Safety and Efficacy of Buagafuran Capsules in the Treatment of Generalized Anxiety Disorder: a Multi-center, Randomized, Double-blind, Double-dummy, Placebo-controlled, Positive-controlled, Fixed-dose Phase Ⅲ Clinical Trial

A placebo-controlled superiority design was used to evaluate the efficacy of 60 mg/ day or 120 mg/ day of Buagafuran capsules in the treatment of GAD

开始日期2023-07-25

申办/合作机构

北京协和药厂有限公司

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NCT06243614 / Recruiting临床3期

A placebo-controlled superiority design was used to evaluate the efficacy of 60-120 mg/ day of Buagafuran capsules in the treatment of GAD.

开始日期2023-07-24

申办/合作机构

北京协和药厂有限公司

[+1]

CTR20231405 / Recruiting临床3期

评价布格呋喃胶囊治疗广泛性焦虑障碍安全性和有效性的多中心、随机、双盲、安慰剂对照、固定剂量Ⅲ期临床试验

主要目的：采用安慰剂对照的优效性设计，评价布格呋喃胶囊60mg/日和120mg/日剂量治疗广泛性焦虑障碍的有效性。次要目的：采用安慰剂对照的优效性设计，评价布格呋喃胶囊60mg/日和120mg/日剂量治疗广泛性焦虑障碍的安全性。探索性目的：如数据允许，基于PopPK分析方法，探索性描述布格呋喃胶囊在广泛性焦虑障碍患者中的PK特征。如数据允许，评估布格呋喃胶囊的暴露量与疗效和不良事件之间的关系。

开始日期2023-07-20

申办/合作机构

中国医学科学院药物研究所

[+1]

100 项与布格呋喃相关的临床结果

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100 项与布格呋喃相关的转化医学

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100 项与布格呋喃相关的专利（医药）

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项与布格呋喃相关的文献（医药）

2023-06-01·Brain Research Bulletin

Antidepressant effect of 4-Butyl-alpha-agarofuran via HPA axis and serotonin system

Article

作者: Peng, Ying ; Chen, Qiuyu ; Shang, Nianying ; Yin, Dali ; Hu, Jinping ; Hu, Jiahuan ; Li, Xinnan ; Liu, Mengyao ; Xiao, Qiong ; Lan, Jiaqi ; Wang, Hongyue ; Xiang, Longgang

Depression is a leading cause of disability worldwide and the psychiatric diagnosis most commonly associated with suicide. 4-Butyl-alpha-agarofuran (AF-5), a derivative of agarwood furan, is currently in phase III clinical trials for generalized anxiety disorder. Herein, we explored the antidepressant effect and its possible neurobiological mechanisms in animal models. In present study, AF-5 administration markedly decreased the immobility time in mouse forced swim test and tail suspension test. In the sub-chronic reserpine-induced depressive rats, AF-5 treatment markedly increased the rectal temperature and decreased the immobility time of model rats. In addition, chronic AF-5 treatment markedly reversed the depressive-like behaviors in chronic unpredictable mild stress (CUMS) rats by reducing immobility time of forced swim test. Single treatment with AF-5 also potentiated the mouse head-twitch response induced by 5-hydroxytryptophan (5-HTP, a metabolic precursor to serotonin), and antagonized the ptosis and motor ability triggered by reserpine. However, AF-5 had no effect on yohimbine toxicity in mice. These results indicated that acute treatment with AF-5 produced serotonergic, but not noradrenergic activation. Furthermore, AF-5 reduced adrenocorticotropic hormone (ACTH) level in serum and normalized the neurotransmitter changes, including the decreased serotonin (5-HT) in hippocampus of CUMS rats. Moreover, AF-5 affected the expressions of CRFR1 and 5-HT2C receptor in CUMS rats. These findings confirm the antidepressant effect of AF-5 in animal models, which may be primarily related to CRFR1 and 5-HT2C receptor. AF-5 appears to be promising as a novel dual target drug for depression treatment.

2023-01-01·Heliyon

Adsorption of sulfur on Lanxess Lewatit® AF 5 resin during the acidic albion leaching process for chalcopyrite

Article

作者: Pickles, Chris ; Marzoughi, Omid ; Ghahreman, Ahmad

Elemental sulfur is one of the major byproducts of the acidic Albion leaching process for chalcopyrite. It is a challenging component in the leach solution as it impedes gold recovery from the residue. Lanxess Lewatit® AF 5 (AF 5) is a microporous carbon-based resin, which is being investigated for the removal of elemental sulfur during this leaching process. In the current research, a series of leaching experiments were performed as a function of temperature, agitation speed and concentrate to AF 5 ratio. Using these results, the adsorption isotherms, the kinetics and the thermodynamics of sulfur removal were studied. One hundred percent of the elemental sulfur could be adsorbed by the AF 5 resin from the acidic Albion leaching process for chalcopyrite. Adsorption isotherms at various temperatures were determined using the Langmuir and Freundlich models. The maximum sorption capacity of AF 5 at 95 °C was 488 mg/g. The kinetic data were fitted to pseudo-first order (PFO) and pseudo-second order (PSO) models and it was shown that the PFO model was best suited to describe the results. The rapid kinetics of sulfur adsorption were attributed to the open pore structure of the AF 5. The Gibbs free energy, enthalpy and entropy of sulfur adsorption by AF 5 were determined as follows: ΔG_ads ^o = -1.9 kJ/mol, ΔH_ads ^o = -9.1 kJ/mol, and ΔS_ads ^o = -0.1 kJ/(mol K). The negative free energy and enthalpy changes demonstrated that the adsorption of elemental sulfur was both spontaneous and exothermic over the temperature range studied.

2022-10-01·Anti-Cancer Agents in Medicinal Chemistry4区 · 医学

Antiproliferative Effects of Artabotrys odoratissimus Fruit Extract and its Bioactive Fraction through Upregulation of p53/γH2AX Signals and G2/M Phase Arrest in MIA PaCa-2 Cells

4区 · 医学

Article

作者: Malleshappa, Pallavi ; Pargi, Meghana ; Malleshappa, Kumaraswamy Honnenahally ; Jain Raviraj, Sandeep Kumar ; Urumarudappa, Santhosh Kumar J. ; Narayanappa, Prashanth

Background:Artabotrys odoratissimus (Annonaceae) is a medicinal and ornamental plant widely cultivated in Southeast Asia for its famous ylang ylang essential oil. The fruits of this plant are used for health benefits, but very little is studied about the bioactive principles, their role in regulating oxidative stress and tumour progression.Objective:The study aimed to evaluate the antiproliferative effects of fruit extract of Artabotrys odoratissimus and its bioactive fraction using cell-based assays.Methods:The free radical scavenging and antiproliferative effects of Artabotrys odoratissimus fruit ethyl acetate (FEA) extract and its bioactive fraction were evaluated using cell viability assays, colony formation assay, double staining assay, reactive oxygen species (ROS) assay, comet assay, cell cycle analysis, and western blotting.Results:The extract showed phenolic content of 149.8±0.11μg/mg Gallic acid equivalents and flavonoid content of 214.47±4.18 μg/mg Quercetin. FEA showed an IC50 value of 76.35 μg/ml in the ABTS assay and an IC50 value of 134.3±7.8 μg/ml on MIA PaCa-2 cells. The cells treated with 125 μg/ml and 250 μg/ml FEA showed increased apoptotic cells in Double staining assay, DNA damage during comet assay, enhanced ROS, and cell cycle arrest at G2M phase at 125 μg/ml and 250 μg/ml. The active fraction AF5 showed an IC50 value of 67±1.26 μg/ml on MIA PaCa-2 cells during MTT assay, displayed potential antiproliferative effects, and showed a marked increase in the expression of γH2AX and p53.Conclusion:These results prove that the fruit extract and the bioactive fraction demonstrate oxidative stress-mediated DNA damage, leading to apoptosis in the MIA PaCa-2 cell line.

100 项与布格呋喃相关的药物交易

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