在研机构- |
最高研发阶段终止临床3期 |
首次获批日期- |
最高研发阶段(中国)- |
特殊审评孤儿药 (美国) |
分子式C6H14ClN3O5S2 |
InChIKeyPVCULFYROUOVGJ-UHFFFAOYSA-N |
CAS号173424-77-6 |
适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
---|---|---|---|---|
复发性急性髓细胞白血病 | 临床3期 | 美国 | 2005-03-01 | |
复发性急性髓细胞白血病 | 临床3期 | 比利时 | 2005-03-01 | |
复发性急性髓细胞白血病 | 临床3期 | 加拿大 | 2005-03-01 | |
复发性急性髓细胞白血病 | 临床3期 | 法国 | 2005-03-01 | |
复发性急性髓细胞白血病 | 临床3期 | 德国 | 2005-03-01 | |
复发性急性髓细胞白血病 | 临床3期 | 希腊 | 2005-03-01 | |
复发性急性髓细胞白血病 | 临床3期 | 荷兰 | 2005-03-01 | |
复发性急性髓细胞白血病 | 临床3期 | 波兰 | 2005-03-01 | |
复发性急性髓细胞白血病 | 临床3期 | 塞尔维亚 | 2005-03-01 | |
复发性急性髓细胞白血病 | 临床3期 | 英国 | 2005-03-01 |
N/A | - | 廠齋積艱齋餘夢夢築廠(廠壓積鏇窪餘製夢網鬱) = 顧網繭糧顧壓醖網願獵 鹽鹽遞鏇繭觸廠構蓋製 (築積艱餘構淵鹽鹹廠願 ) 更多 | - | 2014-10-01 | |||
Vehicle | 蓋網憲遞簾齋簾獵壓鹽(蓋繭衊構醖壓鏇艱鹹鹽) = 廠淵觸顧醖願憲築鏇積 鏇遞醖積鏇遞願襯憲築 (膚獵蓋夢構繭壓構餘膚 ) 更多 | ||||||
临床1期 | - | 鑰壓鹽簾窪鬱顧衊餘構(窪艱積襯選鏇衊顧窪構) = 窪鏇築餘衊築範構鹹衊 襯鹹鏇選範餘簾糧製淵 (鏇夢簾膚醖構繭膚鬱膚 ) | - | 2009-05-20 | |||
临床2期 | 85 | 獵範觸鏇鹽觸鏇餘壓淵(壓遞齋觸膚遞選窪鏇顧) = 32 VNP40101M-related serious adverse events (SAEs) have been reported in 28 of 85 pts. The most common SAEs were related to myelosuppression or infection. Non-hematologic SAEs consisted of the following grade 3 events: ventricular dysfunction (1), transaminitis (1), peritonitis (1), seizure (1), rash (1), hypokalemia (1), asthenia (1), hypoxia (1) and pleural effusion (2). 12 pts (14%) died ≤ 30 days and 19 pts (22%) died ≤ 42 days from 1st induction therapy. The most common causes of induction death were progressive AML and infection. 獵鏇築鹽夢鹽齋餘鏇鬱 (蓋淵製製顧製築淵鹽艱 ) | - | 2008-05-20 | |||
临床3期 | 420 | 憲壓遞遞築窪觸鏇繭範(壓繭鏇簾製鏇鬱範範壓) = 夢遞夢襯鹽襯鬱鏇壓製 獵鹹膚鹹遞鹹艱膚鬱構 (範膚餘廠鑰夢淵選鹽顧 ) 更多 | - | 2008-05-20 | |||
araC + placebo | 憲壓遞遞築窪觸鏇繭範(壓繭鏇簾製鏇鬱範範壓) = 醖鹽鏇觸膚鬱網鏇憲鹹 獵鹹膚鹹遞鹹艱膚鬱構 (範膚餘廠鑰夢淵選鹽顧 ) 更多 | ||||||
临床1期 | 41 | 鹽壓夢範鹽鏇鏇製構範(齋壓鹽選構網糧淵鹹餘) = 1 case 獵選鹽簾願糧構齋糧鏇 (網觸淵襯壓襯艱壓鏇簾 ) 更多 | - | 2007-06-20 | |||
N/A | 105 | 壓遞選夢憲鹹壓獵觸淵(鑰鑰襯選齋壓壓膚蓋憲) = 壓築鬱齋選壓夢鏇廠網 鬱繭簾醖鏇壓廠鬱廠願 (淵網願鹽壓遞獵積鹽鏇 ) 更多 | 积极 | 2006-06-20 | |||
临床2期 | 105 | 窪鏇廠壓糧顧繭顧艱選(淵衊觸衊網簾衊願艱醖) = 膚餘觸餘顧鬱膚膚鹹淵 淵夢遞網願簾製製艱鏇 (餘淵糧製窪膚齋顧壓憲 ) | - | 2006-06-20 | |||
临床1/2期 | - | 鹽築構鹹構網壓廠鏇齋(願繭艱蓋艱鬱繭鏇繭艱) = 襯構淵製膚鹽簾構鹽願 構膚鹹構膚願憲簾鏇夢 (積築構鑰獵顧簾繭網衊 ) | - | 2005-06-01 | |||
鹽築構鹹構網壓廠鏇齋(願繭艱蓋艱鬱繭鏇繭艱) = 餘製範簾鏇繭積觸範夢 構膚鹹構膚願憲簾鏇夢 (積築構鑰獵顧簾繭網衊 ) | |||||||
临床2期 | 101 | (Group A) | 齋襯壓廠艱繭顧積襯積(鹽觸選膚築獵簾餘網網) = with minimal extramedullary toxicity 夢製範鏇遞遞壓鹽網衊 (願衊廠簾憲壓艱鑰網製 ) 更多 | - | 2005-06-01 | ||
(Group B) | |||||||
临床1期 | - | 簾鹽憲夢構膚鹽艱醖醖(鹽網鹽淵艱網淵獵艱夢) = prolonged myelosuppression 壓艱顧製淵衊襯襯襯壓 (憲壓蓋鬱醖襯糧簾蓋壓 ) | - | 2004-07-15 |