Water reuse in agriculture supports climate resilience and circular economy principles, yet concerns remain regarding contaminants of emerging concern (CECs) in reclaimed water. This study investigates the occurrence, uptake, and potential risks of CECs in maize cultivated under two irrigation scenarios: precision drip irrigation using groundwater and reclaimed wastewater. A wide-scope target analysis of over 2200 CECs was performed in groundwater, raw and treated wastewater, irrigated soil, and maize plant tissues. A total of 104 CECs across nine chemical classes were detected in water samples, with wastewater treatment reducing 67 % of detected compounds. However, several pharmaceuticals and transformation products persisted post-treatment. Soil irrigated with treated wastewater exhibited a greater variety and higher concentrations of CECs than groundwater-irrigated soil. Maize plants accumulated 14 CECs in roots, stems, leaves, and corn, with higher concentrations in reclaimed water-irrigated crops. A human health risk assessment, based on the threshold of toxicological concern and hazard quotient approaches, indicated negligible risks at detected concentrations and expected dietary exposure levels. However, substances flagged for potential genotoxicity via in silico tools, such as acetaminophen and harmane, warrant further evaluation. These findings highlight the need for improved monitoring and targeted removal strategies to ensure safe and sustainable agricultural applications.