Two neutral polysaccharides named POP-1 and PCP-1 were purified from Polygonatum odoratum and P. cyrtonema, respectively. Results showed that both of them were composed of fructose and glucose, and the average molecular weights of them were about 5 kDa. FT-IR, 1D- and 2D-NMR analyses revealed that both POP-1 and PCP-1 contained a (2→1)-linked β-d-fructofuranose (Fruf) backbone and (2→6)-linked β-d-Fruf side chains with an internal α-d-glucopyranose (Glcp) in neokestose form. The difference between these two purified polysaccharides were that PCP-1 possessed of an acetyl group attached at O-3 of α-d-Glcp residue. In addition, PCP-1 exhibited a little better immune stimulating activity than POP-1 on cell viability and IL-6 production of RAW 264.7 macrophages. These results indicated that the acetyl group might affect the immunoregulatory activity and PCP-1 have more potential to be explored as an immunomodulatory agent.

2018-09-26·ACS Applied Materials & Interfaces2区 · 材料科学

Selective Adsorption and Separation of Xylene Isomers and Benzene/Cyclohexane with Microporous Organic Polymers POP-1

2区 · 材料科学

Article

作者: Chen, Tingting ; Chen, Qibin ; Liu, Honglai ; Tan, Huiling

The separation of chemical substances with analogous chemical structures and physical properties remains a great challenge. In this work, triptycene-like microporous organic polymers (MOPs), POP-1, was synthesized via choosing 1,4-dimethoxybenzene (DMB) and triptycene as external cross-linkers and building blocks, respectively, and POP-1 was employed to separate xylene isomers and benzene (Bz)/cyclohexane (Cy). Results show that POP-1 has a higher uptake for m-xylene (0.29 g/g) and Bz (1.02 g/g); more intriguingly, their complete separation can be realized within 0.6 min using a column packed with POP-1. The interaction between POP-1 networks and adsorbates was also investigated using theoretical (density functional theory together with noncovalent interaction analysis) and experimental (inverse gas chromatography) approaches. Especially, both results present a good agreement, that is, weak interactions such as CH/π interactions play a dominant role in defining the separation performance of POP-1 for xylene isomers and Bz/Cy mixtures. Our findings suggest that MOPs may open up a new route for separating the chemicals that are similar in structure and size.

2017-07-01·Science Bulletin

Construction of porous covalent organic polymer as photocatalysts for RhB degradation under visible light

Article

作者: Xing, Lingbao ; Su, Zhongmin ; Lin, Hongtao ; Zhou, Ziyan ; Liu, Pingxiao ; Wang, Haining

In the present work, a novel porous, and chemically stable amine-based covalent organic polymer (POP-1) was designed and synthesized under solvothermal conditions. The porosity, crystallinity, chemical stability, electrochemical properties, and diffuse reflectance of POP-1 were investigated via N₂ sorption experiment, power X-ray diffraction, thermogravimetric analysis, cyclic voltammetry, and ultraviolet visible near infrared spectrometry, respectively. POP-1 exhibits good chemical stability in both acidic and alkaline aqueous solutions, as well as in organic solvents. Undoped POP-1 can be directly used as a photocatalyst for rhodamine B irradiation degradation under light-emitting diode and natural light. The E_a of POP-1 for RhB degradation is 82.37kJ/mol. Furthermore, POP-1 can be reused as a catalyst in RhB degradation without degraded catalytic activity.

100 项与 POP-1 相关的药物交易

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适应症	最高研发状态	国家/地区	公司	日期
实体瘤	临床前	澳大利亚	Propanc Pty Ltd.	2022-01-30
肿瘤	临床前	澳大利亚	Propanc Biopharma, Inc.	-
卵巢癌	临床前	西班牙	Propanc Biopharma, Inc.	-
胰腺癌	临床前	西班牙	Propanc Biopharma, Inc.	-