A Phase 1/2, Open Label, Multicenter Study to Assess the Safety, Tolerability and Efficacy of MB-106 in Patients With Relapsed or Refractory CD20+ B-Cell Non-Hodgkin Lymphoma or Chronic Lymphocytic Leukemia

Study to Assess the Safety, Tolerability and Efficacy of MB-106 in Patients with Relapsed or Refractory B-Cell NHL or CLL

开始日期2022-05-24

申办/合作机构

Mustang Bio, Inc.

[+1]

NCT05645744 / TerminatedN/A

A Long-term Follow-up Study in Patients Previously Treated With Mustang Bio, Inc. CAR-T Cell Investigational Products

A long-term follow-up study to assess safety and efficacy in patients previously treated with Mustang Bio chimeric antigen receptor (CAR)-T cell investigational products.

开始日期2021-09-29

申办/合作机构

Mustang Bio, Inc.

100 项与 CD20-targeted CAR T cell therapy (Mustang Bio) 相关的临床结果

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100 项与 CD20-targeted CAR T cell therapy (Mustang Bio) 相关的转化医学

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100 项与 CD20-targeted CAR T cell therapy (Mustang Bio) 相关的专利（医药）

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项与 CD20-targeted CAR T cell therapy (Mustang Bio) 相关的文献（医药）

2021-12-01·Biomarker research3区 · 医学

Advances in chimeric antigen receptor T-cell therapy for B-cell non-Hodgkin lymphoma

3区 · 医学

ReviewOA

作者: Wang, Xin ; Zhang, Ya ; Yin, Zixun

Abstract:

B-cell non-Hodgkin lymphoma (B-NHL) is a group of heterogeneous disease which remains incurable despite developments of standard chemotherapy regimens and new therapeutic agents in decades. Some individuals could have promising response to standard therapy while others are unresponsive to standard chemotherapy or relapse after autologous hematopoietic stem-cell transplantation (ASCT), which indicates the necessity to develop novel therapies for refractory or relapsed B-NHLs. In recent years, a novel cell therapy, chimeric antigen receptor T-cell therapy (CAR-T), was invented to overcome the limitation of traditional treatments. Patients with aggressive B-NHL are considered for CAR-T cell therapy when they have progressive lymphoma after second-line chemotherapy, relapse after ASCT, or require a third-line therapy. Clinical trials of anti-CD19 CAR-T cell therapy have manifested encouraging efficacy in refractory or relapsed B-NHL. However, adverse effects of this cellular therapy including cytokine release syndrome, neurotoxicity, tumor lysis syndrome and on-target, off-tumor toxicities should attract our enough attention despite the great anti-tumor effects of CAR-T cell therapy. Although CAR-T cell therapy has shown remarkable results in patients with B-NHL, the outcomes of patients with B-NHL were inferior to patients with acute lymphoblastic leukemia. The inferior response rate may be associated with physical barrier of lymphoma, tumor microenvironment and low quality of CAR-T cells manufactured from B-NHL patients. Besides, some patients relapsed after anti-CD19 CAR-T cell therapy, which possibly were due to limited CAR-T cells persistence, CD19 antigen escape or antigen down-regulation. Quite a few new antigen-targeted CAR-T products and new-generation CAR-T, for example, CD20-targeted CAR-T, CD79b-targeted CAR-T, CD37-targeted CAR-T, multi-antigen-targeted CAR-T, armored CAR-T and four-generation CAR-T are developing rapidly to figure out these deficiencies.

项与 CD20-targeted CAR T cell therapy (Mustang Bio) 相关的新闻（医药）

2024-07-10

·BioSpace

Moleculin Completes End of Phase 2 Meeting with FDA for Annamycin in AML

HOUSTON, July 10, 2024 /PRNewswire/ --Moleculin Biotech, Inc, (Nasdaq: MBRX) ("Moleculin" or the "Company"), a clinical stage pharmaceutical company with a broad portfolio of drug candidates targeting hard-to-treat tumors and viruses, today announced the completion of its End of Phase 2 (EOP2) meeting with the U.S. Food and Drug Administration (FDA) for its Phase 1B/2 clinical trial evaluating Annamycin in combination with Cytarabine (also known as "Ara-C" and for which the combination of Annamycin and Ara-C is referred to as AnnAraC) for the treatment of subjects with AML as both first line therapy and for subjects who are refractory to or relapsed after induction therapy (MB-106). The Company expects to report outcomes from the EOP2 meeting upon receipt of official minutes from FDA which is expected by the end of Q3 2024. "The Moleculin team, along with our regulatory advisors and key opinion leaders, discussed with FDA the MB-106 safety and efficacy clinical findings and proposed next steps for our AML clinical development program," commented Walter Klemp, Chairman and Chief Executive Officer of Moleculin. "We are grateful to the FDA for what we consider to be a very productive meeting and look forward to reporting its outcome before the end of August." The EOP2 meeting was supported by second-line treatment results from the Company's ongoing MB-106 clinical trial. As recently reported on June 14, 2024, a total of 22 subjects have been enrolled (the Intent-to-Treat population, ITT), 20 (Lines 1st-7th) of whom have completed efficacy evaluations with 9 subjects (45%) achieving a composite complete remission (CRc or CR/CRi), consisting of 8 (40%) subjects with complete remission (CR) and one subject with complete remission with an incomplete recovery of peripheral blood counts (CRi), following treatment with AnnAraC. Efficacy outcomes for 2 additional subjects (enrolled and treated) are pending. Of the 10 ITT subjects for whom AnnAraC was administered in the 2nd line setting, 5 achieved a CR (50%) and 6 achieved a CRc (60%). Of the 13 subjects in the ITT evaluable population that were 1st or 2nd line treatment, 7 achieved a CR (54%) and 8 achieved a CRc (62%). The mDOR for the 9 subjects who achieved a CRc is approximately 7 months and climbing. Annamycin currently has Fast Track Status and Orphan Drug Designation from the U.S. Food and Drug Administration for the treatment of relapsed or refractory acute myeloid leukemia, in addition to Orphan Drug Designation for the treatment of soft tissue sarcoma. Furthermore, Annamycin has Orphan Drug Designation for the treatment of relapsed or refractory acute myeloid leukemia from the European Medicines Agency (EMA). For more information about the ongoing MB-106 Phase 1B/2 trial, visit clinicaltrialsregister.eu and reference EudraCT 2020-005493-10 or clinicaltrials.gov and reference NCT05319587. About Moleculin Biotech, Inc. Moleculin Biotech, Inc. is a clinical stage pharmaceutical company with a growing pipeline, including Phase 2 clinical programs, for hard-to-treat tumors and viruses. The Company's lead program, Annamycin is a next-generation anthracycline designed to avoid multidrug resistance mechanisms and to eliminate the cardiotoxicity common with currently prescribed anthracyclines. Annamycin is currently in development for the treatment of acute myeloid leukemia (AML) and soft tissue sarcoma (STS) lung metastases. All interim and preliminary data related to its active clinical trials are subject to change. Additionally, the Company is developing WP1066, an Immune/Transcription Modulator capable of inhibiting p-STAT3 and other oncogenic transcription factors while also stimulating a natural immune response, targeting brain tumors, pancreatic and other cancers. Moleculin is also engaged in the development of a portfolio of antimetabolites, including WP1122 for the potential treatment of viruses, as well as certain cancer indications. For more information about the Company, please visit and connect on Twitter, LinkedIn and Facebook. Forward-Looking Statements Some of the statements in this release are forward-looking statements within the meaning of Section 27A of the Securities Act of 1933, Section 21E of the Securities Exchange Act of 1934 and the Private Securities Litigation Reform Act of 1995, which involve risks and uncertainties. Although Moleculin believes that the expectations reflected in such forward-looking statements are reasonable as of the date made, expectations may prove to have been materially different from the results expressed or implied by such forward-looking statements. Moleculin has attempted to identify forward-looking statements by terminology including 'believes,' 'estimates,' 'anticipates,' 'expects,' 'plans,' 'projects,' 'intends,' 'potential,' 'may,' 'could,' 'might,' 'will,' 'should,' 'approximately' or other words that convey uncertainty of future events or outcomes to identify these forward-looking statements. These statements are only predictions and involve known and unknown risks, uncertainties, and other factors, including those discussed under Item 1A. "Risk Factors" in our most recently filed Form 10-K filed with the Securities and Exchange Commission (SEC) and updated from time to time in our Form 10-Q filings and in our other public filings with the SEC. Any forward-looking statements contained in this release speak only as of its date. We undertake no obligation to update any forward-looking statements contained in this release to reflect events or circumstances occurring after its date or to reflect the occurrence of unanticipated events. Investor Contact: JTC Team, LLC Jenene Thomas (833) 475-8247 MBRX@jtcir.com Company Codes: NASDAQ-SMALL:MBRX

临床2期孤儿药临床结果快速通道

2024-06-24

·echemi

U.S. Biotech Company MustangBio Sees Meteoric 480% Stock Surge on Promising CD20 CAR-T Therapy

MustangBio, a leading U.S. biotech company, has recently achieved a remarkable breakthrough. Their CD20 CAR-T therapy, MB-106, has shown impressive results in a clinical trial for Waldenström's macroglobulinemia (WM) patients, driving the company's stock price to surge nearly 480% in a single day. This highly anticipated MB-106 CAR-T therapy has emerged as a shining star in the biomedical field, thanks to its exceptional efficacy and outstanding safety profile. WM, a rare B-cell non-Hodgkin's lymphoma, has long been a challenge for patients and the medical community. While existing therapies like CD20 monoclonal antibodies and BTK inhibitors can provide some symptom relief, their efficacy is often limited, and patients frequently relapse. However, the clinical data for MB-106 has brought renewed hope. It is reported that 90% of the WM patients participating in the clinical trial achieved an overall response, with 3 cases even reaching a complete response. Moreover, one patient experienced a remarkable 31-month durable response after receiving the treatment. This groundbreaking achievement not only offers hope for a cure for WM patients but has also garnered widespread attention within the industry. The success of MB-106 is no coincidence. It targets the CD20 antigen, which is highly expressed in B-cell lymphomas. Currently, there is no approved CD20 CAR-T therapy globally, making MB-106 a potential first-in-class product that could bring significant commercial value to the company. In addition to WM, MB-106 is also being developed for relapsed/refractory B-cell lymphomas and chronic lymphocytic leukemia, conditions with significant unmet treatment needs. The ability of MB-106 to address these gaps, along with its potential to deliver better efficacy and quality of life for patients, further underscores its market potential and the company's overall growth prospects. MustangBio's pipeline is diverse, with MB-106 being just one of its many promising programs, including a gene therapy for XSCID. This breadth demonstrates the company's comprehensive capabilities and commitment to the biomedical field. As MB-106 continues to progress in clinical trials and move towards commercialization, MustangBio's commercial potential will become increasingly evident, generating attractive returns for investors. In conclusion, MustangBio's leading R&D capabilities and impressive product performance have positioned the company as a rising star in the biotech industry. The success of MB-106 is just a glimpse of the company's potential, and we have every reason to believe that this "low-profile" biotech firm is poised to become a future industry giant, contributing even more significantly to the advancement of human health.

临床结果免疫疗法细胞疗法

2024-06-23

·药明康德

完全缓解率达100%的CAR-T疗法；延长胰腺癌患者生存期的组合疗法…… | 一周盘点

▎药明康德内容团队编辑本期看点 1. CD19靶向候选CAR-T细胞疗法GLPG5101在1项早期临床试验中治疗5例套细胞淋巴瘤（MCL）患者，客观缓解率（ORR）和完全缓解率（CRR）均为100%。 2. 靶向信号调节蛋白（SIRP）的抗体疗法ELA026治疗初治恶性肿瘤相关噬血细胞性淋巴组织细胞增多症（mHLH）的总缓解率达100%，并提高了此类患者的两个月生存率。 3. 抗体疗法Natrunix联用化疗治疗晚期胰腺癌，在早期临床试验中延长了患者的生存期并改善了化疗的耐受性。药明康德内容团队整理 GLPG5101：公布1/2期临床试验数据 Galapagos公司公布了其CD19靶向候选CAR-T细胞疗法GLPG5101治疗复发/难治性非霍奇金淋巴瘤（NHL）的1/2期临床试验ATALANTA-1的新数据。该细胞疗法从制备到回输到患者体内的中位时间仅需7天。截至2023年12月20日的数据，在研究的第一部分，中位随访时间为13.1个月，接受GLPG5101治疗的16例可评估患者的ORR为87.5%（14/16），CRR为75%（12/16）。71%的患者在数据截止时保持缓解。在研究的第二部分，中位随访时间为4.2个月，15例可评估患者的ORR和CRR均为93.3%（14/15）。100%的患者在数据截止时保持持续缓解。合并两部分的研究结果后根据肿瘤类型进行划分，弥漫性大B细胞淋巴瘤（DLBCL）患者的ORR为78%（7/9），CRR为56%（5/9）；滤泡性淋巴瘤（FL）或边缘区淋巴瘤（MZL）患者的ORR和CRR均为94%（16/17）；套细胞淋巴瘤患者的ORR和CRR均为100%（5/5）。安全性方面，大多数治疗伴发不良事件为1/2级，在研究的第一部分观察到2例3级细胞因子释放综合征（CRS），在研究的第二部分观察到1例3级免疫效应细胞相关神经毒性综合征（ICANS）。 ELA026：公布1b期临床试验的新数据 Electra Therapeutics公司公布了其靶向信号调节蛋白（SIRP）的单克隆抗体ELA026治疗继发性噬血细胞性淋巴组织细胞增生症（sHLH）的1b期研究的最新临床数据。ELA026靶向细胞表面的SIRP，能够靶向清除血液循环中驱动炎症的髓系细胞和T细胞，并且不破坏SIRPα/CD47免疫检查点功能。该疗法旨在治疗伴有异常髓系和T细胞活性的重度炎性疾病。此次公布的结果显示，ELA026在sHLH患者中具有良好的安全性，不良事件可控。在已完成入组的队列1和2中（n=12），ELA026在第4周时的总缓解率为75%，在8例未接受过治疗的mHLH（sHLH的一种亚型）患者中，总缓解率为100%，两个月时的生存率为88%。此类患者在自然史研究中的两个月时的死亡率约为50%。 Natrunix：公布1/2期临床试验数据 XBiotech公司公布了其靶向白细胞介素-1α（IL-1α）的抗体疗法Natrunix联用化疗治疗晚期胰腺癌的1/2期多中心研究的数据。除了能够作为一种抗癌疗法，该公司认为Natrunix还有望改善化疗的耐受性。该研究中采用的化疗方案为ONIVYDE（ON）+5-氟尿嘧啶（5FU）+亚叶酸（LV）。此次公布的结果显示，与安慰剂+化疗组相比，Natrunix+化疗组在24周的治疗周期内发生任何类型的不良事件的数量（297例对比336例）、发生重大不良事件的患者比例（9/33对比12/32）和住院天数（80天对比120天）均明显减少。此外，接受Natrunix+化疗组患者的生存期得到了延长，接受治疗第330天时有8例患者存活，而安慰剂+化疗组没有患者存活超过330天。 ▲患者的生存曲线（图片来源：参考资料[9]） Petrelintide：公布1b期临床试验数据 Zealand Pharma公司公布了其在研长效、潜在“best-in-class”减重疗法petrelintide的1b期试验第二部分的顶线结果。Petrelintide（ZP8396）是一种适合每周一次皮下注射的长效胰淀素类似物，具有中性pH下的化学和物理稳定性。胰淀素在胰腺β细胞中产生，并与胰岛素一起分泌以响应摄入的营养物质。目前的临床或临床前数据表明，petrelintide有潜力实现与GLP-1受体激动剂相当的体重减轻，但具有更好的耐受性，为患者提供更好的用药体验和体重减轻，同时保留患者的肌肉质量。此次公布的结果显示，患者在接受16周高剂量petrelintide治疗后，体重较基线平均减少了8.6%，而安慰剂组仅为1.7%。安全性方面，petrelintide显示良好的耐受性，没有出现严重的不良事件。所有胃肠道（GI）不良事件均为轻度，除了一名受试者在第三次治疗后因中度恶心和呕吐而停止治疗。值得注意的是，没有其他受试者因不良事件停止治疗或报告呕吐，只有两例轻度腹泻报告。恶心在活性组中报告比例为16.7-33.3%，在安慰剂组为16.7%。少数参与者报告了注射部位反应，均为轻度。未观察到患者产生抗药抗体。新闻稿指出，该积极结果支持petrelintide作为GLP-1受体激动剂类药物之外，在体重管理上的另一选择。 Amezalpat（TPST-1120）：公布1b/2期临床试验的新数据 Tempest Therapeutics公司公布了其在研口服、选择性小分子PPAR⍺拮抗剂amezalpat（TPST-1120）在一项全球随机的1b/2期临床试验中获得的积极结果。临床前数据显示，amezalpat可直接杀死肿瘤细胞，并靶向肿瘤微环境中的抑制性免疫通路。这两种类型中的靶向细胞皆依赖脂肪酸代谢，该代谢过程由PPARα转录因子调节。在一项针对接受过多次治疗的晚期实体瘤患者的1期临床试验中，amezalpat单药治疗和与PD-1抑制剂nivolumab联合应用均导致肿瘤缩小及生物标志物的变化。此次公布的结果显示，与标准治疗方案相比，amezalpat与标准治疗方案（抗PD-L1抗体atezolizumab和抗VEGF抗体bevacizumab）联用，在无法切除或转移性肝细胞癌（HCC）患者的一线治疗中，显著提高患者的中位总生存期（OS）达6个月（21个月对比15个月）。此外，按照RECIST v1.1标准评估，amezalpat组的确认客观缓解率（cORR）为30%，对照组为13.3%。安全性方面，amezalpat的耐受性良好，两组之间的安全数据相当。 ▲Amezalpat试验的OS结果（图片来源：参考资料[29]） MB-106：公布1/2期临床试验数据 Mustang Bio公司公布了其在研、可通过门诊给药、靶向CD20的自体CAR-T细胞疗法MB-106治疗华氏巨球蛋白血症（WM）的1/2期临床试验最新数据。该试验中的所有十例患者均曾接受过布鲁顿酪氨酸激酶抑制剂（BTKi）的治疗，并且在接受BTKi治疗期间病情持续恶化。患者之前接受过中位9线疗法，只有一例患者在接受MB-106治疗后开始接受额外的抗WM治疗。总体而言，接受MB-106治疗的患者中有90%（9/10）对治疗产生应答，包括3名患者达完全缓解（CR）、2名达非常好的部分缓解和4名部分缓解。此外，1例患者的病情稳定。其中一名获得CR的患者已持续缓解31个月，该患者的免疫球蛋白M（IgM）水平在接受MB-106治疗后迅速降至正常范围，此后一直保持正常。安全性方面，9例患者发生了CRS（5例患者为1级，4例患者为2级），一例患者经历了1级ICANS。尽管剂量增加，但并未观察到3级或4级CRS或2、3或4级ICANS。 NX-594：公布1a/b期临床试验数据 Nurix Therapeutics公司公布了其在研口服BTK降解剂NX-5948治疗复发难治性慢性淋巴细胞白血病（CLL）的1a/b期临床试验的积极数据。NX-5948是一种生物利用度高、可穿越血脑屏障的口服BTK小分子降解剂。 ▲NX-5948的疗效结果（图片来源：参考资料[5]）此次公布的结果显示，NX-594在复发难治性CLL患者身上引起了快速、深度的缓解，ORR达69.2%，这些患者之前曾接受大量治疗并带有BTK抑制剂耐药突变。最早在第一次肿瘤扫描（8周）时就观察到患者出现缓解，许多患者在治疗时间延长后缓解加深。截至4月17日数据截止，所有缓解仍在持续。 ▲一例患者接受NX-5948治疗24周内，脑脊液中的恶性肿瘤细胞消除（图片来源：参考资料[5]） ▲一例曾接受过11线疗法的患者在接受NX-5948治疗后肿瘤持久消退（图片来源：参考资料[2]）此外，一例在进入研究时伴有中枢神经系统受累的CLL患者在接受NX-5948治疗的24周内消除了脑脊液（CSF）中的恶性肿瘤细胞，并在36周时达到接近CR的标准。还有一例曾接受过11线疗法的患者在接受NX-5948治疗后肿瘤持久消退已超过6个月。安全性方面，NX-5948在所有评估剂量下均耐受性良好，最常见的治疗不良事件为紫癜/挫伤、血小板减少和中性粒细胞减少。Nurix预计在2025年启动NX-5948的关键临床试验。 SL-172154：公布1b期临床试验数据 Shattuck Labs公布了其在研疗法SL-172154在1b期剂量扩展临床试验的最新中期数据。SL-172154（SIRPα-Fc-CD40L）是一款在研重定向检查点激动剂（ARC）融合蛋白，旨在同时抑制CD47/SIRPα检查点的相互作用并激活CD40共刺激受体，以增强晚期癌症患者的抗肿瘤免疫反应。此次公布的结果显示，SL-172154与阿扎胞苷（AZA）联用作为高风险骨髓增生异常综合征（HR-MDS）和TP53突变（TP53m）急性髓性白血病（AML）患者的一线疗法时，患者的ORR分别达67%与43%，CRR分别为42%与29%。截至2024年4月23日，SL-172154表现出可控的安全性。输液相关反应（IRRs）是SL-172154治疗过程中最常见的不良事件。 KT-333：公布1期临床试验的新数据 Kymera Therapeutics公布了其在研药物KT-333的1期临床试验的更新数据。KT-333是一种潜在“first-in-class”、强效、高选择性的STAT3靶向小分子降解剂。根据新闻稿，KT-333是靶向未成药转录因子的首个进入临床阶段的降解剂。 ▲KT-333试验临床结果摘要（图片来源：参考资料[3]）此次公布的结果显示，KT-333完成初步临床概念验证，在多种血液恶性肿瘤中展示了抗肿瘤活性。其中，两名经典霍奇金淋巴瘤患者达到CR，1名STAT3突变的NK细胞淋巴瘤患者达到CR。安全性方面，KT-333耐受性良好，主要不良事件为1级和2级，包括口腔炎和疲劳。 ▲欲了解更多前沿技术在生物医药产业中的应用，请长按扫描上方二维码，即可访问“药明直播间”，观看相关话题的直播讨论与精彩回放参考资料（可上下滑动查看） [1] Shattuck Labs Announces Updated Positive Interim Data from the Phase 1B Dose Expansion Clinical Trial of SL-172154 in Combination with Azacitidine (AZA) in Frontline Higher-Risk Myelodysplastic Syndromes (HR-MDS) and TP53 mutant (TP53m) Acute Myeloid Leukemia (AML) Patients. 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Retrieved June 21, 2024, from https://www.businesswire.com/news/home/20240614920813/en [21] Cabaletta Bio Reports Positive Initial Clinical Data from Phase 1/2 RESET-Myositis™ and RESET-SLE™ Trials of CABA-201. Retrieved June 21, 2024, from https://www.globenewswire.com/news-release/2024/06/14/2898772/0/en/Cabaletta-Bio-Reports-Positive-Initial-Clinical-Data-from-Phase-1-2-RESET-Myositis-and-RESET-SLE-Trials-of-CABA-201.html [22] ORYZON Presents Preliminary Data From Ongoing Phase Ib FRIDA Trial with Iadademstat Plus Gilteritinib in Relapsed/Refractory FLT3-mut AML Patients at EHA-2024. Retrieved June 21, 2024, from https://www.globenewswire.com/news-release/2024/06/14/2898942/0/en/ORYZON-Presents-Preliminary-Data-From-Ongoing-Phase-Ib-FRIDA-Trial-with-Iadademstat-Plus-Gilteritinib-in-Relapsed-Refractory-FLT3-mut-AML-Patients-at-EHA-2024.html [23] Enlivex Announces Positive Interim Data Readout from a Phase I/II Trial Evaluating Allocetra in End-Stage Knee Osteoarthritis. Retrieved June 21, 2024, from https://www.globenewswire.com/news-release/2024/06/17/2899579/0/en/Enlivex-Announces-Positive-Interim-Data-Readout-from-a-Phase-I-II-Trial-Evaluating-Allocetra-in-End-Stage-Knee-Osteoarthritis.html [24] Cessation Therapeutics Announces Oral Presentation of Preliminary Findings from First-in-Human Study of Anti-Fentanyl Monoclonal Antibody, CSX-1004. Retrieved June 21, 2024, from https://www.businesswire.com/news/home/20240619579616/en [25] Innate Pharma Shares Updated Results From the Sanofi Developed Blood Cancer Phase 1/2 SAR443579/IPH6101 Trial. Retrieved June 21, 2024, from https://www.businesswire.com/news/home/20240616126553/en [26] Tempest Unveils New Survival Data for Amezalpat (TPST-1120) in Randomized First-Line HCC Study Demonstrating a Six-Month Improvement over Control Arm. Retrieved June 21, 2024, from https://ir.tempesttx.com/news-releases/news-release-details/tempest-unveils-new-survival-data-amezalpat-tpst-1120-randomized [27] Escend Announces Poster Presentation at the Annual Meeting of the European Hematology Association (EHS) from an Investigator-Initiated Phase I/II study evaluating ES-3000 in Myelodysplastic Syndrome (MDS). Retrieved June 21, 2024, from https://www.prnewswire.com/news-releases/escend-announces-poster-presentation-at-the-annual-meeting-of-the-european-hematology-association-ehs-from-an-investigator-initiated-phase-iii-study-evaluating-es-3000-in-myelodysplastic-syndrome-mds-302177666.html [28] Tubulis Doses First Patient in Phase I/IIa Trial Investigating ADC Candidate TUB-040 in Ovarian Cancer and Lung Adenocarcinoma. Retrieved June 21, 2024, from https://www.businesswire.com/news/home/20240620456143/en/ [29] Amezalpat (TPST-1120) Randomized 1L HCC Data Updat. Retrieved June 20, 2024 https://ir.tempesttx.com/static-files/8ba2d665-884e-47f7-89c2-adbba73378b2 [30] Mustang Bio Announces Favorable Efficacy and Safety Data from Complete Waldenstrom Macroglobulinemia Cohort of Phase 1/2 Clinical Trial of MB-106, CD20-Targeted Autologous CAR-T Therapy. Retrieved June 18, 2024 from https://ir.mustangbio.com/news-events/press-releases/detail/180/mustang-bio-announces-favorable-efficacy-and-safety-data 免责声明：药明康德内容团队专注介绍全球生物医药健康研究进展。本文仅作信息交流之目的，文中观点不代表药明康德立场，亦不代表药明康德支持或反对文中观点。本文也不是治疗方案推荐。如需获得治疗方案指导，请前往正规医院就诊。版权说明：本文来自药明康德内容团队，欢迎个人转发至朋友圈，谢绝媒体或机构未经授权以任何形式转载至其他平台。转载授权请在「药明康德」微信公众号回复“转载”，获取转载须知。分享，点赞，在看，聚焦全球生物医药健康创新

细胞疗法临床结果免疫疗法临床2期

100 项与 CD20-targeted CAR T cell therapy (Mustang Bio) 相关的药物交易

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研发状态

10 条进展最快的记录,

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适应症	最高研发状态	国家/地区	公司	日期
难治性B细胞淋巴瘤	临床2期	美国	Mustang Bio, Inc.	2022-05-24
滤泡性淋巴瘤	临床2期	美国	Mustang Bio, Inc.	2022-05-24
复发性套细胞淋巴瘤	临床2期	美国	Mustang Bio, Inc.	2022-05-24
难治性套细胞淋巴瘤	临床2期	美国	Mustang Bio, Inc.	2022-05-24
复发性慢性淋巴细胞白血病	临床2期	美国	Mustang Bio, Inc.	2022-05-24
小淋巴细胞淋巴瘤	临床2期	美国	Mustang Bio, Inc.	2022-05-24
复发性巨球蛋白血症	临床2期	美国	Mustang Bio, Inc.	2022-05-24
华氏巨球蛋白血症难治	临床2期	美国	Mustang Bio, Inc.	2022-05-24
复发性B细胞淋巴瘤	临床2期	美国	Mustang Bio, Inc.	2017-12-05
非霍奇金淋巴瘤	临床2期	美国	Fred Hutchinson Cancer Research Center	2017-12-05

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临床结果

适应症

分期

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


NCT05360238 (Biospace) 人工标引	临床1/2期	巨球蛋白血症	10	MB-106	築顧衊構鑰遞範艱醖壓(遞襯廠窪鬱簾鏇蓋淵繭) = 顧獵築膚簾憲獵繭網蓋繭鹽構範選構範顧夢夢 (鹹齋餘遞窪顧顧醖鬱夢 ) 更多	积极	2024-06-17
Biospace 人工标引	临床1/2期	非霍奇金淋巴瘤 \| 慢性淋巴细胞白血病	9	MB-106	構顧築製遞廠壓獵鹽築(廠壓壓衊壓艱願製鑰鑰) = 願構鹽壓夢糧蓋鑰廠廠築簾鑰窪壓獵壓壓範壓 (壓糧鹽艱簾醖艱製醖齋 ) 更多	积极	2023-12-11
ASH2023	临床1期	难治性惰性非霍奇金淋巴瘤	4	MB-106	鬱鹽鹽範範遞鏇壓繭衊(衊醖淵醖憲膚淵簾願鬱) = 選繭鹽簾網衊選構艱衊觸顧鹽繭願製醖夢醖選 (蓋觸齋蓋膚網築願觸壓 ) 更多	-	2023-12-09
ICML2023	N/A	滤泡性淋巴瘤	-	MB-106	鹽獵廠構膚簾觸憲範網(衊網選蓋憲鬱壓淵鑰願) = 鏇壓築衊築淵觸廠襯選繭壓鬱淵鏇壓遞選鬱範 (鏇願夢壓鏇簾憲簾繭齋 ) 更多	-	2023-06-09
EHA2023	临床1/2期	淋巴浆细胞性淋巴瘤 \| 巨球蛋白血症	6	CD20 CAR-T therapy with MB-106	憲艱蓋壓構範窪醖願願(網願衊夢廠製鑰糧願築) = 鹹繭築顧艱製壓衊顧蓋窪獵齋觸築壓觸鏇積夢 (築遞齋壓願製衊憲夢繭 ) 更多	-	2023-06-08
NCT03277729 (Corporate Publications) 人工标引	临床1/2期	滤泡性淋巴瘤	18	MB-106	蓋壓壓糧製遞繭鏇鹹鏇(願鬱鬱淵壓醖製遞顧網) = 構糧醖淵願製簾願醖淵醖鏇鑰鏇積鬱積積糧製 (襯淵鹹憲壓願範鏇廠壓 ) 更多	积极	2022-06-13
EHA2022 人工标引	临床1/2期	复发性滤泡性淋巴瘤 \| 滤泡性淋巴瘤	16	MB 106	遞築蓋艱鏇網淵憲積衊(鑰衊衊餘憲簾簾築糧鹹) = No pts had tumor lysis syndrome or Gr 3-4 infections. In the first 28 days, thrombocytopenia (Gr 3-4: 12.5%) and neutropenia (Gr 3-4: 94%) were common but there were no bleeding complications, and the rate of febrile neutropenia was 25%. 簾築壓餘鏇願簾獵繭糧 (製網艱鑰艱醖蓋獵顧廠 )	积极	2022-05-12
EHA2022 人工标引	临床1/2期	复发性滤泡性淋巴瘤 \| 滤泡性淋巴瘤	16	MB 106 (Pts who received DL3 or DL4)		积极	2022-05-12