An open-label Phase 1/2a study of oral BAL101553 in adult patients with advanced solid tumors and in adult patients with recurrent or progressive glioblastoma or high-grade glioma

开始日期2021-03-10

申办/合作机构

Basilea Pharmaceutica International Ltd.

NCT03250299 / Terminated临床1期

Phase I Study to Determine the Safety and Tolerability of the Oral Microtubule Destabilizer BAL101553 in Combination With Standard Radiation in Patients With MGMT Promoter Unmethylated Newly Diagnosed Glioblastoma

This Phase I study investigated the side-effects and best dose of microtubule-targeted agent BAL101553 when given together with radiation therapy in treating patients with newly-diagnosed O6-methylguanine-DNA methyltransferase (MGMT) promoter unmethylated glioblastoma (GBM). Drugs used in chemotherapy, such as microtubule-targeted agent BAL101553, work in different ways to stop the growth of tumor cells, either by killing the cells, stopping them from dividing, or stopping them from spreading. Radiation therapy uses high-energy x-rays to kill tumor cells and shrink tumors. Giving microtubule-targeted agent BAL101553 and radiation therapy may work better in treating patients with GBM.

开始日期2017-12-15

申办/合作机构

Basilea Pharmaceutica AG

[+1]

NCT02895360 / Completed临床1/2期

An Open-label Phase 1/2a Study of BAL101553 Administered as Intravenous 48-hour Infusions in Adult Patients With Advanced Solid Tumors or Recurrent Glioblastoma

Single-agent, open-label, multi-center sequential dose escalation and expansion study of BAL101553, administered as an intravenous (IV) infusion over 48 hours to adults with advanced or recurrent solid tumors or recurrent glioblastoma.

开始日期2016-08-24

申办/合作机构

Basilea Pharmaceutica AG

100 项与 Lisavanbulin 相关的临床结果

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100 项与 Lisavanbulin 相关的转化医学

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100 项与 Lisavanbulin 相关的专利（医药）

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项与 Lisavanbulin 相关的文献（医药）

2024-01-01·Neuro-oncology advances

Lisavanbulin (BAL101553), a novel microtubule inhibitor, plus radiation in patients with newly diagnosed, MGMT promoter unmethylated glioblastoma

Article

作者: Ye, Xiaobu ; Fiveash, John B ; Desideri, Serena ; Nabors, Burt ; Kaindl, Thomas ; Bagley, Stephen J ; Grossman, Stuart A ; Litherland, Karine ; Strowd, Roy E ; Surakus, Trisha ; Kleinberg, Lawrence R ; Lane, Heidi A ; Fisher, Joy D ; Engelhardt, Marc ; Lieberman, Frank S ; Holdhoff, Matthias ; Walbert, Tobias

Abstract:

Background:

Lisavanbulin (BAL101553) is a small, lipophilic, oral microtubule destabilizer with promising antitumoral activity observed in preclinical glioblastoma (GBM) models.

Methods:

This multicenter phase 1 study sought to determine the MTD of oral Lisavanbulin in combination with standard RT (60 Gy/30 fractions) but without temozolomide in patients with newly diagnosed MGMT promoter unmethylated GBM (uGBM). Dose escalation followed a modified 3 + 3 design. Secondary objectives included estimation of OS and PFS and pharmacokinetic analysis.

Results:

Twenty-six patients with uGBM (median age, 63 years, 42.3% male, 61.5% with gross total resection, median Karnofsky performance status 80) were enrolled; 2 tumors had an IDH1 mutation. Predefined dose levels of Lisavanbulin, administered daily concomitantly with RT, were: 4 mg (5 pts), 6 mg (5 pts), 8 mg (7 pts), 12 mg (5 pts), and 15 mg (4 pts). The initial starting dose was 8 mg. Due to grade 4 aseptic meningoencephalitis in the first patient, the dose was decreased to 4 mg. Dose escalation resumed and continued to 15 mg with dose-limiting toxicities of grade 2 confusion and memory impairment observed at 12 mg. Avanbulin exposures increased in a relatively dose-proportional manner with increasing oral dose of Lisavanbulin from 4 to 15 mg.

Conclusions:

Lisavanbulin in combination with RT was considered safe up to the highest predefined oral dose level of 15 mg daily.

2023-04-01·Investigational new drugs

Safety and anti-tumor activity of lisavanbulin administered as 48-hour infusion in patients with ovarian cancer or recurrent glioblastoma: a phase 2a study

Article

作者: von Moos, Roger ; Engelhardt, Marc ; Lane, Heidi ; Roth, Patrick ; Haefliger, Simon ; Stathis, Anastasios ; Joerger, Markus ; Marszewska, Michalina ; Hottinger, Andreas F ; Kaindl, Thomas ; Hundsberger, Thomas

Abstract:

Purpose. Lisavanbulin (BAL101553) is the prodrug of avanbulin (BAL27862), a microtubule-destabilizing agent. The goal of this study (NCT02895360) was to characterize the safety, tolerability and antitumor activity of lisavanbulin administered as a 48-hour intravenous (IV) infusion at the recommended Phase 2 dose (RP2D) of 70 mg/m2. Results from the Phase 1 dose-escalation portion of the study identifying the RP2D have been previously reported. Here, we present the findings from the Phase 2a portion of this study. Methods. This multi-center, open-label study included patients with ovarian, fallopian-tube, or primary peritoneal cancer that was either platinum-resistant or refractory (11 patients), or with first recurrence of glioblastoma (12 patients). Lisavanbulin was administered as a 48-hour IV infusion on Days 1, 8, and 15 of a 28-day cycle. Results. Lisavanbulin was well tolerated in both patient cohorts. Thirteen patients (56.5%) developed 49 adverse events assessed as related to study treatment. The majority were mild or moderate; four were grade 3/4. Sixteen SAEs were reported in nine patients (39.1%), with none considered related to study treatment. No AEs led to permanent treatment discontinuation. Three patients in the ovarian cancer cohort had stable disease with lesion size reductions after two cycles of treatment; in the glioblastoma cohort, one patient showed partial response with a > 90% glioblastoma area reduction as best response, and one patient had stable disease after eight cycles of treatment. Conclusion. This study demonstrated a favorable safety and tolerability profile of 48-hour continuous IV infusion of lisavanbulin in patients with solid extracranial tumors or glioblastoma. Clinicaltrials.gov registration: NCT02895360.

2023-01-01·American journal of cancer research

The microtubule-targeted agent lisavanbulin (BAL101553) shows anti-tumor activity in lymphoma models.

Article

作者: Bertoni, Francesco ; Engelhardt, Marc ; Forster-Gross, Nicole ; Bachmann, Felix ; Cascione, Luciano ; Aresu, Luca ; Risi, Giorgia ; Arribas, Alberto J ; Lane, Heidi ; Napoli, Sara ; Spriano, Filippo

Microtubules are major components of the cellular cytoskeleton, ubiquitously founded in all eukaryotic cells. They are involved in mitosis, cell motility, intracellular protein and organelle transport, and maintenance of cytoskeletal shape. Avanbulin (BAL27862) is a microtubule-targeted agent (MTA) that promotes tumor cell death by destabilization of microtubules. Due to its unique binding to the colchicine site of tubulin, differently from other MTAs, avanbulin has previously shown activity in solid tumor cell lines. Its prodrug, lisavanbulin (BAL101553), has shown early signs of clinical activity, especially in tumors with high EB1 expression. Here, we assessed the preclinical anti-tumor activity of avanbulin in diffuse large B cell lymphoma (DLBCL) and the pattern of expression of EB1 in DLBCL cell lines and clinical specimens. Avanbulin showed a potent in vitro anti-lymphoma activity, which was mainly cytotoxic with potent and rapid apoptosis induction. Median IC50 was around 10 nM in both ABC and GCB-DLBCL. Half of the cell lines tested showed an induction of apoptosis already in the first 24 h of treatment, the other half in the first 48 h. EB1 showed expression in DLBCL clinical specimens, opening the possibility for a cohort of patients that could potentially benefit from treatment with lisavanbulin. These data show the basis for further preclinical and clinical evaluation of lisavanbulin in the lymphoma field.

项与 Lisavanbulin 相关的新闻（医药）

2024-06-20

·BioSpace

Basilea partners oncology drug candidate lisavanbulin with Glioblastoma Foundation

Allschwil, Switzerland, June 20, 2024 Basilea Pharmaceutica Ltd, Allschwil (SIX: BSLN), a commercial-stage biopharmaceutical company committed to meeting the needs of patients with severe bacterial and fungal infections, announced today that it has entered into an asset purchase agreement with the Glioblastoma Foundation Inc., for Basilea’s oncology drug candidate lisavanbulin (BAL101553), which has been developed as a potential therapy for glioblastoma, the most common type of primary brain cancer.1 Dr. Marc Engelhardt, Chief Medical Officer of Basilea, said: “Glioblastoma is one of the most lethal types of brain cancer and available therapeutic options are very limited. Partnering lisavanbulin with the Glioblastoma Foundation is important to us, as it enables patients to continue having access to this promising anticancer drug candidate, now that Basilea has changed its strategic focus to anti-infectives.” Dr. Gita Kwatra, Chief Executive Officer of the Glioblastoma Foundation, said: “We are delighted to partner with Basilea and take over the development of lisavanbulin for glioblastoma patients. Lisavanbulin has shown excellent activity against glioblastoma in PDX preclinical models as well as efficacy in phase 1 and 2 studies. We strongly believe that lisavanbulin will be effective in a subset of glioblastoma patients and we are looking forward to initiating clinical trials of lisavanbulin in the US.” Under the terms of the agreement, Basilea sells and transfers all rights to lisavanbulin to the Glioblastoma Foundation for an undisclosed initial purchase price. In addition, Basilea will participate in future proceeds from any potential commercial partnerships at a fixed double-digit percentage. The Glioblastoma Foundation will continue the post-trial access program for patients from previous clinical studies to continue to receive lisavanbulin. Also, the Glioblastoma Foundation will further explore the therapeutic value of lisavanbulin for the treatment of glioblastoma. About lisavanbulin (BAL101553) Lisavanbulin (BAL101553, the prodrug of BAL27862)2, has been investigated as a potential therapy for glioblastoma in clinical phase 1 and 2 studies.3, 4, 5 In preclinical studies, lisavanbulin demonstrated in-vitro and in-vivo activity against diverse treatment-resistant cancer models, including tumors refractory to conventional approved therapeutics and radiotherapy.6, 7, 8 Lisavanbulin efficiently distributes to the brain, with anticancer activity in glioblastoma models.9, 10 The active moiety, BAL27862, binds to the colchicine site of tubulin, with distinct effects on microtubule organization,11 resulting in the activation of the "spindle assembly checkpoint" which promotes tumor cell death.12 Lisavanbulin has been granted Orphan Drug Designation by the US Food and Drug Administration (FDA) for the treatment of malignant glioma (brain cancer), including glioblastoma. About Glioblastoma Foundation The mission of the Glioblastoma Foundation is to transform the standard of care for glioblastoma. It is based in Durham, North Carolina (USA) and supports the development of new drugs and other effective therapies for glioblastoma. Because each glioblastoma is different, it is likely that no one drug will work for everyone, and any therapies for glioblastoma will need to be targeted. The Glioblastoma Foundation supports the development of targeted therapies for glioblastoma. The organization also provides support for patients, and raises awareness of glioblastoma. For more information, please visit glioblastomafoundation.org. About Basilea Basilea is a commercial-stage biopharmaceutical company founded in 2000 and headquartered in Switzerland. We are committed to discovering, developing and commercializing innovative drugs to meet the needs of patients with severe bacterial and fungal infections. We have successfully launched two hospital brands, Cresemba for the treatment of invasive fungal infections and Zevtera for the treatment of bacterial infections. In addition, we have preclinical and clinical anti-infective assets in our portfolio. Basilea is listed on the SIX Swiss Exchange (SIX: BSLN). Please visit basilea.com. Disclaimer This communication expressly or implicitly contains certain forward-looking statements, such as "believe", "assume", "expect", "forecast", "project", "may", "could", "might", "will" or similar expressions concerning Basilea Pharmaceutica Ltd, Allschwil and its business, including with respect to the progress, timing and completion of research, development and clinical studies for product candidates. Such statements involve certain known and unknown risks, uncertainties and other factors, which could cause the actual results, financial condition, performance or achievements of Basilea Pharmaceutica Ltd, Allschwil to be materially different from any future results, performance or achievements expressed or implied by such forward-looking statements. Basilea Pharmaceutica Ltd, Allschwil is providing this communication as of this date and does not undertake to update any forward-looking statements contained herein as a result of new information, future events or otherwise. For further information, please contact: Peer Nils Schröder, PhD Head of Corporate Communications & Investor Relations Basilea Pharmaceutica International Ltd, Allschwil Hegenheimermattweg 167b 4123 Allschwil Switzerland Phone +41 61 606 1102 E-mail media_relations@basilea.com investor_relations@basilea.com This press release can be downloaded from . References B. M. Alexander, T. F. Cloughesy. Adult Glioblastoma. Journal of Clinical Oncology 2017 (35), 2402-2409 J. Pohlmann, F. Bachmann, A. Schmitt-Hoffmann et al. BAL101553: An optimized prodrug of the microtubule destabilizer BAL27862 with superior antitumor activity. Cancer Research 2011, 71 (8 supplement), abstract 1347 ClinicalTrials.gov identifier: NCT03250299 ClinicalTrials.gov identifier: NCT02895360; M. Joerger, T. Hundsberger, S. Haefliger et al. Safety and anti-tumor activity of lisavanbulin administered as 48-hour infusion in patients with ovarian cancer or recurrent glioblastoma: a phase 2a study. Investigational New Drugs 2023 (41), 267-275 ClinicalTrials.gov identifier: NCT02490800; J. S. Lopez, S. Häfliger, R. Plummer et al. Evaluation of response-predictive biomarkers for lisavanbulin: A phase II study in patients with recurrent glioblastoma. ESMO Open 2023, Vol 8, 1, Suppl 2, 100941. A. Sharma, A. Broggini-Tenzer, V. Vuong et al. The novel microtubule targeting agent BAL101553 in combination with radiotherapy in treatment-refractory tumor models. Radiotherapy Oncology 2017 (124), 433-438 G. E. Duran, H. Lane, F. Bachmann et al. In vitro activity of the novel tubulin active agent BAL27862 in MDR1(+) and MDR1(-) human breast and ovarian cancer variants selected for resistance to taxanes. Cancer Research 2010, 70 (8 supplement), abstract 4412 F. Bachmann, K. Burger, G. E. Duran et al. BAL101553 (prodrug of BAL27862): A unique microtubule destabilizer active against drug refractory breast cancers alone and in combination with trastuzumab. Cancer Research 2014, 74 (19 supplement), abstract 831 A. Schmitt-Hoffmann, D. Klauer, K. Gebhardt et al. BAL27862: a unique microtubule-targeted agent with a potential for the treatment of human brain tumors. Molecular Cancer Therapeutics 2009, 8 (12 supplement), C233 A. C. Mladek, J. L. Pokorny, H. Lane et al. The novel tubulin-binding 'tumor checkpoint controller' BAL101553 has anti-cancer activity alone and in combination treatments across a panel of GBM patient-derived xenografts. Cancer Research 2016, 76 (14 supplement), abstract 4781 A. E. Prota, F. Danel, F. Bachmann et al. The novel microtubule-destabilizing drug BAL27862 binds to the colchicine site of tubulin with distinct effects on microtubule organization. Journal of Molecular Biology 2014 (426), 1848-1860 F. Bachmann, K. Burger, H. Lane. BAL101553 (prodrug of BAL27862): the spindle assembly checkpoint is required for anticancer activity. Cancer Research 2015, 75 (15 supplement), abstract 3789 Press release (PDF)

孤儿药临床1期引进/卖出临床2期临床结果

2024-06-20

·Pharmaceutical Technology

Basilea sells rights to microtubule drug to Glioblastoma Foundation

Basilea joined an asset purchase agreement for its brain cancer therapy following a negative Phase II study. Credit: Taljat David via Shutterstock. Basilea has signed an asset purchase agreement with the Glioblastoma Foundation for the company’s glioblastoma candidate, lisavanbulin (BAL101553). Under the terms of the deal, Basilea will sell and transfer all rights for lisavanbulin to the charitable organisation for an undisclosed initial purchase cost. In the future, Basilea will continue to take part in any potential commercial partnerships at a fixed double-digit percentage. The Glioblastoma Foundation plans to take over lisavanbuilin’s post-access trial programme, allowing patients from previous clinical studies to continue receiving the drug. The charity will also oversee any further clinical studies investigating the use of lisavanbulin in glioblastoma. Lisavanbulin is a checkpoint inhibitor that binds to tubulin, which blocks the cell cycle and triggers cell death in cancer cells. The company was developing the drug for brain cancer, and the drug even received an US Food and Drug Administration orphan drug designation in 2021 for the treatment of malignant glioma, a type of brain cancer. However, after a disappointing Phase I/II trial (NCT02490800) readout, the Swiss pharmaceutical company decided not to expand the glioblastoma patient cohort for lisavanbulin in 2022. In the open-label study of nine patients with measurable disease at stage one, one patient demonstrated a partial response to lisavanbulin whilst another showed a 44% target lesion area reduction, as per an American Society of Clinical Oncology 2023 abstract. However, despite sustained activity in these subjects, they were unable to meet formal stage transition criteria leading to an early study completion. Glioblastomas are fast-growing brain tumours that are commonly treated through surgery radiotherapy and chemotherapy. According to the American Brain Tumor Association, glioblastomas make up approximately 14% of all primary brain tumors, with 12,000 cases diagnosed each year in the US. See Also: AZD-1705 by AstraZeneca for Dyslipidemia: Likelihood of Approval Sabestomig by AstraZeneca for Crohn’s Disease (Regional Enteritis): Likelihood of Approval In a 20 June press release, Dr Gita Kwatra, the Glioblastoma Foundation’s CEO, said, “We strongly believe that lisavanbulin will be effective in a subset of glioblastoma patients and we are looking forward to initiating clinical trials of lisavanbulin in the US.” The recent announcement marks Basilea’s second publicly declared deal of 2024. In January 2024, the company signed an agreement with Spexis to acquire its preclinical antibiotics programme. Before this, in October 2024, Basilea sought out a partner for its antibiotic ceftobiprole.

孤儿药临床结果临床2期ASCO会议

2023-11-13

·FierceBiotech

Basilea continues pipeline fill-up by paying Pfizer $37M for Amplyx antifungal

A deal with Pfizer follows a busy few weeks that saw Basilea Pharmaceutica acquire an invasive mold infection drug from Gravitas Therapeutics and an endolysin antibacterial from Tonabacase. Only two and a half years after Pfizer acquired infectious disease biotech Amplyx for an undisclosed sum, the Big Pharma has sold the lead antifungal asset from that deal to Basilea Pharmaceutica. In its third deal in a month, Basilea is handing over $37 million upfront for the rights to the broad-spectrum antifungal, called fosmanogepix, as well as the rights to a preclinical antifungal compound. Today’s deal means the Swiss biotech will be liable to pay up to $110 million to Pfizer in commercial milestones should the drug reach the market. Basilea is also taking on the obligations and rights from previous agreements for the drug, which add up to $396 million in various development, regulatory and commercial milestone payments. Fosmanogepix has remained in phase 2 development for the treatment of a fungal disease called candidemia and invasive mold infections since Amplyx came under Pfizer’s wing, but Basilea plans to kick-start a phase 3 trial in mid-2024. Pfizer will retain the right of first negotiation for the commercial license to fosmanogepix if it clears phase 3 trials. It won’t be Basilea’s first interaction with Pfizer, however—the Big Pharma secured the Europe rights to Basilea’s approved antifungal Cresemba back in 2017 and also has the license in China. Basilea CEO David Veitch hailed today’s deal as a “transformative transaction for us.” As well as Cresemba, the company also owns the antibiotic Zevtera, and Veitch said gaining fosmanogepix “provides a strong commercial near-term opportunity beyond our currently marketed anti-infectives.” It follows a busy few weeks of dealmaking that saw Basilea acquire an invasive mold infection drug from Gravitas Therapeutics and an endolysin antibacterial from South Korea’s Tonabacase. “We have now executed three transactions over the course of the last few weeks that have significantly strengthened our clinical-stage portfolio, and we continue to see interesting opportunities for further transactions in the future,” Veitch added. The recent deals are the latest example of Basilea’s pivot away from oncology to focus solely on anti-infectives, a move that got off to a bumpy start at the beginning of the year when preclinical profiling of an antifungal program purchased from Fox Chase Chemical Diversity Center for an undisclosed fee led the company to hand the asset back. The terminated agreement was part of an overall restructuring at Basilea that also included the decision not to expand studies for lisavanbulin, a tumor checkpoint controller. Instead, the restructured company pivoted from oncology to focus solely on anti-infectives, such as Zevtera, which is already marketed in Europe and is now awaiting an FDA decision.

引进/卖出并购临床2期

100 项与 Lisavanbulin 相关的药物交易

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外链

KEGG	Wiki	ATC	Drug Bank
D11494	-	-	DB15224

研发状态

10 条进展最快的记录,

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适应症	最高研发状态	国家/地区	公司	日期
肿瘤	临床2期	瑞士	Basilea Pharmaceutica AG	2016-08-01
高级别胶质瘤	临床2期	比利时	Basilea Pharmaceutica AG	2015-05-20
高级别胶质瘤	临床2期	德国	Basilea Pharmaceutica AG	2015-05-20
高级别胶质瘤	临床2期	瑞士	Basilea Pharmaceutica AG	2015-05-20
高级别胶质瘤	临床2期	英国	Basilea Pharmaceutica AG	2015-05-20
复发性胶质母细胞瘤	临床2期	比利时	Basilea Pharmaceutica AG	2015-05-20
复发性胶质母细胞瘤	临床2期	德国	Basilea Pharmaceutica AG	2015-05-20
复发性胶质母细胞瘤	临床2期	瑞士	Basilea Pharmaceutica AG	2015-05-20
复发性胶质母细胞瘤	临床2期	英国	Basilea Pharmaceutica AG	2015-05-20
晚期恶性实体瘤	临床2期	英国	Basilea Pharmaceutica AG	2011-06-01

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临床结果

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分期

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


NCT03250299 (ABTC1601, ASCO2023) 人工标引	临床1期	胶质母细胞瘤一线 MGMT Promoter Methylation Negative	26	Lisavanbulin	憲範觸齋醖選壓壓膚淵(積夢選網網觸襯衊鏇淵) = 觸餘糧遞衊鏇簾築遞淵顧簾積壓顧鏇艱繭鏇憲 (窪壓鏇齋齋壓蓋鹹膚網 ) 更多	积极	2023-05-26
NCT02895360 (Pubmed)	临床2期	卵巢癌 \| 复发性胶质母细胞瘤	43	Lisavanbulin 70 mg/m2	襯築壓簾襯鏇願選醖顧(夢夢觸壓範繭構糧構簾) = Thirteen patients (56.5%) developed 49 adverse events assessed as related to study treatment. The majority were mild or moderate; four were grade 3/4. Sixteen SAEs were reported in nine patients (39.1%), with none considered related to study treatment. No AEs led to permanent treatment discontinuation. 醖範夢觸築襯衊廠襯構 (餘選積蓋襯衊糧醖蓋構 )	-	2023-02-16
NCT02490800 (ASCO2021)	临床2期	复发性胶质母细胞瘤	71	Lisavanbulin	窪繭獵鑰獵築鏇齋膚膚(築襯蓋夢鏇積衊遞構鏇) = Both patients show strong end-binding protein 1 (EB1) expression in their GB tissues as assessed by immunohistochemistry staining 艱簾網鬱獵鏇齋艱鏇淵 (鏇淵艱衊簾獵遞鏇鏇獵 ) 更多	-	2021-05-28
NCT02490800 (ESMO2020)	临床1期	复发性胶质瘤	28	Lisavanbulin	觸構窪夢憲範願窪網壓(願鏇淵餘醖網築積壓醖) = 顧蓋網衊築憲選構繭鏇獵獵糧齋餘淵願鑰壓獵 (鏇齋積積憲獵鏇齋憲蓋 ) 更多	积极	2020-09-17
NCT02895360 (Pubmed \| Invest New Drugs)	临床1期	HR阳性/HER2低表达实体瘤	43	BAL101553	願觸憲顧蓋鹹構糧觸醖(艱憲顧淵壓餘衊廠齋範) = 願糧蓋觸鬱襯鹽壓選廠淵獵蓋簾糧淵願範鏇壓 (襯遞憲觸淵衊襯齋夢構 )	-	2020-08-01
NCT02895360 (ASCO2018)	临床1/2期	HR阳性/HER2低表达实体瘤	20	BAL101553	餘糧遞憲膚範糧糧選餘(餘顧選憲鬱網鏇鏇繭襯) = Adverse events (AEs) were assessed by CTCAEv4.03 grade (G) 淵遞構蓋願淵觸鏇顧鹹 (艱選鏇鑰顧積鬱鏇鹹艱 )	-	2018-06-01
NCT02490800 (ASCO2018)	临床1/2期	HR阳性/HER2低表达实体瘤	26	BAL101553	遞艱遞齋範鬱醖選構獵(繭鑰憲淵艱艱範鬱構鑰) = BAL101553 was generally well tolerated at doses ≤16 mg, with one G3 event of increased alkaline phosphatase not considered clinically significant and G1/G2 events that did not show organ-specific patterns. Dose-limiting toxicities were seen at doses ≥20 mg: G3–4 hyponatremia, G3 hypokalemia and G2 hallucinations (all reversible) 壓網鬱鑰艱鑰衊窪襯糧 (窪積選積鑰簾壓製觸範 )	-	2018-06-01
NCT02490800 (ASCO2017)	临床1/2期	HR阳性/HER2低表达实体瘤	19	BAL101553	膚網窪網選簾遞網願築(淵構簾選鑰衊簾艱餘夢) = 醖鏇鏇鑰襯鹹壓壓壓衊壓選簾選繭顧鑰製齋窪 (壓鏇範蓋遞壓製齋齋鬱 ) 更多	-	2017-05-30
AACR2014	临床1期	乳腺癌	-	BAL101553	齋網鹹齋繭廠壓餘襯遞(餘獵鏇範製顧襯窪淵鹹) = 鏇繭膚糧鏇壓簾鑰鏇構構鹹膚蓋遞憲觸鹹積簾 (窪顧糧鹹製壓觸齋獵齋 ) 更多	积极	2014-10-01
AACR2014	临床1期	乳腺癌	-	Combination of BAL101553 and Trastuzumab	簾糧鑰淵蓋壓鬱觸簾艱(網願觸襯鏇繭廠襯齋網) = 積廠觸鬱築鏇鏇鏇製獵壓獵積淵餘築遞願膚築 (窪顧範築遞鏇鑰蓋積顧 )	积极	2014-10-01