Effectiveness of Combination of Oral Melatonin with Non-Pharmacological Measures vs Non-Pharmacological measures alone on Quality of Sleep in critically ill Adult patients- Randomised Controlled Trial - NIL

开始日期2024-10-01

申办/合作机构-

CTRI/2024/08/073110 / Not yet recruitingN/A

A comparative study of oral melatonin versus pregabalin for attenuation of hemodynamic response to laryngoscopy and endotracheal intubation: A prospective randomized open label study. - NIL

开始日期2024-09-25

申办/合作机构-

IRCT20110301005942N9 / Suspended临床3期IIT

The effect of adding oral melatonin in In Vitro Fertilization (IVF) cycles on the quality and quantity of eggs and embryos and the rate of clinical and chemical pregnancy in infertile women.

开始日期2024-09-20

申办/合作机构-

100 项与 Melatonin oral gel(Spherium Biomed SL) 相关的临床结果

登录后查看更多信息

100 项与 Melatonin oral gel(Spherium Biomed SL) 相关的转化医学

登录后查看更多信息

100 项与 Melatonin oral gel(Spherium Biomed SL) 相关的专利（医药）

登录后查看更多信息

项与 Melatonin oral gel(Spherium Biomed SL) 相关的文献（医药）

2024-08-01·Journal of periodontology

Clinicoradiographic comparative evaluation of 1% melatonin gel plus platelet-rich fibrin over platelet-rich fibrin alone in treatment of Grade II furcation defects: A randomized controlled double-blind clinical trial.

Article

作者: Lathiya, Vrushali N ; Dhande, Srushti K ; Rathod, Surekha R ; Kolte, Abhay P ; Kasliwal, Palak A

BACKGROUND:

The present study aims to evaluate and compare the effects of 1% melatonin gel plus platelet-rich fibrin (PRF) and PRF alone in treatment of furcation defects, clinically and radiographically using cone-beam computed tomography.

METHODS:

This split-mouth clinical trial included 23 patients with 46 bilateral Grade II furcation defects in first or second maxillary or mandibular molars. Control group was treated with PRF alone while the test group was treated with 1% melatonin gel and PRF. Clinical attachment level (CAL) and horizontal probing depth (HPD) were primary outcome parameters while secondary outcome parameters were pocket probing depth (PPD) and defect volume (DV) assessed at 3 and 6 months postoperatively.

RESULTS:

Significantly greater mean reduction of PPD, HPD, and CAL gain was observed in test group (2.23 ± 0.41, 2.36 ± 0.68, and 2.97 ± 0.62 mm, respectively) in comparison with control group (2.83 ± 0.78, 2.85 ± 0.67, and 3.21 ± 0.86 mm, respectively) at 6 months. A significant reduction in the mean DV was exhibited radiographically in test group (1.06 ± 0.5 mm³ ) as compared with control group (3.94 ± 1.32 mm³ ) at the end of 6 months. Both the groups showed improvements in assessed parameters.

CONCLUSIONS:

In Grade II furcation defects the combination therapy of 1% melatonin + PRF shows a statistically significant degree of bone fill within the periodontal tissues and also better results in terms of decrease in PPD, HPD, and a greater CAL gain.

2024-05-31·ALTERNATIVE THERAPIES IN HEALTH AND MEDICINE

Comparison of Topical 1% Melatonin Gel and Non-Surgical Periodontal Therapy for Stage I and Stage IV Periodontal Disease.

Article

作者: Wang, Qin ; Tang, Tian

Background:

Oral health is crucial for overall well-being, and periodontal disease can lead to serious complications such as intraosseous defects. In recent years, local administration of 1% melatonin gel has been explored as a potential treatment option for intraosseous defects. However, its efficacy compared to traditional non-surgical periodontal therapy (NSPT) is not fully understood.

Primary Study Objective:

To evaluate and compare the efficacy of 1% melatonin gel local administration with non-surgical periodontal therapy (NSPT) in the treatment of stage I and stage IV periodontal bone defects.

Methods/Design:

One hundred participants diagnosed with stage I and stage IV periodontal disease were recruited from Hangzhou Younuo Dental Clinic between December 2020 and March 2022. The participants were divided into two groups: a study group and a control group. The study group received local administration of 1% melatonin gel, while the control group received non-surgical periodontal therapy (NSPT). Oral examinations, including X-ray examinations, were conducted to assess the severity of bone defects before treatment initiation. The primary outcome measures included treatment efficacy, periodontal indicators (PD and BI levels), inflammatory response indicators (IL-1β, IL-6, and TNF-α levels), bone defect heights, and alveolar bone densities.

Results:

The treatment efficacy in the study group was significantly higher than that in the control group (95% CI -3.0 to -1.8, P = .011). Post-treatment, the study group had lower PD and BI levels compared to the control group (95% CI -1.0 to -0.8, P < .001; 95% CI -1·2 to -0.7, P < .001). Post-treatment, the study group had lower levels of IL-1β, IL-6, and TNF-α compared to the control group, (95% CI 0.3 to -0.8, P < .001; 95% CI -4.1 to -2.1, P < .001; 95% CI -3.5 to -1.6, P < .001). Post-treatment, the study group had lower bone defect heights and higher alveolar bone densities compared to the control group (95% CI 0.7 to 1.1, P = .028; 95% CI -2.2 to -1·8, P < .001).

Conclusion:

Local administration of 1% melatonin gel may be an effective treatment option for improving bone defects, enhancing periodontal indicators, alleviating inflammatory responses, and improving oral health in patients with stage I and stage IV periodontal disease.

2024-05-31·ALTERNATIVE THERAPIES IN HEALTH AND MEDICINE

Comparison of Topical 1% Melatonin Gel and Non-Surgical Periodontal Therapy for Stage I and Stage IV Periodontal Disease.

Article

作者: Wang, Qin ; Tang, Tian

Background:

Primary Study Objective:

To evaluate and compare the efficacy of 1% melatonin gel local administration with non-surgical periodontal therapy (NSPT) in the treatment of stage I and stage IV periodontal bone defects.

Methods/Design:

Results:

Conclusion:

项与 Melatonin oral gel(Spherium Biomed SL) 相关的新闻（医药）

2023-08-14

·PRNewswire

6 Tips to Get Sleep Back on Track

MISSION, Kan., Aug. 14, 2023 /PRNewswire/ -- (Family Features) For many people, changing seasons are about resetting routines and adjusting to a different pace of life. With fall activities in full swing, families should be intentional about their sleep routines to avoid missing the magical moments ahead. Continue Reading Photo courtesy of Natrol According to SleepScore, people lose an average of 15 1/2 hours of sleep (about 10 minutes each night) during summer months due to the "summer sleep slump." Addressing this challenge, Natrol, a leading sleep, mood and stress supplement brand, along with behavioral sleep specialist Shelby Harris, intend to help people gain control over their sleep and mood to be more present each day. "Sleep is supposed to help you live your day to the fullest," Harris said. "There are smart behavioral shifts you can make to maximize your sleep routine this fall, and sometimes that can include melatonin supplements. I always say, 'If you are taking a sleep aid that makes you sleepy throughout the day, what is the point of taking it?'" Harris recommends these easy tips to improve your sleep routine. Consider Sleep Cycle Changes Before trying to reset routines, consider the changes you're hoping to make. Track the sleep you're getting now and pay attention to factors that may hinder your current sleep cycle, from struggling to fall asleep to tossing and turning during the night, then think about the ways you might be able to improve those hindrances. Make Adjustments Gradually Remember, changes don't happen overnight. For many people, the solution is as simple as going to bed earlier. Rather than trying to make up that extra 30 minutes immediately, it's often helpful to slowly adjust routines. Try starting your bedtime ritual 5 minutes earlier each night to work toward your goal. Set Aside Time to Unwind Despite the hectic nature of fall schedules, it's important to prioritize time to unwind before bed. Whether it's reading a book, meditating or finding another slow-paced activity you enjoy, a calming, screenless way to slow your mind may help you fall asleep quicker. Be Thoughtful About Light Exposure It may seem obvious, but too much light exposure (indoor and out) at night can cause sleep issues. Be mindful of your own comfort by ensuring TVs and computers are powered down, smartphones are set aside, outdoor lights are off and curtains are drawn. Keeping the room dark can make a big difference when trying to fall and stay asleep throughout the night. Turn to a Drug-Free Sleep Aid Supplement If you follow consistently good bedtime habits but still have trouble falling asleep, try a low-milligram melatonin supplement, like those from Natrol, which are designed to help people sleep better so they can feel well-rested and ready to take on the day.† "Melatonin is not a one-stop solution to help get your sleep back on track," Harris said. "If you are taking melatonin, finding a brand with USP Verified options, like Natrol's 5MG Fast Dissolve Tablets, for example, is extremely important." Prioritize Your Wake-Up Routine That snooze button might be tempting, but those extra few minutes of sleep may do more harm than good. Ensure you wake up feeling refreshed by sticking to a consistent sleep cycle. Whether it's a morning stretch or simply forcing your feet to hit the floor, prioritizing movement and exposure to light can help kickstart the day. Find more ways to help get your sleep back on track by visiting Natrol.com. †These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease. Michael French [email protected] 1-888-824-3337 editors.familyfeatures.com About Family Features Editorial Syndicate A leading source for high-quality food, lifestyle and home and garden content, Family Features provides readers with topically and seasonally relevant tips, takeaways, information, recipes, videos, infographics and more. Find additional articles and information at Culinary.net and eLivingToday.com. SOURCE Family Features Editorial Syndicate

2023-08-14

·PRNewswire

USANA continues its industry-leading scientific innovation by announcing three new products at Americas & Europe Convention

SALT LAKE CITY, Aug. 14, 2023 /PRNewswire/ -- As a global leader in the health and wellness industry, USANA strives to continuously develop products featuring new, cutting-edge formulations. During its annual Americas & Europe Convention in Salt Lake City, USANA launched three new products. To learn more about USANA, please visit USANA.com . Continue Reading Barrier Balm Fizzy Energy Drink & 24hr Nutrition Pack "Our teams here at USANA have been working hard to create these new products," said Jim Brown, USANA's president and CEO. "We are constantly researching and developing what we provide to our customers. Nutrition is essential to a healthy life and that is why USANA is committed to creating new and innovative products." USANA Celavive Postbiotic Barrier Balm Barrier Balm is an ultra-hydrating cream that acts like a second skin to replenish and hydrate your skin's moisture barrier. USANA's postbiotic skincare works in harmony with your skin to promote the appearance of a well-balance complexion. Apply morning and night to your entire face and neck to keep your skin barrier hydrated—or use to visibly spot-treat any exceptionally dry skin. Key Ingredients: Cupuacu Butter Lactobacillus Ferment Olivol Botanical Blend Borage Oil Ceramide EOP, NS, NP, AS, AP 24hr Nutrition Pack - Revolve This new, daily nutrition pack provides broad-spectrum multivitamin and multimineral support with the patented InCelligence Complex. It also includes an AM Energy Optimizer to promote energy and cognitive function, and a PM Sleep Optimizer that primes your body for restful and restorative sleep. All of this is conveniently packaged in individual serving packets.* Key Ingredients: AM packet: Core Nutrition + Antioxidants providing broad-spectrum multivitamin and multimineral support featuring the patented InCelligence Complex AM Energy Optimizer containing a B vitamin complex, Korean ginseng, and green tea for naturally derived caffeine MagneCal D formulated with the ideal ratio of calcium, magnesium, and vitamin D PM packet: MagneCal D PM Sleep Optimizer formulated with L-theanine, ashwagandha, melatonin, and GABA Fizzy Energy Drink – Revolve This stick pack is a bubbly way to keep you moving throughout the day. As an on-the-go drink, it supports energy, physical performance, cognitive support, and hydration. The Fizzy Energy Drink has 60 mg of caffeine and a light, bubbly citrus-berry flavor. Key Ingredients: B Vitamin Complex Natural Caffeine from Green Tea Korean Ginseng L-Taurine Chromium "Expanding our portfolio and creating new products is something that USANA strives for each and every day," said Dr. Rob Sinnott, USANA's chief scientific officer. "Our new nutrition line, Revolve, represents a holistic approach to supporting your body's natural circadian rhythm. And as an addition to our Celavive line, postbiotic skincare works to hydrate your skin barrier." About USANA USANA (NYSE: USNA) prides itself on providing consumers the highest quality nutritional products in the world. From its award-winning supplements to its innovative Celavive skincare and Active Nutrition lines, USANA has proven for more than 30 years why it's a company you can trust. How about giving us a try? Shop at USANA.com or learn more about USANA's sustainability efforts here. Media Contact: Amy Haran Executive Vice President of Communications (801) 954-7641 media(at)USANAinc(dot)com International Headquarters SOURCE USANA

2023-07-31

·PRNewswire

MELANOCTINA BILAYER Is Delivering a Non-Drowsy Dose of High-Quality Sleep

Health Brand PLAMECA's Natural Sleep Aid Features Bilayer Technology That Helps Individuals Both Fall and Stay Sleep FORT LAUDERDALE, Fla., July 31, 2023 /PRNewswire/ -- Sleep is a critical part of life. Most experts recommend that adults get at least seven hours of sleep each night. Quality matters, as well, as disrupted or light sleep can leave a person feeling drained and exhausted during the day. Despite its importance, high quality and sufficient quantity of sleep is rare in America. In 2016, the CDC reported that one in three American adults was not getting enough sleep on a regular basis. At the time, things like notifications, blue lights, and busy modern schedules were already a factor. Since then, additional elements, like the pandemic and financial stress, have only piled onto the problem. The need for sleep has pushed many individuals toward strong, chemical-based solutions. Sleep pills may be effective, but Sleep Foundation reports that side effects can undermine the very reason they exist. For instance, sleep medication can leave people feeling drowsy, sluggish, and unable to focus (and that doesn't even address more serious concerns like allergic reactions and addiction). Health brand PLAMECA has created an alternative to stronger meds in the form of its MELANOCTINA BILAYER natural sleep supplement. "Sometimes the body just needs a little natural support falling and staying asleep," says the brand's managing Director, Óscar Fernández. "Of course, falling asleep and staying asleep are two different things, which is why we created our bilayer technology." MELANOCTINA BILAYER's unique scientific manufacturing method consists of two distinct layers. The first provides a neat 5 mg dose of melatonin to help an individual naturally fall asleep. The second inner layer is a formulation that includes natural sleep inducers, such as valerian, lemon balm, California poppy, passionflower, and vitamins B6 and B12. These are designed to kick in after a person drifts off to help them stay asleep longer. "Sleep is a foundational part of life," Fernández declares. "It isn't something we should skimp on. Even so, sleep medications are often an overcorrection. By using a thoughtful, multi-layered natural solution like MELANOCTINA BILAYER, you can restore your sleep patterns and feel rested again without the fear of unnecessary side effects." About Plameca PLAMECA is a phytotherapy company founded in 1984 with the initial intention of providing medicinal herbs and plants — which it did for 1,500 retailers across the Spanish geography. In 1994, PLAMECA expanded to manufacture its own food supplements, creating a range of products using herbal extracts, vitamins, and minerals. Currently, PLAMECA products are manufactured in modern facilities using up-to-date scientific methods and are sold in 33 countries. The company has also invested $11 million in an aggressive expansion plan to expand its health and wellness focus over the next five years. Learn more at plameca.com. Juan M Desvalls [email protected] Tel. + 34 677518038 SOURCE Plameca

100 项与 Melatonin oral gel(Spherium Biomed SL) 相关的药物交易

登录后查看更多信息

外链

KEGG	Wiki	ATC	Drug Bank
-	-	-	DB01065

研发状态

10 条进展最快的记录,

后查看更多信息

适应症	最高研发状态	国家/地区	公司	日期
自闭症谱系障碍	临床3期	-	Neurim Pharmaceuticals Ltd.	2020-09-01
头颈部肿瘤	临床2期	西班牙	Spherium Biomed SL	2015-11-01
口腔炎	临床2期	西班牙	Spherium Biomed SL	2015-11-01