编者按:2026年欧洲肿瘤内科学会(ESMO)年会将于当地时间10月23日至27日在西班牙马德里举办。继大会常规摘要公布之后,9月22日ESMO官网正式披露了突破性摘要(Late-Breaking Abstract,LBA)日程,中国创新研究大幅入选。
在大会的三场主席研讨会中(Presidential Symposium),陆舜教授(LBA6)、徐瑞华院士(LBA7)、周俭院士(LBA8)、谢璐教授(LBA9)的重要成果入选。此外,药物研发专场(Developmental therapeutics)、免疫治疗研发专场(Investigational immunotherapy)亦有多项中国研究入选,彰显了我国强劲的创新研发实力。本文整理上述专场口头报告研究题目与关键信息,邀请预览本次ESMO大会的部分亮点。
Presidential Symposium
主席研讨会
专题:主席研讨会 I
时间:2026.10.24 16:30 - 18:15
地点:Alicante Auditorium - Hall 6
摘要号:LBA1
标题:INTerpath-001: Phase 3 study of the mRNA-based individualized neoantigen therapy (INT) intismeran autogene (intismeran) plus pembrolizumab (pembro) vs pembro alone for adjuvant treatment of resected stage IIB-IV melanoma (MEL)
中文标题:INTerpath-001:基于mRNA的个体化新抗原疗法(INT)intismeran autogene(intismeran)联合帕博利珠单抗(pembro)对比帕博利珠单抗单药用于已切除IIB-IV期黑色素瘤(MEL)辅助治疗的III期研究
讲者:Georgina V. Long (澳大利亚)
摘要号:LBA2
标题:Perioperative durvalumab with or without tremelimumab plus neoadjuvant enfortumab vedotin in muscle-invasive bladder cancer: results from the Phase 3 VOLGA trial
中文标题:围手术期度伐利尤单抗联合或不联合替西木单抗加新辅助维恩妥尤单抗治疗肌层浸润性膀胱癌:III期VOLGA试验结果
讲者:Thomas B. Powles (英国)
摘要号:LBA3
标题:Tarlatamab plus durvalumab (durva) vs durva as 1L maintenance (1LM) therapy following durva, platinum, and etoposide (1L durva + EP) in extensive-stage small cell lung cancer (ES-SCLC): Primary analysis of the phase 3 DeLLphi-305 trial
中文标题:塔拉妥单抗联合度伐利尤单抗(durva)对比度伐利尤单抗作为广泛期小细胞肺癌(ES-SCLC)在度伐利尤单抗+铂类+依托泊苷(1L durva + EP)后一线维持(1LM)治疗:III期DeLLphi-305试验主要分析
讲者:Jacob Sands(美国)
摘要号:LBA4
标题:Darolutamide with androgen deprivation therapy (ADT) and definitive or salvage locoregional radiation therapy (RT) for localised, very high-risk prostate cancer: interim analysis of an international, placebo-controlled, randomised phase 3 trial (DASL-HiCaP; ANZUP1801)
中文标题:达罗他胺联合雄激素剥夺治疗(ADT)及根治性或挽救性局部放疗(RT)治疗局限性极高危前列腺癌:一项国际、安慰剂对照、随机III期试验(DASL-HiCaP;ANZUP1801)的中期分析
讲者:Tamim Niazi (加拿大)
专题:主席研讨会 Ⅱ
时间:2026.10.25 16:30 - 18:15
地点:Alicante Auditorium - Hall 6
摘要号:LBA5
标题:Krascendo 1: efficacy and safety of divarasib (diva) vs sotorasib (soto) or adagrasib (ada) in previously treated locally advanced or metastatic KRAS G12C-mutated NSCLC
中文标题:Krascendo 1——divarasib(diva)对比索托拉西布(soto)或阿达格拉西布(ada)治疗既往经治的局部晚期或转移性KRAS G12C突变NSCLC的疗效和安全性
讲者:Ferdinandos Skoulidis(美国)
摘要号:LBA6
标题:Osimertinib (osi) + savolitinib (savo) vs platinum–pemetrexed (plat–pem) in EGFRm MET-overexpressed (OE) and/or -amplified (AMP) advanced NSCLC post-osi: SAFFRON Phase (Ph) 3 primary results
中文标题:奥希替尼(osi)联合赛沃替尼(savo)对比铂类–培美曲塞(plat–pem)治疗奥希替尼后EGFR突变伴MET过表达(OE)和/或扩增(AMP)的晚期NSCLC:SAFFRON III期(Ph 3)主要结果
讲者:陆舜 教授(上海交通大学医学院附属胸科医院)
摘要号:LBA7
标题:CLARITY-Gastric 01 (CG-01): a Phase 3 study of sonesitatug vedotin (Sone-Ve) in second or later-line (2L+) advanced or metastatic Claudin 18.2 (CLDN18.2) positive gastroesophageal carcinoma (GEC)
中文标题:CLARITY-Gastric 01(CG-01):sonesitatug vedotin(Sone-Ve)用于二线或后线(2L+)晚期或转移性Claudin 18.2(CLDN18.2)阳性胃食管癌(GEC)的III期研究
讲者:徐瑞华 教授(中山大学肿瘤防治中心)
摘要号:LBA8
标题:Ivonescimab plus chemotherapy versus durvalumab plus chemotheray as first-line treatment for advanced biliary tract cancer: a randomized, controlled, double- blinded, phase 3 trial (HARMONi-GI1)
中文标题:依沃西单抗联合化疗对比度伐利尤单抗联合化疗一线治疗晚期胆道癌:一项随机、对照、双盲、III期试验(HARMONi-GI1)
讲者:周俭 教授(复旦大学附属中山医院)
专题:主席研讨会Ⅲ
时间:2026.10.26 16:30 - 18:15
地点:Alicante Auditorium - Hall 6
摘要号:LBA9
标题:Risvutatug Rezetecan (Ris-Rez) versus Gemcitabine and Docetaxel (GD) in Heavily Pretreated Patients (pts) with Relapsed or Refractory (R/R) Osteosarcoma: Primary Results from the Phase 3 ARTEMIS-011 Study
中文标题:瑞康立伏妥塔单抗(Ris-Rez)对比吉西他滨和多西他赛(GD)治疗重度经治的复发或难治性(R/R)骨肉瘤患者(pts):III期ARTEMIS-011研究主要结果
讲者:谢璐 教授(北京大学人民医院)
摘要号:LBA10
标题:MOIO: Interim analyses of a Phase III Randomized Non Inferiority Trial Assessing Reduced Frequency Immune Checkpoint Inhibitors in Responding Patients with Advanced/Metastatic Cancer.
中文标题:MOIO:一项评估降低频率免疫检查点抑制剂用于缓解期晚期/转移性癌症患者的III期随机非劣效性试验的中期分析
讲者:Gwenaëlle Gravis (法国)
摘要号:LBA11
标题:Sacituzumab Tirumotecan in Previously Treated Advanced or Recurrent Endometrial Cancer: Results from the Phase 3 TroFuse-005/ENGOT-en23/GOG-3095 Study
中文标题:芦康沙妥珠单抗(sac-TMT)用于既往经治的晚期或复发性子宫内膜癌:III期TroFuse-005/ENGOT-en23/GOG-3095研究结果
讲者:Domenica Lorusso (意大利)
摘要号:LBA12
标题:KEYNOTE-C93/GOG-3064/ENGOT-en15: Phase 3, Randomized, Open-Label Study of First-Line (1L) Pembrolizumab (Pembro) vs Carboplatin (C) + Paclitaxel (P) in Mismatch Repair-Deficient (dMMR) Advanced or Recurrent Endometrial Carcinoma (a/rEC)
中文标题:KEYNOTE-C93/GOG-3064/ENGOT-en15:帕博利珠单抗(Pembro)对比卡铂(C)联合紫杉醇(P)一线(1L)治疗错配修复缺陷(dMMR)晚期或复发性子宫内膜癌(a/rEC)的III期、随机、开放标签研究
讲者:Brian M. Slomovitz (美国)
Proffered paper: Developmental therapeutics
优选论文报告:药物研发专场
时间:2026.10.24 14:45 - 16:15
地点:Burgos Auditorium - Hall 3
摘要号:999O
标题:Elfetabart drozuntecan (Elfe-D; DB-1311/BNT324 [B7H3 ADC]) + pumitamig (PD-L1 x VEGF-A bsAb) in patients with advanced solid tumors: First results from a global phase 2 trial
中文标题:Elfetabart drozuntecan【Elfe-D;DB-1311/BNT324 (B7H3 ADC)】联合 pumitamig(PD-L1 x VEGF-A双抗)治疗晚期实体瘤患者:全球2期试验的初步结果
讲者:郭晔 教授(同济大学附属东方医院)
摘要号:1000O
标题:HS-20122, a Novel EGFR/cMET Bispecific Antibody Drug Conjugate, in Advanced Solid Tumors
中文标题:HS-20122,一种治疗晚期实体瘤的新型EGFR/cMET双特异性抗体偶联药物
讲者:赵洪云 教授(中山大学肿瘤防治中心)
摘要号:1001O
标题:Safety and efficacy of IBI3001, an anti-EGFR/B7H3 bispecific ADC, in patients (pts) with advanced solid tumors: Results of a multi-regional phase 1 study
中文标题:IBI3001(抗EGFR/B7H3双抗ADC)在晚期实体瘤患者中的安全性与疗效:一项多中心、1期研究结果
讲者:胡毅 教授(中国人民解放军总医院)
摘要号:1002O
标题:Early clinical activity of SL-28, representing a new class of allogeneic leukocyte therapy, in biologically distinct advanced solid tumors: an interim analysis
中文标题:SL-28(一种新型同种异体白细胞疗法)在不同生物学特征的晚期实体瘤中的早期临床活性:中期分析
讲者:George Tetz(美国)
摘要号:1003O
标题:Phase I study of GCC CAR-T therapy in patients with advanced colorectal cancer
中文标题:GCC CAR-T细胞疗法在晚期结直肠癌患者中的I期研究
讲者:刘畅 教授(北京大学肿瘤医院)
Rapid Oral : Developmental therapeutics
快速口头报告:药物研发专场
时间:2026.10.25 08:30 – 10:00
地点:Cordoba Auditorium - Hall 4
摘要号:1004RO
标题:First-in-human Multicenter Phase 1 Study of ISM6331, an AI-Designed Pan-TEAD Inhibitor, in Patients with Mesothelioma or Other Advanced Solid Tumors
中文标题:ISM6331(AI设计的泛TEAD抑制剂)在间皮瘤或其他晚期实体瘤患者中的首次人体多中心I期研究
讲者:Melina E. Marmarelis(美国)
摘要号:1005RO
标题:Efficacy and Safety of Pralsetinib in RET Fusion-Positive Solid Tumors: Pooled Analysis of the ARROW and TAPISTRY Trials
中文标题:普拉替尼治疗RET融合阳性实体瘤的疗效与安全性:ARROW和TAPISTRY研究的汇总分析
讲者:Vivek Subbiah(美国)
摘要号:LBA33
标题:Safety and efficacy of GFH276 monotherapy in previously treated RAS-mutated advanced solid tumors
中文标题:GFH276单药治疗既往经治的RAS突变晚期实体瘤的安全性与疗效
讲者:马宇翔 教授(中山大学肿瘤防治中心)
摘要号:1006RO
标题:Phase 1 study of FMC-376, a KRAS G12C equipotent ON+OFF inhibitor in pts with advanced KRAS G12C mutant solid tumors
中文标题:FMC-376 (KRAS G12C等效力ON+OFF抑制剂)在晚期KRAS G12C突变实体瘤患者中的I期研究
讲者:Marcelo V. Negrao(美国)
摘要号:1007RO
标题:Safety and Efficacy of Oral KRAS G12D Inhibitor INCB161734 as Monotherapy or in Combination with Cetuximab (Cetux) in Patients (pts) with Advanced/Metastatic Colorectal Cancer (CRC)
中文标题:口服KRAS G12D抑制剂INCB161734单药或联合西妥昔单抗治疗晚期/转移性结直肠癌患者的安全性与疗效
讲者:Jayesh Desai(澳大利亚)
摘要号:1008RO
标题:IBI363 (TAK-928) plus XELOX as the first line (1L) treatment for advanced gastric or gastroesophageal junction adenocarcinoma (G/GEJA)
中文标题:IBI363(TAK-928)联合XELOX方案一线治疗晚期胃或胃食管交界处腺癌
讲者:俞鹏飞 教授(浙江省肿瘤医院)
摘要号:1009RO
标题:JMT108, a novel anti-PD-1/IL-15 bifunctional fusion protein, in patients with advanced solid tumors: results from a first-in-human phase I/II study
中文标题:JMT108(新型抗PD-1/IL-15双功能融合蛋白)在晚期实体瘤患者中的首次人体I/II期研究结果
讲者:林榕波 教授(福建省肿瘤医院)
摘要号:LBA34
标题:First-in-human study of MRG007 (ARR-217), a CDH17-directed exatecan ADC, in patients with locally advanced or metastatic solid tumors
中文标题:靶向CDH17的依喜替康ADC MRG007(ARR-217)在局部晚期或转移性实体瘤患者中的首次人体研究
讲者:李健 教授(北京大学肿瘤医院)
Proffered paper: Investigational immunotherapy
优选论文报告:免疫治疗研发专场
时间:2026.10.23 13:30 - 15:00
地点:Leon Auditorium - Hall 4
摘要号:1946O
标题:Targeting PRAME+ Tumors with IMA203CD8, a PRAME-directed TCR T-cell Therapy: Results from a Phase 1 Study
中文标题:靶向PRAME的TCR T细胞疗法IMA203CD8治疗PRAME阳性肿瘤的I期研究结果
讲者:Antonia Busse(德国)
摘要号:1947O
标题:Early predictors of long-term benefit in immunotherapy: analysis of 520 Kaplan-Meier curves (PREDICT-IO Study)
中文标题:免疫治疗长期获益的早期预测因素:520条Kaplan-Meier曲线分析(PREDICT-IO研究)
讲者:Daniel Montero Morenete(西班牙)
摘要号:1948O
标题:START-001: Phase 2 results of invikafusp alfa, a first-in-class T cell receptor β-chain–targeted bispecific antibody, as monotherapy in patients with TMB-H solid tumors resistant to immune checkpoint blockade (ICB)
中文标题:START-001:invikafusp alfa(一种首创的靶向T细胞受体β链的双特异性抗体)单药治疗对免疫检查点抑制剂耐药的TMB-H实体瘤患者的II期研究结果
讲者:Elena Garralda(西班牙)
摘要号:1949O
标题:Phase 1b/2 study of anti-CCR8 antibody QLP2117 plus anti-PD-1 antibody QL2107 in patients (pts) with advanced solid tumors
中文标题:抗CCR8单抗QLP2117联合抗PD-1单抗QL2107在晚期实体瘤患者中的1b/2期研究
讲者:王峰 教授(中山大学肿瘤防治中心)
Rapid Oral : Investigational immunotherapy
快速口头报告:免疫治疗研发专场
时间:2026.10.24 08:30 - 10:00
地点:Cadiz Auditorium - NCC
摘要号:1950RO
标题:Phase 1b/2a study of LK101, a personalized neoantigen DC vaccine, as first-line maintenance therapy in locally advanced/metastatic NSCLC
中文标题:LK101(个性化新抗原DC疫苗)作为局部晚期/转移性NSCLC一线维持治疗的1b/2a期研究
讲者:段建春 教授(中国医学科学院肿瘤医院)
摘要号:LBA52
标题:Personalized Neoantigen Vaccine Combined with Precision Critical Lesion Radiotherapy (CLERT) in Advanced Solid Tumors: Updated Results from the iNATURE Phase II Trial
中文标题:个性化新抗原疫苗联合精准关键病灶放疗(CLERT)治疗晚期实体瘤:iNATURE II期研究的更新结果
讲者:孔凤鸣 教授(香港大学深圳医院)
摘要号:1955RO
标题:Initial Results With IMA402 a PRAME-Targeted T-cell Receptor (TCR)-based Bispecific T-cell Engager (TCER) in Advanced Solid Tumors
中文标题:IMA402,一种靶向PRAME的基于T细胞受体(TCR)的双特异性T细胞衔接器(TCER),在晚期实体瘤中的初步结果
讲者:Dirk Schadendorf(德国)
摘要号:1951RO
标题:Efficacy of pumitamig (PD-L1 × VEGF-A bsAb) plus chemotherapy in patients with SCLC or TNBC with brain metastases: a subgroup analysis of two phase 2 trials
中文标题:Pumitamig(PD-L1 × VEGF-A双特异性抗体)联合化疗在伴有脑转移的SCLC或TNBC患者中的疗效:两项2期研究的亚组分析
讲者:Kevin N. Franks(英国)
摘要号:1952RO
标题:IBI363 (TAK-928) plus bevacizumab (Bev) vs docetaxel (DTX) in patients (pts) with locally advanced or metastatic immunotherapy (IO)-resistant lung adenocarcinoma (LUAC) without actionable genomic alterations: a randomized phase Ib study
中文标题:IBI363(TAK-928)联合贝伐珠单抗(Bev)对比多西他赛(DTX)治疗无可驱动基因阳性的局部晚期或转移性免疫治疗(IO)耐药肺腺癌(LUAC)患者:一项随机Ib期研究
讲者:周建娅 教授(浙江大学医学院附属第一医院)
摘要号:1953RO
标题:Safety and efficacy of CS2009, a first-in-class PD-1/VEGF/CTLA-4 trispecific antibody, in metastatic colorectal cancer (mCRC): Results from a phase 1/2 study
中文标题:首创PD-1/VEGF/CTLA-4三特异性抗体CS2009治疗转移性结直肠癌(mCRC)中的疗效与安全性:1/2期研究结果
讲者:王峰 教授(中山大学肿瘤防治中心)
摘要号:1954RO
标题:INCA33890, a TGFβR2xPD-1 Bispecific Antibody, With Standard of Care (SoC) Anticancer Therapies for Microsatellite Stable Colorectal Cancer (MSS CRC)
中文标题:TGFβR2×PD-1双特异性抗体INCA33890联合标准治疗(SoC)用于微卫星稳定结直肠癌(MSS CRC)
讲者:Sreenivasa R. Chandana(美国)
(来源:《肿瘤瞭望》编辑部)
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