预约演示
更新于：2025-08-13
Amorolfine Hydrochloride
盐酸阿莫罗芬
更新于：2025-08-13
概要
基本信息
非在研机构 |
权益机构- |
最高研发阶段批准上市 |
首次获批日期 日本 (1991-12-18), |
最高研发阶段(中国)批准上市 |
特殊审评- |
登录后查看时间轴
结构/序列
分子式C21H36ClNO |
InChIKeyXZKWIPVTHGWDCF-KUZYQSSXSA-N |
CAS号78613-38-4 |
关联
15
项与 盐酸阿莫罗芬 相关的临床试验NCT06689852
MULTICENTRIC, RANDOMIZED, EVALUATOR BLINDED CLINICAL INVESTIGATION for the EVALUATION of EFFICACY and SAFETY of TWO PRODUCTS for the TREATMENT of ONYCHOMYCOSIS
ChiCTR2300074178
Q-switched Nd:YAG laser versus Amorolfine Hydrochloride Cream in treatment of Distal lateral subungual onychomycosis in older adults
NCT05482763
Pilot Study on the Evaluation of the Efficacy, Tolerability and Safety of Topical and Oral Antifungals in the Treatment of Onychomycosis and Creation of a Library of Dermatological Clinical Isolates
100 项与 盐酸阿莫罗芬 相关的临床结果
登录后查看更多信息
100 项与 盐酸阿莫罗芬 相关的转化医学
登录后查看更多信息
100 项与 盐酸阿莫罗芬 相关的专利（医药）
登录后查看更多信息
412
项与 盐酸阿莫罗芬 相关的文献（医药）2025-08-05Microbiology Spectrum
Article
作者: Li, Xiaofang ; Liu, Weida ; Xie, Wenting ; Liang, Guanzhao ; Mei, Huan ; Zheng, Hailin ; Kong, Xue ; Ge, Naicen
ABSTRACT:
The worldwide emergence of
Trichophyton indotineae
has garnered significant attention due to its growing resistance to conventional antifungal therapies, posing significant challenges to the effective management of dermatophytosis. The
in vitro
activities of 16 antifungals were tested against 37
T. indotineae
isolates using the broth microdilution method according to Clinical and Laboratory Standards Institute protocol M38-A3. Luliconazole and amorolfine exhibited low MICs, while itraconazole showed moderately decreased susceptibility, making them preferred treatment options. Echinocandins demonstrated favourable
in vitro
activity against
T. indotineae
, but their potential as therapeutic alternatives for recalcitrant dermatophytosis remains uncertain due to pharmacokinetic and pharmacodynamic limitations. In contrast, terbinafine, fluconazole, griseofulvin, oteseconazole, isavuconazole, ravuconazole, and amphotericin B exhibited elevated MICs for many strains, with strong correlations between certain azoles, indicating potential cross-resistance. A difference in the susceptibility to terbinafine and voriconazole between Chinese and Indian isolates was observed. These findings could provide valuable insights into antifungal resistance patterns and help guide treatment strategies for
T. indotineae
infections.
IMPORTANCE:
Trichophyton indotineae
is a novel emerging dermatophyte that has rapidly spread globally in recent years. Its resistance to first-line antifungal agents, particularly terbinafine and fluconazole, has significantly limited treatment options, emphasizing the urgent need for alternative therapies. This study provides comprehensive antifungal susceptibility data for 16 available antifungal agents, offering valuable insights into potential treatment strategies.
2025-06-01ENVIRONMENTAL RESEARCH
Torrefaction of sewage sludge: An approach to nutrient recycling and contaminant reduction in agriculture
Article
作者: Pierdonà, Lorenzo ; Paul, Chandra Sekhar ; Košnář, Zdeněk ; Doležal, Petr ; Nang, Sreynet ; Mercl, Filip ; Tlustoš, Pavel
The disposal of sewage sludge, a byproduct of wastewater treatment, presents both opportunities and challenges in agricultural applications due to its rich nutrient content and potential pollutant load. This study investigates the effects of torrefaction, a low-temperature thermochemical treatment, on the elemental composition and organic pollutant content of sewage sludge and its impact on maize (Zea mays L.). Sewage sludge from a municipal wastewater treatment plant was torrefied at 320 C for 3 h, then applied to soil in a field experiment. The torrefaction process concentrated mineral nutrients such as phosphorus and potassium but reduced nitrogen and sulfur content. The content of available phosphorus and potassium decreased by only 28 % and 24 %, respectively. Importantly, torrefaction significantly decreased the concentrations of pharmaceuticals, synthetic musk compounds, and endocrine-disrupting compounds in the sludge, with reductions of over 90 % for most compounds. Persistent organic pollutants, including polychlorinated biphenyls and organochlorine pesticides, also showed significant reductions (99 and 95 %, respectively), although polycyclic aromatic hydrocarbons (PAHs) increased by 20 % due to torrefaction. Despite this, the PAH content in torrefied sludge (Σ16 PAH <3 mg/kg) remained below regulatory limits set for soil application. At higher application doses, the effect of torrefied sludge on agronomic performance of maize did not differ from that of dried sewage sludge. Torrefaction has demonstrated promising results in improving the safety and efficacy of sewage sludge as a fertilizer by reducing organic contaminants and increasing phosphorus and potassium contents without significantly diminishing their availability. However, the limited effectiveness of torrefaction in reducing PAH content must be carefully considered when evaluating its suitability for soil applications. Furthermore, the condensate produced during the torrefaction process was not analyzed in this study and may represent a potentially hazardous by-product due to its pollutant content.
2025-06-01Case Studies in Chemical and Environmental Engineering
Untargeted metabolomic LC-HRMS combined with chemometric reveal metabolites change from sorghum flakes affected by food processing
作者: Anggraeni, Ayu Septi ; Suratno ; Noviana, Ika Mulawati Purwanti ; Utami, Indrawati Dian ; Nurfahmi, Laely ; Khasanah, Yuniar ; Alam, Lucky Prabowo Miftachul ; Windarsih, Anjar
A non-targeted UHPLC-HRMS metabolomics approach combined with chemometric anal. was employed to assess the change in metabolite profiles of sorghum flakes based on food processing techniques.The result showed that fatty acids were the most abundant metabolites, followed by lipids, amino acids, alkaloids, amines, and polyphenols, representing key metabolic markers influenced by food processing in sorghum flakes.Specific metabolites, including 15S-Hydroxyeicosatrienoic acid (15S-HETrE), terminaline, vitamin E acetate, furan fatty acid F6, all-trans-retinal, and fingolimod, exhibited increased concentrations during oven processing compared to raw sorghum, likely due to their thermal stability.This study provides valuable insights into effect of food processing effect on metabolites profiles.
100 项与 盐酸阿莫罗芬 相关的药物交易
登录后查看更多信息
研发状态
10 条最早获批的记录, 后查看更多信息
登录
| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 传染性皮肤病 | 中国 | 2000-04-10 | |
| 皮肤念珠菌病 | 日本 | 1993-10-01 | |
| 银屑病 | 日本 | 1993-10-01 | |
| 足癣 | 日本 | 1993-10-01 | |
| 白癜风 | 日本 | 1993-10-01 | |
| 真菌病 | 日本 | 1991-12-18 |
登录后查看更多信息
临床结果
临床结果
适应症
分期
评价
查看全部结果
临床4期 | 50 | (Loceryl NL+Cosmetic Varnish) | 遞餘壓窪範積醖製繭製(艱鏇醖壓選積廠鏇窪齋) = 簾廠夢繭襯齋簾窪築餘 夢鹹鑰窪鬱襯遞鹹獵壓 (願願顧夢構衊遞獵夢選, 9.1) 更多 | - | 2018-10-09 | ||
(Loceryl NL 12 Weeks) | 遞餘壓窪範積醖製繭製(艱鏇醖壓選積廠鏇窪齋) = 網遞夢鏇憲構醖選蓋窪 夢鹹鑰窪鬱襯遞鹹獵壓 (願願顧夢構衊遞獵夢選, 6.2) 更多 | ||||||
临床4期 | 20 | (Loceryl NL) | 鹹顧鏇窪艱艱壓糧簾鹹 = 壓醖鏇憲衊艱鹽網餘鬱 衊獵齋築夢顧顧構網觸 (憲艱獵襯網積壓憲壓醖, 範繭窪鹹廠鹽願觸蓋艱 ~ 壓衊憲積製鹽夢選蓋簾) 更多 | - | 2018-10-03 | ||
(Ciclopirox NL) | 鹹顧鏇窪艱艱壓糧簾鹹 = 衊獵襯鏇廠選遞襯窪糧 衊獵齋築夢顧顧構網觸 (憲艱獵襯網積壓憲壓醖, 鹹繭築鬱鑰簾襯蓋夢膚 ~ 齋襯鏇鹹餘願醖衊繭獵) 更多 |
登录后查看更多信息
转化医学
使用我们的转化医学数据加速您的研究。
登录
或
药物交易
使用我们的药物交易数据加速您的研究。
登录
或
核心专利
使用我们的核心专利数据促进您的研究。
登录
或
临床分析
紧跟全球注册中心的最新临床试验。
登录
或
批准
利用最新的监管批准信息加速您的研究。
登录
或
特殊审评
只需点击几下即可了解关键药物信息。
登录
或
Eureka LS:
全新生物医药AI Agent 覆盖科研全链路，让突破性发现快人一步
立即开始免费试用!
智慧芽新药情报库是智慧芽专为生命科学人士构建的基于AI的创新药情报平台，助您全方位提升您的研发与决策效率。
立即开始数据试用!
智慧芽新药库数据也通过智慧芽数据服务平台，以API或者数据包形式对外开放，助您更加充分利用智慧芽新药情报信息。
生物序列数据库
生物药研发创新
免费使用
化学结构数据库
小分子化药研发创新
免费使用