Influenza-PAL(Influenza-PAL) - 药物靶点：TLR7 x TLR8_在研适应症：流感病毒感染_专利_临床

概要

基本信息

药物类型

灭活疫苗、预防性疫苗

别名-

靶点

TLR7 x TLR8

作用机制

TLR7激动剂(Toll样受体7激动剂)、TLR8激动剂(Toll样受体8激动剂)

治疗领域

感染呼吸系统疾病

在研适应症

流感病毒感染

非在研适应症-

原研机构

Folia Biotech, Inc.

在研机构

Folia Biotech, Inc.

非在研机构-

最高研发阶段临床1期

首次获批日期-

最高研发阶段(中国)-

特殊审评-

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关联

100 项与 Influenza-PAL 相关的临床结果

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100 项与 Influenza-PAL 相关的转化医学

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100 项与 Influenza-PAL 相关的专利（医药）

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17

项与 Influenza-PAL 相关的文献（医药）

2024-07-02·Future Medicinal Chemistry

Palbociclib-derived multifunctional molecules for lysosomal targeting and diagnostic-therapeutic integration

Article

作者: Zhao, Siqin ; Ma, Rui ; Zhang, Xiaoyang ; Wang, Xiaoming ; Zhou, Yuting ; Chen, Hao ; Chen, Lvyi ; Yang, Haili ; Xu, Letian ; Deng, Xukun ; Gu, Hongwei ; Baatar, Munkhtsetseg

Aim: Lysosomal pH changes are associated with drug resistance, cell growth and invasion of tumors, but effective and specific real-time monitoring of lysosomal pH compounds for cancer therapy is lacking. Materials & methods: Here, based on the covalent linkage of the anticancer drug palbociclib and fluorescent dye fluorescein isothiocyanate (FITC), we designed and developed a novel palbociclib-derived multifunctional molecule (Pal-FITC) for lysosomal targeting and diagnostic therapeutic integration. Results & discussion: Pal-FITC fluoresces is 20-fold stronger than that of FITC and shows a linear response in the pH range of 4.0-8.2 (R² = 0.9901). Pal-FITC blocks cells in G1 phase via Cyclin D-CDK4/6-Rb. Conclusion: Our study provides new strategies for tumor-targeted imaging and personalized therapy.

2021-10-21·The Journal of clinical endocrinology and metabolism2区 · 医学

Branched-chain Amino Acids and Relationship With Inflammation in Youth With Obesity: A Randomized Controlled Intervention Study

2区 · 医学

Article

作者: Balagopal, P Babu ; Churilla, James R ; Cosentino, Ralph G ; Prado, Wagner L ; Hossain, Md Jobayer ; Josephson, Samantha ; Molle-Rios, Zarela

Abstract:

Context:

Elevated concentrations of branched-chain amino acids (BCAA) are strong predictors of type 2 diabetes mellitus (T2DM). Their association with cardiovascular disease (CVD) remains uncertain, particularly in youth.

Objective:

We investigated the role of BCAA and aromatic amino acids (AAA) in obesity, their relationships with novel biomarkers of CVD, and response to a physical activity-based lifestyle intervention (PAL-I) in a randomized controlled study in youth with normal weight (NW) and obesity (OB).

Methods:

Age (14-18 years) and Tanner stage (≥IV) matched youth (OB, n = 15 and NW, n = 6) were studied; the 15 participants with OB underwent a 3-month randomized controlled PAL-I. Circulating amino acid profile, glucose, insulin, lipids, adiponectin, retinol binding protein-4, fibrinogen, high-sensitivity C-reactive protein, interleukin-6, and 25-hydroxy vitamin-D, along with body composition, were measured at baseline and after PAL-I. Independent t tests, analysis of covariance, and mixed-effect models were used for analysis of the data.

Results:

Compared with NW, the concentration of various amino acids, including BCAA and AAA, were altered in OB (P < 0.05). BCAA and AAA showed baseline correlations with body composition and novel biomarkers of CVD, particularly inflammatory factors (all P < 0.05). The PAL-I produced only negligible effects (P > 0.05) on BCAA and AAA. Glutamine, glycine, and aspartic acid decreased with PAL-I (all P < 0.05).

Conclusion:

The novel finding of the BCAA–inflammation relationship, along with strong correlations with nontraditional biomarkers of CVD, may raise the prospect of BCAA as a biomarker of CVD and evoke a potential link between obesity, T2DM, and CVD.

2021-08-13·Drug metabolism and personalized therapy

Follow up: palmitic acid ester of tetrahydrocannabinol (THC) and palmitic acid diester of 11-hydroxy-THC – unsuccessful search for additional THC metabolites

Article

作者: Hess, Cornelius ; Nidadavolu, Prakash ; Maas, Alexandra ; Bilkei-Gorzo, Andras ; Madea, Burkhard ; Kraemer, Michael

Abstract:

Objectives:

In a previous investigation we searched for the occurrence of palmitic acid ester compounds of delta9-tetrahydrocannabinol (THC) and its primary metabolite 11-hydroxy-delta9-THC (11-OH-THC) in human body fluids and tissues (THC palmitic acid monoester [THC-Pal] and 11-OH-THC palmitic acid diester [11-OH-THC-DiPal]). As those esters could not be detected in various human body fluids (e.g. blood) or tissues (e.g. adipose tissue) we extended the investigation analyzing adipose tissue samples of mice previously given synthetic THC or a cannabis extract.

Methods:

In total, 48 adipose tissue samples previously tested positive for THC by means of a liquid chromatographic triple quadrupole mass spectrometric (LC-QQQ-MS) method were analyzed for the presence of THC-Pal and 11-OH-THC-DiPal by means of LC-QQQ-MS.

Results:

THC-Pal and 11-OH-THC-DiPal were not detected among the adipose tissue samples analyzed despite the presence of high THC concentrations within the adipose tissue. THC concentrations in adipose tissue were in a range of approximately 7–2,595 ng/g (median: 468 ng/g, average: 704 ng/g).

Conclusions:

A (site-specific) synthesis of 11-OH-THC palmitic acid monoesters (11-hydroxy-delta9-THC-1-palmitate and 11-palmitoyloxy-delta9-THC) still remains to be done. After synthesis of these monoesters, their presence in the body fluids and tissues after THC administration should be investigated.

100 项与 Influenza-PAL 相关的药物交易

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