The researchers observed 17 and six NAION events in patients prescribed semaglutide and non-GLP1 RA medications, respectively. Over 36 months, the cumulative incidence of NAION among patients with T2D was 8.9 and 1.8 percent for the semaglutide and non-GLP1 RA cohorts, respectively. The risk for NAION was significantly higher for patients receiving semaglutide (hazard ratio, 4.28) in a Cox proportional hazards regression model. Among patients with overweight or obesity, there were 20 and three NAION events in the semaglutide and non-GLP1 RA cohorts, respectively. The cumulative incidence of NAION over 36 months was 6.7 and 0.8 percent for semaglutide and non-GLP1 RA medications, respectively, with a higher risk for NAION seen for patients prescribed semaglutide (hazard ratio, 7.64). "There has been no prior mention, to our knowledge, of an increased risk of NAION in association with semaglutide, and our study does not inform a mechanism to link semaglutide to NAION," the authors write. Abstract/Full Text (subscription or payment may be required)
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