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更新于：2025-05-16
Amorolfine Hydrochloride
盐酸阿莫罗芬
更新于：2025-05-16
概要
基本信息
非在研机构- |
权益机构- |
最高研发阶段批准上市 |
首次获批日期 日本 (1991-12-18), |
最高研发阶段(中国)批准上市 |
特殊审评- |
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结构/序列
分子式C21H36ClNO |
InChIKeyXZKWIPVTHGWDCF-KUZYQSSXSA-N |
CAS号78613-38-4 |
关联
15
项与 盐酸阿莫罗芬 相关的临床试验NCT06689852
MULTICENTRIC, RANDOMIZED, EVALUATOR BLINDED CLINICAL INVESTIGATION for the EVALUATION of EFFICACY and SAFETY of TWO PRODUCTS for the TREATMENT of ONYCHOMYCOSIS
ChiCTR2300074178
Q-switched Nd:YAG laser versus Amorolfine Hydrochloride Cream in treatment of Distal lateral subungual onychomycosis in older adults
NCT05482763
Pilot Study on the Evaluation of the Efficacy, Tolerability and Safety of Topical and Oral Antifungals in the Treatment of Onychomycosis and Creation of a Library of Dermatological Clinical Isolates
100 项与 盐酸阿莫罗芬 相关的临床结果
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100 项与 盐酸阿莫罗芬 相关的转化医学
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100 项与 盐酸阿莫罗芬 相关的专利（医药）
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469
项与 盐酸阿莫罗芬 相关的文献（医药）2025-06-01Case Studies in Chemical and Environmental Engineering
Untargeted metabolomic LC-HRMS combined with chemometric reveal metabolites change from sorghum flakes affected by food processing
作者: Anggraeni, Ayu Septi ; Suratno ; Noviana, Ika Mulawati Purwanti ; Utami, Indrawati Dian ; Nurfahmi, Laely ; Khasanah, Yuniar ; Alam, Lucky Prabowo Miftachul ; Windarsih, Anjar
A non-targeted UHPLC-HRMS metabolomics approach combined with chemometric anal. was employed to assess the change in metabolite profiles of sorghum flakes based on food processing techniques.The result showed that fatty acids were the most abundant metabolites, followed by lipids, amino acids, alkaloids, amines, and polyphenols, representing key metabolic markers influenced by food processing in sorghum flakes.Specific metabolites, including 15S-Hydroxyeicosatrienoic acid (15S-HETrE), terminaline, vitamin E acetate, furan fatty acid F6, all-trans-retinal, and fingolimod, exhibited increased concentrations during oven processing compared to raw sorghum, likely due to their thermal stability.This study provides valuable insights into effect of food processing effect on metabolites profiles.
2025-05-01Annales Pharmaceutiques Francaises
Amorolfine hydrochloride loaded solid lipid nanoparticles: Preparation, characterization and ex vivo nail permeation study to treat onychomycosis
Article
作者: Ahmed, Tasleem ; Mahato, Arun Kumar ; Shanthi, Nithya
Onychomycosis is a disease of the nail plate caused by fungi, leading to the progressive defacing of the nail. The infection requires a longer period of treatment orally and topically. The treatment with the topical route is difficult due to the low availability of drugs across the infected nail. This failure in topical treatment is the drawback of the conventional drug delivery system (DDS), particularly drug penetration issues across the nail plate. The solid lipid nanoparticle (SLN) approach was used to overcome such issues. The drug amorolfine hydrochloride (AOF) was incorporated into SLN by using the micro-emulsion cold dilution method. Monostrearin and stearic acid were used as solid lipids in the formulation of drug-loaded SLNs. The nanoparticle formulation was optimized by varying the type of solid lipids and bile salts. Sodium taurocholate (STC) and sodium tauroglycholate (STG) are the bile salts used as biosurfactants in the formulation. The SLNs prepared with stearic acid and STG demonstrated higher drug encapsulation efficiency (71.73%) and drug loading efficiency (13.03%) than monostearin. Bile salts have affected the particle size range and STG was found to produce smaller size particles with stearic acid (406nm) than STC. Process parameter homogenization speed was also optimized and 403 relative centrifugal force (RCF) was optimal to produce smaller-size particles (406nm). The drug permeation through the nail plate and anti-fungal studies were also performed for AOF-SLNs loaded cream and marketed cream (Amfocin). The SLNs have improved the permeation (1.63-fold) and anti-fungal activity (2.50-fold) of AOF. Transmission electron microscopy (TEM) images revealed a spherical shape of SLNs with no aggregation. The physical stability was performed and SLNs have higher stability at refrigeration storage. The SLNs were incorporated in cream for the final application for onychomycosis. The analytical method of high-performance liquid chromatography (HPLC) was used for the quantification of AOF in the formulations.
2025-04-01JOURNAL OF BIOLOGICAL CHEMISTRY
In vitro inhibition of voltage-dependent sodium currents by the antifungal drug amorolfine
Article
作者: Waxman, Stephen G ; Ghovanloo, Mohammad-Reza ; Tyagi, Sidharth ; Effraim, Philip R
Voltage-gated sodium (Nav) channels are critical for electrical signaling, and their pharmacological modulation can be leveraged for the development of therapeutic agents targeting various disorders. The local anesthetic (LA) site on Nav channels is particularly important, as it is a common target for many clinically used inhibitors, including anticonvulsants and antiarrhythmics. Our goal was to identify novel Nav channel inhibitors by leveraging physicochemical criteria, focusing on potential LA site binding candidates. We identified amorolfine (AMF), a phenyl-propyl morpholine derivative, as a putative modulator. Our results demonstrate that AMF acts as a state-dependent inhibitor of Nav channels, with a ∼30-fold preference for inactivated states. It stabilizes channel inactivation and prevents channel from conducting, driven through its stabilization of inactivation. These findings suggest that AMF represents a new compound that inhibits Nav channels, offering insights into the development of future therapeutic agents targeting Nav and potentially other ion channels.
100 项与 盐酸阿莫罗芬 相关的药物交易
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研发状态
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 传染性皮肤病 | 中国 | 2000-04-10 | |
| 皮肤念珠菌病 | 日本 | 1993-10-01 | |
| 银屑病 | 日本 | 1993-10-01 | |
| 足癣 | 日本 | 1993-10-01 | |
| 白癜风 | 日本 | 1993-10-01 | |
| 真菌病 | 日本 | 1991-12-18 |
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临床结果
临床结果
适应症
分期
评价
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临床4期 | 50 | (Loceryl NL+Cosmetic Varnish) | 獵膚鹹範鑰製築鏇醖遞(淵製醖鑰壓夢壓築網膚) = 鹽壓選鏇夢築願鏇鹹醖 淵積鹹廠壓鹽膚壓築艱 (積淵簾鬱淵糧鹽鹹窪遞, 9.1) 更多 | - | 2018-10-09 | ||
(Loceryl NL 12 Weeks) | 獵膚鹹範鑰製築鏇醖遞(淵製醖鑰壓夢壓築網膚) = 糧艱鏇鬱選襯艱構鏇製 淵積鹹廠壓鹽膚壓築艱 (積淵簾鬱淵糧鹽鹹窪遞, 6.2) 更多 | ||||||
临床4期 | 20 | (Loceryl NL) | 鹽糧鏇觸襯遞憲憲鬱簾 = 醖鏇淵構餘廠積鹹積積 糧鑰淵齋糧衊鬱選膚鏇 (顧鏇壓夢夢憲鬱選鏇鹽, 築憲醖壓壓築壓窪衊積 ~ 顧鑰鏇淵簾蓋遞鏇獵糧) 更多 | - | 2018-10-03 | ||
(Ciclopirox NL) | 鹽糧鏇觸襯遞憲憲鬱簾 = 構糧積鹽選廠蓋獵夢範 糧鑰淵齋糧衊鬱選膚鏇 (顧鏇壓夢夢憲鬱選鏇鹽, 齋夢艱觸廠齋壓廠壓選 ~ 淵鏇膚襯製網網糧繭淵) 更多 |
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