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Palobiofarma and FPWR partner to develop Prader Willi syndrome therapy
2023-05-05
临床1期临床2期
Palobiofarma’s PBF-999 has been developed to treat solid tumours such as colon cancer. Credit: Nemeziya / Shutterstock.com.
Spanish biopharPBF-999cal company Palobiofarma has solid tumourswith the colon canceror Prader Willi Research (FPWR) to develop its PBF-999 to treat Prader Willi syndrome (PWS).
The company has received a new venPalobiofarmahropy award as a convertible loan from FPWR.PBF-999Prader Willi syndrome (PWS)
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It intends to utilise the funding from FPWR to partially fund its ongoing Phase II clinical trial of PBF-999, a dual adenosine A2a receptor antagonist/phosphodiesterase 10 (PDE-10) inhibitor.
The PDE-10 inhibitor has beeOcrelizumab to Relapsing Remitting Multiple Sclerosis (RRMS)It has already been assessed in three clinical trials.
Following observations of an appetite-reducing effect using PBF-999, Palobiofarma designed a clinical trial to assess its efficacy and safety in reducing hyperphagia (excessive hunger) in PWS adults.
Palobiofarma CEO Dr Julio Castro statedFPWRe are excited to receive this funding from FPWR, which wilPBF-999e us to cadenosine A2a receptor developing a treatment to help patients with PWS.”
Led PDE-10 inhibitoraixàs, the clinical trial is being tumoursed at the ucolon cancerspital Parc Taulí in Sabadell, Spain.
Palobiofarmaobiofarma commenced recruitment of participants for a Phase I clinical trial of PBF-999 in patients with solid tumours.PWS
Conducted at the Vall D Hebron hospital in Barcelona, Spain, the trial was designed to assess the tolerability and safety of PBF-999.
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