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更新于：2026-02-27
Fluorescein Sodium
荧光素钠
更新于：2026-02-27
概要
基本信息
最高研发阶段批准上市 |
最高研发阶段(中国)批准上市 |
特殊审评- |
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结构/序列
分子式C20H12Na2O5 |
InChIKeyMOUPEUAUBSXMLI-UHFFFAOYSA-N |
CAS号518-47-8 |
关联
61
项与 荧光素钠 相关的临床试验NCT07356349
AuthenTicity of Point of Care Urine samplEs Using Oral fluoreScein Sodium in adulTs With substancE Use Disorder
NCT04008121
A Pilot Study to Assess the Feasibility and Safety of MB-102 in Ocular Angiography as Compared to Fluorescein Sodium
NCT06873815
A Single-Arm Prospective Trial of Fluorescein Mapping in Patients Undergoing Vulvectomy for Extramammary Paget's Disease
100 项与 荧光素钠 相关的临床结果
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100 项与 荧光素钠 相关的转化医学
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100 项与 荧光素钠 相关的专利（医药）
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9,338
项与 荧光素钠 相关的文献（医药）2026-03-01SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
Metrological comparison of fiber-optic and conventional spectrophotometry for visible spectra of liquid dye solutions
Article
作者: de Nigris, Antonio ; Ambrosone, Luigi ; Quero, Giuseppe
This study evaluates the consistency between optical fiber Spectroscopy and conventional spectrophotometry for three representative dyes - Fluorescein, Methylene Blue, and Nile Red - measured in both polystyrene and quartz cuvettes. For the non-fluorescent dyes, Methylene Blue and Nile Red, optical fiber and spectrophotometry produce fully consistent spectra across all concentrations and in both materials, with scaling factors close to unity and negligible offsets, confirming that non-emissive analytes are reliably quantified by both techniques. Fluorescein, however, exhibits concentration-dependent deviations caused by its strong fluorescence, with opposite trends in quartz and polystyrene due to their different optical properties and their distinct ability to re-collect emitted light. Despite these effects, the distortions remain systematic and attributable to well-defined physical mechanisms. These findings demonstrate that optical fiber is robust for non-fluorescent compounds and can be applied confidently to solid or gel matrices, whereas fluorescent analytes require calibration strategies that account for matrix-dependent emission contributions - an essential consideration for absorption studies and drug-release monitoring in heterogeneous materials.
2026-02-01Contact Lens & Anterior Eye
Scleral lens landing zone toricity and tear exchange
Article
作者: Fisher, Damien ; Collins, Michael J ; Iqbal, Asif ; Alonso-Caneiro, David ; Vincent, Stephen J
PURPOSE:
To quantify the effect of landing zone toricity on tear exchange during short-term scleral lens wear using a profilometry based method.
METHODS:
Nine healthy participants wore scleral lenses (KATT™, Capricornia) with a spherical and 150 μm toric landing zone in a randomised order on separate days, with other lens parameters held constant. Following the instillation of 10 µl of 2 % sodium fluorescein, Eye Surface Profiler images were captured over 100 min of lens wear. A second dose of 10 µl of 2 % sodium fluorescein was instilled after 90 min of lens wear. Fluorescence intensity data were extracted and analysed over central (5 mm diameter, coincident with the centre of the horizontal visible iris diameter [HVID]) and peripheral regions (1 mm annulus, with the HVID as the outer border).
RESULTS:
Fluorescence intensity varied throughout lens wear, with the toric lens design displaying greater fluorescence intensity than the spherical design at 0, 60, and 100 min (all p < 0.05), when averaged across both regions. The ingress of sodium fluorescein was evident with the toric lens design in both central and peripheral regions during the first 30 min of wear, followed by a gradual decline, while the spherical design stabilised after 5-10 min. The toric lens design displayed tear exchange following the reapplication of sodium fluorescein after 90 min of lens wear, while the spherical design did not.
CONCLUSIONS:
Scleral lenses with a toric landing zone facilitated greater central and peripheral tear exchange than a spherical lens design. Alterations to the scleral landing zone which enhance tear exchange may have clinical implications for reducing peripheral corneal oedema during lens wear.
2026-01-01INDIAN JOURNAL OF OPHTHALMOLOGY
Comparison of intraocular pressure measurements with and without fluorescein using Goldmann applanation tonometry
Article
作者: Katić, Karla ; Krešo, Ante ; Rančić, Anita ; Znaor, Ljubo ; Perišić, Nora
Background::
This study aimed to evaluate the effect of fluorescein on intraocular pressure (IOP) measurements using Goldmann applanation tonometry (GAT). The study compared IOP readings with and without fluorescein to determine its influence on measurement accuracy in clinical practice.
Methods::
This cross-sectional study included 39 patients (78 eyes). IOP was measured three times under each condition: fluorescein-free with green light and fluorescein-aided with cobalt blue light. The prespecified primary comparison was between the first fluorescein-free reading and the first fluorescein-aided reading, separated by approximately 1 minute (the time needed to apply fluorescein). Statistical analysis (repeated-measures ANOVA for within-series change; Wilcoxon signed-rank tests for paired comparisons) was used to compare measurements, while corneal astigmatism, keratometry, and central corneal thickness were assessed for their potential influence on discrepancies. A sensitivity analysis excluding patients with >3.0 D corneal astigmatism was conducted.
Results::
No significant difference was found between the first fluorescein-free and first fluorescein-aided IOP measurements (Wilcoxon
P
= 0.75; mean difference +0.04 mmHg). Consecutive measurements showed significant IOP reductions within each group, attributed to mechanical effects of the tonometer (repeated-measures ANOVA
P
< 0.01). Corneal parameters, including central corneal thickness and keratometry, did not significantly affect the differences. Results were unchanged after excluding patients with >3.0 D astigmatism.
Conclusions::
Fluorescein does not significantly affect IOP measurements using GAT, supporting fluorescein-free measurement as a viable alternative in routine practice. Further research is needed to evaluate its application in cases of high astigmatism or altered corneal geometry.
30
项与 荧光素钠 相关的新闻（医药）2026-01-30
2026-01-26
100 项与 荧光素钠 相关的药物交易
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研发状态
批准上市
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 造影剂 | 美国 | 2006-03-28 | |
| 胆管疾病 | 中国 | 1985-01-01 | |
| 角膜损伤 | 中国 | 1985-01-01 | |
| 角膜溃疡 | 中国 | 1985-01-01 | |
| 胆囊疾病 | 中国 | 1985-01-01 | |
| 脑膜结核 | 中国 | 1985-01-01 | |
| 诊断试剂 | 美国 | 1976-11-10 | |
| 视神经疾病 | 日本 | 1976-09-29 | |
| 视网膜疾患 | 日本 | 1976-09-29 | |
| 葡萄膜疾病 | 日本 | 1976-09-29 |
未上市
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 开角型青光眼 | 临床3期 | 美国 | 2001-01-01 | |
| 淋巴结阳性乳腺癌 | 临床2期 | 美国 | 2014-06-01 |
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临床结果
临床结果
适应症
分期
评价
查看全部结果
N/A | 3 | 網壓壓築鑰網齋鏇獵淵 = 獵鏇餘衊蓋鬱遞繭選餘 襯積艱鏇獵壓齋網淵餘 (艱網憲淵夢鑰餘餘積網, 壓獵獵窪鬱淵膚齋壓觸 ~ 鹽鹹艱憲構鏇鑰顧構艱) 更多 | - | 2024-06-26 | |||
N/A | - | 2 | Microscopic Resection+Sodium Fluorescein | 顧願鬱製築積獵鏇簾觸(夢餘窪積夢廠鑰網鏇獵) = 構鑰齋糧築鏇鬱獵餘壓 鑰糧淵願獵顧襯糧襯築 (齋醖衊鬱遞憲醖選網壓, 膚積獵壓範鬱築醖壓願 ~ 鹹築鑰築蓋繭鹽蓋齋艱) 更多 | - | 2024-02-14 | |
临床2期 | 12 | YELLOW560 filter+Fluorescein Sodium | 艱簾網製範選膚鹹衊鹹 = 衊襯夢製構鏇簾襯醖網 範簾獵淵遞餘鑰觸鬱獵 (鹽願窪餘艱製窪糧範積, 獵鏇壓蓋廠遞餘齋觸獵 ~ 築夢艱襯鹽鏇鏇夢窪廠) 更多 | - | 2023-08-01 | ||
早期临床1期 | 100 | 網製糧選糧獵願壓淵鏇 = 衊繭壓簾餘積壓衊範鹽 鬱艱齋鹽夢鑰蓋壓願選 (鹽壓製糧糧夢淵夢鬱憲, 獵餘糧鏇廠選鏇繭鑰醖 ~ 獵積蓋願廠選築範膚積) 更多 | - | 2021-12-10 | |||
N/A | - | 37 | 範願鏇艱獵簾遞鏇窪積 = 鏇製願餘願積遞膚繭構 壓夢壓鏇繭膚築遞鏇醖 (築選鏇繭獵窪餘廠淵繭, 淵餘艱餘艱廠醖鑰網製 ~ 選襯鬱醖鏇網獵壓製醖) 更多 | - | 2021-04-01 | ||
临床1期 | 6 | Cellvizio 100 Series System with Confocal Miniprobes+Fluorescite | 襯簾壓膚衊鬱齋醖顧襯 = 醖憲糧構鹽遞餘鬱醖壓 淵願夢鏇鑰蓋積廠鹽淵 (選膚顧鑰觸簾鏇壓鹹範, 網餘繭範顧遞鹹鑰衊鑰 ~ 艱蓋獵獵窪選顧選餘鏇) 更多 | - | 2020-07-07 | ||
N/A | 176 | (Normal Saline) | 願遞齋鏇鏇夢鬱鏇襯範 = 網憲糧獵鬱鏇鑰觸鏇夢 餘鬱憲齋選觸鏇遞觸觸 (襯襯網鹹餘鬱獵淵網糧, 鑰獵簾糧繭鬱壓齋鏇醖 ~ 鹽蓋製網鑰窪顧築鏇壓) 更多 | - | 2019-10-23 | ||
Dextrose 10% (Dextrose 10%) | 願遞齋鏇鏇夢鬱鏇襯範 = 選願衊鹽顧構顧餘願壓 餘鬱憲齋選觸鏇遞觸觸 (襯襯網鹹餘鬱獵淵網糧, 窪糧構網獵鏇顧繭構築 ~ 淵憲願襯艱壓觸淵窪選) 更多 | ||||||
临床4期 | 140 | (A- Pyridium) | 艱顧淵衊糧淵醖糧獵壓(繭糧製網憲積選淵網窪) = 齋齋觸構築餘蓋艱淵遞 艱窪蓋網構鏇構壓鏇構 (網艱遞構膚餘願夢膚窪, 鏇積簾憲鏇築簾夢鹽築 ~ 積願簾鹽簾繭鹹艱範夢) 更多 | - | 2019-05-30 | ||
(B- Sodium Fluorescein) | 艱顧淵衊糧淵醖糧獵壓(繭糧製網憲積選淵網窪) = 衊鑰淵鬱顧壓構鹽廠鏇 艱窪蓋網構鏇構壓鏇構 (網艱遞構膚餘願夢膚窪, 淵鬱蓋製膚窪構淵獵齋 ~ 鹽齋襯選齋築範簾鬱壓) 更多 | ||||||
临床1/2期 | 90 | 醖鏇觸鬱窪鏇遞製憲糧 = 鏇鏇鹹遞觸憲範製築壓 獵積選構鏇製簾遞觸鹽 (餘膚顧襯鬱艱廠獵淵顧, 鹽壓積範製衊廠壓淵醖 ~ 繭築餘憲膚簾窪膚網構) 更多 | - | 2017-12-20 | |||
N/A | 10 | Diagnostic Microscopy+Fluorescein Sodium Injection | 選窪衊觸蓋顧鬱窪鑰積 = 夢積壓蓋簾鏇顧夢選衊 願築衊製襯範繭壓網獵 (願繭選繭鏇蓋憲製網鏇, 夢範鑰襯遞憲淵鹹積範 ~ 簾淵壓築淵願鬱積網築) 更多 | - | 2017-06-06 |
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