预约演示
更新于：2026-09-28
Carboxyamidotriazole
羧胺三唑
更新于：2026-09-28
概要
基本信息
原研机构 |
权益机构- |
最高研发阶段临床3期 |
首次获批日期- |
最高研发阶段(中国)临床2期 |
特殊审评- |
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结构/序列
分子式C17H12Cl3N5O2 |
InChIKeyWNRZHQBJSXRYJK-UHFFFAOYSA-N |
CAS号99519-84-3 |
关联
11
项与 羧胺三唑 相关的临床试验ITMCTR2025001431
A Clinical Intervention Study Investigating Cai's Therapy in the Management of Overweight and Obesity
JPRN-UMIN000034416
Effect of topical antiglaucoma medications on prevention for intraocular pressure elevation after cataract surgery in eyes with glaucoma : a randomized clinical comparative study.
CTR20160395
随机、双盲、多中心羧胺三唑胶丸联合NP对照安慰剂联合NP治疗初治的Ⅳ期非小细胞肺癌患者的Ⅲ期临床研究
100 项与 羧胺三唑 相关的临床结果
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100 项与 羧胺三唑 相关的转化医学
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100 项与 羧胺三唑 相关的专利（医药）
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272
项与 羧胺三唑 相关的文献（医药）2026-08-01ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION
Improved Functional Independence Associated With Canine Assisted Intervention During Inpatient Rehabilitation: A Real-World Observational Study Using Inverse Probability Weighting
Article
作者: Haas, Tara ; Vahidy, Farhaan S ; Abbott, Rhonda ; Bako, Abdulaziz ; Sander, Angelle M ; Juengst, Shannon B ; Larkin, Elizabeth ; Adair, Christine ; Khan, Osman ; Filigrana, Molly ; Harik, Lindsey ; Laymon, Julie
OBJECTIVE:
To evaluate the association between canine assisted intervention (CAI) and functional independence among patients receiving inpatient rehabilitation.
DESIGN:
Retrospective cohort study.
SETTING:
Inpatient Rehabilitation Facility (IRF).
PARTICIPANTS:
Adults (n=1619) discharged from an IRF on or after August 2024, when the facility dog program was initiated.
INTERVENTIONS:
Exposure to CAI, defined as participation in at least 1 therapy session involving a trained facility dog during inpatient rehabilitation.
MAIN OUTCOME MEASURES:
The primary outcome was functional independence, measured by change in a composite GG Self-care and Mobility score from admission to discharge. Change in Self-Care and change in Mobility were analyzed separately as key secondary outcomes. The association between CAI exposure and improvement in composite functional independence was assessed using Inverse probability of treatment weighting. Among CAI-exposed patients, exploratory dose-response analyses examined associations between cumulative CAI exposure and improvement in composite functional independence score.
RESULTS:
Among 1619 patients, 269 (16.6%) received CAI. Exposure to CAI was associated with greater improvement in composite functional independence score (average treatment effect among the treated: 2.4 points; 95% CI, 0.01-4.76; P=.049). The associations of CAI with Self-Care and Mobility domain estimates were directionally consistent but did not independently reach significance (P=.060 and P=.210). Among CAI recipients, higher cumulative exposure was associated with progressively greater improvement in composite functional independence, with a significant dose-response trend (P=.048).
CONCLUSIONS:
In this IRF cohort, CAI exposure was associated with greater improvements in composite functional independence, suggesting that CAI may be a meaningful addition to rehabilitation care. Prospective studies are needed to confirm these findings and to define optimal patient selection and dosing.
2026-08-01Foot and Ankle Surgery
Effects and optimal dosage of Tai Chi for chronic ankle instability: A systematic review and meta-analysis
Review
作者: He, Ying ; Yuan, Juntong ; Xu, Man ; Hao, Tongtong
BACKGROUND:
Chronic ankle instability (CAI) exhibits a remarkably high incidence among individuals following acute lateral ankle sprains, serving as a primary contributor to the impairment of postural balance and overall quality of life. As a traditional therapy emphasizing postural control and continuous movement, Tai Chi has shown potential in musculoskeletal rehabilitation. However, its specific efficacy and optimal dosage for CAI remain to be clarified.
OBJECTIVE:
This study evaluates how Tai Chi affects functional recovery in CAI patients. We specifically examine the role of intervention dosage on clinical outcomes. Our goal is to offer a solid evidence-based reference for rehabilitation practice.
METHODS:
This study follows a protocol registered in PROSPERO. We identified relevant RCTs from eleven major databases before the December 2025 deadline. Two authors performed the screening and data collection process independently. Methodological quality was assessed via the PEDro scale and RoB 2 tool. All statistical analyses were executed in STATA 15.
RESULTS:
The meta-analysis of nine studies (n = 380) revealed a significant improvement in Cumberland Ankle Instability Tool (CAIT) scores favoring Tai Chi over control interventions (SMD = 0.773, 95 % CI [0.481, 1.066], P = 0.030). Balance: Tai Chi significantly improved postero-medial balance (SMD = 0.789, P < 0.001). Although anterior (SMD = 1.155) and postero-lateral balance showed trends of improvement, these changes did not attain statistical significance (P > 0.05). Analysis of the Unipedal Stance Test (UST) demonstrated no statistically significant difference between the intervention and control groups (P = 0.634). Subgroup analysis: Moderating effects showed that longer intervention durations (12 weeks) and longer session lengths (60 min) had lower heterogeneity and more consistent improvement effects.
CONCLUSION:
Tai Chi practice significantly enhances functional outcomes for individuals with CAI. It specifically shows a strong positive effect on postero-medial balance. Our subgroup findings indicate that a 12-week program is most effective. This protocol should involve two 60-minute sessions per week. Due to high heterogeneity in some outcomes and limited sample sizes, further high-quality studies with larger samples are needed for verification.
2026-04-01Ophthalmology and Therapy
Comparative Effectiveness of Timolol-Based Fixed-Combination Regimens for Glaucoma: a Retrospective Cohort Study Using Target Trial Emulation Framework
Article
作者: Chuang, Lan-Hsin ; Shao, Shih-Chieh ; Lai, Chi-Chun ; Yang, Avery Shuei-He ; Lai, Chin ; Lai, Edward Chia-Cheng
INTRODUCTION:
Glaucoma is a leading cause of irreversible blindness, and many patients ultimately require escalation beyond monotherapy to maintain adequate intraocular pressure control. Although timolol-based fixed-combination therapies are widely used, real-world evidence comparing their long-term effectiveness across different drug classes remains limited. This study was conducted to compare long-term outcomes among prostaglandin analog (PGA)/timolol, carbonic anhydrase inhibitor (CAI)/timolol, and α-agonist (AA)/timolol regimens.
METHODS:
We emulated a hypothetical open-label pragmatic trial using Taiwan's National Health Insurance Research Database, and included patients with incident glaucoma between 2011 and 2021 who initially received monotherapy and subsequently initiated a timolol-containing fixed-combination therapy with PGA, CAI, or AA. Propensity score-based overlap weighting was applied to balance baseline covariates, and Cox proportional hazards models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs). The primary outcome was treatment failure, defined as the initiation of additional topical anti-glaucoma medication, incisional surgery or laser treatment, or a diagnosis of blindness. Patients were followed from fixed-combination therapy initiation until occurrence of treatment failure, death, or 31 December 2021.
RESULTS:
After weighting, the cohorts included 5714 (PGA/timolol versus CAI/timolol), 5070 (PGA/timolol versus AA/timolol), and 18,654 (AA/timolol versus CAI/timolol) patients. PGA/timolol initiation was associated with a lower rate of treatment failure compared with CAI/timolol (HR: 0.85, 95% CI 0.80-0.91) and AA/timolol (HR: 0.87, 95% CI 0.81-0.93). PGA/timolol also reduced the need for additional medications and intraocular pressure-lowering procedures compared with other regimens. CAI/timolol and AA/timolol showed no significant difference in treatment failure rates (HR: 0.97, 95% CI 0.94-1.00).
CONCLUSIONS:
In a nationwide real-world setting, PGA/timolol demonstrated superior long-term effectiveness compared with both CAI/timolol and AA/timolol, resulting in lower treatment failure rates and reduced need for additional medications or procedures. These findings suggest that PGA/timolol may be associated with the most favorable long-term effectiveness among timolol-based fixed combinations.
100 项与 羧胺三唑 相关的药物交易
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研发状态
10 条进展最快的记录, 后查看更多信息
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 非小细胞肺癌 | 申请上市 | 中国 | 2021-07-08 | |
| 转移性非小细胞肺癌 | 临床3期 | 美国 | 1999-04-01 | |
| 非小细胞肺癌IIIA期 | 临床3期 | 美国 | 1999-04-01 | |
| 非小细胞肺癌IIIB期 | 临床3期 | 美国 | 1999-04-01 | |
| EGFR突变的非小细胞肺癌 | 临床2期 | 中国 | 2026-04-23 | |
| 转移性肾细胞癌 | 临床2期 | 美国 | 2000-10-01 | |
| 多形性胶质母细胞瘤 | 临床2期 | 美国 | 2000-03-01 | |
| 神经胶质肉瘤 | 临床2期 | 美国 | 2000-03-01 | |
| 输卵管癌 | 临床2期 | 美国 | 1998-04-01 | |
| 铂类耐药性原发性腹膜癌 | 临床2期 | 美国 | 1998-04-01 |
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临床结果
临床结果
适应症
分期
评价
查看全部结果
临床2期 | 55 | (CAI With RT - Arm 1) | 壓遞鑰願繭網願觸製齋(鏇鏇淵憲夢淵鏇襯鏇憲) = 鑰鬱餘憲艱製夢製構遞 獵襯構淵憲製選襯鹹鏇 (製蓋糧繭夢壓襯鏇顧範, 網窪顧餘餘顧鹹淵鬱構 ~ 齋製壓壓艱糧構範壓衊) 更多 | - | 2015-05-08 | ||
(CAI With RT + Enzyme Inducing Anticonvulsants) | 餘積壓餘願衊齋糧簾觸(餘繭憲膚鹽觸蓋壓顧鑰) = 選糧築鬱壓廠齋範範選 鏇餘壓獵顧願鑰衊夢窪 (襯齋憲積鏇鬱構製繭餘, 1.22) | ||||||
临床3期 | 186 | (Carboxyamidotriazole) | 顧築鹽醖糧簾顧齋鏇淵(網憲蓋醖選遞鬱鏇鑰窪) = 築顧壓襯鹽糧構顧鑰願 簾繭糧願醖網窪獵網襯 (繭遞積築鑰鏇憲鏇鹹構, 糧繭鬱繭顧夢艱餘鹽齋 ~ 鏇糧糧鏇糧顧網顧顧齋) 更多 | - | 2010-12-22 | ||
placebo (Placebo) | 顧築鹽醖糧簾顧齋鏇淵(網憲蓋醖選遞鬱鏇鑰窪) = 觸製壓鬱憲壓製壓鬱憲 簾繭糧願醖網窪獵網襯 (繭遞積築鑰鏇憲鏇鹹構, 願壓壓糧範襯構廠顧窪 ~ 範艱顧製衊蓋憲齋鹽蓋) 更多 | ||||||
临床3期 | 晚期非小细胞肺癌 维持 | 186 | 膚艱衊製齋繭鑰獵鹽壓(顧顧顧淵鹽鬱廠願鹹衊) = 艱繭夢衊簾顧鹽憲窪艱 鹹繭夢選淵鏇選繭構願 (鹹製憲築夢顧網醖餘願 ) 更多 | 不佳 | 2005-06-01 | ||
Placebo | 膚艱衊製齋繭鑰獵鹽壓(顧顧顧淵鹽鬱廠願鹹衊) = 獵膚獵構齋衊醖糧觸築 鹹繭夢選淵鏇選繭構願 (鹹製憲築夢顧網醖餘願 ) 更多 |
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