; Yong Tae Kwon; Hyeong-Reh Choi Kim Cancer Res (2025) 85 (2): 342–359. Translational Cancer Biology（癌症转化生物学） 14 The EP3–ZNF488 Axis Promotes Self-Renewal of Glioma Stem-Like Cells to Induce Resistance to Tumor Treating Fields EP3-ZNF488轴促进胶质瘤干样细胞的自我更新，诱导对肿瘤治疗领域的耐药性 Dongjiang Chen; Son B. Le; Harshit Manektalia; Tianyi Liu; Tarun E. Hutchinson; Adam O’Dell; Bodour Salhia; David D. Tran Cancer Res (2025) 85 (2): 360–377. Computational Cancer Biology and Technology（癌症生物学计算机与技术） 15 The Functional Transcriptomic Landscape Informs Therapeutic Strategies in Multiple Myeloma 功能转录组学特征为多发性骨髓瘤的治疗方法提供信息 Praneeth Reddy Sudalagunta; Rafael R. Canevarolo; Mark B. Meads; Maria Silva; Xiaohong Zhao; Christopher L. Cubitt; Samer S. Sansil; Gabriel DeAvila; Raghunandan Reddy Alugubelli; Ryan T. Bishop; Alexandre Tungesvik; Qi Zhang; Oliver Hampton; Jamie K. Teer; Eric A. Welsh; Sean J. Yoder; Bijal D. Shah; Lori Hazlehurst; Robert A. Gatenby; Dane R. Van Domelen; Yi Chai; Feng Wang; Andrew DeCastro; Amanda M. Bloomer; Erin M. Siegel; Conor C. Lynch; Daniel M. Sullivan; Melissa Alsina; Taiga Nishihori; Jason Brayer; John L. Cleveland; William Dalton; Christopher J. Walker; Yosef Landesman; Rachid Baz; Ariosto S. Silva; Kenneth H. Shain Cancer Res (2025) 85 (2): 378–398. Correction（更正） 16 Correction: Mathematical Model-Driven Deep Learning Enables Personalized Adaptive Therapy 更正：数学模型驱动的深度学习实现了个性化自适应治疗 Kit Gallagher; Maximilian A.R. Strobl; Derek S. Park; Fabian C. Spoendlin; Robert A. Gatenby; Philip K. Maini; Alexander R.A. Anderson Cancer Res (2025) 85 (2): 399. Editor’s Note（编者按） 17 Editor’s Note: Mitochondrially Targeted p53 Has Tumor Suppressor Activities In vivo 编者按：线粒体靶向p53在体内具有肿瘤抑制活性 Flaminia Talos; Oleksi Petrenko; Patricio Mena; Ute M. Moll Cancer Res (2025) 85 (2): 400. Cancer Res[Jour] AND 85[volume] AND 3 [issue] 癌症研究 85卷 3期 https://aacrjournals.org/cancerres/issue/ In the Spotlight(焦点) 1 In Search of Representative Translational Cancer Model Systems 寻找具有代表性的转化癌症模型系统 Hannah E. Trembath; Philip M. Spanheimer Cancer Res (2025) 85 (3): 407–409 2 Adapt or Perish: Efficient Selenocysteine Insertion Is Critical for Metastasizing Cancer Cells 适应或危险：有效的硒代半胱氨酸插入对转移癌症细胞至关重要 Namgyu Lee; Dohoon Kim Cancer Res (2025) 85 (3): 410–412 Review(综述) 3 Fungal Influences on Cancer Initiation, Progression, and Response to Treatment 真菌对癌症发生、进展和治疗反应的影响 Hazrat Bilal; Muhammad Nadeen Khan; Sabir Khan; Muhammad Shafiq; Wenjie Fang; Yuebin Zeng; Yangzhong Guo; Xiaohui Li; Bing Zhao; Qiao-Li Lv; Bin Xu Cancer Res (2025) 85 (3): 413–423 Cancer Biology(癌症生物学) 4 Conditional Activation of c-MYC in Distinct Catecholaminergic Cells Drives Development of Neuroblastoma or Somatostatinoma 不同儿茶酚胺能细胞中c-MYC的条件激活驱动神经母细胞瘤或生长抑素瘤的发展 Tingting Wang; Lingling Liu; Jie Fang; Hongjian Jin; Sivaraman Natarajan; Heather Sheppard; Meifen Lu; Gregory Turner; Thomas Confer; Melissa Johnson; Jeffrey Steinberg; Larry Ha; Nour Yadak; Richa Jain; David J. Picketts; Xiaotu Ma; Andrew Murphy; Andrew M. Davidoff; Evan S. Glazer; John Easton; Xiang Chen; Ruoning Wang; Jun Yang Cancer Res (2025) 85 (3): 424–441 5 Mutant PP2A Induces IGFBP2 Secretion to Promote Development of High-Grade Uterine Cancer 突变体PP2A诱导IGFBP2分泌促进高级别子宫癌的发展 Terrance J. Haanen, III; Sophie Boock; Catherine G. Callahan; Irene Peris; Kaitlin P. Zawacki; Brynne Raines; Charles A. Nino; Brian Tran; Alexis Harold; Gabrielle Hodges Onishi; Matthew Hinderman; Amanda Dowdican; Wei Huang; Derek J. Taylor; Sarah E. Taylor; Mark W. Jackson; Analisa DiFeo; Caitlin M. O’Connor; Goutham Narla Cancer Res (2025) 85 (3): 442–461 Cancer Immunology(癌症免疫学) 6 Scavenger Receptor CD36 in Tumor-Associated Macrophages Promotes Cancer Progression by Dampening Type-I IFN Signaling 肿瘤相关巨噬细胞中的清除剂受体CD36通过抑制I型IFN信号传导促进癌症进展 Ziyan Xu; Alexandra Kuhlmann-Hogan; Shihao Xu; Hubert Tseng; Dan Chen; Shirong Tan; Ming Sun; Victoria Tripple; Marcus Bosenberg; Kathryn Miller-Jensen; Susan M. Kaech Cancer Res (2025) 85 (3): 462–476 7 Ferroptotic Neutrophils Induce Immunosuppression and Chemoresistance in Breast Cancer 嗜铁中性粒细胞诱导癌症的免疫抑制和化疗耐药性 Wenfeng Zeng; Ruihua Zhang; Penghan Huang; Minxia Chen; Houying Chen; Xin Zeng; Jiang Liu; Jiahui Zhang; Di Huang; Liyan Lao Cancer Res (2025) 85 (3): 477–496 8 The circRNA cEMSY Induces Immunogenic Cell Death and Boosts Immunotherapy Efficacy in Lung Adenocarcinoma circRNA-cEMSY诱导肺腺癌免疫原性细胞死亡并提高免疫治疗效果 Yijian Zhang; Xuming Song; Yipeng Feng; Yuxian Qian; Bing Chen; Te Zhang; Hui Wang; Yuzhong Chen; Xinnian Yu; Hanlin Ding; Rutao Li; Pengfei Ge; Lin Xu; Gaochao Dong; Feng Jiang Cancer Res (2025) 85 (3): 497–514 Cancer Metabolism and Molecular Mechanisms(癌症代谢和分子机制) 9 CSTF2 Supports Hypoxia Tolerance in Hepatocellular Carcinoma by Enabling m6A Modification Evasion of PGK1 to Enhance Glycolysis CSTF2通过使m6A修饰避开PGK1来增强糖酵解，从而支持肝细胞癌的缺氧耐受 Qiangnu Zhang; Yusen Zhang; Chuli Fu; Xiaoyan He; Zuotian Huang; Geyan Wu; Teng Wei; Wen Jin; Lesen Yan; Meilong Wu; Gongze Peng; LinLan Fan; Mingyue Li; Yuehua Guo; Jiangang Bi; Yu Bai; Stephanie Roessler; Guang-Rong Yan; Liping Liu Cancer Res (2025) 85 (3): 515–534 10 PRDM16 Induces Methylation of FLT3 to Promote FLT3-ITD Signaling and Leukemia Progression PRDM16诱导FLT3甲基化促进FLT3-ITD信号传导和白血病进展 Fengxian Zhai; Guozheng Pan; Lei Xue; Can Cheng; Jiabei Wang; Yao Liu; Lianxin Liu Cancer Res (2025) 85 (3): 535–550 Translational Cancer Biology(转化癌症生物学) 11 Kinome-Focused CRISPR-Cas9 Screens in African Ancestry Patient-Derived Breast Cancer Organoids Identify Essential Kinases and Synergy of EGFR and FGFR1 Inhibition 在非洲裔患者来源的乳腺癌类器官中进行以Kinome为中心的CRISPR-Cas9 筛选，鉴定出关键激酶以及 EGFR 和 FGFR1 抑制的协同作用 Florencia P. Madorsky Rowdo; Rachel Martini; Sarah E. Ackermann; Colin P. Tang; Marvel Tranquille; Adriana Irizarry; Ilkay Us; Omar Alawa; Jenna E. Moyer; Michael Sigouros; John Nguyen; Majd Al Assaad; Esther Cheng; Paula S. Ginter; Jyothi Manohar; Brian Stonaker; Richard Boateng; Joseph K. Oppong; Ernest K. Adjei; Baffour Awuah; Ishmael Kyei; Francis S. Aitpillah; Michael O. Adinku; Kwasi Ankomah; Ernest B. Osei-Bonsu; Kofi K. Gyan; Syed Hoda; Lisa Newman; Juan Miguel Mosquera; Andrea Sboner; Olivier Elemento; Lukas E. Dow; Melissa B. Davis; M. Laura Martin Cancer Res (2025) 85 (3): 551–566 12 Modeling Drug Responses and Evolutionary Dynamics Using Patient-Derived Xenografts Reveals Precision Medicine Strategies for Triple-Negative Breast Cancer 利用患者来源的异种移植物建立药物反应和进化动力学模型揭示了癌症三阴性乳腺癌的精确医学策略 Abigail Shea; Yaniv Eyal-Lubling; Daniel Guerrero-Romero; Raquel Manzano Garcia; Wendy Greenwood; Martin O’Reilly; Dimitra Georgopoulou; Maurizio Callari; Giulia Lerda; Sophia Wix; Agnese Giovannetti; Riccardo Masina; Elham Esmaeilishirazifard; Wei Cope; Alistair G. Martin; Ai Nagano; Lisa Young; Steven Kupczak; Yi Cheng; Helen Bardwell; Elena Provenzano; Justine Kane; Jonny Lay; Louise Grybowicz; Karen McAdam; Carlos Caldas; Jean Abraham; Oscar M. Rueda; Alejandra Bruna Cancer Res (2025) 85 (3): 567–584 13 Loss of CDKN2A Enhances the Efficacy of Immunotherapy in EGFR-Mutant Non–Small Cell Lung Cancer CDKN2A缺失增强EGFR突变型非小细胞肺癌免疫治疗效果 Simeng Wang; Jia-Cheng Lai; Yu Li; Chengfang Tang; Jiajia Lu; Min Han; Xianjiang Ye; Lina Jia; Wei Cui; Jingyu Yang; Chunfu Wu; Lihui Wang Cancer Res (2025) 85 (3): 585–601 Cancer Landscapes(癌症特征) 14 Multiomics Analysis Reveals Molecular Changes during Early Progression of Precancerous Lesions to Lung Adenocarcinoma in Never-Smokers 多组学分析揭示不吸烟者癌前病变向肺腺癌早期发展过程中的分子变化 Yun-Ching Chen; Chia-Lang Hsu; Hui-Min Wang; Shang-Gin Wu; Yih-Leong Chang; Jin-Shing Chen; Yu-Ching Wu; Yen-Ting Lin; Ching-Yao Yang; Mong-Wei Lin; Jang-Ming Lee; Shuenn-Wen Kuo; Ke-Cheng Chen; Hsao-Hsun Hsu; Pei-Ming Huang; Yen-Lin Huang; Chong-Jen Yu; Mehdi Pirooznia; Bevan E. Huang; Rob Yang; Jin-Yuan Shih; Pan-Chyr Yang Cancer Res (2025) 85 (3): 602–617 Computational Cancer Biology and Technology(计算癌症生物学与技术) 15 Fluorescence Lifetime Imaging Enables In Vivo Quantification of PD-L1 Expression and Intertumoral Heterogeneity 荧光寿命成像能够在体内定量PD-L1表达和肿瘤间异质性 Rahul Pal; Murali Krishnamoorthy; Aya Matsui; Homan Kang; Satoru Morita; Hajime Taniguchi; Tatsuya Kobayashi; Atsuyo Morita; Hak Soo Choi; Dan G. Duda; Anand T.N. Kumar Cancer Res (2025) 85 (3): 618–632 Cancer Res[Jour] AND 85[volume] AND 3_Supplement [issue] 癌症研究 85卷3期增刊 https://aacrjournals.org/cancerres/issue/85/3_Supplement Abstracts: AACR Special Conference in Cancer Research: DNA Methylation, Clonal Hematopoiesis, and Cancer; February 1-4, 2025; San Diego, CA 摘要：美国癌症研究协会之癌症研究特别会议：DNA甲基化、克隆造血与癌症；2025年2月1日至4日；加州，圣地亚哥  CLONAL HEMATOPOIESIS  克隆性造血 DNA METHYLATION IN A CHROMATIN CONTEXT  染色质背景下的DNA甲基化 INTERPRETING METHYLATION SIGNALS  解读甲基化信号 NEW CONCEPTS IN CANCER EPIGENETICS  癌症表观遗传学的新概念 NEW DNMTIS, COMBINATIONS, AND RESPONSES  新的DNMTIS、组合和反应 NORMAL AND ABNORMAL METHYLATION PATTERNS AND DETECTION  正常和异常甲基化模式和检测 ROLE OF DNA METHYLATION AND HYDROXYMETHYLATION IN IMMUNE CELL FUNCTION DNA甲基化和羟甲基化在免疫细胞功能中的作用 OTHER TOPICS 其他主题 Cancer Res[Jour] AND 85[volume] AND 4 [issue] 癌症研究 85卷4期 https://aacrjournals.org/cancerres/issue/ In the Spotlight(亮点) 1 Deterministic Role of FOXF2 in Organ-Specific Macrometastasis Transition FOXF2在器官特异性大转移的转化中的决定性作用 Igor L. Bado Cancer Res (2025) 85 (4): 639–641 2 MHC Hammer Decodes HLA Disruption in Tumors MHC Hammer解码HLA在肿瘤中的破坏 Timothy Sears; Hannah Carter Cancer Res (2025) 85 (4): 642–643 Cancer Biology(癌症生物学) 3 Breast Cancer Subtype–Specific Organotropism Is Dictated by FOXF2-Regulated Metastatic Dormancy and Recovery 乳腺癌亚型特异性器官亲和性由FOXF2调控的转移性休眠和恢复决定 Wen-Jing Jiang; Tian-Hao Zhou; Huan-Jing Huang; Lin-Sen Li; Hao Tan; Rui Zhang; Qing-Shan Wang; Yu-Mei Feng Cancer Res (2025) 85 (4): 644–659 4 HBV Remodels PP2A Complexes to Rewire Kinase Signaling in Hepatocellular Carcinoma HBV重组PP2A复合物以重新连接肝细胞癌中的激酶信号 Rigney E. Turnham; Adriana Pitea; Gwendolyn M. Jang; Zhong Xu; Huat Chye Lim; Alex L. Choi; John Von Dollen; Rebecca S. Levin; James T. Webber; Elizabeth McCarthy; Junjie Hu; Xiaolei Li; Li Che; Ananya Singh; Alex Yoon; Gary K.L. Chan; Robin K. Kelley; Danielle L. Swaney; Wei Zhang; Sourav Bandyopadhyay; Fabian J. Theis; Manon Eckhardt; Xin Chen; Kevan M. Shokat; Trey Ideker; Nevan J. Krogan; John D. Gordan Cancer Res (2025) 85 (4): 660–674 5 Chromatin Helicase CHD6 Establishes Proinflammatory Enhancers and Is a Synthetic Lethal Target in FH-Deficient Renal Cell Carcinoma 染色质解旋酶CHD6在FH-缺陷肾细胞癌中建立促炎增强因子并成为合成致死靶点 Juan Jin; Jun Luo; Xiaodong Jin; Kiat Shenq Lim; Yang He; Jiawei Ding; Yan Shen; Yuchen Hou; Hanqing Liu; Xiaoyu Zhu; Jing Zhao; Wenjie Zhou; Hai Huang; Yi Gao; Jun Xiao; Hongchao He; Qunyi Li; Lianxin Liu; Li Chen; Qiang He; Chuanjie Zhang Cancer Res (2025) 85 (4): 675–691 Cancer Immunology(癌症免疫学) 6 Adenosine Uptake through the Nucleoside Transporter ENT1 Suppresses Antitumor Immunity and T-cell Pyrimidine Synthesis 腺苷通过核苷转运蛋白ENT1摄取抑制抗肿瘤免疫和T细胞嘧啶合成 David Allard; Jeanne Cormery; Salma Bricha; Camille Fuselier; Farnoosh Abbas Aghababazadeh; Lucie Giraud; Emma Skora; Benjamin Haibe-Kains; John Stagg Cancer Res (2025) 85 (4): 692–703 7 Mapping of the T-cell Landscape of Biliary Tract Cancer Unravels Anatomic Subtype-Specific Heterogeneity 胆道癌的T细胞图谱揭示解剖亚型特异性异质性 Jianhua Nie; Shuyuan Zhang; Ying Guo; Caiqi Liu; Jiaqi Shi; Haotian Wu; Ruisi Na; Yingjian Liang; Shan Yu; Fei Quan; Kun Liu; Mingwei Li; Meng Zhou; Ying Zhao; Xuehan Li; Shengnan Luo; Qian Zhang; Guangyu Wang; Yanqiao Zhang; Yuanfei Yao; Yun Xiao; Sheng Tai; Tongsen Zheng Cancer Res (2025) 85 (4): 704–722 Cancer Metabolism and Molecular Mechanisms(癌症代谢和分子机制) 8 Energy Stress–Induced circEPB41(2) Promotes Lipogenesis in Hepatocellular Carcinoma 能量应激诱导的环EPB41(2)促进肝细胞癌的脂肪生成 Yang Yang; Jingjing Luo; Zhongyu Wang; Kaiyue Liu; Keyi Feng; Fang Wang; Yide Mei Cancer Res (2025) 85 (4): 723–738 9 PTBP1 Lactylation Promotes Glioma Stem Cell Maintenance through PFKFB4-Driven Glycolysis PTBP1乳糖化通过PFKFB4驱动的糖酵解促进胶质瘤干细胞的维持 Zijian Zhou; Xianyong Yin; Hao Sun; Jiaze Lu; Yuming Li; Yang Fan; Peiwen Lv; Min Han; Jing Wu; Shengjie Li; Zihao Liu; Hongbo Zhao; Haohan Sun; Hao Fan; Shan Wang; Tao Xin Cancer Res (2025) 85 (4): 739–757 Therapeutic Development and Chemical Biology(治疗进展与生物化学) 10 A Potent, Selective, Small-Molecule Inhibitor of DHX9 Abrogates Proliferation of Microsatellite Instable Cancers with Deficient Mismatch Repair 一种强效、选择性、小分子DHX9抑制剂可抑制错配修复缺陷的微卫星不稳定癌症的增殖 Jennifer Castro; Matthew H. Daniels; David Brennan; Brian Johnston; Deepali Gotur; Young-Tae Lee; Kevin E. Knockenhauer; Chuang Lu; Jie Wu; Sunaina Nayak; Cindy Collins; Rishabh Bansal; Shane M. Buker; April Case; Julie Liu; Shihua Yao; Brian A. Sparling; E. Allen Sickmier; Serena J. Silver; Stephen J. Blakemore; P. Ann Boriack-Sjodin; Kenneth W. Duncan; Scott Ribich; Robert A. Copeland Cancer Res (2025) 85 (4): 758–776 11 Imlunestrant Is an Oral, Brain-Penetrant Selective Estrogen Receptor Degrader with Potent Antitumor Activity in ESR1 Wild-Type and Mutant Breast Cancer Imlunestrant是一种口服的，脑渗透的选择性雌激素受体降解剂，对ESR1野生型和突变型乳腺癌具有有效的抗肿瘤活性 Shripad V. Bhagwat; Cecilia Mur; Matthew Vandekopple; Baohui Zhao; Weihua Shen; Carlos Marugán; Andrew Capen; Lisa Kindler; Jennifer R. Stephens; Lysiane Huber; Mark A. Castanares; David Garcia-Tapia; Jeff D. Cohen; Jolie Bastian; Brian Mattioni; Eunice Yuen; Thomas K. Baker; Vivian Rodriguez Cruz; Dongling Fei; Jason R. Manro; Nicholas Pulliam; Michele S. Dowless; Maria Jesus Ortiz Ruiz; Chunping Yu; Loredana Puca; Anke Klippel; Francesca Bacchion; Roohi Ismail-Khan; Vanessa Rodrik-Outmezguine; Sheng-Bin Peng; María Jose Lallena; Xueqian Gong; Alfonso de Dios Cancer Res (2025) 85 (4): 777–790 Translational Cancer Biology(癌症转化生物学) 12 Plasma Cell–Free DNA Chromatin Immunoprecipitation Profiling Depicts Phenotypic and Clinical Heterogeneity in Advanced Prostate Cancer 血浆游离 DNA 染色质免疫沉淀图谱描绘了晚期前列腺癌的表型和临床异质性 Joonatan Sipola; Aslı D. Munzur; Edmond M. Kwan; Clara C.Y. Seo; Benjamin J. Hauk; Karan Parekh; Yi Jou (Ruby) Liao; Cecily Q. Bernales; Gráinne Donnellan; Ingrid Bloise; Emily Fung; Sarah W.S. Ng; Gang Wang; Gillian Vandekerkhove; Matti Nykter; Matti Annala; Corinne Maurice-Dror; Kim N. Chi; Cameron Herberts; Alexander W. Wyatt; David Y. Takeda Cancer Res (2025) 85 (4): 791–807 13 Targeting the PREX2/RAC1/PI3Kβ Signaling Axis Confers Sensitivity to Clinically Relevant Therapeutic Approaches in Melanoma 靶向PREX2/RAC1/PI3Kβ信号轴赋予黑色素瘤临床相关治疗方法的敏感性 Catriona A. Ford; Dana Koludrovic; Patricia P. Centeno; Mona Foth; Elpida Tsonou; Nikola Vlahov; Nathalie Sphyris; Kathryn Gilroy; Courtney Bull; Colin Nixon; Bryan Serrels; Alison F. Munro; John C. Dawson; Neil O. Carragher; Valeria Pavet; David C. Hornigold; Philip D. Dunne; Julian Downward; Heidi C.E. Welch; Simon T. Barry; Owen J. Sansom; Andrew D. Campbell Cancer Res (2025) 85 (4): 808–824 Corrections(更正) 14 Correction: p38γ MAPK Is Essential for Aerobic Glycolysis and Pancreatic Tumorigenesis 更正：p38γ MAPK是有氧糖酵解和胰腺肿瘤发生至关重要 Fang Wang; Xiao-Mei Qi; Ryan Wertz; Matthew Mortensen; Catherine Hagen; John Evans; Yuri Sheinin; Michael James; Pengyuan Liu; Susan Tsai; James Thomas; Alexander Mackinnon; Michael Dwinell; Charles R. Myers; Ramon Bartrons Bach; Liwu Fu; Guan Chen Cancer Res (2025) 85 (4): 825 15 Correction: Long Noncoding RNA MIR17HG Promotes Colorectal Cancer Progression via miR-17-5p 更正：长非编码RNA MIR17HG通过miR-17-5p促进结直肠癌癌症进展 Jie Xu; Qingtao Meng; Xiaobo Li; Hongbao Yang; Jin Xu; Na Gao; Hao Sun; Shenshen Wu; Giuseppe Familiari; Michela Relucenti; Haitao Zhu; Jiong Wu; Rui Chen Cancer Res (2025) 85 (4): 826 Cancer Res[Jour] AND 85[volume] AND 5[issue] 癌症研究85卷 5期 https://aacrjournals.org/cancerres/issue/ In the Spotlight（焦点） 1 Unlocking the Role of Senescent Cell–Derived Extracellular Vesicles in Immune-Mediated Tumor Suppression 解锁衰老细胞来源的细胞外囊泡在免疫介导的肿瘤抑制中的作用 Sofia Almeida; Sonia A. Melo Cancer Res (2025) 85 (5): 833–835. 2 Switching Drivers: Epigenetic Rewiring to Genetic Progression in Glioma 驱动转换：胶质瘤中从表观遗传重塑到遗传进展 Kristen L. Drucker; Robert B. Jenkins; Daniel Schramek Cancer Res (2025) 85 (5): 836–837. Review（综述） 3 DOT1L Mediates Stem Cell Maintenance and Represents a Therapeutic Vulnerability in Cancer DOT1L介导干细胞的维持并成为癌症的治疗靶点 Hetakshi Kurani; Joyce M. Slingerland Cancer Res (2025) 85 (5): 838–847. Resource Report（资源报告） 4 spatialGE Is a User-Friendly Web Application That Facilitates Spatial Transcriptomics Data Analysis spatialGE：一个对用户友好的网络应用程序，以便于空间转录组数据分析 Oscar E. Ospina; Roberto Manjarres-Betancur; Guillermo Gonzalez-Calderon; Alex C. Soupir; Inna Smalley; Kenneth Y. Tsai; Joseph Markowitz; Mariam L. Khaled; Ethan Vallebuona; Anders E. Berglund; Steven A. Eschrich; Xiaoqing Yu; Brooke L. Fridley Cancer Res (2025) 85 (5): 848–858. Cancer Biology（癌症生物学） 5 Senescent Cell–Derived Extracellular Vesicles Inhibit Cancer Recurrence by Coordinating Immune Surveillance 衰老细胞来源的细胞外囊泡通过协调免疫监视抑制癌症复发 Tahereh Ziglari; Nicholas L. Calistri; Jennifer M. Finan; Daniel S. Derrick; Ernesto S. Nakayasu; Meagan C. Burnet; Jennifer E. Kyle; Matthew Hoare; Laura M. Heiser; Ferdinando Pucci Cancer Res (2025) 85 (5): 859–874. 6 Gain-of-Function Chromatin Remodeling Activity of Oncogenic FOXL2C134W Reprograms Glucocorticoid Receptor Occupancy to Drive Granulosa Cell Tumors 致癌性FOXL2C134W的获得性功能染色质重塑活性通过重新编码糖皮质激素受体占位来驱动颗粒细胞瘤 Thomas Welte; Veena K. Vuttaradhi; Eleonora Y. Khlebus; Allison Brodsky; Alejandra Flores Legarreta; Joseph Celestino; Reid T. Powell; Clifford C. Stephan; Nghi Nguyen; Jian Li; Shiro Takamatsu; Katherine Calzoncinth; Anil K. Sood; David M. Gershenson; P. Andrew Futreal; Barrett Lawson; R. Tyler Hillman Cancer Res (2025) 85 (5): 875–893. 7 Accumulation of CD38 in Hybrid Epithelial/Mesenchymal Cells Promotes Immune Remodeling and Metastasis in Breast Cancer 杂交上皮/间质细胞中CD38的累积可促进免疫重塑和乳腺癌转移 Tanvi H. Visal; Recep Bayraktar; Petra den Hollander; Michael A. Attathikhun; Tieling Zhou; Jing Wang; Li Shen; Corina-Elena Minciuna; Meng Chen; Elizve Barrientos-Toro; Harsh Batra; Maria Gabriela Raso; Fei Yang; Edwin R. Parra; Aysegul A. Sahin; George A. Calin; Sendurai A. Mani Cancer Res (2025) 85 (5): 894–911. Cancer Immunology（癌症免疫学） 8 SEMA3G–NRP1 Signaling Functions as an Immune Checkpoint That Enables Tumor Immune Evasion by Impairing T-cell Cytotoxicity SEMA3G-NRP1信号功能可作为免疫检测点，其通过损害T细胞毒性使肿瘤逃避免疫 Hao Chi; Shouyan Deng; Ke Xu; Yibo Zhang; Teng Song; Jianghong Yu; Yiting Wang; Jiayang Liu; Yuan Zhang; Jiawei Shi; Yungang Wang; Jie Xu Cancer Res (2025) 85 (5): 912–924. 9 Targeting Arachidonic Acid Metabolism Enhances Immunotherapy Efficacy in ARID1A-Deficient Colorectal Cancer 靶向花生四烯酸代谢可增强ARID1A缺陷型结直肠癌的免疫治疗效果 Luying Cui; Ruiqi Liu; Shuling Han; Chunhui Zhang; Bojun Wang; Yuli Ruan; Xuefan Yu; Yien Li; Yuanfei Yao; Xin Guan; Yuanyu Liao; Dan Su; Yue Ma; Shuijie Li; Chao Liu; Yanqiao Zhang Cancer Res (2025) 85 (5): 925–941. Cancer Metabolism and Molecular Mechanisms（癌症代谢与分子机制） 10 Selenoprotein O Promotes Melanoma Metastasis and Regulates Mitochondrial Complex II Activity 硒蛋白O促进黑色素瘤转移并调节线粒体复合体II活性 Luiza Martins Nascentes Melo; Marie Sabatier; Vijayashree Ramesh; Krystina J. Szylo; Cameron S. Fraser; Alex Pon; Evann C. Mitchell; Kelly A. Servage; Gabriele Allies; Isa V. Westedt; Feyza Cansiz; Jonathan Krystkiewicz; Andrea Kutritz; Dirk Schadendorf; Sean J. Morrison; Jessalyn M. Ubellacker; Anju Sreelatha; Alpaslan Tasdogan Cancer Res (2025) 85 (5): 942–955. Therapeutic Development and Chemical Biology（治疗学进展与生物化学） 11 A Pan-RAS Inhibitor with a Unique Mechanism of Action Blocks Tumor Growth and Induces Antitumor Immunity in Gastrointestinal Cancer 一种具有独特作用机制的泛RAS抑制剂可阻断胃肠癌症肿瘤生长并诱导抗肿瘤免疫 Jeremy B. Foote; Tyler E. Mattox; Adam B. Keeton; Xi Chen; Forrest T. Smith; Kristy Berry; Thomas W. Holmes; Junwei Wang; Chung-hui Huang; Antonio Ward; Amit K. Mitra; Veronica Ramirez-Alcantara; Cherlene Hardy; Karianne G. Fleten; Kjersti Flatmark; Karina J. Yoon; Sujith Sarvesh; Ganji P. Nagaraju; Dhana Sekhar Reddy Bandi; Yulia Y. Maxuitenko; Jacob Valiyaveettil; Julienne L. Carstens; Donald J. Buchsbaum; Jennifer Yang; Gang Zhou; Elmar Nurmemmedov; Ivan Babic; Vadim Gaponeko; Hazem Abdelkarim; Michael R. Boyd; Greg Gorman; Upender Manne; Sejong Bae; Bassel F. El-Rayes; Gary A. Piazza Cancer Res (2025) 85 (5): 956–972. 12 Antibody–Drug Conjugates Targeting the EGFR Ligand Epiregulin Elicit Robust Antitumor Activity in Colorectal Cancer 针对EGFR配体表皮调节素的抗体-药物偶联物在结直肠癌中显示出强大的抗肿瘤活性 Joan Jacob; Yasuaki Anami; Peyton C. High; Zhengdong Liang; Shraddha Subramanian; Sukhen C. Ghosh; Solmaz AghaAmiri; Cara Guernsey-Biddle; Ha Tran; Julie Rowe; Ali Azhdarinia; Kyoji Tsuchikama; Kendra S. Carmon Cancer Res (2025) 85 (5): 973–986. Computational Cancer Biology and Technology（计算癌症生物学与技术） 13 Spatiotemporal Profiling Defines Persistence and Resistance Dynamics during Targeted Treatment of Melanoma 时空特征分析定义了黑色素瘤靶向治疗期间持久性和耐药性动力学 Jill C. Rubinstein; Sergii Domanskyi; Todd B. Sheridan; Brian Sanderson; SungHee Park; Jessica Kaster; Haiyin Li; Olga Anczukow; Meenhard Herlyn; Jeffrey H. Chuang Cancer Res (2025) 85 (5): 987–1002. Editor’s Note（编者注） 14 Editor’s Note: PTEN Loss Contributes to Erlotinib Resistance in EGFR-Mutant Lung Cancer by Activation of Akt and EGFR 编辑注：PTEN缺失通过激活Akt和EGFR导致EGFR突变型肺癌对厄洛替尼耐药 Martin L. Sos; Mirjam Koker; Barbara A. Weir; Stefanie Heynck; Rosalia Rabinovsky; Thomas Zander; Jens M. Seeger; Jonathan Weiss; Florian Fischer; Peter Frommolt; Kathrin Michel; Martin Peifer; Craig Mermel; Luc Girard; Michael Peyton; Adi F. Gazdar; John D. Minna; Levi A. Garraway; Hamid Kashkar; William Pao; Matthew Meyerson; Roman K. Thomas Cancer Res (2025) 85 (5): 1003. Cancer Res[Jour] AND 85[volume] AND 5_Supplement[issue] 癌症研究85卷 5期增刊 https://aacrjournals.org/cancerres/issue/85/5_Supplement Abstracts: AACR Special Conference in Cancer Research: Functional and Genomic Precision Medicine in Cancer: Different Perspectives, Common Goals; March 11-13, 2025; Boston, MA 摘要：《癌症研究》之美国癌症研究协会特别会议：癌症中的功能与基因组学精准医学：不同视角，共同目标；2025年3月11-13日；波士顿，马萨诸塞州 CHALLENGES IN TISSUE ACQUISITION AND HANDLING FOR PRECISION MEDICINE 精准医学中组织获取与处理的挑战 CHALLENGES OF INTRA-TUMOR AND INTRA-PATIENT HETEROGENEITY FOR PRECISION MEDICINE 精准医学中肿瘤内和患者内异质性的挑战 CLINICAL TRIAL DESIGN FOR OPTIMAL IMPLEMENTATION OF PRECISION MEDICINE 为实现精准医学最优化的临床试验设计 FUNCTIONAL AND GENOMIC PRECISION MEDICINE IN BLOOD CANCERS 血液科恶性肿瘤中的功能与基因组学精准医学 FUNCTIONAL AND GENOMIC PRECISION MEDICINE IN SOLID TUMORS 实体瘤中的功能与基因组学精准医学 IMMUNOTHERAPY-PREDICTIVE BIOMARKERS 免疫治疗预测生物标志物 KEYNOTE LECTURE 主题演讲 MACHINE LEARNING TO INTEGRATE MULTIPLE DATA LAYERS 整合多层数据的机器学习 NEW OMICS FOR PRECISION MEDICINE 精准医学的新组学 REGULATORY AND NON-REGULATORY CHALLENGES TO THE WIDE ADOPTION OF PRECISION DIAGNOSTICS 精准诊断广泛采用中的监管与非监管挑战 VERTEBRATE MODELS FOR MODELING DISEASE AND GUIDING THERAPY 用于疾病建模和指导治疗的脊椎动物模型 OTHER TOPICS 其他主题 Cancer Res[Jour] AND 85[volume] AND 6[issue] 癌症研究 85卷 6期 https://aacrjournals.org/cancerres/issue/ In the Spotlight（焦点） 1 CAR-T Entering a New “Phase”: Improving CAR-T Function by Harnessing Phase Separation CAR-T 进入新“阶段”：利用相分离改善 CAR-T 功能 Xiaolei Su Cancer Res (2025) 85 (6): 1011–1012. 2 Breaking the Rhythm: Harnessing the Menstrual Cycle for Better Chemotherapy 打破节奏：利用月经周期提高化疗效果 Pranay Dey; Cathrin Brisken Cancer Res (2025) 85 (6): 1013–1014. Resource Report（资源报告） 3 Comparative Single-Cell Transcriptomics of Human Neuroblastoma and Preclinical Models Reveals Conservation of an Adrenergic Cell State 人类神经母细胞瘤与临床前模型的单细胞转录组学比较揭示了肾上腺素能细胞状态的保守性 Bethel Tesfai Embaie; Hirak Sarkar; Adele M. Alchahin; Jörg Otte; Thale Kristin Olsen; Conny Tümmler; Polina Kameneva; Artem V. Artemov; Natalia Akkuratova; Igor Adameyko; Jan-Bernd Stukenborg; Malin Wickström; Per Kogner; John Inge Johnsen; Shenglin Mei; Peter V. Kharchenko; Ninib Baryawno Cancer Res (2025) 85 (6): 1015–1034. Cancer Biology（癌症生物学） 4 CLK1 Activates YAP to Promote Intrahepatic Cholangiocarcinogenesis CLK1激活YAP促进肝内胆管癌发生 Shuai Xue; Xiangzheng Chen; Guoteng Qiu; Haotian Liao; Zeyuan Qiang; Zheng Zhang; Xuping Feng; Lin Xu; Rui Xie; Hongyu Zhou; Jiwei Huang; Yong Zeng; Haichuan Wang Cancer Res (2025) 85 (6): 1035–1048. 5 MICAL2 Promotes Pancreatic Cancer Growth and Metastasis MICAL2促进胰腺癌的生长和转移 Bharti Garg; Sohini Khan; Asimina S. Courelli; Ponmathi Panneerpandian; Deepa Sheik Pran Babu; Evangeline S. Mose; Kevin Christian Montecillo Gulay; Shweta Sharma; Divya Sood; Alexander T. Wenzel; Alexei Martsinkovskiy; Nirakar Rajbhandari; Jay Patel; Dawn Jaquish; Edgar Esparza; Katelin Jaque; Neetu Aggarwal; Guillem Lambies; Anthony D’Ippolito; Kathryn Austgen; Brian Johnston; David A. Orlando; Gun Ho Jang; Steven Gallinger; Elliot Goodfellow; Pnina Brodt; Cosimo Commisso; Pablo Tamayo; Jill P. Mesirov; Hervé Tiriac; Andrew M. Lowy Cancer Res (2025) 85 (6): 1049–1063. 6 Hypoxia-Induced Senescent Fibroblasts Secrete IGF1 to Promote Cancer Stemness in Esophageal Squamous Cell Carcinoma 缺氧诱导的衰老成纤维细胞分泌IGF1促进食管鳞状细胞癌的癌干性 Zhengjie Ou; Liang Zhu; Xinjie Chen; Tianyuan Liu; Guoyu Cheng; Rucheng Liu; Shaosen Zhang; Wen Tan; Dongxin Lin; Chen Wu Cancer Res (2025) 85 (6): 1064–1081. Cancer Immunology（癌症免疫学） 7 Myeloid Cells Induce Infiltration and Activation of B Cells and CD4+ T Follicular Helper Cells to Sensitize Brain Metastases to Combination Immunotherapy 髓系细胞诱导B细胞和CD4+T滤泡辅助细胞浸润和激活，使脑转移瘤对联合免疫治疗敏感 Toshifumi Ninomiya; Naoya Kemmotsu; Fumiaki Mukohara; Masaki Magari; Ai Miyamoto; Youki Ueda; Takamasa Ishino; Joji Nagasaki; Tomohiro Fujiwara; Hidetaka Yamamoto; Hidetoshi Hayashi; Kota Tachibana; Joji Ishida; Yoshihiro Otani; Shota Tanaka; Shinichi Toyooka; Isamu Okamoto; Yosuke Togashi Cancer Res (2025) 85 (6): 1082–1096. Cancer Metabolism and Molecular Mechanisms（癌症代谢与分子机制） 8 SNHG17 Reprograms Energy Metabolism of Breast Cancer by Activating Mitochondrial DNA Transcription SNHG17通过激活线粒体DNA转录重塑乳腺癌的能量代谢 Lin Gao; Jingyi Huang; Jinquan Xia; Pan Zhao; Shaowei Dong; Wei Jiang; Qianqian Zhou; Zhenglei Xu; Hui Luo; Wenbin Zhou; Jichao Sun; Guangsuo Wang; Qingshan Geng; Jigang Wang; Chang Zou Cancer Res (2025) 85 (6): 1097–1112. 9 MTHFD2 Enhances cMYC O-GlcNAcylation to Promote Sunitinib Resistance in Renal Cell Carcinoma MTHFD2增强cMYC的O-GlcNAcylation，促进肾细胞癌对舒尼替尼的耐药 Jinwen Liu; Gaowei Huang; Hao Lin; Rui Yang; Wenhao Zhan; Cheng Luo; Yukun Wu; Lingwu Chen; Xiaopeng Mao; Junxing Chen; Bin Huang Cancer Res (2025) 85 (6): 1113–1129. Translational Cancer Biology（癌症转化生物学） 10 Immune Checkpoint Blockade Delays Cancer Development and Extends Survival in DNA Polymerase Mutator Syndromes 免疫检查点阻断可延缓DNA聚合酶突变综合征中的癌症进展并延长生存期 Akshada Sawant; Fuqian Shi; Eduardo Cararo Lopes; Zhixian Hu; Somer Abdelfattah; Jennele Baul; Jesse R. Powers; Christian S. Hinrichs; Joshua D. Rabinowitz; Chang S. Chan; Edmund C. Lattime; Shridar Ganesan; Eileen P. White Cancer Res (2025) 85 (6): 1130–1144. 11 Oxidative Phosphorylation Is a Metabolic Vulnerability of Endocrine Therapy–Tolerant Persister Cells in ER+ Breast Cancer 氧化磷酸化是ER+乳腺癌中内分泌治疗耐受持久细胞的代谢弱点 Steven Tau; Mary D. Chamberlin; Huijuan Yang; Jonathan D. Marotti; Patricia C. Muskus; Alyssa M. Roberts; Melissa M. Carmichael; Lauren Cressey; Christo Philip C. Dragnev; Eugene Demidenko; Riley A. Hampsch; Shannon M. Soucy; Fred W. Kolling; Kimberley S. Samkoe; James V. Alvarez; Arminja N. Kettenbach; Todd W. Miller Cancer Res (2025) 85 (6): 1145–1161. 12 Evolutionary Pressures Shape Undifferentiated Pleomorphic Sarcoma Development and Radiotherapy Response 进化压力塑造未分化多形性肉瘤的进展和放疗反应 Erik S. Blomain; Shaghayegh Soudi; Ziwei Wang; Anish Somani; Ajay Subramanian; Serey C.L. Nouth; Eniola Oladipo; Christin New; Deborah E. Kenney; Neda Nemat-Gorgani; Thomas Kindler; Raffi S. Avedian; Robert J. Steffner; David G. Mohler; Susan M. Hiniker; Alexander L. Chin; Anusha Kalbasi; Michael S. Binkley; Marius Fried; Matthias M. Gaida; Matt van de Rijn; Everett J. Moding Cancer Res (2025) 85 (6): 1162–1174. Retraction（撤回） 13 Retraction: Cell-Permeable NM23 Blocks the Maintenance and Progression of Established Pulmonary Metastasis 撤回：细胞通透型NM23可阻断已形成的肺转移持续和进展 Junghee Lim; Giyong Jang; Seeun Kang; Guewha Lee; Do Thi Thuy Nga; Do Thi Lan Phuong; Hyuncheol Kim; Wael El-Rifai; H. Earl Ruley; Daewoong Jo Cancer Res (2025) 85 (6): 1175. Cancer Res[Jour] AND 85[volume] AND 7[issue] 癌症研究85卷 7期 https://aacrjournals.org/cancerres/issue/ Priority Report(特邀报道) 1 ZNFX1 Functions as a Master Regulator of Epigenetically Induced Pathogen Mimicry and Inflammasome Signaling in Cancer 在癌症中作为表观遗传诱导的病原体模拟和炎症小体信号传导的主要调节因子的ZNFX1功能 Lora Stojanovic; Rachel Abbotts; Kaushelendra Tripathi; Collin M. Coon; Saranya Rajendran; Elnaz Abbasi Farid; Galen Hostetter; Joseph W. Guarnieri; Douglas C. Wallace; Sheng Liu; Jun Wan; Gennaro Calendo; Rebecca Marker; Zahra Gohari; Mohammed M.A. Inayatullah; Vijay K. Tiwari; Tanjina Kader; Sandro Santagata; Ronny Drapkin; Stefan Kommoss; Jacobus Pfisterer; Gottfried E. Konecny; Ryan Coopergard; Jean-Pierre J. Issa; Boris J.N. Winterhoff; Michael J. Topper; George E. Sandusky; Kathy D. Miller; Stephen B. Baylin; Kenneth P. Nephew; Feyruz V. Rassool Cancer Res (2025) 85 (7): 1183–1198 Cancer Biology(癌症生物学) 2 ST6GAL1-Mediated Sialylation of PECAM-1 Promotes a Transcellular Diapedesis–Like Process That Directs Lung Tropism of Metastatic Breast Cancer ST6GAL1 介导的 PECAM-1 唾液酰化促进了一种跨细胞渗出样过程，引导转移性乳腺癌的肺趋向性 Shih-Yin Chen; Pei-Lin He; Li-Yu Lu; Meng-Chieh Lin; Shih-Hsuan Chan; Jia-Shiuan Tsai; Wen-Ting Luo; Lu-Hai Wang; Hua-Jung Li Cancer Res (2025) 85 (7): 1199–1218 Cancer Immunology(癌症免疫学) 3 Comparison of Lean, Obese, and Weight-Loss Models Reveals TREM2 Deficiency Attenuates Breast Cancer Growth Uniquely in Lean Mice and Alters Clonal T-cell Populations 消瘦、肥胖和减肥模型的比较显示TREM2缺乏在消瘦小鼠中可特异性削弱乳腺癌生长并改变克隆T细胞群 Elysa W. Pierro; Matthew A. Cottam; Hanbing An; Brian D. Lehmann; Jennifer A. Pietenpol; Kathryn E. Wellen; Liza Makowski; Jeffrey C. Rathmell; Barbara Fingleton; Alyssa H. Hasty Cancer Res (2025) 85 (7): 1219–1235 4 Targeting ARPC1B Overcomes Immune Checkpoint Inhibitor Resistance in Glioblastoma by Reversing Protumorigenic Macrophage Polarization 靶向ARPC1B通过逆转促肿瘤型巨噬细胞极化克服胶质母细胞瘤对免疫检查点抑制剂的耐药性 Tianqi Liu; Tao Sun; Xin Chen; Jianqi Wu; Xiaoqian Sun; Xing Liu; Haixu Yan; Qiang Fu; Zirong Fan; Xiangyu Wang; Peng Cheng; Wen Cheng; Anhua Wu Cancer Res (2025) 85 (7): 1236–1252 Cancer Metabolism and Molecular Mechanisms(癌症代谢与分子机制) 5 Mutant KRAS and CK2 Cooperatively Stimulate SLC16A3 Activity to Drive Intrahepatic Cholangiocarcinoma Progression KRAS和CK2突变协同刺激SLC16A3活性以驱动肝内胆管癌进展 Ran Chen; Cuihong Ma; Haoran Qian; Xinyu Xie; Yuxue Zhang; Dayun Lu; Shunjie Hu; Mao Zhang; Fen Liu; Yunhao Zou; Qiang Gao; Hu Zhou; Hailong Liu; Moubin Lin; Gaoxiang Ge; Daming Gao Cancer Res (2025) 85 (7): 1253–1269 6 Targeting TUT1 Depletes Tri-snRNP Pools to Suppress Splicing and Inhibit Pancreatic Cancer Cell Survival 靶向TUT1使Tri-snRNP池耗尽抑制剪接同时抑制胰腺癌细胞存活 Ziwei Guo; Junran Huang; Zhi J. Lu; Yongsheng Shi; Charles J. David; Mo Chen Cancer Res (2025) 85 (7): 1270–1286 Therapeutic Development and Chemical Biology(治疗学进展与生物化学) 7 STING Agonist VB-85247 Induces Durable Antitumor Immune Responses by Intravesical Administration in a Non–Muscle-Invasive Bladder Cancer STING激动剂VB-85247通过膀胱内给药诱导非肌层侵袭性膀胱癌患者持久性抗肿瘤免疫反应 Miglena G. Prabagar; Michael McQueney; Venu Bommireddy; Rachael Siegel; Gary L. Schieven; Ku Lu; Ruziboy Husanov; Reema Deepak; David Diller; Chia-Yu Huang; Eli Mordechai; Rukiye-Nazan Eraslan Cancer Res (2025) 85 (7): 1287–1296 Translational Cancer Biology(癌症转化生物学) 8 Profiling the Activity of the Potent and Highly Selective CDK2 Inhibitor BLU-222 Reveals Determinants of Response in CCNE1-Aberrant Ovarian and Endometrial Tumors 强效高选择性CDK2抑制剂BLU-222的活性分析揭示了CCNE1异常卵巢和子宫内膜肿瘤反应的决定因素 Nealia C. House; Victoria E. Brown; Maxine Chen; Liang Yuan; Sydney L. Moore; Jian Guo; Yoon Jong Choi; Lakshmi Muthuswamy; Scott Ribich; Philip Ramsden; Kerrie L. Faia Cancer Res (2025) 85 (7): 1297–1309 9 Tumor Suppressors Condition Differential Responses to the Selective CDK2 Inhibitor BLU-222 肿瘤抑制因子状态对选择性CDK2抑制剂BLU-222的不同反应 Adam P. Dommer; Vishnu Kumarasamy; Jianxin Wang; Thomas N. O’Connor; Michelle Roti; Sidney Mahan; Karen McLean; Erik S. Knudsen; Agnieszka K. Witkiewicz Cancer Res (2025) 85 (7): 1310–1326 Convergence Science(融合医学) 10 Genomic Analysis Reveals Racial and Age-Related Differences in the Somatic Landscape of Breast Cancer and the Association with Socioeconomic Factors 基因组分析揭示了与种族和年龄相关的乳腺癌体细胞特征差异及其与社会经济因素的关联 Sarah C. Van Alsten; Michael I. Love; Benjamin C. Calhoun; Eboneé N. Butler; Charles M. Perou; Katherine A. Hoadley; Melissa A. Troester Cancer Res (2025) 85 (7): 1327–1340 Correction(更正) 11 Correction: Comprehensive DNA Methylation Analysis Indicates That Pancreatic Intraepithelial Neoplasia Lesions Are Acinar-Derived and Epigenetically Primed for Carcinogenesis 更正：综合DNA甲基化分析表明胰腺上皮内瘤变病变是腺泡衍生的，并在表观遗传上为癌变做好了准备 Emily K.W. Lo; Brian M. Mears; H. Carlo Maurer; Adrian Idrizi; Kasper D. Hansen; Elizabeth D. Thompson; Laura D. Wood; Ralph H. Hruban; Kenneth P. Olive; Andrew P. Feinberg Cancer Res (2025) 85 (7): 1341 Editor's Note(编者注) 12 Editor’s Note: TRIM59 Promotes Gliomagenesis by Inhibiting TC45 Dephosphorylation of STAT3 编者注：TRIM59通过抑制STAT3的TC45去磷酸化促进胶质瘤形成 Youzhou Sang; Yanxin Li; Lina Song; Angel A. Alvarez; Weiwei Zhang; Deguan Lv; Jianming Tang; Feng Liu; Zhijie Chang; Shigetsugu Hatakeyama; Bo Hu; Shi-Yuan Cheng; Haizhong Feng Cancer Res (2025) 85 (7): 1342 Cancer Res[Jour] AND 85[volume] AND 8[issue] 癌症研究 85卷8期 https://aacrjournals.org/cancerres/issue/ In the Spotlight（焦点） 1 Condensates as a Culprit in RAS Activation and Inhibitor Resistance 冷凝物是RAS激活与抑制剂耐药的“罪魁祸首” Hannah C. Bergo; Logan B. Leak; Trever G. Bivona Cancer Res (2025) 85 (8): 1349–1351. 2 Distinct States of Nuclear Speckles Emerge as New Predictors of Cancer Prognosis 核斑点出现的不同状态成为癌症预后的新型预测因子 Lisa Martina; Michał Małszycki; Tuğçe Aktaş Cancer Res (2025) 85 (8): 1352–1353. Review（综述） 3 Circulating Tumor Microenvironment in Metastasis 转移中的循环肿瘤微环境 Rui Tang; Shujuan Luo; Hui Liu; Yan Sun; Manran Liu; Lu Li; Haoyu Ren; Martin K. Angele; Nikolaus Börner; Keda Yu; Zufeng Guo; Guobing Yin; Haojun Luo Cancer Res (2025) 85 (8): 1354–1367. Cancer Biology（癌症生物学） 4 SMAD4 and KRAS Status Shapes Cancer Cell–Stromal Cross-Talk and Therapeutic Response in Pancreatic Cancer SMAD4和KRAS状态决定胰腺癌中癌细胞-间质相互作用及治疗反应 Eloise G. Lloyd; Muntadher Jihad; Judhell S. Manansala; Wenlong Li; Priscilla S.W. Cheng; Gianluca Mucciolo; Marta Zaccaria; Sara Pinto Teles; Joaquín Araos Henríquez; Sneha Harish; Rebecca Brais; Sally Ashworth; Weike Luo; Paul M. Johnson; Lisa Veghini; Mireia Vallespinos; Vincenzo Corbo; Giulia Biffi Cancer Res (2025) 85 (8): 1368–1389. 5 Lineage Tracing and Single-Cell RNA Sequencing Reveal a Common Transcriptional State in Breast Cancer Tumor–Initiating Cells Characterized by IFN/STAT1 Activity 谱系追踪和单细胞RNA测序揭示乳腺癌肿瘤一种由IFN/STAT1活性表征的起始细胞中的共同转录状态 Eric P. Souto; Ping Gong; John D. Landua; Ramakrishnan Rajaram Srinivasan; Abhinaya Ganesan; Lacey E. Dobrolecki; Stephen C. Purdy; Xingxin Pan; Michael Zeosky; Anna Chung; S. Stephen Yi; Heide L. Ford; Michael T. Lewis Cancer Res (2025) 85 (8): 1390–1409. 6 Replication-Poison Treatment in BRCA1-Deficient Breast Cancer Causes MRE11 Over-Resection That Induces Single-Stranded DNA Accumulation and Mitotic Catastrophe BRCA1缺陷型乳腺癌中的复制毒素治疗导致MRE11过度切除，进而诱发单链DNA积累和有丝分裂灾难 Imene Tabet; Esin Orhan; Ermes Candiello; Lise Fenou; Carolina Velázquez; Beatrice Orsetti; Geneviève Rodier; William Jacot; Cyril Ribeyre; Claude Sardet; Charles Theillet Cancer Res (2025) 85 (8): 1410–1423. Cancer Immunology（癌症免疫学） 7 Single-Cell Analyses Reveal a Functionally Heterogeneous Exhausted CD8+ T-cell Subpopulation That Is Correlated with Response to Checkpoint Therapy in Melanoma 单细胞分析揭示了功能异质性的耗竭型CD8+ T细胞亚群，该亚群与黑色素瘤对检查点疗法的反应相关 Kelly M. Mahuron; Osmaan Shahid; Prachi Sao; Clinton Wu; Alexandra M. Haugh; Laura A. Huppert; Lauren S. Levine; Margaret M. Lowe; Michael Alvarado; Markee Micu; Katy K. Tsai; Melissa Chow; Meromit Singer; Jason M. Schenkel; Arlene H. Sharpe; Michael D. Rosenblum; Kristen E. Pauken; Adil I. Daud Cancer Res (2025) 85 (8): 1424–1440. 8 An Immune Subtype Classification System Enables the Development of Strategies to Predict and Enhance Immunotherapy Responses in Colorectal Cancer 免疫亚型分类系统助力制定策略，以预测并增强结直肠癌对免疫疗法的反应 Dingchang Li; Xianqiang Liu; Wenxing Gao; Wen Zhao; Shuaifei Ji; Sizhe Wang; Jinran Yang; Dingling Li; Zhengyao Chang; Yi Chen; Xu Sun; Jingcheng Zhou; Yanan Jiao; Xiaohui Du; Guanglong Dong Cancer Res (2025) 85 (8): 1441–1458. 9 Ribosomal RNA Biosynthesis Functionally Programs Tumor-Associated Macrophages to Support Breast Cancer Progression 核糖体RNA生物合成在功能上调控肿瘤相关巨噬细胞以支持乳腺癌进展 Brandon J. Metge; Li’an Williams; Courtney A. Swain; Dominique C. Hinshaw; Amr R. Elhamamsy; Dongquan Chen; Rajeev S. Samant; Lalita A. Shevde Cancer Res (2025) 85 (8): 1459–1478. Cancer Metabolism and Molecular Mechanisms（癌症代谢与分子机制） 10 Concurrent Inhibition of the RAS-MAPK Pathway and PIKfyve Is a Therapeutic Strategy for Pancreatic Cancer 同时抑制RAS-MAPK通路和PIKfyve是胰腺癌的一种治疗策略 Jonathan M. DeLiberty; Mallory K. Roach; Clint A. Stalnecker; Ryan Robb; Elyse G. Schechter; Noah L. Pieper; Khalilah E. Taylor; Lily M. Pita; Runying Yang; Scott Bang; Kristina Drizyte-Miller; Sarah E. Ackermann; Sheila R. Nicewarner Peña; Elisa Baldelli; Sophia M. Min; David H. Drewry; Emanuel F. Petricoin, III; John P. Morris, IV; Channing J. Der; Adrienne D. Cox; Kirsten L. Bryant Cancer Res (2025) 85 (8): 1479–1495. 11 JMJD6 Rewires ATF4-Dependent Glutathione Metabolism to Confer Ferroptosis Resistance in SPOP-Mutated Prostate Cancer JMJD6重编码ATF4依赖性谷胱甘肽代谢，赋予SPOP突变型前列腺癌铁死亡抗性 Chuanjie Zhang; Jiawei Ding; Kiat Shenq Lim; Wenjie Zhou; Wenyu Miao; Siqi Wu; Hanqing Liu; Da Huang; Chufeng Chen; Hongchao He; Jun Xiao; Dan-feng Xu; Yan Shen; Hai Huang; Yi Gao Cancer Res (2025) 85 (8): 1496–1513. Translational Cancer Biology（癌症转化生物学） 12 The Brain-Penetrant Pan-ErbB Inhibitor Poziotinib Effectively Targets HER2+ Breast Cancer Brain Metastases 脑穿透性泛ErbB抑制剂波齐替尼可有效靶向HER2+乳腺癌脑转移 Danyyl Ippolitov; Yi-Han Lin; Jeremy Spence; Aleksandra Glogowska; Thatchawan Thanasupawat; Jason Beiko; Marc R. Del Bigio; Xin Xu; Amy Q. Wang; Darian Williams; Raul Calvo; Abhijeet Kapoor; Juan J. Marugan; Mark J. Henderson; Thomas Klonisch; Sabine Hombach-Klonisch Cancer Res (2025) 85 (8): 1514–1529. Computational Cancer Biology and Technology（癌症计算生物学与技术） 13 Characterization of an Enhancer RNA Signature Reveals Treatment Strategies for Improving Immunotherapy Efficacy in Cancer 增强子RNA特征分析揭示癌症免疫疗法增效治疗策略 Chenyang Zhang; Yan-Yan Chen; Shuyu Chen; Yunzhe Wang; Yifan Yuan; Xiwen Yang; Wei Hu; Bo Chen; Zengxin Qi; Jason T. Huse; Yun Liu; Bo Wen; Xiuping Liu; Leng Han; Yuxiang Wang; Zhao Zhang Cancer Res (2025) 85 (8): 1530–1543. Convergence Science（融合医学） 14 Interactions between Ploidy and Resource Availability Shape Clonal Evolution in Glioblastoma 倍性与资源可用性之间的相互作用塑造了胶质母细胞瘤中的克隆进化 Zuzanna Nowicka; Frederika Rentzeperis; Vural Tagal; Jamie K. Teer; Didem Ilter; Richard J. Beck; Jackson P. Cole; Ana Forero Pinto; Joanne D. Tejero; Elisa Scanu; Thomas Veith; William Dominguez-Viqueira; Konstantin Maksin; Francisco Carrillo-Perez; Olivier Gevaert; Xiaonan Xu; Florian A. Karreth; Mahmoud A. Abdalah; Giada Fiandaca; Stefano Pasetto; Sandhya Prabhakaran; Andrew Schultz; Awino Maureiq E. Ojwang’; Jill S. Barnholtz-Sloan; Joaquim M. Farinhas; Ana P. Gomes; Parag Katira; Noemi Andor Cancer Res (2025) 85 (8): 1544–1559. Cancer Res[Jour] AND 85[volume] AND 8_Supplement_1[issue] 癌症研究 85卷 8期增刊1期 https://aacrjournals.org/cancerres/issue/85/8_Supplement_1 Proceedings: AACR Annual Meeting 2025; April 25-30, 2025; Chicago, Illinois; Part 1 (Regular Abstracts) 会议录：美国癌症研究协会（AACR）2025年年会；2025年4月25日至30日；伊利诺伊州芝加哥市；第一部分（常规摘要） AACR PROJECT GENIE 美国癌症研究协会（AACR）基因组项目 BIOINFORMATICS, COMPUTATIONAL BIOLOGY, SYSTEMS BIOLOGY, AND CONVERGENT SCIENCE 生物信息学、计算生物学、系统生物学及融合医学 CHEMISTRY 化学 CLINICAL RESEARCH 临床研究 ENDOCRINOLOGY 内分泌学 EXPERIMENTAL AND MOLECULAR THERAPEUTICS 实验与分子治疗学 IMMUNOLOGY 免疫学 MOLECULAR / CELLULAR BIOLOGY AND GENETICS 分子/细胞生物学与遗传学 MULTIDISCIPLINARY 多学科 POPULATION SCIENCES 公共医学 PREVENTION, EARLY DETECTION, AND INTERCEPTION 预防、早期检测与干预 REGULATORY SCIENCE AND POLICY 监管医学与政策 SCIENCE AND HEALTH POLICY 科学与健康政策 TUMOR BIOLOGY 肿瘤生物学 Cancer Res[Jour] AND 85[volume] AND 8_Supplement_2[issue] 癌症研究 85卷8期增刊2期 https://aacrjournals.org/cancerres/issue/85/8_Supplement_2 Proceedings: AACR Annual Meeting 2025; April 25-30, 2025; Chicago, Illinois; Part 2 (Late-Breaking, Clinical Trial, and Invited Abstracts) 会议录：美国癌症研究协会（AACR）2025年年会；2025年4月25日 - 30日；美国伊利诺伊州芝加哥；第二部分（最新突破、临床试验及特邀摘要专场） BIOINFORMATICS / COMPUTATIONAL BIOLOGY / SYSTEMS BIOLOGY / CONVERGENT SCIENCE 生物信息学/计算生物学/系统生物学/融合科学 CHEMISTRY, DRUG DEVELOPMENT 化学、药物研发 CLINICAL RESEARCH 临床研究 CLINICAL TRIALS 临床试验 DRUG DEVELOPMENT 药物研发 EXPERIMENTAL AND MOLECULAR THERAPEUTICS 实验与分子治疗学 EXPERIMENTAL AND MOLECULAR THERAPEUTICS, CHEMISTRY 实验与分子治疗学、化学 IMMUNOLOGY 免疫学 MOLECULAR/CELLULAR BIOLOGY AND GENETICS 分子/细胞生物学与遗传学 MULTIDISCIPLINARY 多学科交叉 POPULATION SCIENCES 公共医学 PREVENTION / EARLY DETECTION / INTERCEPTION 预防/早期检测/干预 SCIENCE AND HEALTH POLICY 科学与健康政策 SURVIVORSHIP 肿瘤生存者关怀 TUMOR BIOLOGY 肿瘤生物学 Cancer Res[Jour] AND 85[volume] AND 9[issue] 癌症研究 85卷 9期 https://aacrjournals.org/cancerres/issue/ Obituary（讣告） 1 Nathan Berger, MD: In Memoriam (1941–2024) 内森·伯格医学博士：悼念（1941–2024） Kathryn H. Schmitz; Linda Nebeling Cancer Res (2025) 85 (9): 1567. In the Spotlight（焦点） 2 Launching SMART 3D Cancer Models 推出SMART 3D癌症模型 Sam Ernst; Olivier De Wever Cancer Res (2025) 85 (9): 1568–1570. 3 The Biology in the Pattern: Metastatic Organotropism and Clinical Outcome Depend on DNA Damage Response and Immune Interactions in Pancreatic Cancer 模式中的生物学：胰腺癌的转移性器官趋向性和临床预后取决于DNA损伤反应和免疫相互作用 Aristeidis Papargyriou; Maximilian Reichert Cancer Res (2025) 85 (9): 1571–1573. 4 In the Right Place and the Right State: Spatial Cross-Talk and Immune State Dictate Leukemia Response to Immunotherapy 位置与状态并重：空间串扰和免疫状态决定白血病对免疫治疗的反应 Giorgio Orofino; Cristina Toffalori; Luca Vago Cancer Res (2025) 85 (9): 1574–1576. Resource Report（资源报告） 5 A 3D Self-Assembly Platform Integrating Decellularized Matrix Recapitulates In Vivo Tumor Phenotypes and Heterogeneity 整合脱细胞基质的3D自组装平台可重现体内肿瘤表型和异质性 Michael J. Buckenmeyer; Elizabeth A. Brooks; Madison S. Taylor; Ireolu K. Orenuga; Liping Yang; Ronald J. Holewinski; Thomas J. Meyer; Melissa Galloux; Marcial Garmendia-Cedillos; Thomas J. Pohida; Thorkell Andresson; Brad St. Croix; Matthew T. Wolf Cancer Res (2025) 85 (9): 1577–1595. Cancer Biology（癌症生物学） 6 CXCL10 Secreted by Pericytes Mediates TNFα-Induced Vascular Leakage in Tumors and Enhances Extravasation of Nanoparticle-Based Chemotherapeutics 周细胞分泌的CXCL10介导肿瘤坏死因子α（TNFα）诱导的肿瘤血管渗漏并增强基于纳米颗粒的化疗药物的渗出 Ann L.B. Seynhaeve; Hui Liu; Marjolein I. Priester; Mike Valentijn; Conny van Holten-Neelen; Rutger W.W. Brouwer; Mandy van Brakel; Willem A. Dik; Wilfred F.J. van IJcken; Reno Debets; Andrew P. Stubbs; Timo L.M. ten Hagen Cancer Res (2025) 85 (9): 1596–1610. 7 Tumorigenesis Driven by BRAFV600E Requires Secondary Mutations That Overcome Its Feedback Inhibition of RAC1 and Migration 由BRAFV600E驱动的肿瘤发生需要二次突变来克服其对RAC1的反馈抑制和迁移 Sunyana Gadal; Jacob A. Boyer; Simon F. Roy; Noah A. Outmezguine; Malvika Sharma; Hongyan Li; Ning Fan; Eric Chan; Yevgeniy Romin; Afsar Barlas; Qing Chang; Priya Pancholi; Neilawattie Merna Timaul; Michael Overholtzer; Rona Yaeger; Katia Manova-Todorova; Elisa de Stanchina; Marcus W. Bosenberg; Neal Rosen Cancer Res (2025) 85 (9): 1611–1627. 8 The Glycosyltransferase XYLT1 Activates NF-κB Signaling to Promote Metastasis of Early-Stage Lung Adenocarcinoma 糖基转移酶XYLT1激活NF-κB信号通路以促进早期肺腺癌的转移 Jian Han; Jianan Du; Xiangmeng Li; Qingbo Zhou; Jiayu Zeng; Jun-Tao Lin; Wenle Zhou; Jiayi Cai; Yaokai Ye; Bosui Yang; Junsheng Wang; Xiang Zhou; Rong Lian; Yi Yang; Xun Zhu; Hongyu Guan; Liping Liu; Junchao Cai; Jueheng Wu; Yun Li; Mengfeng Li; Han Tian Cancer Res (2025) 85 (9): 1628–1643. Cancer Immunology（癌症免疫学） 9 GLI2 Facilitates Tumor Immune Evasion and Immunotherapeutic Resistance by Coordinating WNT and Prostaglandin Signaling GLI2通过协调WNT和前列腺素信号传导促进肿瘤免疫逃逸和免疫治疗耐药性 Nicholas C. DeVito; Y-Van Nguyen; Michael Sturdivant; Michael P. Plebanek; Kaylee A. Villarreal; Nagendra Yarla; Vaibhav Jain; Michael Aksu; Georgia M. Beasley; Balamayooran Theivanthiran; Brent A. Hanks Cancer Res (2025) 85 (9): 1644–1662. Cancer Metabolism and Molecular Mechanisms（癌症代谢与分子机制） 10 Arginine Deprivation Induces Quiescence and Confers Vulnerability to Ferroptosis in Colorectal Cancer 精氨酸剥夺诱导结直肠癌细胞进入静止期并使其对铁死亡敏感 Yanyun Lin; Yanhong Zhang; Tianze Huang; Junguo Chen; Guanman Li; Bin Zhang; Liang Xu; Kai Wang; Hui He; Hao Chen; Danling Liu; Shuang Guo; Xiaosheng He; Ping Lan Cancer Res (2025) 85 (9): 1663–1679. Translational Cancer Biology（癌症转化生物学） 11 Longitudinal Profiling of Circulating Tumor DNA Reveals the Evolutionary Dynamics of Metastatic Prostate Cancer during Serial Therapy 循环肿瘤DNA纵向分析揭示了转移性前列腺癌在连续治疗过程中的进化动态 Yuehui Zhao; Naveen Ramesh; Ping Xu; Emi Sei; Min Hu; Shanshan Bai; Patricia Troncoso; Ana M. Aparicio; Christopher J. Logothetis; Paul G. Corn; Nicholas E. Navin; Amado J. Zurita Cancer Res (2025) 85 (9): 1680–1695. 12 Integrating Plasma Cell-Free DNA Fragment End Motif and Size with Genomic Features Enables Lung Cancer Detection 将血浆游离DNA片段末端基序和基因组特征相应尺寸相结合可实现肺癌检测 Tae-Rim Lee; Jin Mo Ahn; Junnam Lee; Dasom Kim; Juntae Park; Byeong-Ho Jeong; Dongryul Oh; Sang Man Kim; Gyou-Chul Jung; Beom Hee Choi; Min-Jung Kwon; Mengchi Wang; Michael Salmans; Andrew Carson; Bryan Leatham; Kristin Fathe; Byung In Lee; Byoungsok Jung; Chang-Seok Ki; Young Sik Park; Eun-Hae Cho Cancer Res (2025) 85 (9): 1696–1707. 13 Stabilization of RUNX1 Induced by O-GlcNAcylation Promotes PDGF-BB–Mediated Resistance to CDK4/6 Inhibitors in Breast Cancer O-GlcNAc糖基化诱导的RUNX1稳定性促进乳腺癌中血小板衍生生长因子BB（PDGF-BB）介导的对细胞周期蛋白依赖性激酶4/6（CDK4/6）抑制剂的耐药性 Shuyan Zhou; Yi Zhang; Julie Belmar; Chunyan Hou; Yaqin Zhang; Changmin Peng; Yunxiao Meng; Zhuqing Li; Muhammad Jameel Mughal; Yanjun Gao; Edward Seto; Min Shen; Matthew D. Hall; Junfeng Ma; Cynthia X. Ma; Shunqiang Li; Wenge Zhu Cancer Res (2025) 85 (9): 1708–1724. Cancer Landscapes（癌症特征） 14 Genomic Characterization of High-Grade Serous Ovarian Carcinoma Reveals Distinct Somatic Features in Black Individuals 高级别浆液性卵巢癌的基因组特征揭示了黑人个体中独特的体细胞特征 Katherine A. Lawson-Michod; Jeffrey R. Marks; Lindsay J. Collin; David A. Nix; Natalie R. Davidson; Chad D. Huff; Yao Yu; Aaron Atkinson; Courtney E. Johnson; Lucas A. Salas; Lauren C. Peres; Casey S. Greene; Joellen M. Schildkraut; Jennifer A. Doherty Cancer Res (2025) 85 (9): 1725–1737. Corrections（更正） 15 Correction: Alternative Lengthening of Telomeres in Cancer Confers a Vulnerability to Reactivation of p53 Function 更正：癌症中的端粒替代性延长赋予p53功能重新激活的弱点 Shawn J. Macha; Balakrishna Koneru; Trevor A. Burrow; Charles Zhu; Dzmitry Savitski; Rakshandra L. Rahman; Catherine A. Ronaghan; Jonas Nance; Kristyn McCoy; Cody Eslinger; C. Patrick Reynolds Cancer Res (2025) 85 (9): 1738. 16 Correction: SCFFBXW7/GSK3β-Mediated GFI1 Degradation Suppresses Proliferation of Gastric Cancer Cells 更正：SCFFBXW7/GSK3β介导的GFI1降解抑制胃癌细胞的增殖 Xiaoling Kuai; Long Li; Ran Chen; Kangjunjie Wang; Min Chen; Binghau Cui; Yuxue Zhang; Junqiang Li; Hongwen Zhu; Hu Zhou; Jianfei Huang; Jun Qin; Zhiwei Wang; Wenyi Wei; Daming Gao Cancer Res (2025) 85 (9): 1739. Cancer Res[Jour] AND 85[volume] AND 10[issue] 癌症研究 85卷 10期 https://aacrjournals.org/cancerres/issue/ In the Spotlight（焦点） 1 Combining STING Agonists with PARP Inhibitors Mounts an NK-Dependent Defense against Therapy-Resistant Breast Cancer STING激动剂与PARP抑制剂联合使用可启动自然杀伤（NK）细胞依赖性防御机制对抗耐药性乳腺癌 Zahra Gohari; Lora Stojanovic; Feyruz V. Rassool Cancer Res (2025) 85 (10): 1747–1749. 2 From Fat Providers to Cancer Therapy: Adipocytes as Unexpected Allies 从脂肪“供应者”到癌症治疗：脂肪细胞成为意想不到的“盟友” Camille Attané; Catherine Muller Cancer Res (2025) 85 (10): 1750–1752. 3 “Dr. Jekyll and Mr. Hyde”: AT2 Cells in Lung Regeneration and Tumor Development “杰基尔博士与海德先生”：肺再生与肿瘤进展中的AT2细胞 Xinyuan Tong; Gen Lin; Hongbin Ji Cancer Res (2025) 85 (10): 1753–1754. Review（综述） 4 A Critical Appraisal of the Utility of Targeting Therapy-Induced Senescence for Cancer Treatment 靶向治疗诱导的细胞衰老在癌症治疗中的效用评估 Tareq Saleh; Edward F. Greenberg; Anthony C. Faber; Hisashi Harada; David A. Gewirtz Cancer Res (2025) 85 (10): 1755–1768. Resource Report（资源报告） 5 The Lung Cancer Autochthonous Model Gene Expression Database Enables Cross-Study Comparisons of the Transcriptomic Landscapes Across Mouse Models 肺癌原位模型基因表达数据库支持跨小鼠模型转录组图谱的跨研究比较 Ling Cai; Fangjiang Wu; Qinbo Zhou; Ying Gao; Bo Yao; Ralph J. DeBerardinis; George K. Acquaah-Mensah; Vassilis Aidinis; Jennifer E. Beane; Shyam Biswal; Ting Chen; Carla P. Concepcion-Crisol; Barbara M. Grüner; Deshui Jia; Robert A. Jones; Jonathan M. Kurie; Min Gyu Lee; Per Lindahl; Yonathan Lissanu; Corina Lorz; David MacPherson; Rosanna Martinelli; Pawel K. Mazur; Sarah A. Mazzilli; Shinji Mii; Herwig P. Moll; Roger A. Moorehead; Edward E. Morrisey; Sheng Rong Ng; Matthew G. Oser; Arun R. Pandiri; Charles A. Powell; Giorgio Ramadori; Mirentxu Santos; Eric L. Snyder; Rocio Sotillo; Kang-Yi Su; Tetsuro Taki; Kekoa Taparra; Phuoc T. Tran; Yifeng Xia; J. Edward van Veen; Monte M. Winslow; Guanghua Xiao; Charles M. Rudin; Trudy G. Oliver; Yang Xie; John D. Minna Cancer Res (2025) 85 (10): 1769–1783. Cancer Biology（癌症生物学） 6 Palmitic Acid Accumulation Activates Fibroblasts and Promotes Matrix Stiffness in Colorectal Cancer 棕榈酸积累激活成纤维细胞并促进结直肠癌中的基质硬度 Shenghe Deng; Jun Wang; Falong Zou; Denglong Cheng; Mian Chen; Junnan Gu; Jianguo Shi; Jia Yang; Yifan Xue; Zhenxin Jiang; Le Qin; Fuwei Mao; Xiaona Chang; Xiu Nie; Li Liu; Yinghao Cao; Kailin Cai Cancer Res (2025) 85 (10): 1784–1802. 7 SMARCA4 Inhibits Breast Cancer Progression and Metastasis through RHOA Suppression SMARCA4通过抑制RHOA来抑制乳腺癌的进展和转移 Zheng Sun; Zhuo Li; Yong Wei; Lillian Xu; Xiang Hang; Yibin Kang Cancer Res (2025) 85 (10): 1803–1818. 8 Intratumoral Fusobacterium nucleatum Recruits Tumor-Associated Neutrophils to Promote Gastric Cancer Progression and Immune Evasion 瘤内核梭杆菌募集肿瘤相关中性粒细胞以促进胃癌进展和免疫逃逸 Tianhao Zhang; Ying Li; Ertao Zhai; Risheng Zhao; Yan Qian; Zhixin Huang; Yinan Liu; Zeyu Zhao; Xiang Xu; Jianqiu Liu; Zikang Li; Zhi Liang; Ran Wei; Linying Ye; Jinping Ma; Qingping Wu; Jianhui Chen; Shirong Cai Cancer Res (2025) 85 (10): 1819–1841. Cancer Immunology（癌症免疫学） 9 Macrophage-Derived Itaconate Suppresses Dendritic Cell Function to Promote Acquired Resistance to Anti–PD-1 Immunotherapy 巨噬细胞来源的衣康酸抑制树突状细胞功能，促进抗程序性死亡受体1（PD-1）免疫治疗的获得性耐药 Xiao Yang; Yue Deng; Ying Ye; Jingshu Meng; Mengyao Su; Wenwen Wei; You Qin; Haibo Zhang; Yu Tian; Suke Deng; Zhiyun Liao; Zhiyuan Zhou; Jie Li; Yan Hu; Bin Zhang; Yajie Sun; Lu Wen; Zhanjie Zhang; Fang Huang; Chao Wan; Kunyu Yang Cancer Res (2025) 85 (10): 1842–1856. Cancer Metabolism and Molecular Mechanisms（癌症代谢与分子机制） 10 De Novo Serine Synthesis Is a Metabolic Vulnerability That Can Be Exploited to Overcome Sunitinib Resistance in Advanced Renal Cell Carcinoma 从头合成丝氨酸是一种代谢弱点，可被利用来克服晚期肾细胞癌中的舒尼替尼耐药性 Manon Teisseire; Umakant Sahu; Julien Parola; Meng-Chen Tsai; Valérie Vial; Jérôme Durivault; Renaud Grépin; Yann Cormerais; Clément Molina; Arthur Gouraud; Gilles Pagès; Issam Ben-Sahra; Sandy Giuliano Cancer Res (2025) 85 (10): 1857–1873. Therapeutic Development and Chemical Biology（治疗进展与生物化学） 11 Engineered SH3-Derived Sherpabodies Function as a Modular Platform for Targeted T-cell Immunotherapy 人工改造的基于SH3结构域的Sherpabody可作为靶向T细胞免疫治疗的模块化平台 Rogelio A. Hernández-López; Tapio Kesti; Anna R. Mäkelä; Zhe Zhao; Wei Yu; Yurie Tonai; Hector J. Monzo; Kerttu Kalander; Sirpa Leppä; Päivi M. Ojala; Wendell A. Lim; Kalle Saksela Cancer Res (2025) 85 (10): 1874–1887. Translational Cancer Biology（癌症转化生物学） 12 Harnessing STING Signaling and Natural Killer Cells Overcomes PARP Inhibitor Resistance in Homologous Recombination–Deficient Breast Cancer 利用干扰素基因刺激因子（STING）信号传导和自然杀伤（NK）细胞克服同源重组缺陷型乳腺癌中的聚腺苷二磷酸核糖聚合酶（PARP）抑制剂耐药性 Flaminia Pedretti; Mohmed Abdalfttah; Benedetta Pellegrino; Francesca Mateo; Paula Martínez-Sanz; Andrea Herencia-Ropero; Andreu Òdena; Pau Clavell-Revelles; Giorgia Casali; Heura Domènech; Laia Monserrat; Dražen Papić; Alba Mas Malavila; Anna Pascual-Reguant; Herena Eixarch; Marta Guzmán; Olga Rodríguez; Judit Grueso; Sara Simonetti; Roberta Fasani; Paolo Nuciforo; Carmen Espejo; Stefan Florian; Miguel Ángel Pujana; Lara Nonell; Joan Seoane; Viia Valge-Archer; Mark J. O’Connor; Juan C. Nieto; Holger Heyn; Judith Balmaña; Alba Llop-Guevara; Violeta Serra Cancer Res (2025) 85 (10): 1888–1908. 13 FADD Functions as an Oncogene in Chr11q13.3-Amplified Head and Neck Squamous Cell Carcinoma FADD在Chr11q13.3扩增的头颈部鳞状细胞癌中发挥癌基因作用 Yang Zheng; Yinan Chen; Xiaoyan Meng; Li Zhang; Yanni Ma; Rong Zhou; Shuiting Fu; Heng Chen; Xinyang Xuanyuan; Ruixin Jiang; Pengcong Hou; Xiaomeng Song; Yanqiu Wang; Jingjing Sun; Wuchang Zhang; Jiang Li; Zhonglong Liu; Zhiyuan Zhang; Hanlin Zeng; Yue He Cancer Res (2025) 85 (10): 1909–1927. Cancer Landscapes（癌症特征） 14 Colorectal Tumors in Diverse Patient Populations Feature a Spectrum of Somatic Mutational Profiles 不同患者群体中的结直肠肿瘤具有不同的体细胞突变谱特征 Marco Matejcic; Jamie K. Teer; Hannah J. Hoehn; Diana B. Diaz; Kritika Shankar; Jun Gong; Nathalie T. Nguyen; Nicole C. Loroña; Domenico Coppola; Clifton G. Fulmer; Ozlen Saglam; Kun Jiang; W. Douglas Cress; Teresita Muñoz-Antonia; Idhaliz Flores; Edna R. Gordián; José A. Oliveras Torres; Seth I. Felder; Julian Sanchez; Jason B. Fleming; Erin M. Siegel; Jennifer A. Freedman; Julie Dutil; Mariana C. Stern; Brooke L. Fridley; Jane C. Figueiredo; Stephanie L. Schmit Cancer Res (2025) 85 (10): 1928–1944. Editor’s Note（编者注） 15 Editor’s Note: A Novel Role for Carcinoembryonic Antigen-Related Cell Adhesion Molecule 6 as a Determinant of Gemcitabine Chemoresistance in Pancreatic Adenocarcinoma Cells Free 编者注：癌胚抗原相关细胞黏附分子6在胰腺腺癌细胞吉西他滨化疗耐药性中的新作用 Mark S. Duxbury; Hiromichi Ito; Eric Benoit; Talat Waseem; Stanley W. Ashley; Edward E. Whang Cancer Res (2025) 85 (10): 1945. Retractions（撤稿声明） 16 Retraction: HMGA1 Is a Determinant of Cellular Invasiveness and In vivo Metastatic Potential in Pancreatic Adenocarcinoma Free 撤稿声明：高迁移率族蛋白A1（HMGA1）是胰腺腺癌细胞侵袭性和体内转移潜能的决定因素 Siong-Seng Liau; Amarsanaa Jazag; Edward E. Whang Cancer Res (2025) 85 (10): 1946. 17 Retraction: Prostaglandin E2 Enhances Pancreatic Cancer Invasiveness through an Ets-1-Dependent Induction of Matrix Metalloproteinase-2 Free 撤稿声明：前列腺素E2通过Ets-1依赖性诱导基质金属蛋白酶-2来增强胰腺癌的侵袭性 Hiromichi Ito; Mark Duxbury; Eric Benoit; Thomas E. Clancy; Michael J. Zinner; Stanley W. Ashley; Edward E. Whang Cancer Res (2025) 85 (10): 1947. Cancer Res[Jour] AND 85[volume] AND 11[issue] 癌症研究85卷 11期 https://aacrjournals.org/cancerres/issue/ In the Spotlight（焦点） 1 Targeted Degradation of Mutant p53 Reverses the Pro-oncogenic Dominant-Negative Effect 靶向降解突变型p53可逆转其促癌的显性负效应 Jovanka Gencel-Augusto; Guillermina Lozano Cancer Res (2025) 85 (11): 1955–1956 2 PROX1: A Key Regulator of Hepatocyte Identity and Tumorigenesis PROX1：肝细胞特性及肿瘤发生的关键调控因子 Terence Kin Wah Lee; Stephanie Ma Cancer Res (2025) 85 (11): 1957–1959 Cancer Biology(癌症生物学) 3 FGFR2 Abrogation Intercepts Pancreatic Ductal Adenocarcinoma Development FGFR2缺失可阻断胰腺导管腺癌的进展 Claudia Tonelli; Astrid Deschênes; Victoria A. Gaeth; Amanda Jensen; Nandan Vithlani; Melissa A. Yao; Zhen Zhao; Youngkyu Park; David A. Tuveson Cancer Res (2025) 85 (11): 1960–1977 4 The Prolonged Half-Life of the p53 Missense Variant R248Q Promotes Accumulation and Heterotetramer Formation with Wild-Type p53 to Exert the Dominant-Negative Effect p53错义变异体R248Q的半衰期延长促进其与野生型p53的累积及异源四聚体形成，从而发挥显性负效应 Nancy Klemm; Roman R. Schimmer; Nils K. Konrad; Flavian Thelen; Jonas Fullin; Ebru Topçu; Christian Koch; Milena Treacy; Matthew Joseph Leventhal; Marco M. Bühler; Veronika Lysenko; Alexandre P.A. Theocharides; Kari J. Kurppa; Stefan Balabanov; Tuncay Baubec; Andrei V. Krivtsov; Peter G. Miller; Scott A. Armstrong; Benjamin L. Ebert; Markus G. Manz; Cesar Nombela-Arrieta; Steffen Boettcher Cancer Res (2025) 85 (11): 1978–1996 Cancer Immunology(癌症免疫学) 5 Mutation of SMARCA4 Induces Cancer Cell–Intrinsic Defects in the Enhancer Landscape and Resistance to Immunotherapy SMARCA4突变诱导癌细胞增强子特征内在缺陷及对免疫治疗的抵抗 Yawen Wang; Ismail M. Meraz; Md Qudratullah; Sasikumar Kotagiri; Yanyan Han; Yuanxin Xi; Jing Wang; Kadir C. Akdemir; Jack A. Roth; Yonathan Lissanu Cancer Res (2025) 85 (11): 1997–2013 6 Blocking the TCA Cycle in Cancer Cells Potentiates CD36+ T-cell–Mediated Antitumor Immunity by Suppressing ER Stress–Associated THBS2 Signaling 阻断癌细胞中的三羧酸循环通过抑制内质网应激相关的THBS2信号传导，增强CD36+ T细胞介导的抗肿瘤免疫 Jianqiang Yang; Fanghui Chen; Zhenzhen Fu; Fan Yang; Nabil F. Saba; Yong Teng Cancer Res (2025) 85 (11): 2014–2026 Cancer Metabolism and Molecular Mechanisms(癌症代谢和分子机制) 7 SMYD3 Activates Fatty Acid β-Oxidation to Promote Self-Renewal of Leukemia Stem Cells SMYD3激活脂肪酸β-氧化以促进白血病干细胞自我更新 Min Zhou; Zihao Wu; Fen Wei; Chen Duan; Xiaoying Lin; Waiyi Zou; Chang Liu; Jingxuan Pan; Yanli Jin Cancer Res (2025) 85 (11): 2027–2045 8 CRTC2 Forms Co-Condensates with YTHDF2 That Enhance Translational Efficiency of m6A-Modified mRNAs to Drive Hepatocarcinogenesis and Lenvatinib Resistance CRTC2与YTHDF2形成共凝集物，增强m6A修饰mRNA的转化效率，驱动肝细胞癌发生及乐伐替尼耐药 Meixi Wang; Fangdi Zou; Shengxin Wang; Yichen Yang; Cong Xia; Lu Chen; Ben Liu; Lian Li; Mulin Jun Li; Haixin Li; Weijie Song; Ruifang Niu; Zhiyong Yuan; Jie Yang; Xiangchun Li; Kexin Chen; Zhiqiang Wu; Zeyun Mi Cancer Res (2025) 85 (11): 2046–2066 Therapeutic Development and Chemical Biology(治疗进展与化学生物学) 9 An Anti-EGFR Antibody–Drug Radioconjugate Labeled with Actinium-225 Elicits Durable Antitumor Responses in KRAS- and BRAF-Mutant Colorectal Cancer 用锕-225标记的抗EGFR抗体-药物放射性偶联物在KRAS和BRAF突变型结直肠癌中诱导持久的抗肿瘤反应 Anjong Florence Tikum; Nikita W. Henning; Jessica Pougoue Ketchemen; Alireza Doroudi; Hanan Babeker; Fabrice Ngoh Njotu; Emmanuel Nwangele; Alissar Monzer; Bridget Gray; Emina Torlakovic; Maruti Uppalapati; Humphrey Fonge Cancer Res (2025) 85 (11): 2067–2080 Translational Cancer Biology(转化癌症生物学) 10 Perivascular Niche–Resident Alveolar Macrophages Promote Interstitial Pneumonitis Related to Trastuzumab Deruxtecan Treatment 血管周围间隙中的驻留肺泡巨噬细胞促进与德曲妥珠单抗治疗相关的间质性肺炎 Qing Wei; Teng Yang; Ziwen Zhang; Fei Wang; Yuxuan Yang; Jiayu Zhu; Xiu Zhu; Yuanzheng Li; Yun Xing; Ye Lu; Xuefei Tian; Mengyang Fan; Yuchao Zhang; Xiru Xue; Meng Li; Chuanfei Yu; Lan Wang; Takaya Shimura; Jianmin Fang; Zhiwei Cao; Jieer Ying; Peng Guo; Xiangdong Cheng Cancer Res (2025) 85 (11): 2081–2099 11 Targeting the SP/KLF Transcriptional Regulatory Network Synergizes with HDAC Inhibition to Impede Progression of H3K27M Diffuse Intrinsic Pontine Glioma 靶向SP/KLF转录调控网络与HDAC抑制协同作用，阻碍H3K27M弥漫性内生型桥脑胶质瘤的进展 Yu Kong; Fan Wang; Renwei Jing; Qian Zhao; Xuejiao Lv; Yingying Zhao; Ye Yuan; Xianyou Xia; Yu Sun; Yujie Tong; Han Yan; Qian Li; Ting Li; Lei Cao; Deng Liu; Dawei Huo; Shao-Kai Sun; Francisco Morís; Yujie Tang; Xudong Wu Cancer Res (2025) 85 (11): 2100–2116 12 Combining Apatinib and Oxaliplatin Remodels the Immunosuppressive Tumor Microenvironment and Sensitizes Desert-Type Gastric Cancer to Immunotherapy 阿帕替尼联合奥沙利铂重塑免疫抑制性肿瘤微环境，增强沙漠型胃癌对免疫治疗的敏感性 Guang-Tan Lin; Cheng Yan; Lu-Jie Li; Xiao-Wen Qiu; Yu-Xuan Zhao; Ju-Li Lin; Yu-Jing Chen; Chuan Feng; Shao-Qiong Chen; Jian-Wei Xie; Chao-Hui Zheng; Sachiyo Nomura; Chang-Ming Huang; Ping Li; Long-Long Cao Cancer Res (2025) 85 (11): 2117–2133 Editor’s Notes(编者按) 13 Editor’s Note: Normoxic Stabilization of Hypoxia-Inducible Factor-1α by Modulation of the Labile Iron Pool in Differentiating U937 Macrophages: Effect of Natural Resistance-Associated Macrophage Protein 1 编者按：通过调节分化中的U937巨噬细胞内不稳定铁池来稳定常氧条件下的缺氧诱导因子-1α：天然抗性相关巨噬细胞蛋白1的作用 Helen J. Knowles; David R. Mole; Peter J. Ratcliffe; Adrian L. Harris Cancer Res (2025) 85 (11): 2134 14 Editor’s Note: Effects of Transferrin Receptor Blockade on Cancer Cell Proliferation and Hypoxia-Inducible Factor Function and Their Differential Regulation by Ascorbate 编者按：转铁蛋白受体阻断对癌细胞增殖及缺氧诱导因子功能的影响及其受抗坏血酸的不同调控 Dylan T. Jones; Ian S. Trowbridge; Adrian L. Harris Cancer Res (2025) 85 (11): 2135 Cancer Res[Jour] AND 85[volume] AND 12[issue] 癌症研究 85卷 12期 https://aacrjournals.org/cancerres/issue/ In the Spotlight（焦点） 1 Incorporating Centrally Tolerized Mice as a Design Principle to Circumvent Reporter Immunogenicity in Cancer Research Models 将中央耐受小鼠作为设计原则以规避癌症研究模型中报告基因的免疫原性 Candice A. Grzelak; Cyrus M. Ghajar Cancer Res (2025) 85 (12): 2143–2145. 2 To EMT or Not to EMT: Ablation of Mesenchymal Tumor Cell Lineages Reveals the Essential Role of EMT in Pancreatic Cancer Initiation and Evolution 上皮-间质转化（EMT）之惑：间质肿瘤细胞谱系消融揭示EMT在胰腺癌起始和演变中的关键作用 Jessica Peura; Calvin Johnson; Jason R. Pitarresi Cancer Res (2025) 85 (12): 2146–2148. 3 Hotspots of Escape: Oxidative Niches Prime Tumor Cell Dissemination 逃逸热点：氧化微环境促使肿瘤细胞扩散 Mario Palma; Marie Sabatier; Jessalyn M. Ubellacker Cancer Res (2025) 85 (12): 2149–2151. Review（综述） 4 Transforming Cancer Therapy: Unlocking the Potential of Targeting Vascular and Stromal Cells in the Tumor Microenvironment 癌症治疗变革：解锁靶向肿瘤微环境中血管和基质细胞的潜力 Lu Liu; Yuheng Zhang; Hanyu Liu; Jian Yang; Qi Tian; Nareekarn Chueakula; Saravana Ramasamy; Navin Kumar Verma; Christine Cheung; Anjali P. Kusumbe Cancer Res (2025) 85 (12): 2152–2164. Cancer Biology（癌症生物学） 5 Immunological Tolerance to Luciferase and Fluorescent Proteins Using Tol Mice Enables Development of Improved Tumor Models for Investigating Immunity and Metastasis 利用Tol小鼠对荧光素酶和荧光蛋白产生免疫耐受，助力开发用于研究免疫和转移的改进型肿瘤模型 Kabir A. Khan; Areeba A. Qureshi; Ping Xu; Hung-Yang Kuo; Ton N. Schumacher; Iacovos P. Michael; Robert S. Kerbel Cancer Res (2025) 85 (12): 2165–2178. 6 Targeting the Dependence on PIK3C3-mTORC1 Signaling in Dormancy-Prone Breast Cancer Cells Blunts Metastasis Initiation 靶向休眠倾向乳腺癌细胞对PIK3C3-mTORC1信号通路的依赖性，抑制转移起始 Islam E. Elkholi; Amélie Robert; Camille Malouf; Joshua L. Wu; Hellen Kuasne; Stanislav Drapela; Graham Macleod; Steven Hébert; Alain Pacis; Virginie Calderon; Claudia L. Kleinman; Ana P. Gomes; James V. Alvarez; Julio A. Aguirre-Ghiso; Morag Park; Stéphane Angers; Jean-François Côté Cancer Res (2025) 85 (12): 2179–2198. 7 Cancer-Associated Fibroblasts Foster a High-Lactate Microenvironment to Drive Perineural Invasion in Pancreatic Cancer 癌症相关成纤维细胞营造高乳酸微环境，推动胰腺癌神经周围浸润 Tingting Li; Chonghui Hu; Tianhao Huang; Yu Zhou; Qing Tian; Huimou Chen; Rihua He; Yuan Yuan; Yong Jiang; Honghui Jiang; Kaijun Huang; Di Cheng; Rufu Chen; Shangyou Zheng Cancer Res (2025) 85 (12): 2199–2217. Cancer Immunology（癌症免疫学） 8 Age-Associated Modulation of TREM1/2-Expressing Macrophages Promotes Melanoma Progression and Metastasis 年龄相关调节表达TREM1/2的巨噬细胞，促进黑色素瘤进展和转移 Marzia Scortegagna; Rabi Murad; Parinaz Bina; Yongmei Feng; Rebecca A. Porritt; Alexey V. Terskikh; Xiao Tian; Peter D. Adams; Kristiina Vuori; Ze’ev A. Ronai Cancer Res (2025) 85 (12): 2218–2233. 9 Targeting PRC2 Enhances the Cytotoxic Capacity of Anti-CD19 CAR T Cells against Hematologic Malignancies 靶向PRC2可增强抗CD19嵌合抗原受体（CAR）T细胞对血液系统恶性肿瘤的细胞毒能力 Maria Leticia Rodrigues Carvalho; Clara de Oliveira Andrade; Mariela Pires Cabral-Piccin; Gabriela Sarti Kinker; Glauco Akelinghton Freire Vitiello; Raylane Adrielle Gonçalves Cambuí; Luiza de Macedo Abdo; Eduardo Mannarino Correia; Bruno Dalbelo da Silva Elias; Emmanuel Vinicius Oliveira Araujo; Alexandre Silva Chaves; Pedro Henrique Barbosa Pereira; Karina Lobo Hajdu; Amanda Rondinelli; Arianne Fagotti Gusmão; Maria Luisa Marques Pierre; Igor Brasil-Costa; Caroline Pouza Zanella; Marta Maria Moreira Lemos; Marjorie Vieira Batista; Jayr Schmidt Filho; Cheryl Arrowsmith; Vladmir Cláudio Cordeiro de Lima; Martin Hernán Bonamino; Tiago da Silva Medina Cancer Res (2025) 85 (12): 2234–2249. 10 SLC3A2-Mediated Lysine Uptake by Cancer Cells Restricts T-cell Activity in Hepatocellular Carcinoma 癌细胞通过SLC3A2介导的赖氨酸摄取限制肝细胞癌中的T细胞活性 Yating Chang; Naizhen Wang; Shaopeng Li; Jiaqi Zhang; Yipeng Rao; Zilong Xu; Lu Li; Hongning Wu; Jun Chen; Yanhua Lin; Xiaoxuan Huang; Pingguo Liu; Jun Zhang; Yueting Liao; Chaolong Lin; Chenghao Huang; Ningshao Xia Cancer Res (2025) 85 (12): 2250–2267. Translational Cancer Biology（癌症转化生物学） 11 Blocking Nitrosylation Induces Immunogenic Cell Death by Sensitizing NRAS-Mutant Melanoma to MEK Inhibitors 阻断亚硝基化通过使NRAS突变型黑色素瘤对MEK抑制剂敏感而诱导免疫原性细胞死亡 Jyoti Srivastava; Vipin K. Yadav; Rachel V. Jimenez; Pravin R. Phadatare; Ninad A. Inamdar; Montana M. Young; Antonella Bacchiocchi; Ruth Halaban; Bin Fang; Alvaro de Mingo Pulido; Kenneth Y. Tsai; Keiran S.M. Smalley; John M. Koomen; Paulo C. Rodriguez; Sanjay Premi Cancer Res (2025) 85 (12): 2268–2287. 12 A Genome-Wide Synthetic Lethal Screen Identifies Spermidine Synthase as a Target to Enhance Erdafitinib Efficacy in FGFR-Mutant Bladder Cancer 全基因组合成致死筛选确定精脒合成酶为增强厄达替尼在FGFR突变型膀胱癌中疗效的靶点 Yanchao Yu; Xincheng Gao; Huayuan Zhao; Jiayin Sun; Miao Wang; Xing Xiong; Junping Li; Chao Huang; Hui Zhang; Guosong Jiang; Xingyuan Xiao Cancer Res (2025) 85 (12): 2288–2301. 13 Single-Cell Expression Analysis of Ductal Carcinoma In Situ Identifies Complex Genotypic–Phenotypic Relationships Altering Epithelial Composition 导管原位癌的单细胞表达分析确定了改变上皮成分的复杂基因型-表型关系 Xiaodi Qin; Siri H. Strand; Marissa R. Lee; Aashrith Saraswathibhatla; David G.P. van IJzendoorn; ChunFang Zhu; Sujay Vennam; Sushama Varma; Allison Hall; Rachel E. Factor; Lorraine King; Lunden Simpson; Xiaoke Luo; Graham A. Colditz; Shu Jiang; Ovijit Chaudhuri; E. Shelley Hwang; Jeffrey R. Marks; Kouros Owzar; Robert B. West Cancer Res (2025) 85 (12): 2302–2319. Cancer Landscapes（癌症特征） 14 Spatial Profiling Identifies Regionally Distinct Microenvironments and Targetable Immunosuppressive Mechanisms in Pediatric Osteosarcoma Pulmonary Metastases 空间分析确定儿童骨肉瘤肺转移的区域特异性微环境和可靶向的免疫抑制机制 Jason Eigenbrood; Nathan Wong; Paul Mallory; Janice S. Pereira; Demond Williams; Douglass W. Morris-II; Jessica A. Beck; James C. Cronk; Carly M. Sayers; Monica Mendez; Linus Kaiser; Julie Galindo; Jatinder Singh; Ashley Cardamone; Milind Pore; Michael Kelly; Amy K. LeBlanc; Jennifer Cotter; Rosandra N. Kaplan; Troy A. McEachron Cancer Res (2025) 85 (12): 2320–2337. Editor’s Notes（编者按） 15 Editor’s Note: Inverse Correlation of STAT3 and MEK Signaling Mediates Resistance to RAS Pathway Inhibition in Pancreatic Cancer 编者按：STAT3和MEK信号通路的负相关介导胰腺癌对RAS通路抑制的耐药性 Nagaraj S. Nagathihalli; Jason A. Castellanos; Purushottam Lamichhane; Fanuel Messaggio; Chanjuan Shi; Xizi Dai; Priyamvada Rai; Xi Chen; Michael N. VanSaun; Nipun B. Merchant Cancer Res (2025) 85 (12): 2338. 16 Editor’s Note: Lactate Dehydrogenase B Is Critical for Hyperactive mTOR-Mediated Tumorigenesis 编者按：乳酸脱氢酶B对mTOR过度激活介导的肿瘤发生至关重要 Xiaojun Zha; Fang Wang; Ying Wang; Shaozong He; Yanling Jing; Xueyan Wu; Hongbing Zhang Cancer Res (2025) 85 (12): 2339. 17 Editor’s Note: Recombinant Immunoproapoptotic Proteins with Furin Site Can Translocate and Kill HER2-Positive Cancer Cells 编者按：带有弗林蛋白酶位点的重组免疫促凋亡蛋白可转位并杀伤HER2阳性癌细胞 Tao Wang; Jing Zhao; Jun-Lin Ren; Li Zhang; Wei-Hong Wen; Rui Zhang; Wei-Wei Qin; Lin-Tao Jia; Li-Bo Yao; Ying-Qi Zhang; Si-Yi Chen; An-Gang Yang Cancer Res (2025) 85 (12): 2340.