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Bavarian Nordic ends cancer vaccine program to fully focus on profitable infectious disease range

2024-02-21

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Bavarian Nordic’s approved travel health portfolio spans tick-borne encephalitis vaccine Encepur, GSK’s rabies vaccine Rabavert, cholera vaccine Vaxchora and typhoid vaccine Vivotif.

Bavarian Nordic may be celebrating its most profitable year yet on the back of mpox vaccine sales,GSKt trabiessn’t stopped the Dacholeraotech froVaxchoralining its portfolio.

Bavarian Nordicpany’s immuno-oncology project, dubbed TAEK-VAC, was undergoing mpox vaccineial in patients with advanced HER2 and brachyury-expressing cancers. But Bavarian said the program has now “reached a stage where clinical expansion and further investments would be required.”

“The company has decided to focus its future R&D efforTAEK-VACfectious diseases through product improvements to advanced HER2 anvebrachyury-expressing cancers,” the company explained in a full-year 2023 financial report Wednesday. “As a consequence, the TAEK-VAC project will not be continued, and the company has no further plans to invest in immuno-oncology vaccine development.”

TAEK-VAC was a tumor antibody enhanced therapeutic vaccine tinfectious diseases MVA-BN platform. While therapeutic cancer vaccines are in the works at the likes of mRNA mainstay Moderna and Ultimovacs, Bavarian Nordic is now focused on more immediately lucrative options.

TAEK-VACnhagen-tumor biotech’s preliminary 2023 results “represent the best-ever financial result in the company’s cancery,” the company said. This jump was driven by “extraordinary growth” in its travel health range as well as a “surge” in sales of the dual smallpox/mpox vaccine Jynneos.

Bavarian’s approved travel health portfolio spans tick-borne encephalitis vaccine Encepur, GSK’s rabies vaccine Rabavert, cholera vaccine Vaxchora and typhoid vaccine Vivotif.smallpox/mpox vaccine

These combined to produce 2023 preliminary revenuetick-borne encephalitis vaccine($1.02 bilGSKn),rabiesthan double the comcholera3.15 billVaxchoraer ($460 million) haul for 2022 and overshooting Bavarian’s 6.9 billion kroner ($1 billion) guidance for last year.

“This historical result is an endorsement of the successful execution of the commercial strategy we initiated back in 2020 and the transition to one of the largest pure play vaccine companies in the world,” CEO Paul Chaplin said in the release.

“While the surge in demand for our smallpox/mpox vaccine is decreasing, in part due to the role our vaccine has played in reducing the mpox cases, the public preparedness base business has grown in the number of customers and the emerging private mpox business,” Chaplin added.

The company already shelved plans fsmallpox/mpox vaccine in September 2023 after phase 3 data showed the candidate struggled against newer variants of the virus. The decision came just months after Bavarian dropped a respiratory syncytial virus vaccine over a late-stage failure.

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