In the method described here, an aliquot of a urine sample is analyzed to detect barbiturates through dilution and ultra-high-performance chromatography-tandem mass spectrometry (UPLC-MS/MS) using deuterated internal standards. This assay detects the presence of nine barbiturate drugs-amobarbital, barbital, butalbital, butabarbital, mephobarbital, secobarbital, pentobarbital, phenobarbital, and thiopental. This protocol describes two LC separation methods-first LC method (2.2 min/sample) is intended to be used as a first step of the analysis that does not separate amobarbital and pentobarbital, and a second, longer (2.7 min/sample) LC method is intended to be used only for samples which have a peak in the amobarbital/pentobarbital retention time on the shorter LC method. Since the frequency at which amobarbital and pentobarbital are observed in clinical populations is low, the shorter LC method helps gain efficiency in a high-volume laboratory environment. Additional features of this protocol that help in efficiency gain are automated extraction using Hamilton™ liquid handling system and algorithmic data review using Ascent™ software.

2024-01-01·Methods in molecular biology (Clifton, N.J.)

High-Throughput Quantitative LC-MS/MS Analysis of Barbiturates in Human Urine

Article

作者: Gqamana, Putuma P ; Victoria Zhang, Y

We hereby present a fast, high-throughput, and clinical LC-MS/MS assay for the simultaneous analysis of barbiturates in human urine. It is deployed as a quantitative assay for phenobarbital, butalbital, pentobarbital/amobarbital, and secobarbital, as well as for confirmations following positive immunoassay drug screens in patient urine. Briefly, urine specimens are processed via dilute and shoot, i.e., by mixing the sample with 20 times volume of internal standard reagent and injecting 50 μL of that mixture into the analytical instrument. Chromatographic separation is performed using a reversed-phase C18 column in a mobile-phase system doped with <1 mM ammonium fluoride. Mass spectrometric detection occurs via negative-mode electrospray ionization multiple reaction monitoring in the TSQ Quantiva triple-quadrupole instrument. All the analytes in the mixture are detected and quantified simultaneously with respect to internal calibration in the range 20-2500 ng/mL. However, the assay cannot distinguish pentobarbital from amobarbital, which are isobaric analytes. Nonetheless, the assay is sensitive, robust, and amenable to harmonization with other assays that employ barbiturate cutoffs in the range of 20-150 ng/mL.

2024-01-01·The Journal of veterinary medical science

Assessment of thiamylal sodium as a euthanasia drug in mice

Article

作者: TAKIMOTO, Hayato R ; HASHIMOTO, Kazuki ; NIKAIDO, Yuko ; SASAKI, Nobuya ; WATANABE, Masaki ; ISHII, Yuki

Euthanasia agents should rapidly induce death and loss of consciousness without causing pain or distress. Various methods exist for the euthanasia of laboratory animals, and injectable anesthetics, particularly barbiturate derivatives, are widely used due to the rapid onset of unconsciousness induced by these agents. Moreover, pharmaceutical-grade drugs should be used to eliminate undesirable side effects as much as possible. However, in Japan, the sale of pharmaceutical-grade pentobarbital sodium (PB) ended in 2019, and that of secobarbital sodium (SB) ended in 2023, leading to a demand for new pharmaceutical-grade injectable euthanasia drugs. This study evaluates thiamylal sodium (TM), a barbiturate derivative that is available domestically, as a euthanasia agent for mice. The results showed that when administered at dosages of 200 mg/kg or more, TM exhibited effects equivalent to those of PB and SB. In addition, the impact of TM administration on hematological characteristics was examined. In female mice administered TM, decreased blood chloride and calcium levels and increased aspartate aminotransferase and alanine aminotransferase levels, which are markers of liver damage, were observed. These findings suggest that high concentrations of TM may affect renal and liver function. This study revealed that TM is effective as a euthanasia agent at dosages of 200 mg/kg or more. However, considering the potential risks of renal and liver damage due to TM administration, it may be preferable to use alternative euthanasia drugs when these risks could affect the objectives or outcomes of the research.

项与司可巴比妥钠相关的新闻（医药）

2023-06-25

·药闻康策

我国管制毒品目录大全

☝ 点击上方一键预约 ☝ 最新最热的医药健康新闻政策根据刑法、禁毒法的规定，毒品是指鸦片、海洛因、甲基苯丙胺（冰毒）、吗啡、大麻、可卡因，以及国家规定管制的其他能够使人形成瘾癖的麻醉药品和精神药品。我国现已列管449种麻醉品、精神物质（121种麻醉药品、154种精神药品、174种非药用类麻醉药品和精神药品），整类列管芬太尼类物质、合成大麻素类物质，是世界上列管毒品最多、管制最严的国家。一、《麻醉药品品种目录》（2013年版）【121种】序号中文名英文名CAS号备注1醋托啡Acetorphine25333-77-12乙酰阿法甲基芬太尼Acetyl-alpha-methylfentanyl101860-00-83醋美沙多Acetylmethadol509-74-04阿芬太尼Alfentanil71195-58-95烯丙罗定Allylprodine25384-17-26阿醋美沙多Alphacetylmethadol17199-58-57阿法美罗定Alphameprodine468-51-98阿法美沙多Alphamethadol17199-54-19阿法甲基芬太尼Alpha-methylfentanyl79704-88-410阿法甲基硫代芬太尼Alpha-methylthiofentanyl103963-66-211阿法罗定Alphaprodine77-20-312阿尼利定Anileridine144-14-913苄替啶Benzethidine3691-78-914苄吗啡Benzylmorphine36418-34-515倍醋美沙多Betacetylmethadol17199-59-616倍他羟基芬太尼Beta-hydroxyfentanyl78995-10-517倍他羟基-3-甲基芬太尼Beta-hydroxy-3-methylfentanyl78995-14-918倍他美罗定Betameprodine468-50-819倍他美沙多Betamethadol17199-55-220倍他罗定Betaprodine468-59-721贝齐米特Bezitramide15301-48-122大麻和大麻树脂与大麻浸膏和酊Cannabis and Cannabis Resin and Extracts and Tinctures of Cannabis8063-14-76465-30-1 23氯尼他秦Clonitazene3861-76-524古柯叶Coca Leaf25可卡因*Cocaine50-36-226可多克辛Codoxime7125-76-027罂粟浓缩物*Concentrate of Poppy Straw包括罂粟果提取物*，罂粟果提取物粉*28地索吗啡Desomorphine427-00-929右吗拉胺Dextromoramide357-56-230地恩丙胺Diampromide552-25-031二乙噻丁Diethylthiambutene86-14-632地芬诺辛Difenoxin28782-42-533二氢埃托啡*Dihydroetorphine14357-76-734双氢吗啡Dihydromorphine509-60-435地美沙多Dimenoxadol509-78-436地美庚醇Dimepheptanol545-90-437二甲噻丁Dimethylthiambutene524-84-538吗苯丁酯Dioxaphetyl Butyrate467-86-739地芬诺酯*Diphenoxylate915-30-040地匹哌酮Dipipanone467-83-441羟蒂巴酚Drotebanol3176-03-242芽子碱Ecgonine481-37-843乙甲噻丁Ethylmethylthiambutene441-61-244依托尼秦Etonitazene911-65-945埃托啡Etorphine14521-96-146依托利定Etoxeridine469-82-947芬太尼*Fentanyl437-38-748呋替啶Furethidine2385-81-149海洛因Heroin561-27-350氢可酮*Hydrocodone125-29-151氢吗啡醇Hydromorphinol2183-56-452氢吗啡酮*Hydromorphone466-99-953羟哌替啶Hydroxypethidine468-56-454异美沙酮Isomethadone466-40-055凯托米酮Ketobemidone469-79-456左美沙芬Levomethorphan125-70-257左吗拉胺Levomoramide5666-11-558左芬啡烷Levophenacylmorphan10061-32-259左啡诺Levorphanol77-07-660美他佐辛Metazocine3734-52-961美沙酮*Methadone76-99-362美沙酮中间体Methadone Intermediate125-79-14-氰基-2-二甲氨基-4,4-二苯基丁烷63甲地索啡Methyldesorphine16008-36-964甲二氢吗啡Methyldihydromorphine509-56-8653-甲基芬太尼3-Methylfentanyl42045-86-3663-甲基硫代芬太尼3-Methylthiofentanyl86052-04-267美托酮Metopon143-52-268吗拉胺中间体Moramide Intermediate3626-55-92-甲基-3-吗啉基-1,1-二苯基丁酸69吗哌利定Morpheridine469-81-870吗啡*Morphine57-27-2包括吗啡阿托品注射液*71吗啡甲溴化物Morphine Methobromide125-23-5包括其他五价氮吗啡衍生物，特别包括吗啡-Ｎ-氧化物，其中一种是可待因-Ｎ-氧化物72吗啡-N-氧化物Morphine-N-oxide639-46-3731-甲基-4-苯基-4-哌啶丙酸酯1-Methyl-4-phenyl-4-piperidinol propionate (ester)13147-09-6MPPP74麦罗啡Myrophine467-18-575尼可吗啡Nicomorphine639-48-576诺美沙多Noracymethadol1477-39-077去甲左啡诺Norlevorphanol1531-12-078去甲美沙酮Normethadone467-85-679去甲吗啡Normorphine466-97-780诺匹哌酮Norpipanone561-48-881阿片*Opium8008-60-4包括复方樟脑酊*、阿桔片*82奥列巴文Oripavine467-04-983羟考酮*Oxycodone76-42-584羟吗啡酮Oxymorphone76-41-585对氟芬太尼Para-fluorofentanyl90736-23-586哌替啶*Pethidine57-42-187哌替啶中间体APethidine Intermediate A3627-62-14-氰基-1-甲基-4-苯基哌啶88哌替啶中间体BPethidine Intermediate B77-17-84-苯基哌啶-4-羧酸乙酯89哌替啶中间体CPethidine Intermediate C 3627-48-31-甲基-4-苯基哌啶-4-羧酸90苯吗庚酮Phenadoxone467-84-591非那丙胺Phenampromide129-83-992非那佐辛Phenazocine127-35-5931-苯乙基-4-苯基-4-哌啶乙酸酯1-Phenethyl-4-phenyl-4-piperidinol acetate (ester)64-52-8PEPAP94非诺啡烷Phenomorphan468-07-595苯哌利定Phenoperidine562-26-596匹米诺定Piminodine13495-09-597哌腈米特Piritramide302-41-098普罗庚嗪Proheptazine77-14-599丙哌利定Properidine561-76-2100消旋甲啡烷Racemethorphan510-53-2101消旋吗拉胺Racemoramide545-59-5102消旋啡烷Racemorphan297-90-5103瑞芬太尼*Remifentanil132875-61-7104舒芬太尼*Sufentanil56030-54-7105醋氢可酮Thebacon466-90-0106蒂巴因*Thebaine115-37-7107硫代芬太尼Thiofentanyl1165-22-6108替利定Tilidine20380-58-9109三甲利定Trimeperidine64-39-1110醋氢可待因Acetyldihydrocodeine3861-72-1111可待因*Codeine76-57-3112右丙氧芬*Dextropropoxyphene469-62-5113双氢可待因*Dihydrocodeine125-28-0114乙基吗啡*Ethylmorphine76-58-4115尼可待因Nicocodine3688-66-2116烟氢可待因 Nicodicodine808-24-2117去甲可待因Norcodeine467-15-2118福尔可定*Pholcodine509-67-1119丙吡兰Propiram15686-91-6120布桂嗪*Bucinnazine121罂粟壳*Poppy Shell注：1.上述品种包括其可能存在的盐和单方制剂（除非另有规定）。2.上述品种包括其可能存在的异构体、酯及醚（除非另有规定）。3.品种目录有*的麻醉药品为我国生产及使用的品种。二、《精神药品品种目录》（2013年版）【149种】第一类序号中文名英文名CAS号备注1布苯丙胺Brolamfetamine64638-07-9DOB2卡西酮Cathinone71031-15-73二乙基色胺3-[2-(Diethylamino)ethyl]indole7558-72-7DET4二甲氧基安非他明(±)-2,5-Dimethoxy-alpha-methylphenethylamine2801-68-5DMA5(1,2-二甲基庚基）羟基四氢甲基二苯吡喃3-(1,2-dimethylheptyl)-7,8,9,10-tetrahydro-6,6,9-trimethyl-6Hdibenzo[b,d]pyran-1-ol32904-22-6DMHP6二甲基色胺3-[2-(Dimethylamino)ethyl]indole61-50-7DMT7二甲氧基乙基安非他明(±)-4-ethyl-2,5-dimethoxy-α-methylphenethylamine22139-65-7DOET8乙环利定Eticyclidine2201-15-2PCE9乙色胺Etryptamine2235-90-710羟芬胺(±)-N-[alpha-methyl-3,4-(methylenedioxy)phenethyl]hydroxylamine74698-47-8N-hydroxy MDA11麦角二乙胺(+)- Lysergide 50-37-3LSD12乙芬胺(±)-N-ethyl-alpha-methyl-3,4-(methylenedioxy)phenethylamine82801-81-8N-ethyl MDA13 二亚甲基双氧安非他明(±)-N,alpha-dimethyl-3,4-(methylene-dioxy)phenethylamine42542-10-9MDMA14麦司卡林Mescaline54-04--615 甲卡西酮 Methcathinone 5650-44-2 (右旋体)，49656-78-2(右旋体盐酸盐)，112117-24-5(左旋体)，66514-93-0(左旋体盐酸盐).16甲米雷司4-Methylaminorex3568-94-317甲羟芬胺5-methoxy-α-methyl- 3,4-(methylenedioxy) phenethylamine13674-05-0MMDA184-甲基硫基安非他明4-Methylthioamfetamine14116-06-419六氢大麻酚Parahexyl117-51-120副甲氧基安非他明P-methoxy-alpha-methylphenethylamine64-13-1PMA21赛洛新Psilocine520-53-622赛洛西宾Psilocybine520-52-523咯环利定Rolicyclidine2201-39-0PHP24二甲氧基甲苯异丙胺2,5-Dimethoxy-alpha,4-dimethylphenethylamine15588-95-1STP 25替苯丙胺Tenamfetamine4764-17-4MDA26替诺环定Tenocyclidine21500-98-1TCP27四氢大麻酚Tetrahydrocannabinol包括同分异构体及其立体化学变体28三甲氧基安非他明(±)-3,4,5-Trimethoxy-alpha-methylphenethylamine1082-88-8TMA29苯丙胺Amfetamine300-62-930氨奈普汀Amineptine57574-09-1312,5-二甲氧基-4-溴苯乙胺4-Bromo-2,5-dimethoxyphenethylamine66142-81-22-CB32右苯丙胺Dexamfetamine51-64-933屈大麻酚Dronabinol1972-08-3δ-9-四氢大麻酚及其立体化学异构体34芬乙茶碱Fenetylline3736-08-135左苯丙胺Levamfetamine156-34-336左甲苯丙胺Levomethamfetamine33817-09-337甲氯喹酮Mecloqualone340-57-838去氧麻黄碱Metamfetamine537-46-239去氧麻黄碱外消旋体Metamfetamine Racemate7632-10-240甲喹酮Methaqualone72-44-641哌醋甲酯*Methylphenidate113-45-142苯环利定Phencyclidine77-10-1PCP43芬美曲秦Phenmetrazine134-49-644司可巴比妥*Secobarbital76-73-345齐培丙醇Zipeprol34758-83-346安非拉酮Amfepramone90-84-647苄基哌嗪Benzylpiperazine2759-28-6BZP48丁丙诺啡*Buprenorphine52485-79-7491-丁基-3-(1-萘甲酰基)吲哚1-Butyl-3-(1-naphthoyl)Indole208987-48-8JWH-07350恰特草Catha edulis ForsskKhat512,5-二甲氧基-4-碘苯乙胺2,5-Dimethoxy-4-iodophenethylamine69587-11-72C-I522,5-二甲氧基苯乙胺2,5-Dimethoxyphenethylamine3600-86-02C-H53二甲基安非他明Dimethylamfetamine4075-96-154依他喹酮Etaqualone7432-25-955[1-(5-氟戊基)-1H-吲哚-3- 基](2-碘苯基)甲酮(1-(5-Fluoropentyl)-3-(2-iodobenzoyl) indole)335161-03-0AM-694 561-(5-氟戊基)-3-(1-萘甲酰基)-1H-吲哚1-(5-Fluoropentyl)-3-(1-naphthoyl)indole335161-24-5AM-220157γ-羟丁酸*Gamma-hydroxybutyrate591-81-1GHB58氯胺酮*Ketamine6740-88-159马吲哚*Mazindol22232-71-9602-(2-甲氧基苯基)-1-(1-戊基-1H-吲哚-3-基)乙酮2-(2-Methoxyphenyl) -1-(1-pentyl-1H-indol-3-yl)ethanone864445-43-2JWH-25061亚甲基二氧吡咯戊酮Methylenedioxypyrovalerone687603-66-3MDPV624-甲基乙卡西酮4-Methylethcathinone1225617-18-44-MEC634-甲基甲卡西酮4-Methylmethcathinone5650-44-24-MMC643,4-亚甲二氧基甲卡西酮3,4-Methylenedioxy-N-methylcathinone186028-79-5Methylone65莫达非尼Modafinil68693-11-8661-戊基-3-(1-萘甲酰基)吲哚1-Pentyl-3- (1-naphthoyl) indole209414-07-3JWH-01867他喷他多Tapentadol175591-23-868三唑仑*Triazolam28911-01-5第二类序号中文名英文名CAS号备注1异戊巴比妥*Amobarbital57-43-22布他比妥Butalbital77-26-93去甲伪麻黄碱Cathine492-39-74环己巴比妥Cyclobarbital52-31-35氟硝西泮Flunitrazepam1622-62-46格鲁米特*Glutethimide77-21-47喷他佐辛*Pentazocine55643-30-68戊巴比妥*Pentobarbital76-74-49阿普唑仑*Alprazolam28981-97-710阿米雷司Aminorex2207-50-311巴比妥*Barbital57-44-312苄非他明Benzfetamine156-08-113溴西泮Bromazepam1812-30-214溴替唑仑Brotizolam57801-81-715丁巴比妥Butobarbital77-28-116卡马西泮Camazepam36104-80-017氯氮䓬Chlordiazepoxide58-25-318氯巴占Clobazam22316-47-819氯硝西泮*Clonazepam1622-61-320氯拉䓬酸Clorazepate23887-31-221氯噻西泮Clotiazepam33671-46-422氯噁唑仑Cloxazolam24166-13-023地洛西泮Delorazepam2894-67-924地西泮*Diazepam439-14-5　安定25艾司唑仑*Estazolam29975-16-426乙氯维诺Ethchlorvynol113-18-827炔己蚁胺Ethinamate126-52-328氯氟䓬乙酯Ethyl Loflazepate 29177-84-229乙非他明Etilamfetamine457-87-430芬坎法明Fencamfamin1209-98-931芬普雷司Fenproporex16397-28-732氟地西泮Fludiazepam3900-31-033氟西泮*Flurazepam17617-23-134哈拉西泮Halazepam23092-17-335卤沙唑仑Haloxazolam59128-97-136凯他唑仑Ketazolam27223-35-437利非他明Lefetamine7262-75-1 SPA38氯普唑仑Loprazolam61197-73-739劳拉西泮*Lorazepam846-49-140氯甲西泮Lormetazepam848-75-941美达西泮Medazepam2898-12-642美芬雷司Mefenorex17243-57-143甲丙氨酯*Meprobamate57-53-444美索卡Mesocarb34262-84-545甲苯巴比妥Methylphenobarbital115-38-846甲乙哌酮Methyprylon125-64-447咪达唑仑*Midazolam59467-70-848尼美西泮Nimetazepam2011-67-849硝西泮*Nitrazepam146-22-550去甲西泮Nordazepam1088-11-551奥沙西泮*Oxazepam604-75-152奥沙唑仑Oxazolam24143-17-753匹莫林*Pemoline2152-34-354苯甲曲秦Phendimetrazine634-03-755苯巴比妥*Phenobarbital50-06-656芬特明Phentermine122-09-857匹那西泮Pinazepam52463-83-958哌苯甲醇Pipradrol467-60-759普拉西泮Prazepam2955-38-660吡咯戊酮Pyrovalerone3563-49-361仲丁比妥Secbutabarbital125-40-662替马西泮Temazepam846-50-463四氢西泮Tetrazepam10379-14-364乙烯比妥Vinylbital2430-49-165唑吡坦* Zolpidem82626-48-066阿洛巴比妥Allobarbital58-15-167丁丙诺啡透皮贴剂*Buprenorphine Transdermal patch68布托啡诺及其注射剂*Butorphanol and its injection42408-82-269咖啡因*Caffeine58-08-270安钠咖*Caffeine Sodium Benzoate CNB71右旋芬氟拉明Dexfenfluramine3239-44-972地佐辛及其注射剂*Dezocine and Its Injection53648-55-873麦角胺咖啡因片*Ergotamine and Caffeine Tablet379-79-3 74芬氟拉明Fenfluramine458-24-275呋芬雷司Furfennorex3776-93-076纳布啡及其注射剂Nalbuphine and its injection20594-83-6 77氨酚氢可酮片*Paracetamol and Hydrocodone Bitartrate Tablet78丙己君Propylhexedrine101-40-679曲马多*Tramadol27203-92-580扎来普隆*Zaleplon151319-34-581佐匹克隆Zopiclone43200-80-2注：1.上述品种包括其可能存在的盐和单方制剂（除非另有规定）。2.上述品种包括其可能存在的异构体（除非另有规定）。3.品种目录有*的精神药品为我国生产及使用的品种。三、含可待因复方口服液体制剂列入第二类精神药品管理（2015年5月1日起施行）【1种】关于将含可待因复方口服液体制剂列入第二类精神药品管理的公告(2015年第10号) 根据《麻醉药品和精神药品管理条例》的有关规定，国家食品药品监管总局、公安部、国家卫生计生委决定将含可待因复方口服液体制剂（包括口服溶液剂、糖浆剂）列入第二类精神药品管理。　　本公告自2015年5月1日起实行。四、116种物质列入《非药用类麻醉药品和精神药品管制品种增补目录》（2015年10月1日起施行）【116种】序号中文名英文名CAS号备注1N-(2-甲氧基苄基)-2-(2,5-二甲氧基-4-溴苯基)乙胺2-(4-Bromo-2,5-dimethoxyphenyl)-N-(2-methoxybenzyl)ethanamine1026511-90-92C-B-NBOMe22,5-二甲氧基-4-氯苯乙胺4-Chloro-2,5-dimethoxyphenethylamine88441-14-92C-C3N-(2-甲氧基苄基)-2-(2,5-二甲氧基-4-氯苯基)乙胺2-(4-Chloro-2,5-dimethoxyphenyl)-N-(2-methoxybenzyl)ethanamine1227608-02-72C-C-NBOMe42,5-二甲氧基-4-甲基苯乙胺4-Methyl-2,5-dimethoxyphenethylamine24333-19-52C-D5N-(2-甲氧基苄基)-2-(2,5-二甲氧基-4-甲基苯基)乙胺2-(4-Methyl-2,5-dimethoxyphenyl)-N-(2-methoxybenzyl)ethanamine1354632-02-22C-D-NBOMe62,5-二甲氧基-4-乙基苯乙胺4-Ethyl-2,5-dimethoxyphenethylamine71539-34-92C-E7N-(2-甲氧基苄基)-2-(2,5-二甲氧基-4-碘苯基)乙胺2-(4-Iodo-2,5-dimethoxyphenyl)-N-(2-methoxybenzyl)ethanamine919797-19-62C-I-NBOMe82,5-二甲氧基-4-丙基苯乙胺4-Propyl-2,5-dimethoxyphenethylamine207740-22-52C-P92,5-二甲氧基-4-乙硫基苯乙胺4-Ethylthio-2,5-dimethoxyphenethylamine207740-24-72C-T-2102,5-二甲氧基-4-异丙基硫基苯乙胺4-Isopropylthio-2,5-dimethoxyphenethylamine207740-25-82C-T-4112,5-二甲氧基-4-丙硫基苯乙胺4-Propylthio-2,5-dimethox-phenethylamine207740-26-92C-T-7122-氟苯丙胺1-(2-Fluorophenyl)propan-2-amine1716-60-52-FA132-氟甲基苯丙胺N-Methyl-1-(2-fluorophenyl)propan-2-amine1017176-48-52-FMA141-(2-苯并呋喃基)-N-甲基-2-丙胺N-Methyl-1-(benzofuran-2-yl)propan-2-amine806596-15-62-MAPB153-氟苯丙胺1-(3-Fluorophenyl)propan-2-amine1626-71-73-FA163-氟甲基苯丙胺N-Methyl-1-(3-fluorophenyl)propan-2-amine1182818-14-93-FMA174-氯苯丙胺1-(4-Chlorophenyl)propan-2-amine64-12-04-CA184-氟苯丙胺1-(4-Fluorophenyl)propan-2-amine459-02-94-FA194-氟甲基苯丙胺N-Methyl-1-(4-fluorophenyl)propan-2-amine351-03-14-FMA201-[5-(2,3-二氢苯并呋喃基)]-2-丙胺1-(2,3-Dihydro-1-benzofuran-5-yl)propan-2-amine152624-03-85-APDB211-(5-苯并呋喃基)-N-甲基-2-丙胺N-Methyl-1-(benzofuran-5-yl)propan-2-amine1354631-77-85-MAPB226-溴-3,4-亚甲二氧基甲基苯丙胺N-Methyl-(6-bromo-3,4-methylenedioxyphenyl)propan-2-amine6-Br-MDMA236-氯-3,4-亚甲二氧基甲基苯丙胺N-Methyl-(6-chloro-3,4-methylenedioxyphenyl)propan-2-amine319920-71-36-Cl-MDMA241-(2,5-二甲氧基-4-氯苯基)-2-丙胺1-(4-Chloro-2,5-dimethoxyphenyl)propan-2-amine123431-31-2DOC251-(2-噻吩基)-N-甲基-2-丙胺N-Methyl-1-(thiophen-2-yl)propan-2-amine801156-47-8MPA26N-(1-氨甲酰基-2-甲基丙基)-1-(5-氟戊基)吲哚-3-甲酰胺N-(1-Amino-3-methyl-1-oxobutan-2-yl)-1-(5-fluoropentyl)-1H-indole-3-carboxamide1801338-26-05F-ABICA27N-(1-氨甲酰基-2-甲基丙基)-1-(5-氟戊基)吲唑-3-甲酰胺N-(1-Amino-3-methyl-1-oxobutan-2-yl)-1-(5-fluoropentyl)-1H-indazole-3-carboxamide1800101-60-35F-AB-PINACA28N-(1-氨甲酰基-2,2-二甲基丙基)-1-(5-氟戊基)吲哚-3-甲酰胺N-(1-Amino-3,3-dimethyl-1-oxobutan-2-yl)-1-(5-fluoropentyl)-1H-indole-3-carboxamide1801338-27-15F-ADBICA29N-(1-甲氧基羰基-2-甲基丙基)-1-(5-氟戊基)吲唑-3-甲酰胺1-Methoxy-3-methyl-1-oxobutan-2-yl-1-(5-fluoropentyl)-1H-indazole-3-carboxamide1715016-74-25F-AMB30N-(1-金刚烷基)-1-(5-氟戊基)吲唑-3-甲酰胺N-(1-Adamantyl)-1-(5-fluoropentyl)-1H-indazole-3-carboxamide1400742-13-35F-APINACA311-(5-氟戊基)吲哚-3-甲酸-8-喹啉酯Quinolin-8-yl 1-(5-fluoropentyl)-1H-indole-3-carboxylate1400742-41-75F-PB-22321-(5-氟戊基)-3-(2,2,3,3-四甲基环丙甲酰基)吲哚(1-(5-Fluoropentyl)-1H-indol-3-yl)(2,2,3,3-tetramethylcyclopropyl)methanone1364933-54-95F-UR-144331-[2-(N-吗啉基)乙基]-3-(2,2,3,3-四甲基环丙甲酰基)吲哚(1-(2-Morpholin-4-ylethyl)-1H-indol-3-yl)(2,2,3,3-tetramethylcyclopropyl)methanone895155-26-7A-796,260341-(4-四氢吡喃基甲基)-3-(2,2,3,3-四甲基环丙甲酰基)吲哚(1-(Tetrahydropyran-4-ylmethyl)-1H-indol-3-yl)(2,2,3,3-tetramethylcyclopropyl)methanone895155-57-4A-834,73535N-(1-氨甲酰基-2-甲基丙基)-1-(环己基甲基)吲唑-3-甲酰胺N-(1-Amino-3-methyl-1-oxobutan-2-yl)-1-(cyclohexylmethyl)-1H-indazole-3-carboxamide1185887-21-1AB-CHMINACA36N-(1-氨甲酰基-2-甲基丙基)-1-(4-氟苄基)吲唑-3-甲酰胺N-(1-Amino-3-methyl-1-oxobutan-2-yl)-1-(4-fluorobenzyl)-1H-indazole-3-carboxamide1629062-56-1AB-FUBINACA37N-(1-氨甲酰基-2-甲基丙基)-1-戊基吲唑-3-甲酰胺N-(1-Amino-3-methyl-1-oxobutan-2-yl)-1-pe-ntyl-1H-indazole-3-carboxamide1445583-20-9AB-PINACA38N-(1-氨甲酰基-2,2-二甲基丙基)-1-戊基吲哚-3-甲酰胺N-(1-Amino-3,3-dimethyl-1-oxobutan-2-yl)-1-pentyl-1H-indole-3-carboxamide1445583-48-1ADBICA39N-(1-氨甲酰基-2,2-二甲基丙基)-1-戊基吲唑-3-甲酰胺N-(1-Amino-3,3-dimethyl-1-oxobutan-2-yl)-1-pentyl-1H-indazole-3-carboxamide1633766-73-0ADB-PINACA401-[(N-甲基-2-哌啶基)甲基]-3-(1-萘甲酰基)吲哚(1-((1-Methylpiperidin-2-yl)methyl)-1H-indol-3-yl)(naphthalen-1-yl)methanone137642-54-7AM-1220411-[(N-甲基-2-哌啶基)甲基]-3-(1-金刚烷基甲酰基)吲哚(1-((1-Methylpiperidin-2-yl)methyl)-1H-indol-3-yl)(adamantan-1-yl)methanone335160-66-2AM-1248421-[(N-甲基-2-哌啶基)甲基]-3-(2-碘苯甲酰基)吲哚(1-((1-Methylpiperidin-2-yl)methyl)-1H-indol-3-yl)(2-iodophenyl)methanone444912-75-8AM-223343N-(1-金刚烷基)-1-戊基吲哚-3-甲酰胺N-(1-Adamantyl)-1-pentyl-1H-indole-3-carboxamide1345973-50-3 APICA44N-(1-金刚烷基)-1-戊基吲唑-3-甲酰胺N-(1-Adamantyl)-1-pentyl-1H-indazole-3-carboxamide1345973-53-6APINACA451-(1-萘甲酰基)-4-戊氧基萘(4-Pentyloxynaphthalen-1-yl)(naphthalen-1-yl)methanone432047-72-8CB-1346N-(1-甲基-1-苯基乙基)-1-(4-四氢吡喃基甲基)吲唑-3-甲酰胺N-(2-Phenylpropan-2-yl)-1-(tetrahydropyran-4-ylmethyl)-1H-indazole-3-carboxamide1400742-50-8CUMYL-THPINACA471-(5-氟戊基)-3-(4-乙基-1-萘甲酰基)吲哚(1-(5-Fluoropentyl)-1H-indol-3-yl)(4-ethylnaphthalen-1-yl)methanone1364933-60-7EAM-2201481-(4-氟苄基)-3-(1-萘甲酰基)吲哚(1-(4-Fluorobenzyl)-1H-indol-3-yl)(naphthalen-1-yl)methanoneFUB-JWH-018491-(4-氟苄基)吲哚-3-甲酸-8-喹啉酯Quinolin-8-yl 1-(4-fluorobenzyl)-1H-indole-3-carboxylate1800098-36-5FUB-PB-22502-甲基-1-戊基-3-(1-萘甲酰基)吲哚(2-Methyl-1-pentyl-1H-indol-3-yl)(naphthalen-1-yl)methanone155471-10-6JWH-007512-甲基-1-丙基-3-(1-萘甲酰基)吲哚(2-Methyl-1-propyl-1H-indol-3-yl)(naphthalen-1-yl)methanone155471-08-2JWH-015521-己基-3-(1-萘甲酰基)吲哚(1-Hexyl-1H-indol-3-yl)(naphthalen-1-yl)methanone209414-08-4JWH-019531-戊基-3-(4-甲氧基-1-萘甲酰基)吲哚(1-Pentyl-1H-indol-3-yl)(4-methoxynaphthalen-1-yl)methanone210179-46-7JWH-081541-戊基-3-(4-甲基-1-萘甲酰基)吲哚(1-Pentyl-1H-indol-3-yl)(4-methylnaphthalen-1-yl)methanone619294-47-2JWH-122551-戊基-3-(2-氯苯乙酰基)吲哚2-(2-Chlorophenyl)-1-(1-pentyl-1H-indol-3-yl)ethanone864445-54-5JWH-203561-戊基-3-(4-乙基-1-萘甲酰基)吲哚(1-Pentyl-1H-indol-3-yl)(4-ethylnaphthalen-1-yl)methanone824959-81-1JWH-210571-戊基-2-(2-甲基苯基)-4-(1-萘甲酰基)吡咯(5-(2-Methylphenyl)-1-pentyl-1H-pyrrol-3-yl)(naphthalen-1-yl)methanone914458-22-3JWH-370581-(5-氟戊基)-3-(4-甲基-1-萘甲酰基)吲哚(1-(5-Fluoropentyl)-1H-indol-3-yl)(4-methylnaphthalen-1-yl)methanone1354631-24-5MAM-220159N-(1-甲氧基羰基-2,2-二甲基丙基)-1-(环己基甲基)吲哚-3-甲酰胺N-(1-Methoxy-3,3-dimethyl-1-oxobutan-2-yl)-1-(cyclohexylmethyl)-1H-indole-3-carboxamide1715016-78-6MDMB-CHMICA60N-(1-甲氧基羰基-2,2-二甲基丙基)-1-(4-氟苄基)吲唑-3-甲酰胺N-(1-Methoxy-3,3-dimethyl-1-oxobutan-2-yl)-1-(4-fluorobenzyl)-1H-indazole-3-carboxamide1715016-77-5MDMB-FUBINACA611-戊基吲哚-3-甲酸-8-喹啉酯Quinolin-8-yl 1-pentyl-1H-indole-3-carboxylate1400742-17-7PB-2262N-(1-氨甲酰基-2-苯基乙基)-1-(5-氟戊基)吲唑-3-甲酰胺N-(1-Amino-1-oxo-3-phenylpropan-2-yl)-1-(5-fluoropentyl)-1H-indazole-3-carboxamidePX-2631-戊基-3-(4-甲氧基苯甲酰基)吲哚(1-Pentyl-1H-indol-3-yl)(4-methoxyphenyl)methanone1345966-78-0RCS-464N-(1-金刚烷基)-1-(5-氟戊基)吲哚-3-甲酰胺N-(1-Adamantyl)-1-(5-fluoropentyl)-1H-indole-3-carboxamide1354631-26-7STS-135651-戊基-3-(2,2,3,3-四甲基环丙甲酰基)吲哚(1-Pentyl-1H-indol-3-yl)(2,2,3,3-tetramethylcyclopropyl)methanone1199943-44-6UR-144662-氟甲卡西酮1-(2-Fluorophenyl)-2-methylaminopropan-1-one1186137-35-82-FMC672-甲基甲卡西酮1-(2-Methylphenyl)-2-methylaminopropan-1-one1246911-71-62-MMC683,4-二甲基甲卡西酮1-(3,4-Dimethylphenyl)-2-methylaminopropan-1-one1082110-00-63,4-DMMC693-氯甲卡西酮1-(3-Chlorophenyl)-2-methylaminopropan-1-one1049677-59-93-CMC703-甲氧基甲卡西酮1-(3-Methoxyphenyl)-2-methylaminopropan-1-one882302-56-93-MeOMC713-甲基甲卡西酮1-(3-Methylphenyl)-2-methylaminopropan-1-one1246911-86-33-MMC724-溴甲卡西酮1-(4-Bromophenyl)-2-methylaminopropan-1-one486459-03-44-BMC734-氯甲卡西酮1-(4-Chlorophenyl)-2-methylaminopropan-1-one1225843-86-6 4-CMC744-氟甲卡西酮1-(4-Fluorophenyl)-2-methylaminopropan-1-one447-40-54-FMC751-(4-氟苯基)-2-(N-吡咯烷基)-1-戊酮1-(4-Fluorophenyl)-2-(1-pyrrolidinyl)pentan-1-one850352-62-44-F-α-PVP761-(4-甲基苯基)-2-甲氨基-1-丁酮1-(4-Methylphenyl)-2-methylaminobutan-1-one1337016-51-94-MeBP771-(4-甲氧基苯基)-2-(N-吡咯烷基)-1-戊酮1-(4-Methoxyphenyl)-2-(1-pyrrolidinyl)pentan-1-one14979-97-64-MeO-α-PVP781-苯基-2-甲氨基-1-丁酮1-Phenyl-2-methylaminobutan-1-one408332-79-6Buphedrone792-甲氨基-1-[3,4-(亚甲二氧基)苯基]-1-丁酮1-(3,4-Methylenedioxyphenyl)-2-methylaminobutan-1-one802575-11-7Butylone802-二甲氨基-1-[3,4-(亚甲二氧基)苯基]-1-丙酮1-(3,4-Methylenedioxyphenyl)-2-dimethylaminopropan-1-one765231-58-1Dimethylone81乙卡西酮1-Phenyl-2-ethylaminopropan-1-one18259-37-5Ethcathinone823,4-亚甲二氧基乙卡西酮1-(3,4-Methylenedioxyphenyl)-2-ethylaminopropan-1-one1112937-64-0Ethylone831-[3,4-(亚甲二氧基)苯基]-2-(N-吡咯烷基)-1-丁酮1-(3,4-Methylenedioxyphenyl)-2-(1-pyrrolidinyl)butan-1-one784985-33-7MDPBP841-[3,4-(亚甲二氧基)苯基]-2-(N-吡咯烷基)-1-丙酮1-(3,4-Methylenedioxyphenyl)-2-(1-pyrrolidinyl)propan-1-one783241-66-7MDPPP854-甲氧基甲卡西酮1-(4-Methoxyphenyl)-2-methylaminopropan-1-one530-54-1Methedrone861-苯基-2-乙氨基-1-丁酮1-Phenyl-2-ethylaminobutan-1-one1354631-28-9NEB871-苯基-2-甲氨基-1-戊酮1-Phenyl-2-methylaminopentan-1-one879722-57-3Pentedrone881-苯基-2-(N-吡咯烷基)-1-丁酮1-Phenyl-2-(1-pyrrolidinyl)butan-1-one13415-82-2α-PBP891-苯基-2-(N-吡咯烷基)-1-己酮1-Phenyl-2-(1-pyrrolidinyl)hexan-1-one13415-86-6α-PHP901-苯基-2-(N-吡咯烷基)-1-庚酮1-Phenyl-2-(1-pyrrolidinyl)heptan-1-one13415-83-3α-PHPP911-苯基-2-(N-吡咯烷基)-1-戊酮1-Phenyl-2-(1-pyrrolidinyl)pentan-1-one14530-33-7α-PVP921-(2-噻吩基)-2-(N-吡咯烷基)-1-戊酮1-(Thiophen-2-yl)-2-(1-pyrrolidinyl)pentan-1-one1400742-66-6α-PVT932-(3-甲氧基苯基)-2-乙氨基环己酮2-(3-Methoxyphenyl)-2-(ethylamino)cyclohexanone1239943-76-0MXE94乙基去甲氯胺酮2-(2-Chlorophenyl)-2-(ethylamino)cyclohexanone1354634-10-8NENK95N,N-二烯丙基-5-甲氧基色胺5-Methoxy-N,N-diallyltryptamine928822-98-45-MeO-DALT96N,N-二异丙基-5-甲氧基色胺5-Methoxy-N,N-diisopropyltryptamine4021-34-55-MeO-DiPT97N,N-二甲基-5-甲氧基色胺5-Methoxy-N,N-dimethyltryptamine1019-45-05-MeO-DMT98N-甲基-N-异丙基-5-甲氧基色胺5-Methoxy-N-isopropyl-N-methyltryptamine96096-55-85-MeO-MiPT99α-甲基色胺alpha-Methyltryptamine299-26-3AMT1001,4-二苄基哌嗪1,4-Dibenzylpiperazine1034-11-3DBZP1011-(3-氯苯基)哌嗪1-(3-Chlorophenyl)piperazine6640-24-0mCPP1021-(3-三氟甲基苯基)哌嗪1-(3-Trifluoromethylphenyl)piperazine15532-75-9TFMPP1032-氨基茚满2-Aminoindane2975-41-92-AI1045,6-亚甲二氧基-2-氨基茚满5,6-Methylenedioxy-2-aminoindane132741-81-2MDAI1052-二苯甲基哌啶2-Diphenylmethylpiperidine519-74-42-DPMP1063,4-二氯哌甲酯Methyl 2-(3,4-dichlorophenyl)-2-(piperidin-2-yl)acetate1400742-68-83,4-CTMP107乙酰芬太尼N-(1-Phenethylpiperidin-4-yl)-N-phenylacetamide3258-84-2Acetylfentanyl1083,4-二氯-N-[(1-二甲氨基环己基)甲基]苯甲酰胺3,4-Dichloro-N-((1-(dimethylamino)cyclohexyl)methyl)benzamide55154-30-8AH-7921109丁酰芬太尼N-(1-Phenethylpiperidin-4-yl)-N-phenylbutyramide1169-70-6Butyrylfentanyl110哌乙酯Ethyl 2-phenyl-2-(piperidin-2-yl)acetate57413-43-1Ethylphenidate1111-[1-(2-甲氧基苯基)-2-苯基乙基]哌啶1-(1-(2-Methoxyphenyl)-2-phenylethyl)piperidine127529-46-8Methoxphenidine112芬纳西泮7-Bromo-5-(2-chlorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one51753-57-2Phenazepam113β-羟基硫代芬太尼N-(1-(2-Hydroxy-2-(thiophen-2-yl)ethyl)piperidin-4-yl)-N-phenylpropanamide1474-34-6β-Hydroxythiofentanyl1144-氟丁酰芬太尼N-(4-Fluorophenyl)-N-(1-phenethylpiperidin-4-yl)butyramide244195-31-14-Fluorobutyrfentanyl115异丁酰芬太尼N-(1-Phenethylpiperidin-4-yl)-N-phenylisobutyramide119618-70-1Isobutyrfentanyl116奥芬太尼N-(2-Fluorophenyl)-2-methoxy-N-(1-phenethylpiperidin-4-yl)acetamide101343-69-5Ocfentanyl注：上述品种包括其可能存在的盐类、旋光异构体及其盐类（另有规定的除外）。五、卡芬太尼等4种芬太尼类物质列入《非药用类麻醉药品和精神药品管制品种增补目录》（2017年3月1日起施行）【4种】序号中文名英文名CAS号备注1丙烯酰芬太尼N-(1-Phenethylpiperidin-4-yl)-N-phenylacrylamide82003-75-6 Acrylfentanyl2卡芬太尼Methyl4-(N-phenylpropionamido)-1-phenethylpiperidine-4-carboxylate59708-52-0 CarfentanylCarfentanil3呋喃芬太尼N-(1-Phenethylpiperidin-4-yl)-N-phenylfuran-2-carboxamide101345-66-8 Furanylfentanyl 4戊酰太尼N-(1-Phenethylpiperidin-4-yl)-N-phenylpentanamide122882-90-0Valerylfentanyl六、N-甲基-N-(2-二甲氨基环己基)-3，4-二氯苯甲酰胺(U-47700)等4种物质列入《非药用类麻醉药品和精神药品管制品种增补目录》（2017年7月1日起施行）【4种】序号中文名英文名CAS号备注1N-甲基-N-(2-二甲氨基环己基)- 3,4-二氯苯甲酰胺3,4-Dichloro-N-(2-(dimethylamino)cyclohexyl)-N-methylbenzamide121348-98-9U-4770021-环己基-4-(1,2-二苯基乙基)哌嗪1-Cyclohexyl-4-(1,2-diphenylenthyl)piperazine52694-55-0MT-4534-甲氧基甲基苯丙胺N-Methyl--1-(4-methoxyphenyl)propan-2-amine22331-70-0PMMA42-氨基-4-甲基-5-(4-甲基苯基)-4,5-二氢恶唑4-Methyl-5-(4-methylphenyl)-4,5-dihydrooxazol-2-amine1445569-01-64,4’-DMAR七、4-氯乙卡西酮等32种物质列入《非药用类麻醉药品和精神药品管制品种增补目录》（2018年9月1日起施行）【32种】序号中文名英文名CAS号备注14-氯乙卡西酮1-(4-Chlorophenyl)-2-(ethylamino)propan-1-one14919-85-84-CEC21-[3,4-(亚甲二氧基)苯基]-2-乙氨基-1-戊酮1-(3,4-Methylenedioxyphenyl)-2-(ethylamino)pentan-1-one727641-67-0N-Ethylpentylone31-(4-氯苯基)-2-(N-吡咯烷基)-1-戊酮1-(4-Chlorophenyl)-2-(1-pyrrolidinyl)pentan-1-one5881-77-64-Cl-α-PVP41-[3,4-(亚甲二氧基)苯基]-2-二甲氨基-1-丁酮1-(3,4-Methylenedioxyphenyl)-2-(dimethylamino)butan-1-one802286-83-5Dibutylone51-[3,4-(亚甲二氧基)苯基]-2-甲氨基-1-戊酮1-(3,4-Methylenedioxyphenyl)-2-(methylamino)pentan-1-one698963-77-8Pentylone61-苯基-2-乙氨基-1-己酮1-Phenyl-2-(ethylamino)hexan-1-one802857-66-5N-Ethylhexedrone71-(4-甲基苯基)-2-(N-吡咯烷基)-1-己酮1-(4-Methylphenyl)-2-(1-pyrrolidinyl)hexan-1-one34138-58-44-MPHP81-(4-氯苯基)-2-(N-吡咯烷基)-1-丙酮1-(4-Chlorophenyl)-2-(1-pyrrolidinyl)propan-1-one28117-79-54-Cl-α-PPP91-[2-(5,6,7,8-四氢萘基)]-2-(N-吡咯烷基)-1-戊酮1-(5,6,7,8-Tetrahydronaphthalen-2-yl)-2-(1-pyrrolidinyl)pentan-1-oneβ-TH-Naphyrone101-(4-氟苯基）-2-(N-吡咯烷基)-1-己酮1-(4-Fluorophenyl)-2-(1-pyrrolidinyl)hexan-1-one2230706-09-74-F-α-PHP114-乙基甲卡西酮1-(4-Ethylphenyl)-2-(methylamino)propan-1-one1225622-14-94-EMC121-(4-甲基苯基)-2-乙氨基-1-戊酮1-(4-Methylphenyl)-2-(ethylamino)pentan-1-one746540-82-94-MEAPP131-(4-甲基苯基)-2-甲氨基-3-甲氧基-1-丙酮1-(4-Methylphenyl)-2-(methylamino)-3-methoxypropan-1-one2166915-02-0Mexedrone141-[3,4-(亚甲二氧基)苯基]-2-(N-吡咯烷基)-1-己酮1-(3,4-Methylenedioxyphenyl)-2-(1-pyrrolidinyl)hexan-1-one776994-64-0MDPHP151-(4-甲基苯基)-2-甲氨基-1-戊酮1-(4-Methylphenyl)-2-(methylamino)pentan-1-one 1373918-61-64-MPD161-(4-甲基苯基)-2-二甲氨基-1-丙酮1-(4-Methylphenyl)-2-(dimethylamino)propan-1-one1157738-08-34-MDMC173,4-亚甲二氧基丙卡西酮1-(3,4-Methylenedioxyphenyl)-2-(propylamino)propan-1-one201474-93-3Propylone181-(4-氯苯基)-2-乙氨基-1-戊酮1-(4-Chlorophenyl)-2-(ethylamino)pentan-1-one4-Cl-EAPP191-苯基-2-(N-吡咯烷基)-1-丙酮1-Phenyl-2-(1-pyrrolidinyl)propan-1-one19134-50-0α-PPP201-(4-氯苯基)-2-甲氨基-1-戊酮1-(4-Chlorophenyl)-2-(methylamino)pentan-1-one2167949-43-94-Cl-Pentedrone213-甲基-2-[1-(4-氟苄基）吲唑-3-甲酰胺基]丁酸甲酯N-(1-Methoxy-3-methyl-1-oxobutan-2-yl)-1-(4-fluorobenzyl)-1H-indazole-3-carboxamide1715016-76-4AMB-FUBINACA221-(4-氟苄基)-N-(1-金刚烷基)吲唑-3-甲酰胺N-(1-Adamantyl)-1-(4-fluorobenzyl)-1H-indazole-3-carboxamide2180933-90-6FUB-APINACA23N-(1-氨甲酰基-2,2-二甲基丙基)-1-(环己基甲基)吲唑-3-甲酰胺N-(1-Amino-3,3-dimethyl-1-oxobutan-2-yl)-1-(cyclohexylmethyl)-1H-indazole-3-carboxamide1863065-92-2ADB-CHMINACA24N-(1-氨甲酰基-2,2-二甲基丙基)-1-(4-氟苄基)吲唑-3-甲酰胺N-(1-Amino-3,3-dimethyl-1-oxobutan-2-yl)-1-(4-fluorobenzyl)-1H-indazole-3-carboxamide 1445583-51-6ADB-FUBINACA253,3-二甲基-2-[1-(5-氟戊基)吲唑-3-甲酰氨基]丁酸甲酯N-(1-Methoxy-3,3-dimethyl-1-oxobutan-2-yl)-1-(5-fluoropentyl)-1H-indazole-3-carboxamide1715016-75-35F-ADB263-甲基-2-[1-(环己基甲基)吲哚-3-甲酰氨基]丁酸甲酯N-(1-Methoxy-3-methyl-1-oxobutan-2-yl)-1-(cyclohexylmethyl)-1H-indole-3-carboxamide1971007-94-9AMB-CHMICA271-(5-氟戊基)-2-(1-萘甲酰基)苯并咪唑(1-(5-Fluoropentyl)-1H-benzimidazol-2-yl)(naphthalen-1-yl)methanone1984789-90-3BIM-2201281-(5-氟戊基)吲哚-3-甲酸-1-萘酯Naphthalen-1-yl1-(5-fluoropentyl)-1H-indole-3-carboxylate2042201-16-9NM-2201292-苯基-2-甲氨基环己酮2-Phenyl-2-(methylamino)cyclohexanone7063-30-1DCK303-甲基-5-[2-(8-甲基-3-苯基-8-氮杂环[3,2,1]辛烷基)]-1,2,4-噁二唑8-Methyl-2-(3-methyl-1,2,4-oxadiazol-5-yl)-3-phenyl-8-aza-bicyclo[3.2.1]octane146659-37-2RTI-126314-氟异丁酰芬太尼N-(4-Fluorophenyl)-N-(1-phenethylpiperidin-4-yl)isobutyramide244195-32-24-FIBF32四氢呋喃芬太尼N-Phenyl-N-(1-phenethylpiperidin-4-yl)tetrahydrofuran-2-carboxamide2142571-01-3THF-F八、芬太尼类物质列入《非药用类麻醉药品和精神药品管制品种增补目录》（2019年5月1日起施行）【整类】关于将芬太尼类物质列入《非药用类麻醉药品和精神药品管制品种增补目录》的公告根据《麻醉药品和精神药品管理条例》《非药用类麻醉药品和精神药品列管办法》有关规定，公安部、国家卫生健康委员会和国家药品监督管理局决定将芬太尼类物质列入《非药用类麻醉药品和精神药品管制品种增补目录》。“芬太尼类物质”是指化学结构与芬太尼（N-[1-（2-苯乙基）-4-哌啶基]-N-苯基丙酰胺）相比，符合以下一个或多个条件的物质：一、使用其他酰基替代丙酰基；二、使用任何取代或未取代的单环芳香基团替代与氮原子直接相连的苯基；三、哌啶环上存在烷基、烯基、烷氧基、酯基、醚基、羟基、卤素、卤代烷基、氨基及硝基等取代基；四、使用其他任意基团（氢原子除外）替代苯乙基。上述所列管物质如果发现有医药、工业、科研或者其他合法用途，按照《非药用类麻醉药品和精神药品列管办法》第三条第二款规定予以调整。已列入《麻醉药品和精神药品品种目录》和《非药用类麻醉药品和精神药品管制品种增补目录》的芬太尼类物质依原有目录予以管制。本公告自2019年5月1日起施行。九、含羟考酮复方制剂等品种列入精神药品管理（2019年9月1日起施行）【3种】关于将含羟考酮复方制剂等品种列入精神药品管理的公告（2019年第63号）根据《麻醉药品和精神药品管理条例》有关规定，国家药品监督管理局、公安部、国家卫生健康委员会决定将含羟考酮复方制剂等品种列入精神药品管理。现公告如下：一、口服固体制剂每剂量单位含羟考酮碱大于5毫克，且不含其它麻醉药品、精神药品或药品类易制毒化学品的复方制剂列入第一类精神药品管理；二、口服固体制剂每剂量单位含羟考酮碱不超过5毫克，且不含其它麻醉药品、精神药品或药品类易制毒化学品的复方制剂列入第二类精神药品管理；三、丁丙诺啡与纳洛酮的复方口服固体制剂列入第二类精神药品管理。本公告自 2019年9月1日起施行。十、瑞马唑仑列入第二类精神药品管理（2020年1月1日起施行）【1种】关于将瑞马唑仑列入第二类精神药品管理的公告(2019年第108号) 根据《麻醉药品和精神药品管理条例》有关规定，国家药品监管局、公安部、国家卫生健康委决定将瑞马唑仑（包括其可能存在的盐、单方制剂和异构体）列入第二类精神药品管理。本公告自2020年1月1日起实行。十一、合成大麻素类物质和氟胺酮等18种物质列入《非药用类麻醉药品和精神药品管制品种增补目录》（2021年7月1日起施行）【18种+整类】关于将合成大麻素类物质和氟胺酮等18种物质列入《非药用类麻醉药品和精神药品管制品种增补目录》的公告根据《麻醉药品和精神药品管理条例》《非药用类麻醉药品和精神药品列管办法》有关规定，公安部、国家卫生健康委员会和国家药品监督管理局决定将合成大麻素类物质和氟胺酮等18种物质列入《非药用类麻醉药品和精神药品管制品种增补目录》。一、合成大麻素类物质。“合成大麻素类物质”是指具有下列化学结构通式的物质：R1 代表取代或未取代的C3-C8烃基；取代或未取代的含有1-3个杂原子的杂环基；取代或未取代的含有1-3个杂原子的杂环基取代的甲基或乙基。R2 代表氢或甲基或无任何原子。R3 代表取代或未取代的C6-C10的芳基；取代或未取代的C3-C10的烃基；取代或未取代的含有1-3个杂原子的杂环基；取代或未取代的含有1-3个杂原子的杂环基取代的甲基或乙基。R4 代表氢；取代或未取代的苯基；取代或未取代的苯甲基。R5 代表取代或未取代的C3-C10的烃基。X代表 N或C。Y代表 N或CH。Z代表O或NH或无任何原子。上述所列管物质如果发现医药、工业、科研或者其他合法用途，按照《非药用类麻醉药品和精神药品列管办法》第三条第二款规定予以调整。已列入《麻醉药品和精神药品品种目录》和《非药用类麻醉药品和精神药品管制品种增补目录》的合成大麻素类物质依原有目录予以管制。二、氟胺酮等18种物质。（详见附表）本公告自2021年7月1日起施行。序号中文名1氟胺酮2(6aR.10aR)-3-(1,1-二甲基庚基)-6a7.10,10a-四氢-1-羟基-6.6-二甲基-6H-二苯并[b.d]吡喃-9-甲醇31-[3,4(亚甲二氧基)苯基]2-丁氨基-1-戊酮41-[3.4(亚甲二氧基)苯基]2-苄氨基-1-丙酮51-[3.4-(亚甲二氧基)苯基]-2-乙氨基-1-丁酮62乙氨基-1-苯基-1-庚酮71-(4- 氯苯基)-2-二甲氨基-1-丙酮82-T氨基-1-苯基-1-己酮91-[1-(3-甲氧基苯基)环己基]哌啶10a-甲基-5-甲氧基色胺11科纳唑仑12二氯西泮13氟阿普唑仑14NN-二乙基2-(2-(4-异丙氧基苯基)-5-硝基1H苯并[d]咪唑-1-基)-1-乙胺15氟溴唑仑161-(12-二苯基乙基)哌啶172-(3- 氟苯基)-3-甲基吗啉18依替唑仑来源：中国禁毒报药闻康策新媒体矩阵微信公众号点击下方一键关注【免责声明】1.“药闻康策”部分文章信息来源于网络转载是出于传递更多信息之目的，并不意味着赞同其观点或证实其内容的真实性。如对内容有疑议，请及时与我司联系。2.“药闻康策”致力于提供合理、准确、完整的资讯信息，但不保证信息的合理性、准确性和完整性，且不对因信息的不合理、不准确或遗漏导致的任何损失或损害承担责任。3.“药闻康策”所有信息仅供参考，不做任何商业交易或医疗服务的根据，如自行使用“药闻康策”内容发生偏差，我司不承担任何责任，包括但不限于法律责任，赔偿责任。欢迎转发分享、点赞、点在看

临床结果ASH会议临床2期

2023-01-30

·Business Wire

Sleep Disorder Treatment Drugs Markets in China 2023: Demand to Grow by 5% Annually Through 2032 - ResearchAndMarkets.com

DUBLIN--( BUSINESS WIRE )--The "Sleep Disorder Treatment Drugs Markets in China" report has been added to ResearchAndMarkets.com's offering. China's demand for Sleep Disorder Treatment Drugs has grown at a fast pace in the past decade. In the next decade, both production and demand will continue to grow. The Chinese economy maintains a high speed growth which has been stimulated by the consecutive increases of industrial output, import & export, consumer consumption and capital investment for over two decades. This new study examines China's economic trends, investment environment, industry development, supply and demand, industry capacity, industry structure, marketing channels and major industry participants. Historical data (2012, 2017 and 2022) and long-term forecasts through 2027 and 2032 are presented. Major producers in China are profiled. The primary and secondary research is done in China in order to access up-to-date government regulations, market information and industry data. Data were collected from the Chinese government publications, Chinese language newspapers and magazines, industry associations, local governments' industry bureaus, industry publications, and our in-house databases. Interviews are conducted with Chinese industry experts, university professors, and producers in China. Economic models and quantitative methods are applied in this report to project market demand and industry trends. Metric system is used and values are presented in either Yuan (RMB, current price) and/or US dollars. Our market research reports provide hard-to-find market data and analyses. Today, China has the largest market in the world. Tremendous fast-growing markets for imports and business opportunities for companies around the world. If you want to expand your business or sell your products in China, our research reports provide the insights and projections into Chinese markets necessary for you to do so. Key Topics Covered: I. INTRODUCTION Report Scope and Methodology Executive Summary II. BUSINESS ENVIRONMENT Economic Outlook Key Economic Indicators Industrial Output Population and Labor Foreign Investment Foreign Trade Financial and Tax Regulations Banking System and Regulations Foreign Exchange Taxes, Tariff and Custom Duties III. SLEEP DISORDER TREATMENT DRUGS INDUSTRY ASSESSMENTS Sleep Disorder Treatment Drugs Industry Structure Market Size Market Growth Driver Sleep Disorder Treatment Drugs Sales Volume Major Producer Facility Locations and Sales Volume Market Share of Key Producers Labor Cost Potential Entrants Major Distributors Major Foreign Investments Technology Development IV. SLEEP DISORDER TREATMENT DRUGS PRODUCTION AND DEMAND Overview Sales Volume of Sleep Disorder Treatment Drugs by Region Sleep Disorder Treatment Drugs Sales Volume Western Sleep Disorder Treatment Drugs Sales Volume Barbiturates Phenobarbital Secobarbital Amobarbital Benzodiazepines Midazolam Estazolam Triazolam Others Non-benzodiazepines Zolpidem Zopiclone Zaleplon Others Chinese Traditional Sleep Disorder Treatment Drugs Sales Volume Acanthopanacis Senticosi Gastrodin Chinese Patent Medicines Sleep Disorder Treatment Drugs Imports and Exports Pricing Trends V. SLEEP DISORDER TREATMENT DRUGS MARKET OUTLOOK Sleep Disorder Treatment Drugs Markets Outlook Government Regulations Health Care Insurance Industry Overview Consumer Spending Trends Northeast North Southeast Central Southwest Northwest Demographic Trends Health Care Industry Trends Hospitals and Hospital Beds VI. MARKETING STRATEGIES China Market Entry Overview China's Distribution System Sleep Disorder Treatment Drugs Distribution Channels Transportation and Freight Infrastructure Communications China's Market Entry Export to China Indirect export Direct Export License and Contract Manufacture Assembling in China Contract Manufacturing Trade Permit Investment Equity Joint Venture Contractual Joint Venture Wholly Foreign-Owned Enterprise VII. SLEEP DISORDER TREATMENT DRUGS PRODUCER DIRECTORY Sleep Disorder Treatment Drugs Producer Profiles and Directory A selection of companies mentioned in this report includes Wusuli River Pharmaceutical Group Wandashan Pharmaceutical Factory For more information about this report visit https://www.researchandmarkets.com/r/irmoip About ResearchAndMarkets.com ResearchAndMarkets.com is the world's leading source for international market research reports and market data. We provide you with the latest data on international and regional markets, key industries, the top companies, new products and the latest trends.

2023-01-26

·Business Wire

China Sleep Disorder Treatment Drugs Industry Forecasts 2023: Demand to Grow by 5% Annually Through 2032 - ResearchAndMarkets.com

DUBLIN--( BUSINESS WIRE )--The "Sleep Disorder Treatment Drugs Industry Forecasts - China Focus" report has been added to ResearchAndMarkets.com's offering. This study focuses on China's Sleep Disorder Treatment Drugs industry forecasts. In the two past decades, the industry has been growing at a fast pace. The dramatic expansions of the manufacturing capabilities and rising consumer consumptions in China have transformed China's society and economy. China is one of the world's major producers for industrial and consumer products. Far outpacing other economies in the world, China is the world's fastest growing market for the consumptions of goods and services. The Chinese economy maintains a high speed growth which has been stimulated by the consecutive increases of industrial output, imports & exports, consumer consumption and capital investment for over two decades. Rapid consolidation between medium and large players is anticipated since the Chinese government has been encouraging industry consolidation with an effort to regulate the industry and to improve competitiveness in the world market. Although China has enjoyed the benefits of an expanding market for production and distribution, the industry is suffering from minimal innovation and investment in R&D and new product development. The sector's economies of scale have yet to be achieved. Most domestic manufacturers lack the autonomic intellectual property and financial resources to develop their own brand name products. This new study focuses on industry trends and forecasts with historical data (2012, 2017 and 2022) and long-term forecasts through 2027 and 2032 are presented. The primary and secondary research is done in China in order to access up-to-date government regulations, market information and industry data. Data were collected from the Chinese government publications, Chinese language newspapers and magazines, industry associations, local governments' industry bureaus, industry publications, and our in-house databases. The analyst is one of the leading sources for up-to-date market information and research on the fastest-growing Chinese markets. We have published over 1,500 reports focusing on the Chinese markets, industry forecasts and company profiles. We provide hard-to-find market data and analyses. Our publications are intended to help international marketers identify business opportunities and promote their product sales in the Chinese markets. Key Topics Covered: I. INTRODUCTION Report Scope and Methodology Executive Summary II. BUSINESS ENVIRONMENT Economic Outlook Key Economic Indicators Industrial Output Population and Labor Foreign Investment Foreign Trade Financial and Tax Regulations Banking System and Regulations Foreign Exchange Taxes, Tariff and Custom Duties Market Trends Technology Development Market Development Major Industry Development Regional Development Enterprise Development Labor Market Development III. SLEEP DISORDER TREATMENT DRUGS PRODUCTION AND DEMAND Overview Sales Volume of Sleep Disorder Treatment Drugs by Region Sleep Disorder Treatment Drugs Sales Volume Western Sleep Disorder Treatment Drugs Sales Volume Barbiturates Phenobarbital Secobarbital Amobarbital Benzodiazepines Midazolam Estazolam Triazolam Others Non-benzodiazepines Zolpidem Zopiclone Zaleplon Others Chinese Traditional Sleep Disorder Treatment Drugs Sales Volume Acanthopanacis Senticosi Gastrodin Chinese Patent Medicines Sleep Disorder Treatment Drugs Imports and Exports Pricing Trends For more information about this report visit https://www.researchandmarkets.com/r/njb95-disorder?w=4 About ResearchAndMarkets.com ResearchAndMarkets.com is the world's leading source for international market research reports and market data. We provide you with the latest data on international and regional markets, key industries, the top companies, new products and the latest trends.

100 项与司可巴比妥钠相关的药物交易

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外链

KEGG	Wiki	ATC	Drug Bank
D01310	司可巴比妥钠	N05CA06	DB00418

研发状态

10 条最早获批的记录,

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适应症	国家/地区	公司	日期
麻醉	日本	Nichi-Iko Pharmaceutical Co., Ltd.	1961-09-29
镇静	日本	Nichi-Iko Pharmaceutical Co., Ltd.	1961-09-29
入睡和睡眠障碍	美国	Eli Lilly & Co.	1950-07-19