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更新于：2026-10-23
Ecabet Sodium Hydrate
依卡倍特钠
更新于：2026-10-23
概要
基本信息
权益机构- |
最高研发阶段批准上市 |
首次获批日期 日本 (1993-10-01), |
最高研发阶段(中国)批准上市 |
特殊审评- |
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结构/序列
分子式C20H28NaO5S |
InChIKeyJNTMHWBQZJIWMT-YGJXXQMASA-N |
CAS号86408-72-2 |
关联
8
项与 依卡倍特钠 相关的临床试验JPRN-UMIN000011296
Comparison of an Ecabet Sodium and PPI in the treatment of endoscopic submucosal dissection (ESD)-induced ulcers in early gastric cancer: prospective randomized study
JPRN-UMIN000007735
Randomised comparison study: eradication therapy for Helicobacter pylori with or without ecabet sodium after endoscopic submucosal dissection (ESD) of early gastric cancer
NCT01308177
Efficacy of an Ecabet Sodium and Proton Pump Inhibitor (PPI) Combination Therapy in the Treatment of Iatrogenic Ulcer After Endoscopic Submucosal Dissection: A Prospective Randomized Controlled Trial
100 项与 依卡倍特钠 相关的临床结果
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100 项与 依卡倍特钠 相关的转化医学
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100 项与 依卡倍特钠 相关的专利（医药）
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128
项与 依卡倍特钠 相关的文献（医药）2025-11-01FOOD CHEMISTRY
Identification of rice taste quality markers using metabolomics techniques
Article
作者: Li, Jiangtao ; Ren, Kangzi ; Lin, Qinlu ; Long, Zhao ; Fu, Xiangjin ; Liu, Chun ; Shu, Jun ; Guo, Weidan
To identify the taste quality molecule markers in rice, sensory evaluation and metabolites analysis based on UPLC-MS/MS of 35 rice samples were carried out. Among the detected 3864 metabolites, the bioactive compound - ecabet, an effective and safe agent in the treatment of gastric ulcer and gastritis, was identified from the polished rice (25.43 mg/100 g) and brown rice samples (129.90 mg/100 g). Metabolites positively and negatively correlated with rice taste quality were mainly enriched in glycerolipid and thiamine metabolism pathways, respectively. Ten metabolites were identified as potential markers of rice taste quality. Among them, ginsenoyne F, 2-acetyl-3-methylfuran, 3,4-methylenedioxycinnamaldehyde, isopulegone caffeate, and glyceric acid were positively correlated with the taste quality of rice, while terbumeton was negatively correlated. This study is meaningful in elucidating the taste quality formation mechanism of rice grain.
2025-01-01JOURNAL OF ETHNOPHARMACOLOGY
Lipopolysaccharide aggravating anaphylactoid reactions caused by traditional Chinese Medicine injections via p38/ERK/NF-κB signaling pathways
Article
作者: Qiu, Zichao ; Liu, Fangmei ; Peng, Guoping ; Tang, Shuwan ; Li, Cunyu
ETHNOPHARMACOLOGICAL RELEVANCE:
Currently, adverse reactions limit the development of traditional Chinese medicine injections (TCMI), and severe anaphylactoid shock is one of the serious adverse reactions, which presents a significant challenge. The presence of abnormal inflammatory mediators before the administration of TCMI will most likely result in severe anaphylactoid reactions. Not only that, the lack of clinically relevant safety evaluations impedes the widespread use of TCMI, and there is an urgent need for studies to reveal the mechanisms of anaphylactoid shock caused by TCMI.
AIM OF THE STUDY:
To investigate the effects and underlying mechanisms of lipopolysaccharide (LPS)-induced inflammation, which aggravates anaphylactoid reactions caused by TCMI, utilizing a guinea pig model.
METHODS:
The dose and duration of LPS administration and different doses of compound 48/80 (C48/80) were examined by using guinea pigs as a model. Shuanghuanglian (SHLI) and Qingkailing (QKLI) injections, these two representative TCMI, were used for validation. The plasma biochemical indices, including histamine, 5-hydroxytryptamine, tumor necrosis factor-α, interleukin 6, immunoglobulin E, C5a, tryptase, and platelet activating factor, as well as the pathological characteristics of the lung, were analyzed. Futhermore, plasma metabolomics was employed to reveal changes in metabolic pathways in vivo when inflammation co-exists with TCMI. In addition, Western blot analysis was conducted to assess the expression of critical signaling pathways.
RESULTS:
Stimulation with 2 mg/kg of LPS for 12 h induced inflammatory responses in the guinea pig model. C48/80 (3.0 mg/kg) in combination with LPS resulted in an increase in anaphylactoid-related indicators in the plasma. High doses of SHLI and QKLI aggravated plasma indices and lung histological injury caused by LPS-induced inflammation. A total of 36 and 63 differential metabolites were significantly altered after LPS stimulation in the SHLI-and QKLI-treated guinea pig groups, respectively. The associated metabolic pathways include central carbon metabolism in cancer, the tricarboxylic acid cycle, glyoxylate and dicarboxylate metabolism. The p38/ERK/NF-κB signal pathway may be significantly affected by TCMI in vivo after LPS stimulation.
CONCLUSION:
LPS-induced inflammation aggravated anaphylactoid reactions caused by SHLI and QKLI, with a correlation to dosage. After the presence of LPS, the administration of TCMI interferes with the immune response by over-activating the p38/ERK/NF-κB signaling pathway. This activation leads to an excessive release of inflammatory factors and anaphylactoid mediators. These results present a new direction for mitigating adverse clinical reactions associated with TCMI.
2023-01-01Plant biotechnology journal
Structural and mechanistic insights into the precise product synthesis by a bifunctional miltiradiene synthase
Article
作者: Yuru Tong ; Tao Jiang ; Xiaoli Ma ; Kang Chen ; Wei Gao ; Haifeng Xu ; Ping Su ; Guanghong Cui ; Luqi Huang ; Tianyuan Hu
Summary:
Selaginella moellendorffii miltiradiene synthase (SmMDS) is a unique bifunctional diterpene synthase (diTPS) that catalyses the successive cyclization of (E,E,E)‐geranylgeranyl diphosphate (GGPP) via (+)‐copalyl diphosphate (CPP) to miltiradiene, which is a crucial precursor of important medicinal compounds, such as triptolide, ecabet sodium and carnosol. Miltiradiene synthetic processes have been studied in monofunctional diTPSs, while the precise mechanism by which active site amino acids determine product simplicity and the experimental evidence for reaction intermediates remain elusive. In addition, how bifunctional diTPSs work compared to monofunctional enzymes is attractive for detailed research. Here, by mutagenesis studies of SmMDS, we confirmed that pimar‐15‐en‐8‐yl+ is an intermediate in miltiradiene synthesis. Moreover, we determined the apo‐state and the GGPP‐bound state crystal structures of SmMDS. By structure analysis and mutagenesis experiments, possible contributions of key residues both in class I and II active sites were suggested. Based on the structural and functional analyses, we confirmed the copal‐15‐yl+ intermediate and unveiled more details of the catalysis process in the SmMDS class I active site. Moreover, the structural and experimental results suggest an internal channel for (+)‐CPP produced in the class II active site moving towards the class I active site. Our research is a good example for intermediate identification of diTPSs and provides new insights into the product specificity determinants and intermediate transport, which should greatly facilitate the precise controlled synthesis of various diterpenes.
100 项与 依卡倍特钠 相关的药物交易
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研发状态
批准上市
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 急性胃炎 | 日本 | 1995-11-22 | |
| 慢性胃炎 | 日本 | 1995-11-22 | |
| 胃溃疡 | 日本 | 1993-10-01 |
未上市
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 溃疡性结肠炎 | 临床3期 | 日本 | - | |
| 干眼综合征 | 临床2期 | 美国 | - | |
| 干眼综合征 | 临床2期 | 日本 | - |
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临床结果
临床结果
适应症
分期
评价
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临床2期 | 183 | (Ecabet Ophthalmic Solution) | 積膚製襯範簾餘鏇觸獵(鹽繭鑰網選製壓鏇網獵) = 範衊積觸繭積觸衊憲壓 膚醖構簾積醖鬱壓簾願 (獵襯鏇襯繭襯窪衊鏇顧, 4.70) 更多 | - | 2020-09-03 | ||
placebo (Vehicle) | 積膚製襯範簾餘鏇觸獵(鹽繭鑰網選製壓鏇網獵) = 齋淵夢網窪憲製範淵製 膚醖構簾積醖鬱壓簾願 (獵襯鏇襯繭襯窪衊鏇顧, 4.40) 更多 |
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