预约演示
更新于：2026-02-26
Fenoterol Hydrobromide
氢溴酸非诺特罗
更新于：2026-02-26
概要
基本信息
药物类型 小分子化药 |
别名 1-(3,5-dihydroxyphenyl)-1-hydroxy-2-((4-hydroxyphenyl)isopropylamino)ethane、1-(p-hydroxyphenyl)-2-((β-hydroxy-β-(3',5'-dihydroxyphenyl))ethyl)aminopropane、3,5-dihydroxy-α-(((p-hydroxy-α-methylphenethyl)amino)methyl)benzyl alcohol + [13] |
作用方式 激动剂 |
作用机制 β2-adrenergic receptor激动剂(β2-肾上腺素能受体激动剂) |
非在研适应症- |
原研机构- |
权益机构- |
最高研发阶段批准上市 |
最高研发阶段(中国)- |
特殊审评- |
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结构/序列
分子式C17H22BrNO4 |
InChIKeySGZRQMALQBXAIQ-UHFFFAOYSA-N |
CAS号1944-12-3 |
关联
9
项与 氢溴酸非诺特罗 相关的临床试验NCT05294965
Beta 2 Adrenergic Stimulation vs Cold Exposure to Activate Human Brown Adipose Tissue
NCT03910985
Assessment of Reactance Parameters Measured by the Forced Oscillation Technique for the Bronchodilator Response in Subjects With Chronic Obstructive Pulmonary Disease (COPD)
NCT02054299
Effects of Genetic Polymorphisms in the Organic Cation Transporter OCT1 on Cellular Uptake and Metabolism of Antidepressants and Other Organic Cationic Drugs
100 项与 氢溴酸非诺特罗 相关的临床结果
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100 项与 氢溴酸非诺特罗 相关的转化医学
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100 项与 氢溴酸非诺特罗 相关的专利（医药）
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2,051
项与 氢溴酸非诺特罗 相关的文献（医药）2026-04-01JOURNAL OF CHROMATOGRAPHY A
A new HPTLC-image analysis approach for assessing interactions and antioxidant profiles of adrenergic drugs
Article
作者: Casoni, Dorina ; Cimpoiu, Claudia ; Silveșan, Larisa
This study proposes a new approach for the in-vitro evaluation of antioxidant profile of adrenergic drugs using high-performance thin-layer chromatography coupled with image analysis techniques (HPTLC-IA). In this regard, stationary phases of different polarity (Silica gel and RP-8, RP-18 W, CN and DIOL) were selected to simulate different environments and interactions that adrenergic drugs might encounter in the human body. Antioxidant activity was quantified using both DPPH• and ABTS⁺• radical scavenging assays on all five stationary phases. Image processing and analysis was used to quantitatively compare the free radical scavenging potential of the analyzed compounds after converting the RGB image into different color channels, namely the green channel for the DPPH test, and the red channel for ABTS. Chromatographic data were processed using multivariate analysis. Results revealed that highly polar compounds, that is norepinephrine, etilefrine, metaraminol and midodrine exhibited strong interactions with silica gel but limited retention on reversed-phase, while lipophilic derivatives, namely naphazoline, xylometazoline, clenbuterol and bambuterol demonstrated strong affinity for non-polar and moderately polar phases, predicting good membrane penetration and blood-brain barrier permeability. Interestingly, some β-agonists (bambuterol, fenoterol, buphenine and irsoxsuprine) with polar groups showed unexpectedly weak silica gel retention, highlighting their dominant lipophilic contributions. Regarding the antioxidant activity, the results showed that phase interactions with the stationary phase significantly influenced the activity of adrenergic drugs. Thus, the polar phases (silica gel, DIOL) enhanced radical scavenging activity, whereas non-polar phases often reduced it. The developed HPTLC-IA method, integrating selective stationary phases and two-radical assays, offers a novel and cost-effective approach for screening the possible variation of antioxidant activity of drugs after their interaction with physiological media constituents.
2026-04-01ANALYTICA CHIMICA ACTA
SERS fingerprinting of β2-agonists for anti-doping based on Au–COF substrate
Article
作者: Liu, Siqing ; Li, Xingju ; Lin, Ruxi ; Chen, Liping ; Luo, Xiaojun ; Zhang, Yunxin
BACKGROUND:
β2-agonists, also known as β2-adrenoceptor agonists, are secreted by the adrenal medulla of the animal body and have a characteristic catecholamine structure. When inhaled, the drug rapidly relaxes the smooth muscles of the airways in asthma patients, improves ventilation, and temporarily increases alertness during exercise and helps relieve fatigue. However, the use of β2-agonists to improve physical performance in a short period of time can lead to extreme dependence and irritation, and there are still many unknown hazards. They are now on the World Anti-Doping Organization (WADA) prohibited list.
RESULTS:
Surface-enhanced Raman spectroscopy (SERS) can directly detect the characteristic peaks associated with β2-agonist compounds in a fast and sensitive manner. This study is the first to utilize a direct Raman detection technique, achieving successful acquisition of the fingerprint spectra of three target analytes (vilanterol, fenoterol, bambuterol) as well as the establishment of a corresponding fingerprint spectral analysis method. To further improve its performance, in this study, gold nanoparticles were synthesized via redox methods and integrated with covalent organic framework (COF) to construct a novel highly sensitive detection platform for β2-agonists. The Au-COF composite exhibits high adsorption performance and can significantly enhance the SERS signal of the target, thereby achieving low detection limits, including 9.25 × 10-6 g ·mL-1 for bambuterol, 9.76 × 10-6 g mL-1 for vilanterol, and 7.54 × 10-6 g·mL-1 for fenoterol, which makes it promising for improving the overall sensitivity of β2-agonist detection.
SIGNIFICANCE:
This study develops a novel analytical method utilizing Au-COF composites for highly sensitive SERS detection. It pioneers the application of this strategy in the qualitative and quantitative analysis of trace β2-agonists. The research not only significantly expands the scope of Au-COF composites but also provides a technologically promising approach with substantial practical value for ensuring medical safety through clinical medication monitoring and for detecting banned substances in sports.
2026-03-30RAPID COMMUNICATIONS IN MASS SPECTROMETRY
Investigation of In‐Trap High‐Energy Collision Dissociation Methodology and Dissociation Conditions Using Dual‐Pressure Linear Ion Trap Mass Spectrometry
Article
作者: Xu, Heyi ; Yang, Guang ; Liu, Meiying ; Yao, Li ; Qu, Ziyu ; Xie, Jie ; Zhang, Di ; Fang, Xiang ; Jiang, You
ABSTRACT:
Rationale:
Dissociation is a critical analytical method in mass spectrometry research. Among various dissociation techniques, higher energy collision dissociation (HCD) stands out as a pivotal tool due to its ability to generate more low‐mass fragment ions and directly perform dissociation during mass spectrometric detection. However, existing HCD implementations rely on specialized instrument configurations, such as collision cell structures or triple quadrupole mass spectrometers, which inevitably increase instrument development costs and technical complexity. To address this limitation, this study proposes an HCD method based on dual‐pressure linear ion trap mass spectrometry that requires no additional hardware modifications.
Methods:
Instead, it achieves HCD solely by optimizing the instrument's gas flow system and control parameters. By employing a nitrogen‐helium gas mixture as the collision gas and testing with a reserpine standard sample, optimal dissociation conditions were obtained through adjustments to the gas mixture ratio and ion trap DC offset voltage settings.
Results:
This approach successfully realizes in‐trap HCD directly within the dual‐pressure linear ion trap, eliminating the need for a dedicated collision cell. Furthermore, it enables HCD‐based MS3 functionality, a capability unavailable in traditional triple quadrupole systems.
Conclusions:
Validation experiments using veterinary drug residues fenoterol and ractopamine demonstrated the method's universality by comparing its dissociation results with those from conventional ion trap collision‐induced dissociation (CID) and triple quadrupole method. The findings confirm that this strategy can be extended to other ion trap mass spectrometry platforms, offering broader applicability.
100 项与 氢溴酸非诺特罗 相关的药物交易
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研发状态
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 慢性支气管炎 | 日本 | 1999-03-15 | |
| 尘肺病 | 日本 | 1999-03-15 | |
| 肺气肿 | 日本 | 1999-03-15 | |
| 哮喘 | - | - | 1971-01-01 |
| 慢性阻塞性肺疾病 | - | - | 1971-01-01 |
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