C-terminal-alpha-synuclein (ICBI)(C-terminal-alpha-synuclein (ICBI)) - 药物靶点：α-synuclein_在研适应症：帕金森病_专利_临床

概要

基本信息

药物类型

生物药

别名-

靶点

α-synuclein

作用机制

α-synuclein抑制剂(α-突触核蛋白抑制剂)

治疗领域

神经系统疾病内分泌与代谢疾病

在研适应症

帕金森病

非在研适应症-

原研机构

Innovative California Biosciences International, Inc.

在研机构

Innovative California Biosciences International, Inc.

非在研机构-

最高研发阶段临床前

首次获批日期-

最高研发阶段(中国)-

特殊审评-

关联

100 项与 C-terminal-alpha-synuclein (ICBI) 相关的临床结果

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100 项与 C-terminal-alpha-synuclein (ICBI) 相关的转化医学

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100 项与 C-terminal-alpha-synuclein (ICBI) 相关的专利（医药）

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1

项与 C-terminal-alpha-synuclein (ICBI) 相关的文献（医药）

1984-10-01·Cellular Immunology3区 · 医学

Isolation and identification of an α2 subclass lymphotoxin (LT) subunit from the high-molecular-weight (complex) human LT class

3区 · 医学

Article

作者: Gale A. Granger ; Jim Klostergaard ; James J. Devlin

The high-molecular-weight (MW) complex class (MW = greater than or equal to 200,000) of lymphotoxin (LT) may be involved in the process of lymphocyte-mediated cytolysis. This LT class was produced by concanavalin A-stimulated human adenoid and tonsil lymphocytes in vitro and purified approximately 1000 fold by a scheme employing lectin affinity chromatography on concanavalin A-Sepharose, negative hydrophobic affinity chromatography on phenyl-Sepharose, and molecular sieving on Ultrogel AcA 44. A cell-lytic subunit, termed C-alpha toxin, was dissociated from this partially purified complex LT (Cx) preparation. The identification of C-alpha toxin as an alpha 2 LT form was established by its comigration with the alpha 2 LT form during native polyacrylamide gel electrophoresis (PAGE), molecular sieving, and isoelectricfocusing. In addition, C-alpha toxin was neutralized by antiserum raised against purified alpha 2 LT, and the latter was neutralized by antiserum raised against C-alpha toxin. Furthermore, preliminary evidence indicates that both alpha 2 LT and C-alpha toxin are composed of peptides with apparent MW of approximately 69,000. Additional data indicate the Cx LT form is composed of alpha 2 LT and other subunits.

100 项与 C-terminal-alpha-synuclein (ICBI) 相关的药物交易

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