Comparing the efficacy of Allicin derivatives capsule and Placebo as an adjuvant for patients with COVID-19: A double-blind randomized placebo controlled clinical trial

开始日期2020-06-21

申办/合作机构-

IRCT20180705040351N1 / Completed临床4期IIT

Comparison of the effect a period of consumption Allicin and Silybum Marianum supplementation with four weeks wrestling selective training on some of the antioxidant and oxidative indicators in trained wrestlers

开始日期2018-07-23

申办/合作机构

Islamic Azad University

100 项与大蒜素相关的临床结果

登录后查看更多信息

100 项与大蒜素相关的转化医学

登录后查看更多信息

100 项与大蒜素相关的专利（医药）

登录后查看更多信息

988

项与大蒜素相关的文献（医药）

2024-11-01·Parasite Epidemiology and Control

An update on Leishmania martiniquensis infections: Transmission, clinical characteristics, and treatment

Review

作者: Ahmadi, Somayyeh ; Rahimi Esboei, Bahman ; Esboei, Bahman Rahimi ; Hataminejad, Maryam ; Fakhar, Mahdi ; Hosseini, Seyed Abdollah

Leishmaniasis, caused by intracellular protozoa of the Leishmania genus, continues to be a global health issue, with approximately 700,000 to 1 million new cases occur annually worldwide. The disease is transmitted via the bite of infected female sand flies of the genus Phlebotomus, resulting in a range of symptoms known as cutaneous, mucocutaneous, and visceral leishmaniasis. The species Leishmania (Mundinia) martiniquensis, discovered in 1995, has been linked to cases in individuals with HIV, presenting with diverse clinical pictures. Interestingly, biting midges, not sandflies, has proved to serve as its potentially biological vector. This study focuses on understanding the transmission, clinical aspects, and effective treatment of L. martiniquensis infections. A comprehensive search strategy was employed to identify relevant published papers on the epidemiology, transmission, clinical characteristics, and treatment of L. martiniquensis up to August 2024. The clinical manifestations encompass localized cutaneous leishmaniasis, disseminated cutaneous leishmaniasis, mucocutaneous leishmaniasis, and visceral leishmaniasis. Leishmaniasis is associated with comorbidities such as inadequate nutrition, population displacement, and reduced immunity. Risk factors for Leishmania infection include the presence of domestic animals, age, gender, and environmental factors. Amphotericin B deoxycholate (AmB) is the main treatment. Combination therapy with allicin and andrographolide may reduce AmB side effects. Recent research investigates other treatments including 8-hydroxyquinoline, which works synergistically with AmB against L. martiniquensis.

2024-11-01·Plant Physiology and Biochemistry

Photoperiod and temperature as dominant environmental drivers triggering chemical compositions of garlic bulb during growth

Article

作者: Liu, Hanqiang ; Cheng, Zhihui ; Ali, Muhammad ; Pan, Yupeng

Photoperiod and temperature are crucial for plant growth and development, but the accumulation patterns and regulatory mechanisms of garlic in response to these factors remain unclear. Compared to normal conditions (12/12 h light/dark; 22/15 °C day/night), increasing the photoperiod by 1 h each month with normal temperature (13/11, 14/10, 15/9, 16/8 h; light/dark; 22/15 °C day/night) or increasing photoperiod by 1 h with a 1.5 °C increase in temperature (13/11, 14/10, 15/9, 16/8 h light/dark; 23.5/16, 25/17, 26.5/18, 28/19 °C day/night) at monthly intervals substantially affects garlic growth in early G204, mid-G666, and late G390 harvest cultivars. For both increased photoperiod and temperature, the environment most favorable for bulb growth is characterized by the maximum accumulation of hormones (IAA, JA, and ZT) during bulb formation, while higher levels of ACC, phenolic acids, and organosulfur compounds are observed during the harvesting stage. Furthermore, the accumulation patterns of alliin and allicin in garlic bulbs for G204, G666, and G390 cultivars significantly increased, with fold changes of (2.0, 1.8, and 1.9) and (1.8, 1.7, and 1.5), respectively, in response to increased photoperiod and temperature conditions. Additionally, the accumulation pattern in G204, and G666 was similar but notably distinct from late harvest G390 during growth. In this study, metabolomics models were constructed to assess chemical composition variations and predict the differences among three garlic varieties during the growth stages. These models revealed functional component variations and provided reliable predictions, offering valuable insights for estimating garlic chemical compositions and identifying optimal environmental conditions for growth.

2024-11-01·World Neurosurgery

ROS-responsive Hydrogel Loaded with Allicin Suppresses Cell Apoptosis for the Treatment of Intervertebral Disc Degeneration in a Rat Model

Article

作者: Zhou, Ke ; Huang, Qing ; Lu, Liangjie ; Hu, Keqi ; Zhang, Ting ; Gan, Kaifeng

BACKGROUNDIntervertebral disc degeneration (IVDD) is a common cause of lower back pain, and cell apoptosis plays a key role in its progression. This study explores the therapeutic potential of a reactive oxygen species (ROS)-responsive hydrogel loaded with allicin for treating IVDD.METHODSAllicin was encapsulated in a ROS-responsive hydrogel, and its controlled release was studied in vitro. Nucleus pulposus (NP) cells were treated with hydrogen peroxide to induce apoptosis, and the effects of the hydrogel were examined using qPCR and Western blotting. An in vivo rat model of IVDD was also established to assess the efficacy of the treatment.RESULTSThe ROS-responsive hydrogel effectively inhibited apoptosis in NP cells by reducing ROS levels and modulating the expression of apoptotic and anti-apoptotic genes. In the rat model, the hydrogel loaded with allicin significantly reduced IVDD, preserving disc morphology and matrix integrity.CONCLUSIONSROS-responsive hydrogel loaded with allicin shows potential as a therapeutic approach for IVDD by inhibiting cell apoptosis and reducing disc degeneration in vivo.

项与大蒜素相关的新闻（医药）

2024-11-17

·生物谷

大蒜——对抗酒精性肝病（ALD）的良药！Genes Nutr | 大蒜素能够降低炎症因子和TLR4的表达，并提升酒精脱氢酶水平

肝脏是我们身体里的“大功臣”，默默地为我们处理各种毒素和废物。然而，它常常受到肝病的威胁，特别是酒精性肝病（Alcoholic Liver Disease，ALD）。长期过量饮酒是引发ALD的“导火索”。在日常生活中，有些人因应酬或不良习惯而长期饮酒过量，这可能导致肝脏逐渐积累脂肪，引发炎症，最终恶化成肝硬化甚至肝癌。这就像一颗隐藏在体内的“定时炸弹”，随时可能爆发，严重危害我们的健康和生活质量。目前，ALD的治疗进展缓慢，传统治疗方法效果有限，而且药物可能引发不良反应，让患者在治疗过程中倍感痛苦。然而，大自然总是充满惊喜。大蒜，这种厨房中常见的调味品，可能蕴含着治疗ALD的巨大潜力。自古以来，大蒜就被用于保健，它富含多种活性成分，如含硫化合物和酶类。以往的研究发现，这些成分具有抗氧化、抗炎和调节代谢等多种生物学活性，可能有助于保护肝脏。然而，大蒜在ALD治疗中的具体作用机制尚未完全明确。近日，山西医科大学第二医院的研究团队在《基因与营养》（Genes & Nutrition）杂志上发表了一篇题为“Exploring the Therapeutic Potential of Garlic in Alcoholic Liver Disease: A Network Pharmacology and Experimental Validation Study”的研究论文。在这项研究中，研究人员运用网络药理学和分子对接技术，对大蒜治疗ALD的活性化合物与关键靶点进行了预测。大蒜活性成分及干预靶点的确定：通过对TCMSP数据库的筛选，依据口服生物利用度（OB）大于30%且排除低特异性成分的条件，研究人员确认了26种大蒜活性成分。同时，综合多个数据库信息，收集到503个大蒜潜在靶点，为后续研究大蒜在治疗ALD中的作用提供了基础数据。图1：大蒜的主要有效成分酒精性肝病潜在治疗靶点的获取：从DisGeNET、GeneCards和DiGSeE数据库分别检索与ALD相关的靶点，经过整理和合并，确定了717个主要靶点。将这些靶点与大蒜靶点取交集，最终得到83个潜在治疗靶点。构建相互作用网络及通路分析：将83个潜在治疗靶点导入String数据库构建PPI网络，并获取GO主题和KEGG通路信息。随后将活性成分、潜在治疗靶点、GO主题和信号通路导入Cytoscape软件，成功构建成分-疾病-靶点相互作用网络。图2：大蒜活性成分-ALD-靶点相互作用网络 GO和KEGG通路富集分析结果显示，基因功能在分子功能（MF）、细胞组成（CC）和生物过程（BP）方面有不同程度的富集，如GO-BPs涉及脂肪酸代谢等过程，靶点主要富集在107个KEGG通路，包括与ALD密切相关的药物代谢-细胞色素P450等通路。这些分析结果表明大蒜可能通过多种生物学过程和信号通路对ALD产生影响。同时，通过特定算法筛选出10个核心靶点，如IL6、TNF等。分子对接验证活性成分与靶点的结合：以大蒜主要活性成分作为配体，与从PPI网络中选取的核心靶点进行分子对接。设定分子结合能小于-4.2 kcal/mol为有意义的结合强度标准，发现SobrolA、Benzaldoxime和(+)-L-Alliin等成分对炎症因子（IL6、TNF、IL1B）和受体TLR4表现出较强的结合能力，且SobrolA对酒精脱氢酶（ADH1A、ADH1B、ADH1C、ADH5）的结合稳定性最佳。这一结果从分子层面揭示了大蒜活性成分与ALD相关靶点的相互作用机制。图3：活性成分与炎症因子的分子对接结果蛋白质-蛋白质相互作用网络分析的深入见解：详细的蛋白质-蛋白质相互作用网络分析展示了活性成分与受体结合的具体模式和结合位点信息。例如，SobrolA与IL6、TNF、IL1B和TLR4的结合方式及结合位点各不相同，这进一步解释了活性成分如何在分子水平上发挥作用，为理解大蒜治疗ALD的机制提供了更微观的视角。人类组织中关键基因表达状态的分析与差异探讨：利用GSE28619数据集对人类组织中关键基因在ALD中的表达进行分析，发现ADH1A和ADH1C在酒精性肝炎患者肝组织中表达下调，而ADH1B和ADH5无明显变化，炎症因子TNF、IL6、IL1B和受体TLR4的表达差异不显著。这一结果与之前网络药理学和分子对接的结论不完全一致，促使研究人员进行实验验证。通过实验发现ALD小鼠炎症因子和TLR4表达增加，ADH水平降低。图4：ALD中人体组织中关键基因的表达大蒜治疗ALD的潜在机制及乙醇代谢的关联：乙醇在肝脏的氧化代谢主要依赖酒精脱氢酶（ADH），ALD患者肝脏中ADH表达下调，影响乙醇解毒，进而导致肝损伤。研究推测大蒜可能通过增加ADH活性来促进乙醇代谢，从而抑制ALD进展。这一假设与实验中观察到的ALD小鼠ADH水平降低相呼应，为大蒜治疗ALD的机制提供了一种合理的解释。大蒜核心基因及活性成分在治疗中的关键作用：通过算法筛选和信号通路分析确定的10个核心基因，如IL6、TNF、AKT1等，在大蒜治疗ALD过程中发挥关键作用。分子对接验证了部分活性成分对这些核心基因的强结合能力，实验也证实大蒜素治疗可提高ADH活性、降低炎症因子和TLR4表达。因此，SobrolA、(+)-L-Alliin、Benzaldoxime和Allicin等成分因其对关键ALD相关基因的显著亲和力，成为治疗ALD极具潜力的天然药物候选者。这些发现为开发基于大蒜的ALD治疗方法提供了重要的理论依据。图5：大蒜素对小鼠血清中抗炎因子和TLF4表达的影响总体而言，本研究运用网络药理学和分子对接技术，在大蒜治疗ALD方面取得重要成果。通过数据库筛选确定了大蒜的26种活性成分及503个潜在靶点，与ALD相关数据库取交集得到83个潜在治疗靶点，构建的相互作用网络和通路分析揭示了大蒜可能通过多种途径影响ALD。分子对接验证了部分活性成分与核心靶点的强结合能力，虽人类组织基因表达分析初有不符但经实验验证了ALD小鼠炎症因子和TLR4表达及ADH水平变化。研究表明大蒜可能通过减轻炎症反应和增强乙醇代谢阻碍ALD进展，其中SobrolA等成分极具潜力，为开发治疗ALD的药物提供了理论依据，凸显了植物药在肝病治疗中的重要性。参考文献： Gao, S., Gao, T., Li, L. et al. Exploring the therapeutic potential of garlic in alcoholic liver disease: a network pharmacology and experimental validation study. Genes Nutr 19, 13 (2024). https://doi.org/10.1186/s12263-024-00748-3 本文仅用于学术分享，转载请注明出处。若有侵权，请联系微信：bioonSir 删除或修改！点击下方「阅读原文」，前往生物谷官网查询更多生物相关资讯~

2024-08-09

·CPHI制药在线

天然药物抗呼吸道病毒感染作用机制研究进展

关注并星标CPHI制药在线呼吸道病毒是以呼吸道为侵入门户，在呼吸道黏膜上皮细胞中增殖，引起呼吸道局部感染或呼吸道以外组织器官病变的一类病毒，主要包括正黏病毒科（流感病毒）、副黏病毒科（副流感病毒、呼吸道合胞病毒、麻疹病毒、腮腺炎病毒、亨德拉病毒、尼帕病毒、人偏肺病毒）、冠状病毒科（SARS-CoV、MERS-CoV、2019-nCoV冠状病毒）、披膜病毒科（风疹病毒）、小RNA病毒科（鼻病毒）等不同病毒科的多种病毒。呼吸道病毒感染是全球范围内人类发病和死亡的主要原因之一，多数急性呼吸道感染是由病毒引起的。天然药物主要通过直接和间接途径发挥抗呼吸道病毒感染类疾病，直接作用是指抑制病毒的吸附和阻止病毒释放，从而保护机体细胞不受损害，间接作用则是通过免疫调节作用起到抗病毒效果。 1、抑制病毒的吸附和阻止病毒释放血管紧张素转化酶2 (angio‐tensin-converting enzyme 2，ACE2) 是存在于宿主细胞上的一种受体，新型冠状病毒表面的刺突蛋白可以协助病毒找到宿主细胞上的 ACE2 受体并诱导病毒与受体细胞相结合，吸附宿主细胞，在酶的反应下病毒的包膜与宿主细胞融合进而入侵宿主细胞。研究发现青蒿素及其衍生物可以缠绕新冠病毒刺突蛋白的Lys353和Lys31 结合位点，从而影响其与人体ACE2受体蛋白的融合，从而阻止病毒吸附宿主细胞。高分辨质谱和ACE2生物色谱法筛选确定连花清瘟中的大黄酸、连翘苷A、连翘苷I、新绿原酸及其异构体对ACE2具有高度抑制作用。姜黄素、醉茄素A、胡椒碱、芒果苷、蒂巴因、小檗碱、穿心莲内酯和印楝素对SARS-CoV-2 的刺突蛋白和ACE2 受体均具有显著的结合亲和力，可以阻断刺突蛋白与ACE2 受体的结合从而抑制病毒吸附宿主细胞。中药丹参水溶性单体成分丹酚酸可通过阻止刺突蛋白六螺旋束结构形成，有效抑制新型冠状病毒的吸附。血凝素（HA）和神经氨酸酶（NA）是流感病毒包膜上的2种糖蛋白，在流感病毒入侵宿主细胞及传播的过程中扮演着重要的角色。HA可识别并结合宿主细胞表面的唾液酸受体，使病毒粘附于宿主细胞表面、介导病毒包膜与胞内体膜融合；NA能够水解宿主细胞表面的唾液酸释放新病毒。研究发现，槲皮素可通过与流感病毒血凝素蛋白结合，竞争性抑制流感病毒血凝素与宿主细胞的唾液酸结合，抑制病毒包膜与宿主细胞膜融合，抑制病毒以胞吞形式入侵宿主细胞。发酵人参提取物可通过抑制HA、NA活性对H1N1、H3N2、H5N1、H7N9病毒起到治疗作用。穿心莲内酯磺化物可通过抑制HA活性实现抗H1N1、H3N2、乙型流感病毒（IBV）的作用。大蒜素可以用作H1N1的NA、HA、M2蛋白通道的有效多靶点抑制剂，黄芩苷可通过抑制病毒的血凝素HA2亚基活性而抑制H5N1禽流感病毒的进入。安石榴苷能抑制流感病毒的神经氨酸酶，阻止唾液酸的分解，阻断病毒释放。诃子酸和诃子林鞣酸可以抑制病毒NA蛋白的活性，破坏病毒与宿主细胞上唾液酸的结合，在感染的细胞中阻止病毒释放。人呼吸道合胞病毒 (human respiratory syncytial virus，HRSV) 含有三种膜结合蛋白：附着蛋白(G)、融合蛋白(F)、病毒孔蛋白 (SH)。蛋白G可与宿主细胞结合，蛋白F可以融合病毒和细胞膜，使病毒核糖核蛋白能够到达细胞质。三种糖蛋白相互作用使病毒入侵宿主细胞。甘草可通过抑制病毒附着、内化减少HRSV感染，18β-甘草次酸是影响甘草抗HRSV 活性的活性成分之一。穿心莲内酯衍生物可有效抑制HRSV包膜表面糖基蛋白荧光肽的裂解，阻止病毒入侵细胞。车前草醇提液可通过与HRSV竞争结合Hep-2细胞表面的特异性受体抑制HRSV的吸附过程，同时可直接杀死病毒，发挥抗RSV作用。 2、抑制病毒的增殖病毒感染特定的活细胞后，可以在病毒核酸的控制下，利用宿主细胞的能量系统、核糖体等合成病毒核酸和蛋白质，最后组装成结构完整、具有感染力的成熟病毒颗粒。冠状病毒3C 样蛋白酶(3C-like protease，3CLpro) 与木瓜蛋白酶样蛋白酶(papain-like protease，PLpro) 在病毒增殖过程能够将多肽链切割分解成病毒复制需要的片段。通过研究发现，木犀草素、β-谷甾醇、芒柄花黄素、紫檀素、蒙花苷、金丝桃苷等通过与3CLpro特异性结合，阻止3CLpro发挥作用。萝卜硫素 (SFN) 是一种缓慢结合的抑制剂，SFN与3CLpro能够发生共价反应，形成了SFN-3CLpro复合物，从而阻断3CLpro的作用。杨梅素可以与3CLpro共价结合，阻止3CLpro发挥作用，从而抑制病毒的增殖。冬凌草甲素不仅能够抑制3CLpro 的活性，而且在高浓度下可以阻止PLpro主导的反应活动，从而阻止病毒的增殖。新橙皮苷、蛇床子素等与PLpro结合，阻止PLpro发挥作用，从而抑制病毒增殖。西北甘草异黄酮和甘草异黄酮 A可以与RNA依赖的RNA聚合酶 (RNA-dependent RNA polymerase，RdRp) 结合形成复合物，阻止RdRp发挥作用，从而抑制病毒的增殖。核因子-κB (nuclear factor-κB，NF-κB) 信号通路可以调节流感病毒RNA合成，在病毒的复制过程中发挥重要作用。葡萄红素B能够抑制H1N1病毒在MDCK和A549细胞中的复制，并通过IκB激酶 (IκB kinase，IKK) 去磷酸化抑制NF-κB 转入细胞核，从而降低了病毒诱导的活性氧 (reactive oxygen species，ROS)的生成。细胞周期蛋白依赖性激酶抑制剂p21可以直接与病毒聚合酶酸性蛋白结合，并通过破坏核糖核蛋白复合物的形成来限制IAV聚合酶活性，从而阻止病毒增殖。免疫调节病毒感染机体时，巨噬细胞是防御系统的第一道屏障，产生各种抗病毒因子如白细胞介素IL-1、IL-6、肿瘤坏死因子TNF⁃α等，介导机体发挥抗病毒免疫应答，进而抑制和清除体内病毒细胞。人参多糖治疗H9N2感染的鸡发现，其胚胎成纤维细胞CEF中MHC Ⅱ基因表达及细胞因子IL-2、IL-4、IL-10水平升高，表明人参多糖可通过增强体液免疫应答促进机体抗病毒活性。儿茶提取物可增强流感病毒感染小鼠的细胞免疫，还能促进特异性中和抗体产生。干扰素是细胞相互交流以预防和根除病毒感染的一种手段，分为Ⅰ型、Ⅱ型、Ⅲ型。先天性免疫细胞分泌的以IFN⁃α 与IFN⁃β 为主的Ⅰ型干扰素（IFN）介导的天然免疫机制是宿主细胞抵抗冠状病毒最重要的方式之一。研究报道，黄檗水提物通过诱导Ⅰ型干扰素（IFN⁃β）或促炎性细胞因子（IL-6、TNF⁃α）和随后刺激在宿主细胞中的抗病毒状态，从而抑制病毒复制，提高小鼠对甲型流感病毒H1N1、H5N2、H7N3、H9N2的感染存活率。IFN⁃γ 属于Ⅲ型干扰素，主要由Ⅰ型辅助性T细胞（Th1细胞）及自然杀伤细胞产生。研究表明，红参水提物可通过抑制HRSV诱导的小鼠树突状和巨噬细胞样细胞中炎性因子TNF⁃α、IL-6、IL-8表达和人肺上皮细培养液中活性氧的形成，降低肺病毒载量，增强干扰素IFN⁃γ分泌以及增加小鼠 HRSV感染后CD8+T细胞和CD11c+树突状细胞的数量等多种机制发挥抗HRSV作用。此外，红参水提取物可诱导甲型流感病毒H5N1感染的小鼠肺组织IFN⁃α、IFN⁃γ 产生，增强免疫从而减轻H5N1流感病毒的感染。视黄酸诱导基因1样受体（RLRs）信号通路在抗病毒免疫的过程中发挥着重要作用。当16HBE细胞被H1N1 病毒感染后，炎症因子IL-4、IFN⁃γ、RLRs通路相关因子RIG-Ⅰ、IFN⁃β 启动子刺激物⁃1（IPS-1）、IRF-7、IRF-3、NF⁃κB水平均升高，穿心莲内酯干预后上述因子水平均降低，提示穿心莲内酯可通过降低其信号因子来影响RLRs信号通路。研究发现，连翘酯苷A可通过降低小鼠肺部免疫细胞的RLRs信号通路相关蛋白RIG-Ⅰ、MAVS、NF?κBp65表达，降低Th 1/Th 2和Th 17/Treg比例，从而减轻甲型流感病毒FM1株在小鼠肺部引起的炎症反应。 Toll样受体（TLRs）信号通路也是和呼吸道病毒相关的天然免疫主要信号通路之一， TLRs可以激活 NF⁃κB等转录因子，促进多种与免疫有关的细胞因子及趋化因子的分泌从而引起炎症反应。玉叶金花水提物能抑制感染流感病毒A/FM1/47（H1N1）小鼠血清TNF⁃α、IL⁃6、 IL-1β过表达及肺组织中TLR7、MyD88、NF⁃Κb mRNA及蛋白表达，提示玉叶金花可通过降低TLR7介导的MyD88依赖的信号转导通路活化抑制 NF⁃κB活性，从而减轻炎症风暴，发挥抗流感病毒作用。研究发现，栀子苷通过影响TLR3/TRIF信号通路，降低炎性细胞因子IL-6、TNF⁃α 表达，促进抗病毒因子IFN⁃β 合成，保护A/FM/1/4（H1N1）建立的流感病毒性肺炎小鼠引起的病毒性肺损伤。黄芩苷可通过抑制TLR4/NF⁃κB信号转导途径，降低下游细胞因子IL-6 水平来发挥抑制 HRSV 感染的作用。参考文献： [1]王剑,张萍萍,于健,等.天然药物抗呼吸道病毒活性成分及其作用机制研究进展[J].药学学报,2024,59(04):853-865. [2]杜正彩,郝二伟,韦棪婷,等.中国-东盟传统药用植物抗呼吸道常见病毒研究进展[J].中成药,2022,44(11):3579-3587. 作者简介：小米虫，药品质量研究工作者，长期致力于药品质量研究及药品分析方法验证工作，现就职于国内某大型药物研发公司，从事药品检验分析及分析方法验证。 END 【智药研习社直播预告】来源：CPHI制药在线声明：本文仅代表作者观点，并不代表制药在线立场。本网站内容仅出于传递更多信息之目的。如需转载，请务必注明文章来源和作者。投稿邮箱：Kelly.Xiao@imsinoexpo.com ▼更多制药资讯，请关注CPHI制药在线▼ 点击阅读原文，进入智药研习社~

临床结果临床研究

2023-10-09

·PRNewswire

Pharmactive's Aged Black Garlic Extract May Relieve Mild Hypertension in New Study

New clinical study indicates ABG10+® supports drug therapy to maintain blood pressure levels in a normal range. MADRID, Oct. 9, 2023 /PRNewswire/ -- Results of a new clinical study have confirmed the blood pressure balancing effect of Pharmactive Biotech Products, SLU's ABG10+®. Aged Black Garlic (ABG10+®) has demonstrated the positive effect in blood pressure in patients exhibiting Grade-1 hypertension receiving prescribed drug treatment. Continue Reading Pharmactive’s Aged Black Garlic Extract May Improve High blood Pressure Levels in New Study Aged Black Garlic is a whole raw garlic bulb (Allium sativum L) that has been aged under controlled temperatures for a certain period of time. Pharmactive's proprietary ageing process potentiates the accumulation of garlic's bioactive complex of antioxidant compounds, including polyphenols, flavonoids, and melanoidins—particularly S-allyl cysteine (SAC). The study, published in the research journal Nutrients, was a randomized, triple-blind controlled trial conducted at the Hospital Universitari Arnau de Vilanova (Lleida, Spain), and in collaboration with the Atherothrombotic Disease Detection and Treatment Unit (UDETMA). Led by Dr. José Carlos Serrano, Ph.D., the study involved 81 volunteers suffering from Stage 1 hypertension and who were already on blood pressure-reducing medication. Over a period of 12 weeks, the subjects received 250mg of ABG10+ daily, which provided 0.25mg of SAC, or a placebo. No changes were made to diet or lifestyle and the subjects were instructed to continue taking their blood pressure medication. Blood pressure measurements were recorded daily at home by the participants as well as at baseline and at the end of the study by specialists. The addition of ABG+ supplementation helped better control blood pressure levels, with reductions observed in both systolic and diastolic blood pressure of 1.8 mmHg and 1.5 mmHg, respectively. Moreover, it was observed via blood serum tests that ABG10+ supplementation may boost the release of nitric oxide and increase the body's antioxidant capacity. ACE (angiotensin converting enzyme) activity seemed to be reduced, and lower blood uric acid levels also were observed. "These secondary parameters help us gain an understanding of the likely mechanism behind ABG10+'s effect on blood pressure," explains Alberto Espinel, Open Innovation Director of Pharmactive. "Nitric oxide is a natural vasorelaxant produced in the body to maintain cardiovascular function, improving blood pressure, and increasing blood flow. Nitric oxide also is a cellular antioxidant and thus helps mitigate oxidative stress and its associated negative effects on blood vessels and the cardiovascular system. Reducing the angiotensin converting enzyme activity is a key strategy to decrease blood pressure in hypertensive patients." The majority of the volunteers enrolled in the study had a medical history of high blood pressure spanning 15 years on average. Despite adhering to their prescribed pharmacological routine, they were still unable to maintain blood pressure levels within a normal range. "This study suggests that incorporating food bioactives such as aged black garlic extract into the treatment regimen could serve as a valuable complement to conventional drug therapy, and could contribute to reduced cardiovascular risk," Espinel adds. "Such intervention could be especially beneficial for the management of arterial high blood pressure in persons experiencing resistance to drug therapy—all without inducing side effects." Hypertension is a leading risk factor for cardiovascular disease, including stroke and heart failure. Research has demonstrated that even modest reductions in blood pressure can lead to meaningful gains in the prevention of such incidents. For example, a reduction of 2mm Hg in systolic blood pressure can reduce the risk of stroke by 10% in middle age. The new study followed favorable outcomes of a 2022 clinical trial involving ABG+, where participants with moderately elevated cholesterol levels achieved significant reduction in diastolic blood pressure (5.85 mmHg on average) compared to placebo. "As garlic ages, its fresh compounds like allicin and sulphur undergo chemical changes, forming new compounds, including SAC and melanoidins," explains Carlos Rodríguez, Communication Manager. "These compounds create the special flavor, aroma, and color of aged black garlic which is why it is a culinary favorite of chefs. Yet these same bioactive compounds are believed to possess powerful antioxidant and support cardio health." Pharmactive's ABG10+ extract is derived from garlic grown and cultivated in Castilla la Mancha, two hours away from the company's facility in Madrid, and gently processed using green technology, without the use of solvents, or chemicals. The ingredient can readily be incorporated into supplements as well as functional foods. About Pharmactive Pharmactive Biotech Products, SLU, is a Madrid-based pioneering biotechnology company that develops and manufactures differentiated natural ingredients supported by science, such as damiana extract, pure saffron extract, and aged black garlic. The company's mission is to make a daily positive and significant impact on people's health and well-being through premium botanical ingredients backed by scientific studies and approved by ethics committees. Be sure to visit Pharmactive at Supply Side West, 25-26 Oct (Booth #2965). For more information, contact: Photo - SOURCE Pharmactive Biotech Products, S.L.