北京大学癌症研究院、肿瘤医院王华课题组诚聘博士后

2024-04-02

临床研究

实验室介绍王华，北京大学国际癌症研究院研究员、北京大学肿瘤医院双聘PI，国家海外高层次人才，北京大学基础医学院博士生导师、博士后合作导师。博士毕业于南开大学，后在美国纪念斯隆-凯特琳癌症研究中心从事博士后研究工作。聚焦肿瘤的表观遗传和转录调控机制，取得系列原创成果，发表在Nature、Cell Research、Blood、Cell、Advanced Science等杂志。研究领域介绍表观遗传调控是决定细胞命运的核心要素，其与转录因子、基因突变等调控途径共同影响了细胞的增殖、代谢、分化和衰老、死亡等过程，因此在肿瘤等重大疾病中，表观因子的异常变化往往起着至关重要的作用。本实验室致力于解析表观遗传及其相关调控因子在肿瘤发生发展中的精细分子机理，在此基础上探索肿瘤耐药新机制和新靶点。主要研究方向包括：1）耐药肿瘤的表观遗传与转录调控新机制；2）肿瘤铁死亡的特异性表观调节机制；3）肿瘤端粒与端粒酶的表观调控机制。前期发表成果1. Hua Wang, Zheng Fan, Pavel Shliaha, Matthew Miele, Ronald Hendrickson, Xuejun Jiang, Kristian Helin*. H3K4me3 regulates RNA polymerase II promoter-proximal pause-release. Nature 615 (2023): 339-348.2. Hua Wang, Xuejun Jiang*. cGASing mitochondria to fend off ferroptosis. Cell Research 33 (2023): 263-264.3. Hua Wang†, Peng Gong†, …, Sherman M. Weissman*, Feng Qi*, Xinghua Pan* and Lin Liu*. Colorectal cancer stem cell states uncovered by simultaneous single-cell analysis of transcriptome and telomeres. Advanced Science (2021): 202004320.4. Bing Li†, Wenbin An†, Hua Wang†, Timour Baslan, Shoron Mowla, Aishwarya Krishnan, …, Charles G. Mullighan, Kristian Helin, Scott W. Lowe, Ross L. Levine*, Raajit K. Rampal*. BMP2/SMAD pathway activation in JAK2/p53-mutant megakaryocyte/erythroid progenitors promotes leukemic transformation. Blood 139, no. 25 (2022): 3630-3646.5. Wei Gu, Hua Wang, Xiaofeng Huang, Judith Kraiczy, Pratik N.P. Singh, …, David Redmond, Randy Longman, Kristian Helin, Ramesh A. Shivdasani and Qiao Zhou*. SATB2 preserves colon stem cell identity and mediates ileum-colon conversion via enhancer remodeling. Cell Stem Cell 29, no. 1 (2022): 101-115.6. Deguang Liang, Yan Feng, Fereshteh Zandkarimi, Hua Wang, Zeda Zhang, …, Wei Gu, Brent R. Stockwell and Xuejun Jiang*. Ferroptosis surveillance independent of GPX4 and differentially regulated by sex hormones. Cell (2023) 186: 1-17.7. Aditya Sankar, Faizaan Mohammad, Arun Sundaramurthy, Hua Wang, Mads Lerdrup, Tulin Tatar, and Kristian Helin*. Histone editing elucidates the functional roles of H3K27 methylation and acetylation in mammals. Nature Genetics (2022):54.8. Jiajun Zhu*, Hua Wang, and Xuejun Jiang*. mTORC1 beyond anabolic metabolism: Regulation of cell death. Journal of Cell Biology 221.12 (2022).9. Hua Wang†, Peng Gong†, Jie Li†, …, and Lin Liu*. Role of CD133 in human embryonic stem cell proliferation and teratoma formation. Stem Cell Research & Therapy (2020) 11:1-14.10. Hua Wang†, Kunshan Zhang†, Yifei Liu, …, Tong Chen, Siguang Li*, and Lin Liu*. Telomere heterogeneity linked to metabolism and pluripotency state revealed by simultaneous analysis of telomere length and RNA-seq in the same human embryonic stem cell. BMC Biology (2017) 15:114.招聘详情博士后多名：对于博士后申请者，将提供北京户口和优质子女教育资源与福利，具体信息请参考网页：https://postdocs.bjmu.edu.cn/zpxx/ab07d8fc0cc841edbb6c595a51b684e3.htm参考专业方向：具有细胞生物学、生物化学、分子生物学，表观遗传学、肿瘤学、基础医学、生物信息学等相关专业的研究背景；以第一作者发表过高水平论文，具有海外留学背景，或有表观遗传学及基因转录调控机制研究、生物信息学分析背景的应聘者优先。应聘材料：申请人将以下材料发送到：hua.wang@pku.edu.cn。邮件标题注明“姓名-[具体职位]-申请”：个人简历，内容包括教育及工作经历、主要研究经历、代表性学术论文等。