更新于：2024-12-21
Indocyanine Green
吲哚菁绿
更新于：2024-12-21
概要
基本信息
原研机构 |
最高研发阶段批准上市 |
首次获批日期 美国 (1959-02-09), |
最高研发阶段(中国)批准上市 |
特殊审评- |
登录后查看时间轴
结构
分子式C43H48N2NaO6S2 |
InChIKeyAANGVCDSLQANGQ-UHFFFAOYSA-N |
CAS号3599-32-4 |
关联
321
项与 吲哚菁绿 相关的临床试验Prospective Analysis of Patients at Risk for Breast Cancer-Related Lymphedema (BCRL) Using Indocyanine Green (ICG) Fluoroscopy and SPYTM Angiography
Magnetic Sentinel Lymph Node Mapping in Gastric Cancer, Safety and Feasibility Clinical Trial
Verification of the Efficacy/Safety of the Mixed Drug Injectable Delivery Vehicle for Treating Intractable Hearing Loss (Pilot Study)
100 项与 吲哚菁绿 相关的临床结果
登录后查看更多信息
100 项与 吲哚菁绿 相关的转化医学
登录后查看更多信息
100 项与 吲哚菁绿 相关的专利（医药）
登录后查看更多信息
4,574
项与 吲哚菁绿 相关的文献（医药）2025-12-01Journal of Gastrointestinal Cancer
Initial Application of Fluorescence Imaging for Intraoperative Localization of Small Neuroendocrine Tumors in the Pancreas: Case Report and Review of the Literature
Review
作者: Shen, Zhengchao ; Fang, Xiaosan ; Wang, Xiaoming ; Wang, Guannan ; Jiang, Yaqi ; Muhammad, Danish Irshad ; Jiang, Bin ; Qian, Daohai ; Xi, Shihang ; Zheng, Xingyuan ; Wang, Xu
BACKGROUND:
Indocyanine green is commonly used for laparoscopic hepatectomy but remains uncommon in pancreatic surgery. Given the increasing number of small neuroendocrine tumors found in the pancreas and the heavy reliance on laparoscopic ultrasound for intraoperative localization, we attempted to use indocyanine green for these tumors. Our results show good localization and have the potential to provide a valuable clinical aid.
CASE PRESENTATION:
This case report details five patients with preoperative diagnosis of pancreatic neuroendocrine tumors of small endocrine tumors, intraoperative successful localization, and successful completion of laparoscopic partial resection of pancreatic tumors by indocyanine green fluorescence staining; none of the patients experienced serious complications after surgery and were discharged from the hospital, and routine pathology confirmed that four cases were pancreatic neuroendocrine tumors of G1 stage, and one case was pancreatic neuroendocrine cell hyperplasia.
CONCLUSION:
Fluorescence imaging technology safely aids in the intraoperative localization of small pancreatic neuroendocrine tumors.
2025-04-01JOURNAL OF COLLOID AND INTERFACE SCIENCE
Corrigendum to “A nanodrug loading indocyanine green and metformin dually alleviating tumor hypoxia for enhanced chemodynamic/sonodynamic therapy” [J. Colloid Interface Sci. 680(Part B) (2025) 341–355]
作者: Ran, Mengnan ; Han, Shisong ; Gan, Huixuan ; Liu, Yun ; Wang, Hao ; Xu, Jiehua ; Wu, Quanxin ; Guo, Ning ; Zhang, Ziying ; Zeng, Weishen
2025-03-01BIOMATERIALS
Tertiary lymphoid structure formation induced by LIGHT-engineered and photosensitive nanoparticles-decorated bacteria enhances immune response against colorectal cancer
Article
作者: Shuai, Xintao ; Jiang, Yujie ; Chen, Qiu ; Gao, Honglin ; Su, Zhongzhen ; Xiao, Zecong ; Li, Tan ; Deng, Shaohui ; Chen, Hui ; Hu, Lijun
Tertiary lymphoid structures (TLSs) are known to enhance the prognosis of patients with colorectal cancer (CRC) by fostering an immunologically active tumor microenvironment (TME). Inducing TLS formation therapeutically holds promise for treating immunologically cold CRC, though it poses technical challenges. Here, we design and fabricate a photosensitive bacterial system named E@L-P/ICG. This system is engineered bacteria internally loaded with the cytokine LIGHT and surface-modified with PLGA/ICG nanoparticles (P/ICG NPs). Once accumulated in orthotopic colonic tumors in mice, E@L-P/ICG generates a mild photothermal effect under laser irradiation due to the photosensitive P/ICG NPs. This photothermal effect triggers the self-rupture of E@L-P/ICG and the death of surrounding tumor cells to release adjuvants and antigens, respectively, which in turn synergistically activate the adaptive immune responses. Furthermore, the cytokine LIGHT released from ruptured E@L-P/ICG stimulates the generation of high endothelial vessels (HEVs), promoting lymphocyte recruitment within the TME. These mechanisms lead to the TLS formation in CRC, which further boosts adaptive immune responses through effective infiltration of T cells and B cells, resulting in effectively inhibited tumor growth and extended survival of mice. Our study shows the potential of the E@L-P/ICG system in photosensitively inducing the TLS formation to treat CRC in clinic.
100 项与 吲哚菁绿 相关的药物交易
登录后查看更多信息
研发状态
批准上市
10 条最早获批的记录, 后查看更多信息
登录
| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 胆管疾病 | 美国 | 2018-11-21 | |
| 宫颈癌 | 美国 | 2018-11-21 | |
| 子宫癌 | 美国 | 2018-11-21 | |
| 血管疾病 | 美国 | 2018-11-21 | |
| 乳腺癌 | 日本 | 2009-09-18 | |
| 黑色素瘤 | 日本 | 2009-09-18 | |
| 造影剂 | 美国 | 1959-02-09 |
未上市
10 条进展最快的记录, 后查看更多信息
登录
| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 肝功能衰竭 | 临床3期 | 美国 | 2015-11-01 | |
| 结肠癌 | 临床2期 | 美国 | 2024-08-14 | |
| 食管癌 | 临床2期 | 美国 | 2024-08-14 | |
| 胶质瘤 | 临床2期 | 美国 | 2024-08-14 | |
| 脑膜瘤 | 临床2期 | 美国 | 2024-08-14 | |
| 非小细胞肺癌 | 临床2期 | 美国 | 2024-08-14 | |
| 卵巢癌 | 临床2期 | 美国 | 2024-08-14 | |
| 胰腺癌 | 临床2期 | 美国 | 2024-08-14 | |
| 甲状旁腺腺瘤 | 临床2期 | 美国 | 2024-08-14 | |
| 前列腺癌 | 临床2期 | 美国 | 2024-08-14 |
登录后查看更多信息
临床结果
临床结果
适应症
分期
评价
查看全部结果
N/A | - | (TTT alone) | 築窪憲憲憲網鹹鏇積鹹(壓淵艱鏇積壓醖鑰遞憲) = 窪鏇襯鹹鹽鏇衊窪顧鬱 構醖獵壓醖製築艱願觸 (襯憲鹽範遞齋遞簾淵鹹 ) | 积极 | 2024-09-19 | ||
(ICG enhanced TTT) | 積糧餘齋簾簾艱願願鏇(醖鬱鏇繭網繭鏇鹽顧獵) = 獵淵遞蓋夢蓋網積繭製 醖夢糧願廠糧衊齋艱窪 (網繭鬱觸願鏇艱壓鬱淵 ) 更多 | ||||||
N/A | - | ICG inhalation for 5 minutes | 網獵選範觸夢醖鑰範簾(衊膚衊積夢廠醖憲遞簾) = No other complications were observed 範鹽製顧鏇糧鏇糧衊夢 (窪壓餘糧齋鏇糧艱構遞 ) 更多 | - | 2024-09-09 | ||
ICG inhalation for 10 minutes | |||||||
N/A | - | - | Indocyanine Green (ICG) Inhalation | 觸觸繭襯構遞憲鹹鑰廠(壓醖糧壓醖顧糧壓鹽鹹) = None of the patients experienced complications related to ICG inhalation 構積窪獵襯築鏇鹽積蓋 (醖獵築蓋觸艱簾鹹繭鹽 ) 更多 | - | 2024-09-07 | |
N/A | - | (Mesh nebulizer) | 積衊鹹窪繭遞獵鏇鑰醖(選顧鹽簾壓顧淵齋製鑰) = no adverse events were recorded 獵構鏇積憲鏇淵範糧範 (網鹽選觸顧壓簾憲膚鏇 ) 更多 | - | 2024-09-07 | ||
N/A | 3 | fluorescent Peptide+indocyanine green | 簾鏇壓衊獵窪網壓憲簾(範糧憲窪簾襯選積鏇窪) = 鬱獵築簾築遞糧網夢窪 鏇構齋範衊鏇積製鏇淵 (淵餘艱淵衊襯廠獵積製, 製夢觸鑰鑰築鏇鹽繭獵 ~ 鬱鑰遞鬱範膚窪鹽鹹選) 更多 | - | 2024-06-26 | ||
N/A | 9 | OnLume Imaging System+Indocyanine green | 衊窪醖窪窪鬱鹽鏇構淵(鑰艱夢襯蓋顧顧積壓願) = 夢襯網壓鏇艱觸簾構襯 範糧鏇鹹觸艱壓淵壓醖 (獵鑰鏇築觸窪鏇網願獵, 觸壓鬱鏇遞餘獵夢廠遞 ~ 醖壓糧蓋網網網淵蓋窪) 更多 | - | 2024-05-23 | ||
N/A | - | - | 衊獵糧廠醖築壓網顧醖(選醖鬱繭網艱鹽鑰鑰壓) = 襯積積襯繭構鑰遞願觸 觸範網選鑰餘築鹹衊窪 (繭範鹹憲選選範淵顧衊, 63.1 ~ 100) 更多 | - | 2024-05-15 | ||
N/A | 12 | (Inguinal lymph-node dissection (ILND)) | 醖壓鑰膚憲襯鏇鑰艱夢(膚觸網衊獵艱窪鹽廠齋) = Postoperative complications were recorded in 8 out of 16 procedures, with a low rate of wound dehiscence and no flap necrosis observed 糧鑰顧簾鹽壓襯簾獵鹽 (艱齋廠築築鬱鹹壓夢淵 ) | 积极 | 2024-05-01 | ||
(Inguino-pelvic lymph-node dissection (IPLND)) | |||||||
N/A | 22 | 糧鹽窪選遞壓窪齋衊襯(觸廠鹹構獵製衊廠夢衊) = There were no allergic reactions to the ICG 願遞膚糧鹹夢醖鏇蓋繭 (鬱範願顧淵獵獵鹹簾築 ) | 积极 | 2024-03-10 | |||
N/A | 69 | (ICG and RI) | 選積夢襯艱齋醖淵夢觸(鹽鑰鹽積鏇艱鹹製願遞) = 繭餘糧夢鏇鹽窪襯壓顧 糧繭艱餘築夢餘範築鏇 (遞遞鑰鹽鏇廠簾鹽鹽鏇 ) 更多 | - | 2023-10-21 | ||
(Blue dye and RI) | 鏇鏇壓憲膚鹹觸醖製鏇(顧膚選獵窪襯淵選艱範) = 壓窪衊鹽鹹觸鹹壓醖糧 膚構鹽憲廠製艱糧衊鬱 (繭範憲遞觸餘壓鹹憲積, 94.3 ~ 99.1) |
登录后查看更多信息
转化医学
使用我们的转化医学数据加速您的研究。
登录
或
药物交易
使用我们的药物交易数据加速您的研究。
登录
或
核心专利
使用我们的核心专利数据促进您的研究。
登录
或
临床分析
紧跟全球注册中心的最新临床试验。
登录
或
批准
利用最新的监管批准信息加速您的研究。
登录
或
特殊审评
只需点击几下即可了解关键药物信息。
登录
或
来和芽仔聊天吧
立即开始免费试用!
智慧芽新药情报库是智慧芽专为生命科学人士构建的基于AI的创新药情报平台，助您全方位提升您的研发与决策效率。
立即开始数据试用!
智慧芽新药库数据也通过智慧芽数据服务平台，以API或者数据包形式对外开放，助您更加充分利用智慧芽新药情报信息。
生物序列数据库
生物药研发创新
免费使用
化学结构数据库
小分子化药研发创新
免费使用