近日,来自北京协和医院的研究者们在Molecular Therapy: Nucleic Acids杂志上发表了题为“Exosomal circ-PTPN22 and circ-ADAMTS6 mark T cell exhaustion and neutrophil extracellular traps in Asian intrahepatic cholangiocarcinoma”的文章,该研究结果揭示了亚洲ICC的一个亚群,其特征是T细胞耗竭和中性粒细胞外陷阱,并以肿瘤组织和血浆外泌体中CIRC-PTPN22和CircADAMTS6的水平升高为标志。这一亚群有可能被血浆外泌体CircRNA检测到,并可通过免疫检查点阻断进行治疗。
Xuezhu Wang et al. Exosomal circ-PTPN22 and circ-ADAMTS6 mark T cell exhaustion and neutrophil extracellular traps in Asian intrahepatic cholangiocarcinoma. Mol Ther Nucleic Acids. 2022 Dec 23;31:151-163. doi: 10.1016/j.omtn.2022.12.012.