Ginkgo Biloba leaves Extract

Ginkgo biloba leaf extract EGb 761® might have diverse therapeutic effects.

We conducted an overview of systematic reviews (SRs) to compile the efficacy and safety of EGb 761®.

The Cochrane Database of Systematic Reviews, MEDLINE (via PubMed), Embase (via OVID) and PROSPERO were searched from inception until July 25th, 2023 with an update on January 30th, 2025. SRs were included if they evaluated the efficacy and safety of oral treatment with EGb 761® under any clinical condition or in healthy subjects for clinical reasons, such as prevention, or for health promotion. Two authors carried out screening, selection, data extraction and risk of bias assessment (AMSTAR 2). The degree of overlap was quantified. The overview was registered a priori (PROSPERO: CRD42023423789).

We screened 126 articles and included reviews on neurocognitive disorders (n = 13), tinnitus, macular degeneration and schizophrenia (all n = 1). For neurocognitive disorders, most SRs were in favor of EGb 761® regarding cognition and behavioral and/or psychological symptoms, while the results for functional activities of daily living varied. EGb 761® might have positive effects on tinnitus, macular degeneration or schizophrenia: however, more evidence is needed. In general, EGb 761® appears to be safe. Methodological quality was poor in all SRs. The overall overlap of the primary studies on neurocognitive disorders was very high, and pairwise overlap varied.

EGb 761® has been studied in various reviews, particularly regarding neurocognitive disorders and has been reported to be safe in many SRs. The results must be treated with caution due to the poor quality of the SRs.

The consumption and utilization of Ginkgo biloba leaves and seeds in traditional herbal treatments have left an indelible mark. Their rich chemical makeup and remarkable pharmacological effects, particularly in the form of EGb761 leaf extracts, have captivated researchers seeking novel treatments for degenerative nerve illnesses like Alzheimer's disease. However, the story of Ginkgo biloba doesn't end there. The Ginkgo biloba seeds, which were once highly regarded as sustenance and medicine but are often overlooked, hold ancient wisdom that awaits discovery and understanding, also, it is advised to consume one to two seeds per day because of the ginkgo toxin side effect. Traditional Chinese medicine has harnessed its potential to combat intestinal tract worm infections, pyogenic skin diseases, enuresis, asthma, cough, and more, owing to its abundant reserves of carbs, protein, fat, and polyphenols. Moreover, recent studies have emerged, suggesting their neuroprotective properties. Fostering awareness and encouraging the consumption of Ginkgo biloba seeds thus becomes paramount. As we embark on a quest to delve into the depths of Ginkgo biloba seeds, this comprehensive review aims to shed light on their key components, bioactivities, processing techniques, and the latest insights into their pharmacological actions. By embracing a holistic understanding of Ginkgo biloba seeds, we lay the foundation for their scientific advancement and the development of this remarkable edible seed. Furthermore, it is essential to acknowledge that while Ginkgo biloba holds immense potential, caution is warranted, as adverse effects such as allergies have been reported, particularly in individuals with known allergies.