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更新于：2025-02-15
Amorolfine Hydrochloride
盐酸阿莫罗芬
更新于：2025-02-15
概要
基本信息
非在研机构- |
最高研发阶段批准上市 |
首次获批日期 日本 (1991-12-18), |
最高研发阶段(中国)批准上市 |
特殊审评- |
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结构/序列
分子式C21H36ClNO |
InChIKeyXZKWIPVTHGWDCF-KUZYQSSXSA-N |
CAS号78613-38-4 |
关联
16
项与 盐酸阿莫罗芬 相关的临床试验NCT06689852
MULTICENTRIC, RANDOMIZED, EVALUATOR BLINDED CLINICAL INVESTIGATION for the EVALUATION of EFFICACY and SAFETY of TWO PRODUCTS for the TREATMENT of ONYCHOMYCOSIS
ChiCTR2300074178
Q-switched Nd:YAG laser versus Amorolfine Hydrochloride Cream in treatment of Distal lateral subungual onychomycosis in older adults
NCT05482763
Pilot Study on the Evaluation of the Efficacy, Tolerability and Safety of Topical and Oral Antifungals in the Treatment of Onychomycosis and Creation of a Library of Dermatological Clinical Isolates
100 项与 盐酸阿莫罗芬 相关的临床结果
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100 项与 盐酸阿莫罗芬 相关的转化医学
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100 项与 盐酸阿莫罗芬 相关的专利（医药）
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478
项与 盐酸阿莫罗芬 相关的文献（医药）2025-06-01Case Studies in Chemical and Environmental Engineering
Untargeted metabolomic LC-HRMS combined with chemometric reveal metabolites change from sorghum flakes affected by food processing
作者: Anggraeni, Ayu Septi ; Suratno ; Noviana, Ika Mulawati Purwanti ; Utami, Indrawati Dian ; Nurfahmi, Laely ; Khasanah, Yuniar ; Alam, Lucky Prabowo Miftachul ; Windarsih, Anjar
A non-targeted UHPLC-HRMS metabolomics approach combined with chemometric anal. was employed to assess the change in metabolite profiles of sorghum flakes based on food processing techniques.The result showed that fatty acids were the most abundant metabolites, followed by lipids, amino acids, alkaloids, amines, and polyphenols, representing key metabolic markers influenced by food processing in sorghum flakes.Specific metabolites, including 15S-Hydroxyeicosatrienoic acid (15S-HETrE), terminaline, vitamin E acetate, furan fatty acid F6, all-trans-retinal, and fingolimod, exhibited increased concentrations during oven processing compared to raw sorghum, likely due to their thermal stability.This study provides valuable insights into effect of food processing effect on metabolites profiles.
2024-12-01CLINICAL MICROBIOLOGY AND INFECTION
Autochthonous Trichophyton rubrum terbinafine resistance in France: assessment of antifungal susceptibility tests
Letter
作者: Magne, Denis ; Monod, Michel ; Hennequin, Christophe ; Challende, Isabelle ; Huguenin, Antoine ; Laloum, Illan ; Bouchara, Jean Philippe ; Desoubeaux, Guillaume ; Normand, Anne Cécile ; Sendid, Boualem ; Imbert, Sébastien ; Foulet, Françoise ; Brin, Cécile ; Cordier, Camille ; Cremer, Geneviève ; Dannaoui, Éric ; Moreno-Sabater, Alicia ; Bidaud, Anne Laure
This trend has raised concerns among healthcare professionals, emphasizing the importance of performing antifungal susceptibility tests to identify T. rubrum terbinafine-resistant isolates.Autochthonous Trichophyton rubrum terbinafine resistance in France from assessment of antifungal susceptibility tests.Over a 2-yr period, 11 isolates from patients with T. rubrum dermatophytosis failing terbinafine treatment (250 mg/d; >6months)were referred to our institution(Table1).The ability of the gradient trip (GT) to determine T. rubrum susceptibility to terbinafine (HiMedia), itraconazole, and voriconazole (BioMerieux) was also evaluated and MIC values were compared with those determined using the EUCAST method.This study reinforces the importance of prioritizing T. rubrum TBRi detection in a context of treatment failure.We recommend different antifungal susceptibility test methods to evaluate the antifungal susceptibility profile of TBRi, guiding clinicians to propose an antifungal susceptibility-based treatment.
2024-12-01Annales Pharmaceutiques Francaises
Amorolfine hydrochloride loaded solid lipid nanoparticles: Preparation, characterization and ex vivo nail permeation study to treat onychomycosis
Article
作者: Ahmed, Tasleem ; Mahato, Arun Kumar ; Shanthi, Nithya
Onychomycosis is a disease of the nail plate caused by fungi, leading to the progressive defacing of the nail. The infection requires a longer period of treatment orally and topically. The treatment with the topical route is difficult due to the low availability of drugs across the infected nail. This failure in topical treatment is the drawback of the conventional drug delivery system (DDS), particularly drug penetration issues across the nail plate. The solid lipid nanoparticle (SLN) approach was used to overcome such issues. The drug amorolfine hydrochloride (AOF) was incorporated into SLN by using the micro-emulsion cold dilution method. Monostrearin and stearic acid were used as solid lipids in the formulation of drug-loaded SLNs. The nanoparticle formulation was optimized by varying the type of solid lipids and bile salts. Sodium taurocholate (STC) and sodium tauroglycholate (STG) are the bile salts used as biosurfactants in the formulation. The SLNs prepared with stearic acid and STG demonstrated higher drug encapsulation efficiency (71.73%) and drug loading efficiency (13.03%) than monostearin. Bile salts have affected the particle size range and STG was found to produce smaller size particles with stearic acid (406nm) than STC. Process parameter homogenization speed was also optimized and 403 relative centrifugal force (RCF) was optimal to produce smaller-size particles (406nm). The drug permeation through the nail plate and anti-fungal studies were also performed for AOF-SLNs loaded cream and marketed cream (Amfocin). The SLNs have improved the permeation (1.63-fold) and anti-fungal activity (2.50-fold) of AOF. Transmission electron microscopy (TEM) images revealed a spherical shape of SLNs with no aggregation. The physical stability was performed and SLNs have higher stability at refrigeration storage. The SLNs were incorporated in cream for the final application for onychomycosis. The analytical method of high-performance liquid chromatography (HPLC) was used for the quantification of AOF in the formulations.
100 项与 盐酸阿莫罗芬 相关的药物交易
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研发状态
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 传染性皮肤病 | 中国 | 2000-04-10 | |
| 皮肤念珠菌病 | 日本 | 1993-10-01 | |
| 银屑病 | 日本 | 1993-10-01 | |
| 足癣 | 日本 | 1993-10-01 | |
| 白癜风 | 日本 | 1993-10-01 | |
| 真菌病 | 日本 | 1991-12-18 |
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临床结果
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适应症
分期
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临床4期 | 50 | (Loceryl NL+Cosmetic Varnish) | 製構蓋顧觸鏇築蓋糧憲(鏇鑰鏇鏇構醖齋簾蓋選) = 築鏇廠觸鬱築淵憲選範 蓋淵鬱衊網鑰簾製餘選 (蓋選襯鑰鹽簾繭廠網鏇, 襯簾醖蓋夢鬱鹽衊顧製 ~ 築願廠鹹網獵壓範鑰蓋) 更多 | - | 2018-10-09 | ||
(Loceryl NL 12 Weeks) | 製構蓋顧觸鏇築蓋糧憲(鏇鑰鏇鏇構醖齋簾蓋選) = 選艱壓鹽選憲鬱憲淵膚 蓋淵鬱衊網鑰簾製餘選 (蓋選襯鑰鹽簾繭廠網鏇, 窪獵鑰構鬱醖醖廠夢鹽 ~ 壓廠製築淵積艱簾構選) 更多 | ||||||
临床4期 | 20 | (Loceryl NL) | 憲窪衊餘顧膚壓製鹹鏇(淵蓋艱齋獵鏇廠網夢鏇) = 淵鹽壓膚鑰築淵願憲蓋 選衊鏇鏇簾衊壓餘構鹹 (積憲繭齋鏇蓋願壓顧鏇, 鹽餘淵壓觸糧鬱蓋鹹鏇 ~ 憲餘鏇願衊鬱構憲築蓋) 更多 | - | 2018-10-03 | ||
(Ciclopirox NL) | 憲窪衊餘顧膚壓製鹹鏇(淵蓋艱齋獵鏇廠網夢鏇) = 鬱壓鏇夢選膚遞蓋鬱蓋 選衊鏇鏇簾衊壓餘構鹹 (積憲繭齋鏇蓋願壓顧鏇, 顧鹹鬱獵衊鹹憲艱廠簾 ~ 壓選淵憲糧襯顧窪繭衊) 更多 |
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