Semaglutide (Novo Nordisk)

*本资料仅供医疗卫生专业人士参考，请勿向非医疗卫生专业人士发放 截至12月14日15点59分，近期共有 242 本期刊发布了 348 篇文章，其中糖尿病相关的文章共 142 篇，覆盖 22 个领域的内容。中国专家参与发表的文章有 39 篇。今日，影响因子最高的文章刊登在 Nature reviews. Endocrinology (IF: 40.000) 期刊上。 今日头条 Headlines 01 Nature communications IF: 15.700 肠道微生物组可预测糖尿病前期患者对膳食纤维的个性化反应：一项随机、开放标签试验 Song, Delei, Feng, Guangli, Ma, Yuhang, Shi, Yu, Qian, Chunfang, Wang, Chaoxun, etc. 肠道菌群如何影响我们对食物的反应？在预防糖尿病的过程中，个性化营养是否可能实现？近日，一项发表在《Nature Communications》上的研究为此提供了新的线索。 这项由Delei Song、Guangli Feng等多位研究者共同完成的随机、开放标签临床试验，旨在探究膳食纤维补充对糖尿病前期人群的干预效果，并深入挖掘肠道微生物在其中扮演的角色。研究共招募了802名糖尿病前期受试者，他们被随机分配至常规护理对照组或膳食纤维干预组，进行了为期6个月的观察。 研究的主要结局指标是糖化血红蛋白（HbA1c）的变化。令人意外的是，从整体人群来看，为期半年的膳食纤维干预并未在改善HbA1c或其他血糖、胰岛素、血脂、肝肾功能及人体测量学指标上展现出统计学上的显著优势。这一结果提示，笼统地建议糖尿病前期人群增加纤维摄入，其效果可能有限。 然而，故事的转折点出现在深入的数据挖掘之后。研究者并未止步于整体分析，他们利用年龄、体重指数（BMI）、HbA1c、胰岛素抵抗指数（HOMA2-IR）和胰岛β细胞功能指数（HOMA2-B）这五个关键代谢指标，对受试者进行了多变量聚类分析。这一方法成功地将人群划分为了四个特征鲜明的亚群，即集群1至4。 分析显示，这四个集群代表了不同的代谢状态，其未来发展为糖尿病及相关并发症的风险各不相同。更重要的是，它们的肠道微生物组构成和血清代谢物谱也存在显著差异。这就像是为人群绘制了一幅更为精细的“代谢-微生物”地图。 当研究者在这幅新地图上重新审视膳食纤维的效果时，有趣的模式出现了。干预并非对所有人无效，而是呈现出明显的“个性化”反应：膳食纤维补充显著改善了集群3和集群4受试者的血糖控制，但对于集群1和集群2的受试者则收效甚微。这种疗效的差异，与干预后观察到的肠道菌群的具体改善情况相一致，进一步将菌群变化与临床获益联系了起来。 基于这一发现，研究团队向前迈进了一步，致力于将这种异质性转化为可应用的临床工具。他们利用LightGBM机器学习算法，开发了一个基于基线肠道微生物组特征的预测模型。该模型能够为每位个体计算出一个“微生物组临床决策评分”，从而有效预测其是否属于能从膳食纤维干预中获得血糖改善的“应答者”。 该研究的主要结论指出，肠道微生物组的反应是决定膳食纤维干预有效性的关键因素。这为理解为何同一种饮食建议在不同人身上效果迥异提供了科学解释。更为重要的是，该研究不仅停留在机制阐述，还提供了一个具有临床转化潜力的预测模型，为未来在糖尿病前期人群中实施以肠道微生物组为导向的精准营养干预奠定了基础。该临床试验已在平台注册，注册号为ChiCTR1900027663。 本文由 天纳乾坤 编辑 扫描二维码查看源文 Nature communications | Ahead of Print. 10.1038/s41467-025-66498-x 02 Pharmacological reviews IF: 17.300 二甲双胍降糖作用机制 Drewe, Jürgen, Foretz, Marc, Krähenbühl, Stephan, etc. 近日，一篇发表在《Pharmacological Reviews》期刊上的综述文章系统梳理了经典降糖药物二甲双胍的作用机制。该文章指出，尽管二甲双胍作为2型糖尿病的基础口服治疗药物已有数十年历史，其确切的作用模式仍不完全清楚。传统观点多聚焦于其对肝脏葡萄糖生成的抑制，然而新的证据表明，其降糖效应是肠道、肝脏及外周组织多重机制共同作用的结果。 文章首先回顾了临床研究证据。长期接受二甲双胍治疗的患者，其血糖改善得益于两方面：一是外周组织，尤其是骨骼肌对葡萄糖的摄取和利用增加；二是肝脏自身葡萄糖的产量减少。这提示，药物作用的靶点远比过去认为的更为广泛。 在肝脏层面，研究证实二甲双胍能够抑制糖异生，其机制可分为两类：一类依赖于激活细胞能量感受器AMPK，另一类则不依赖AMPK，例如直接抑制线粒体呼吸链复合物I或线粒体甘油磷酸脱氢酶。值得注意的是，许多在动物或细胞实验中证实能抑制糖异生的二甲双胍浓度，远高于其在人体治疗时的血药浓度，这引发了对其主要作用场所的再思考。 骨骼肌作为消耗葡萄糖的主要场所，其机制研究提示，二甲双胍可能通过激活AMPK或发挥抗炎作用来提升肌肉的葡萄糖处置能力。此外，肾脏的糖异生过程也可能受到抑制，贡献于整体的血糖降低。 一个关键的转折点来自临床观察：短期静脉注射二甲双胍并未显示出降糖效果。这一现象将研究者的目光引向了肠道。肠道不仅是药物吸收的首过部位，其本身也积极参与血糖调节。目前提出的肠道机制包括：药物抑制肠上皮细胞线粒体复合物I，迫使细胞更多地通过糖酵解途径代谢葡萄糖，从而减少了葡萄糖吸收入血；以及促进葡萄糖向结肠转运。 更引人注目的是二甲双胍对肠道内分泌的影响。它能刺激肠道L细胞分泌胰高血糖素样肽-1（GLP-1）。这种刺激既可直接通过AMPK介导，也可间接通过改变肠道内环境（如增加局部葡萄糖、胆汁酸或特定菌群代谢产物的水平）来实现。分泌增加的GLP-1不仅能以激素形式发挥作用，还能激活“肠-脑-肝”神经轴，即通过迷走神经向大脑传递信号，进而抑制肝脏的葡萄糖生成过程。 综上所述，这篇综述文章描绘了一幅更为全面的二甲双胍作用图谱：它通过抑制肠道葡萄糖吸收、调节肠道激素分泌并激活相关神经轴来影响肝脏；直接作用于肝脏抑制糖异生；同时增强肌肉对葡萄糖的摄取。贯穿于这些器官作用中的一个共同核心机制，是对线粒体复合物I的抑制。因此，二甲双胍的卓越疗效源于其在多个关键代谢器官中协调作用的综合效应。 本文由 天纳乾坤 编辑 扫描二维码查看源文 Pharmacological reviews | Ahead of Print. 10.1016/j.pharmr.2025.100106 03 J Transl Med IF: 07.500 在预测糖尿病风险方面，身体表现优于握力：一项前瞻性队列研究的证据 Zhu, Mingyu, Zhu, Qin, Liu, Hongxia, Du, Rui, Cao, Jie, Chen, Ning, etc. 糖尿病作为一项重大的全球公共卫生挑战，其早期识别和风险预测至关重要。传统上，风险评估多依赖于血糖、血脂等静态代谢指标，但这些指标可能无法充分反映胰岛素抵抗等核心病理机制。鉴于骨骼肌在机体葡萄糖处置中的核心作用，对其功能进行评估或许能为糖尿病风险预警打开新的窗口。然而，肌肉力量（如握力）与身体功能性表现（如从坐位站起的速度）哪一个能更好地预测未来糖尿病风险，此前证据并不明确。 一项最新发表的研究为此提供了重要证据。该研究基于大规模的中国健康与养老追踪调查 (CHARLS) 数据，是一项前瞻性队列研究。研究者纳入了6604名基线时未患糖尿病的参与者，中位年龄为58岁，并在2011年至2020年间进行了随访。研究伊始，所有参与者接受了肌肉力量和身体表现评估，分别通过握力测试和五倍椅子站立测试（5-CST，即记录连续五次从椅子坐姿站起所需的时间）进行。新发糖尿病的判定则依据参与者在随访期间自我报告的医生诊断信息。 经过统计分析，研究人员有了清晰的发现。在平均多年的随访后，数据显示，基线时身体表现较差（即5-CST时间较长）的个体，未来发生糖尿病的风险显著更高。即使在考虑了年龄、性别、体重指数、吸烟饮酒史、教育水平、居住地、高血压病史等多种潜在影响因素后，这种关联依然存在，表明低身体表现是新发糖尿病的独立风险因素。 更深入的分析揭示了这一关联在不同人群中的差异。这种由身体表现不佳带来的糖尿病风险升高，在40至49岁的中年人群中尤为突出。此外，在体重指数低于25 kg/m²的非肥胖人群中，身体表现与糖尿病风险的关联也更强。这意味着，对于这些传统上被认为“低风险”的年轻或体重正常的成年人，简单的身体功能测试可能具有特别的筛查价值。 相比之下，作为常用肌肉力量指标的握力，无论是绝对值还是根据体重调整的相对值，在本研究中均未显示出与新发糖尿病风险的独立关联。当研究人员将5-CST时间作为连续变量分析时，发现每多花费1秒完成测试，糖尿病风险在未调整其他因素前会相应增加，但在完全调整多种混杂因素后，这种连续性的关联不再显著。这提示，身体表现对风险的预测可能更侧重于识别出处于“功能低下”临界状态的群体。 该研究的结论明确指出，在预测糖尿病风险方面，评估下肢功能的简单身体表现测试（五倍椅子站立测试）其价值超过了测量上肢力量的握力测试。这一发现具有直接的现实意义。五倍椅子站立测试无需复杂设备，耗时短，易于在社区诊所或基层医疗中广泛开展。它为临床医生和公共卫生工作者提供了一个高效、低成本的新工具，有助于更早地识别出糖尿病高危个体，特别是那些容易被基于代谢指标的传统风险评估模型所忽略的、相对年轻且不肥胖的人群。 本文由 天纳乾坤 编辑 扫描二维码查看源文 J Transl Med | Ahead of Print. 10.1186/s12967-025-07473-4 04 Nature communications IF: 15.700 低碳水高多不饱和脂肪的“抗脂肪生成”饮食或健康的北欧饮食对比常规护理对2型糖尿病或糖尿病前期患者肝脏脂肪及心脏代谢紊乱的影响：一项随机对照试验（NAFLDiet） Fridén, Michael, Rosqvist, Fredrik, Kullberg, Joel, Berglund, Lars, Vessby, Johan, Martinell, Mats, etc. 近日，一项名为NAFLDiet的随机对照试验结果在《Nature Communications》期刊上发表。该研究探讨了两种特定的饮食模式——一种新型的“抗脂肪生成”低碳水高多不饱和脂肪饮食和一种健康的北欧饮食——对于糖尿病前期或2型糖尿病患者肝脏脂肪及心脏代谢健康的影响，并将其与常规护理进行对比。 这项研究在瑞典乌普萨拉的大学医院进行，于2022年12月完成，共招募了150名糖尿病前期或2型糖尿病参与者。研究采用严格的三臂平行设计，将参与者随机分为三组，分别接受为期12个月的干预。第一组采用主要基于植物的低碳水化合物、高多不饱和脂肪饮食；第二组采用低脂、富含全谷物的健康北欧饮食；第三组则作为对照组，接受常规护理。研究过程中，负责评估结果和提供护理的医护人员对参与者的具体饮食分组并不知情，这有助于减少偏倚，确保结果的客观性。 经过12个月的干预，研究人员利用影像学手段评估了参与者的肝脏脂肪变化，这是本研究关注的主要指标。结果显示，与接受常规护理的组别相比，采用低碳水高多不饱和脂肪饮食和健康北欧饮食的两个组，其肝脏脂肪含量均出现了具有统计学意义的下降，降幅分别达到1.46%和1.76%。然而，在降低肝脏脂肪方面，这两种饮食方式之间并未显示出显著差异。 除了主要指标，研究还观察了饮食干预对其他重要代谢指标的影响。在体重和血糖控制方面，健康北欧饮食组的表现尤为突出，其体重和糖化血红蛋白的降低幅度显著大于其他两组。而低碳水高多不饱和脂肪饮食在体重和血糖控制上与常规护理相比没有明显优势。 在血脂方面，两种干预饮食都成功降低了低密度脂蛋白胆固醇水平，效果与常规护理相比更优。然而，在改善甘油三酯、身体炎症水平以及肝脏相关酶指标方面，只有健康北欧饮食展现出了明确的益处，优于常规护理。 关于安全性，整个研究期间共报告了4例严重不良事件，这些事件均匀分布在三个研究组中，表明两种饮食干预在总体上是安全的。 该研究的发现表明，与常规护理相比，以植物为主的低碳水高多不饱和脂肪饮食和健康的北欧饮食均能有效减少2型糖尿病或糖尿病前期患者的肝脏脂肪堆积，并改善“坏”胆固醇水平。尤为值得注意的是，健康的北欧饮食在未要求参与者刻意限制能量摄入的情况下，还额外带来了减轻体重、改善血糖控制、降低甘油三酯和炎症水平等多重代谢益处。这些结果为临床实践提供了新的证据，提示健康的北欧饮食模式可能是一种切实可行且全面的策略，用于管理2型糖尿病及其常见的并发症——代谢功能障碍相关脂肪性肝病。 本文由 天纳乾坤 编辑 扫描二维码查看源文 Nature communications | Ahead of Print. 10.1038/s41467-025-65613-2 05 Journal of food science IF: 03.400 揭示健康影响：超加工饮料的综合评述 Ouyang, Yerui, Gao, Ziying, Tan, Jiayi, Liu, Panpan, Xiao, Yiwen, Wang, Ya, etc. 近年来，全球范围内超加工饮料的消费量呈现显著上升趋势，这一现象引起了公共卫生和研究领域的广泛关注。为此，研究团队在Journal of food science上发表了一项最新的综合性评述，旨在系统评估这类饮料对健康的潜在影响。 该综述采用了文献计量学方法，对2011年至2025年间发表于PubMed数据库的相关研究文献进行了深入分析与评估。研究团队发现，当前科学界对于超加工饮料的关注，主要集中在探讨其消费与特定健康问题之间的关联，特别是**肥胖**和**心血管疾病**等领域。此外，揭示其背后作用的**分子生物学机制**也是核心研究方向之一。 文章全面梳理了该领域的研究现状，涵盖了从基础理论到具体健康效应、相关生物标志物、学界存在的不同观点，以及对未来研究的展望。综述特别详细审视了超加工饮料与一系列疾病或生理状态的可能联系。证据指向，其消费可能与**体重增加和肥胖**、**机体胰岛素敏感性下降**、**代谢综合征**的发生发展存在关联。不仅如此，研究还触及了其对**社会行为与心理功能**的潜在干扰、某些**癌症**风险的增加，以及引起**肠道微生物群落构成改变**的可能性。 除了总结现有发现，该评述也探讨了该领域未来的研究路径。研究人员指出，明确这些关联与机制，对于引导超加工饮料产业的负责任发展，以及制定相关的公共卫生监管策略，具有重要的理论参考价值。这项综合性的梳理工作，为医学界和公众更清晰地理解超加工饮料的全面健康影响，提供了最新的科学依据和思考框架。 本文由 天纳乾坤 编辑 扫描二维码查看源文 Journal of food science | Volume 90, Issue 12 10.1111/1750-3841.70741 06 International journal of cancer IF: 04.700 糖尿病状态、病程及发病年龄与肺癌风险的关联：来自中国嘉道理生物库的研究结果 Su, Jian, Hua, Jiang, Fan, Xikang, Wan, Xinglin, Lu, Yan, Jin, Jianrong, etc. 一项基于大规模中国人群的前瞻性研究发现，糖尿病状态、病程长短以及发病年龄与肺癌发生风险之间存在显著关联。该研究由 Jian Su, Jiang Hua 等多位研究者共同完成，成果发表在《International journal of cancer》期刊上。 这项研究利用了中国嘉道理生物库的前瞻性数据，旨在深入探究糖尿病这一全球性慢性病与肺癌风险之间的复杂关系。研究共纳入超过51万名基线时无癌症的成年参与者，并对其中近3万名基线糖尿病患者进行了糖尿病病程和发病年龄的专项分析。经过中位9年多的随访，研究团队系统评估了糖尿病不同特征对肺癌发病率的影响。 研究结果显示，与未患糖尿病的参与者相比，糖尿病患者发生肺癌的整体风险增加了15%。这一关联在考虑了多种潜在混杂因素后仍然显著。更为细致的分析揭示了糖尿病特征对风险的影响模式：糖尿病发病年龄越早，肺癌风险越高。具体而言，在40岁之前确诊糖尿病的患者，其发生肺癌的风险是那些在60岁及以上才发病患者的2.81倍。 同时，糖尿病的持续时间也是关键风险因素。研究发现，糖尿病病程越长，肺癌风险越高。与病程不足1年的新发糖尿病患者相比，病程达到或超过15年的长期患者，其肺癌风险增加了1.06倍。这些发现强调了糖尿病管理中，不仅需要关注血糖控制，还需重视病程和发病年龄对长期健康结局的深远影响。 研究还进行了深入的亚组分析，以探索不同人群中的风险差异。分析表明，糖尿病状态与肺癌风险的关联，在平日体力活动水平较低的个体中表现得更为突出。此外，糖尿病病程与肺癌风险之间的正向关联，在超重或肥胖的参与者中也更为明显。这些发现提示，生活方式和体重状况可能会与糖尿病共同作用，影响个体的肺癌易感性。 综上所述，这项大规模队列研究提供了强有力的证据，表明糖尿病是肺癌的一个独立危险因素，且发病年龄越早、病程越长，风险增幅越大。研究结果凸显了对糖尿病患者，尤其是年轻发病或长期患病人群，加强肺癌筛查和综合健康管理的重要性。这些发现为公共卫生策略制定和临床实践提供了新的科学依据。 本文由 天纳乾坤 编辑 扫描二维码查看源文 International journal of cancer | Ahead of Print. 10.1002/ijc.70294 中国发表（39） China Scientific reports IF: 03.900Ahead of Print.No.01Advanced glycation end products exacerbate lipopolysaccharide-induced acute lung injury with diabetes by promoting ferroptosis via AMP-activated protein kinase/acetyl-CoA carboxylase signaling晚期糖基化终末产物通过AMPK/ACC信号通路促进铁死亡从而加重糖尿病背景下的脂多糖诱导急性肺损伤DOI: 10.1038/s41598-025-26647-0 Nature communications IF: 15.700Ahead of Print.No.02Gut microbiome predicts personalized responses to dietary fiber in prediabetes: a randomized, open-label trial肠道微生物组可预测糖尿病前期患者对膳食纤维的个性化反应：一项随机、开放标签试验DOI: 10.1038/s41467-025-66498-x Cell death discovery IF: 07.000Ahead of Print.No.03Glutamine: fructose-6-phosphate amidotransferase (GFAT) in the pathology of diseases: a review谷氨酰胺：果糖-6-磷酸酰胺转移酶（GFAT）在疾病病理学中的作用：一篇综述DOI: 10.1038/s41420-025-02898-8 BMC infectious diseases IF: 03.000Ahead of Print.No.04From urinary tract infection to deafness: community-acquired meningitis in an adult caused by hypervirulent Klebsiella pneumoniae-a case report从尿路感染到失聪：由高毒力肺炎克雷伯菌引起的一名成人社区获得性脑膜炎病例报告DOI: 10.1186/s12879-025-12340-0 British journal of ophthalmology IF: 03.500Ahead of Print.No.05Choroid thickness: a potential biomarker for pseudophakic cystoid macular oedema脉络膜厚度：人工晶状体眼黄斑囊样水肿的潜在生物标志物DOI: 10.1136/bjo-2025-328615 J Am Acad Dermatol IF: 11.800Ahead of Print.No.06Disproportionality Analysis of Dermatologic Adverse Events Associated with Nirogacestat: Insights from the FDA Adverse Event Reporting System (FAERS)尼罗加司他相关皮肤不良事件的不成比例性分析：基于FDA不良事件报告系统（FAERS）的启示DOI: 10.1016/j.jaad.2025.10.166 Journal of Advanced Research IF: 13.000Ahead of Print.No.07Grain proteins ameliorate glucose metabolism disorders by activating intestinal AhR and the hepatic NLK/FOXO1 pathway via gut microbiota-derived indole metabolites粮食蛋白通过肠道菌源吲哚代谢物激活肠道AhR与肝脏NLK/FOXO1通路改善糖代谢紊乱DOI: 10.1016/j.jare.2025.12.010 Journal of Advanced Research IF: 13.000Ahead of Print.No.08Arsenic exposure, arsenic metabolism, and plasma lipidome in relation to type 2 diabetes and glycemic traits: a lipidome-wide association study砷暴露、砷代谢与血浆脂质组在2型糖尿病及血糖性状中的关联：一项脂质组学全关联研究DOI: 10.1016/j.jare.2025.12.009 Environment international IF: 09.700Ahead of Print.No.09A mixture analysis of urinary microplastic levels and risk of gestational diabetes尿液中微塑料水平与妊娠期糖尿病风险的混合效应分析DOI: 10.1016/j.envint.2025.109928 J Nutr Biochem IF: 04.900Ahead of Print.No.10The Role of Folic Acid and Vitamin B12 in Gestational Diabetes Mellitus and Offspring Development: A Narrative Review叶酸与维生素B12在妊娠期糖尿病及子代发育中的作用：一篇叙述性综述DOI: 10.1016/j.jnutbio.2025.110232 J Transl Med IF: 07.500Ahead of Print.No.11Physical performance outweighs grip strength in predicting diabetes risk: evidence from a prospective cohort study在预测糖尿病风险方面，身体表现优于握力：一项前瞻性队列研究的证据DOI: 10.1186/s12967-025-07473-4 Scientific reports IF: 03.900Ahead of Print.No.12Obesity concurrent with gestational diabetes mellitus dysregulates mitochondria-endoplasmic reticulum contacts in human placenta肥胖合并妊娠期糖尿病导致人类胎盘线粒体-内质网接触紊乱DOI: 10.1038/s41598-025-31193-w Nature communications IF: 15.700Ahead of Print.No.13Prevotella copri promotes white adipose browning and ameliorates adiposityPrevotella copri促进白色脂肪棕色化并改善肥胖DOI: 10.1038/s41467-025-67327-x J Expo Sci Environ Epidemiol IF: 04.700Ahead of Print.No.14Joint impact of prenatal polycyclic aromatic hydrocarbons, anxiety and depression exposure on birth outcomes across pre-pregnancy BMI categories产前多环芳烃、焦虑与抑郁暴露对不同孕前体重指数孕妇分娩结局的联合影响DOI: 10.1038/s41370-025-00829-4 npj science of food IF: 07.800Ahead of Print.No.15The Artemisia argyi oil reduces high-fat diet-induced obesity by enhancing thermogenesis in brown adipose tissue艾叶油通过增强棕色脂肪组织产热减少高脂饮食诱导的肥胖DOI: 10.1038/s41538-025-00633-2 BMC pregnancy and childbirth IF: 02.700Ahead of Print.No.16Stillbirth burden and associated factors in Chengdu, Western China: a population-based retrospective study, 2019-2024中国西部成都死产负担及相关因素：一项基于人群的回顾性研究（2019-2024）DOI: 10.1186/s12884-025-08555-3 BMC public health IF: 03.600Ahead of Print.No.17Impact of artificial light at night on obesity and overweight: a systematic review and meta-analysis夜间人工光照对肥胖和超重的影响：一项系统综述与荟萃分析DOI: 10.1186/s12889-025-25883-3 Ageing research reviews IF: 12.400Ahead of Print.No.18Stage-Specific Risk Factors of Cardiometabolic Multimorbidity: A Systematic Review and Meta-Analysis from Incidence to Mortality心血管代谢性多病的阶段特异性危险因素：一项从发病到死亡的系统综述与荟萃分析DOI: 10.1016/j.arr.2025.102991 Arch Biochem Biophys IF: 03.000Ahead of Print.No.19Exploring the multiple mechanisms of Hydroxytyrosol in treating obesity探究羟基酪醇治疗肥胖的多种机制DOI: 10.1016/j.abb.2025.110703 BMC pediatrics IF: 02.000Ahead of Print.No.20The effect of exercise intervention on the triglyceride-glucose (TyG) index in adolescents with overweight or obesity: a systematic review and Bayesian dose-response meta-analysis运动干预对超重或肥胖青少年甘油三酯-葡萄糖（TyG）指数的影响：一项系统综述和贝叶斯剂量反应荟萃分析DOI: 10.1186/s12887-025-06433-7 Diabetology & metabolic syndrome IF: 03.900Ahead of Print.No.21Effect of body shape index trajectories on kidney disease incidence and subsequent death in individuals with type 2 diabetes2型糖尿病患者身体形态指标轨迹对肾脏疾病发病率及随后死亡的影响DOI: 10.1186/s13098-025-02048-1 European journal of pharmacology IF: 04.700Ahead of Print.No.22Exploring copper metabolism and cuproptosis, and their implications in ocular diseases探索铜代谢与铜死亡及其在眼部疾病中的意义DOI: 10.1016/j.ejphar.2025.178472 Journal of ethnopharmacology IF: 05.400Ahead of Print.No.23Unraveling the mechanisms of Schisandra Chinensis Mixture against diabetic nephropathy by integrating serum pharmacochemistry, network pharmacology, transcriptomics, and metabolomics整合血清药物化学、网络药理学、转录组学与代谢组学揭示五味子合剂抗糖尿病肾病的作用机制DOI: 10.1016/j.jep.2025.120983 Diabetology & metabolic syndrome IF: 03.900Ahead of Print.No.24The relation between tirzepatide and adverse cardiovascular events or renal adverse events: a meta-analysis based on randomized controlled trials替尔泊肽与不良心血管事件或肾脏不良事件的关联性：一项基于随机对照试验的荟萃分析DOI: 10.1186/s13098-025-02064-1 The Journal of frailty & aging IF: 03.300Ahead of Print.No.25Association between the Frailty Index and psoriasis: a cross-sectional study of the U.S. NHANES 2003-2006衰弱指数与银屑病的相关性：基于美国NHANES 2003-2006数据的横断面研究DOI: 10.1016/j.tjfa.2025.100102 J Gerontol A Biol Sci Med Sci IF: 03.800Ahead of Print.No.26High-fat diet exacerbates skeletal muscle mass loss via Nrf2/Prdx6 pathway in sarcopenic obesity mice高脂饮食通过Nrf2/Prdx6通路加剧骨骼肌减少性肥胖小鼠的肌肉质量流失DOI: 10.1093/gerona/glaf271 Journal of food science IF: 03.400Volume 90, Issue 12No.27Unveiling the Health Impact: A Comprehensive Review of Ultra-Processed Beverages揭示健康影响：超加工饮料的综合评述DOI: 10.1111/1750-3841.70741 J Gerontol A Biol Sci Med Sci IF: 03.800Ahead of Print.No.28Associations between the triglyceride glucose-body roundness index and frailty trajectory in populations with Cardiovascular-Kidney-Metabolic syndrome: A nationwide prospective cohort study甘油三酯葡萄糖-身体圆度指数与心血管-肾脏-代谢综合征人群衰弱轨迹的关联：一项全国性前瞻性队列研究DOI: 10.1093/gerona/glaf273 Molecular biology reports IF: 02.800Volume 53, Issue 1No.29Tirzepatide improves neutrophilic inflammation in obese asthmatic mice by downregulating Th17 cell differentiation替尔泊肽通过下调Th17细胞分化改善肥胖哮喘小鼠的中性粒细胞炎症DOI: 10.1007/s11033-025-11366-6 Annals of medicine IF: 04.300Volume 57, Issue 1No.30Cellular senescence and polycystic ovary syndrome: mechanisms and therapeutic strategies from a new perspective细胞衰老与多囊卵巢综合征：新视角下的机制与治疗策略DOI: 10.1080/07853890.2025.2565437 Endocrinol Diabetes Metab IF: 02.600Volume 9, Issue 1No.31High-Protein Diet Exacerbates Insulin Resistance via the JNK/IKKβ-IRS-1 Pathway高蛋白饮食经由JNK/IKKβ-IRS-1通路加剧胰岛素抵抗DOI: 10.1002/edm2.70147 International journal of cancer IF: 04.700Ahead of Print.No.32Associations of diabetes status, duration, and onset age with the risk of lung cancer: Results from the China Kadoorie Biobank study糖尿病状态、病程及发病年龄与肺癌风险的关联：来自中国嘉道理生物库的研究结果DOI: 10.1002/ijc.70294 Diabetes, obesity & metabolism IF: 05.700Ahead of Print.No.33Impact of stepwise diabetes technology advances in older adults with type 1 diabetes: A systematic review and meta-analysis of randomised trials逐步升级糖尿病技术对老年1型糖尿病患者的影响：一项随机试验的系统评价和荟萃分析DOI: 10.1111/dom.70355 BMC nephrology IF: 02.400Volume 26, Issue 1No.34Renal gelsolin amyloidosis as a rare cause of proteinuria: a case report and literature review肾源性凝溶胶蛋白淀粉样变性：一种罕见的蛋白质尿病因——病例报告与文献回顾DOI: 10.1186/s12882-025-04599-x BMC public health IF: 03.600Volume 25, Issue 1No.35Association between EAT-Lancet diet adherence and incident type 2 diabetes in Shanghai adults: a prospective cohort study上海成人EAT-Lancet饮食依从性与2型糖尿病发病风险的关联：一项前瞻性队列研究DOI: 10.1186/s12889-025-24961-w BMC medical research methodology IF: 03.400Ahead of Print.No.36Demystifying inconsistent two-sample mendelian randomization estimations using selection diagram利用选择图解构不一致的双样本孟德尔随机化估计DOI: 10.1186/s12874-025-02707-x Comput Methods Biomech Biomed Engin IF: 01.600Ahead of Print.No.37Gestational diabetes mellitus prediction using image-encoded electronic medical records and Transformer-based fusion基于图像编码电子病历与Transformer融合的妊娠期糖尿病预测DOI: 10.1080/10255842.2025.2573868 Journal of Biomedical Research IF: 02.200Ahead of Print.No.38Maternal and neonatal outcomes among women diagnosed with GDM by NICE criteria but not by IADPSG criteria in China: A retrospective cohort study在中国，符合NICE标准但不符合IADPSG标准诊断为GDM的孕妇其母婴结局：一项回顾性队列研究DOI: 10.7555/JBR.39.20250350 Cell Mol Biol Lett IF: 10.200Ahead of Print.No.39A novel tRF-Gly is associated with obesity development through post-transcriptional regulation of lipid metabolism新型tRF-Gly通过脂代谢的转录后调控与肥胖发生相关DOI: 10.1186/s11658-025-00835-2 其他发布内容（101） More Published Articles Molecules and cells IF: 06.500Ahead of Print.No.01Multilayered regulation of longevity in Caenorhabditis elegans秀丽隐杆线虫长寿的多层次调控DOI: 10.1016/j.mocell.2025.100308 J Mol Graph Model IF: 03.000Ahead of Print.No.02Investigating the pH influence on insulin fibril stability: Molecular dynamics insights探究pH值对胰岛素纤维稳定性的影响：分子动力学的见解DOI: 10.1016/j.jmgm.2025.109255 J Pharmacol Sci IF: 02.900Volume 160, Issue 1No.03Acute and chronic effects of imeglimin on peripheral circadian clocks in mice伊格列净对小鼠外周生物钟的急性和慢性作用DOI: 10.1016/j.jphs.2025.11.005 Am J Kidney Dis IF: 08.200Ahead of Print.No.04Effects of Empagliflozin on Kidney and Cardiac Magnetic Resonance Imaging Measures in Patients With CKD: An EMPA-KIDNEY Mechanistic Substudy恩格列净对慢性肾病患者肾脏及心脏磁共振成像指标的影响：一项EMPA-KIDNEY机制性子研究DOI: 10.1053/j.ajkd.2025.09.022 Scientific reports IF: 03.900Ahead of Print.No.05Candida tropicalis culture supernatants modulate Pseudomonas aeruginosa antimicrobial resistance and biofilm formation热带念珠菌培养上清液调节铜绿假单胞菌的抗菌素耐药性与生物膜形成DOI: 10.1038/s41598-025-31858-6 BMC medicine IF: 08.300Volume 23, Issue 1No.06Correction: Development and recalibration of a multivariable type 1 diabetes prediction model for type 1 diabetes across multiple screening studies更正：一个多变量1型糖尿病预测模型的开发与重新校准——跨越多个筛查研究DOI: 10.1186/s12916-025-04581-2 Scientific reports IF: 03.900Ahead of Print.No.07The RNA-binding protein CPEB1 marks healthy adult β cells in mice but is dispensable for β cell identity and functionRNA结合蛋白CPEB1标记小鼠健康成年β细胞，但对β细胞身份和功能非必需DOI: 10.1038/s41598-025-32403-1 Nature communications IF: 15.700Ahead of Print.No.08Structural basis of double-stranded RNA recognition by the J2 monoclonal antibodyJ2单克隆抗体识别双链RNA的结构基础DOI: 10.1038/s41467-025-67414-z BMC endocrine disorders IF: 03.300Ahead of Print.No.09Assessment of analytical performance of a glucometer in Indian adults at a tertiary care hospital印度三级医院成人患者血糖仪分析性能评估DOI: 10.1186/s12902-025-02118-5 Pain management nursing IF: 02.100Ahead of Print.No.10The Use of Nonpharmacologic Approaches to Pain Management Among Nursing Home Residents养老院居民疼痛管理中非药物方法的应用DOI: 10.1016/j.pmn.2025.11.013 Surgery IF: 02.700Ahead of Print.No.11Characterizing liver disease in patients undergoing bariatric surgery: Prevalence and outcomes of 180,544 cases减重手术患者肝病特征分析：180,544例病例的患病率与结局DOI: 10.1016/j.surg.2025.109966 Reumatología clínicaVolume 21, Issue 10No.12Diffuse idiopathic skeletal hyperostosis in patients with prediabetes糖尿病前期患者的弥漫性特发性骨肥厚DOI: 10.1016/j.reumae.2025.502017 Journal of vascular nursing IF: 01.200Volume 43, Issue 4No.13Chronic abdominal pain: Budd-Chiari syndrome with converging pathologies慢性腹痛：巴德-基亚里综合征与多重病理的交汇DOI: 10.1016/j.jvn.2025.08.007 Environ Toxicol Pharmacol IF: 04.200Ahead of Print.No.14Correlation of Per- and poly-fluoroalkyl substances (PFAS) Exposure with Testosterone Levels in the Male Population全氟和多氟烷基物质（PFAS）暴露与男性人群睾丸激素水平的相关性DOI: 10.1016/j.etap.2025.104906 Environmental pollution IF: 07.300Ahead of Print.No.15Preliminary insights into methylation patterns in Agent Orange exposed thyroid cancers: a pilot study橙剂暴露相关甲状腺癌甲基化模式的初步认识：一项初步研究DOI: 10.1016/j.envpol.2025.127475 Med IF: 11.800Volume 6, Issue 12No.16One small molecule for man, one giant leap for mankind with obesity小分子惠及个体，肥胖治疗迈出大步DOI: 10.1016/j.medj.2025.100924 Comput Biol Chem IF: 03.100Ahead of Print.No.17AI-powered literature mining reveals the therapeutic significance of GLP-1 receptor: Simulation of natural agonist candidates based on molecular dynamicsAI驱动的文献挖掘揭示GLP-1受体的治疗意义：基于分子动力学的天然激动剂候选物模拟DOI: 10.1016/j.compbiolchem.2025.108828 European journal of radiology IF: 03.300Ahead of Print.No.18Treatment of non-severe hemoptysis: A retrospective propensity score-matched comparison between conservative management and bronchial artery embolization非严重咯血的治疗：保守治疗与支气管动脉栓塞术的回顾性倾向评分匹配比较DOI: 10.1016/j.ejrad.2025.112604 Ecotoxicol Environ Saf IF: 06.100Ahead of Print.No.19Protective role of dietary fiber against lead-induced cellular and renal toxicity in a diabetic mouse model: Implications for environmental health and safety膳食纤维在糖尿病小鼠模型中对铅诱导的细胞和肾毒性的保护作用：对环境健康与安全的启示DOI: 10.1016/j.ecoenv.2025.119518 Journal of hazardous materials IF: 11.300Ahead of Print.No.20Food packaging characterization, composition profiles and in vitro testing of micro(bio)plastics from selected petroleum- and plant-based food containers食品包装表征、成分谱及体外测试：基于石油和植物的食品容器中的微（生物）塑料DOI: 10.1016/j.jhazmat.2025.140782 Eur J Obstet Gynecol Reprod Biol IF: 01.900Ahead of Print.No.21The impact of early amniotomy on delivery outcomes in pregnancies with fetal macrosomia早期人工破膜对胎儿巨大儿妊娠分娩结局的影响DOI: 10.1016/j.ejogrb.2025.114881 J Trace Elem Med Biol IF: 03.300Ahead of Print.No.22Fluoride-induced gut dysbiosis in metabolic disorders: Mechanisms and public health implications氟化物诱导的代谢性疾病肠道菌群失调：机制与公共卫生意义DOI: 10.1016/j.jtemb.2025.127806 Int J Health Geogr IF: 03.200Ahead of Print.No.23Understanding regional disparities in obesity: a multiscale geographically weighted analysis in the United States理解美国肥胖的地区差异：一项多尺度地理加权分析DOI: 10.1186/s12942-025-00438-2 BMC research notes IF: 01.700Ahead of Print.No.24Neuropathic pain in knee osteoarthritis: functional burden beyond cartilage thickness-a cross-sectional study膝骨关节炎中的神经病理性疼痛：超越软骨厚度的功能负担——一项横断面研究DOI: 10.1186/s13104-025-07589-2 Orphanet J Rare Dis IF: 03.500Ahead of Print.No.25Clinical assessment of growth patterns, weight, and dietary management in children and adults with phenylketonuria - a retrospective study儿童及成人苯丙酮尿症患者生长模式、体重与饮食管理的临床评估——一项回顾性研究DOI: 10.1186/s13023-025-04136-x Archives of disease in childhood IF: 03.200Ahead of Print.No.26Mining the archives: a hundred years of changing attitudes to growth and development挖掘档案：关于生长发育态度的百年变迁DOI: 10.1136/archdischild-2025-329814 Psychology of sport and exercise IF: 03.300Ahead of Print.No.27Translating Physical Activity Intentions into Behavior in Adults with Overweight/Obesity: The Role of Daily Stressors and Stress Pile-Up将超重/肥胖成人的体力活动意图转化为行为：日常压力源与压力累积的作用DOI: 10.1016/j.psychsport.2025.103053 Clinical nutrition ESPEN IF: 02.600Ahead of Print.No.28Impact of muscle mass, muscle density and obesity on clinical outcomes in critically ill patients with COVID-19肌肉质量、肌肉密度和肥胖对COVID-19危重症患者临床结局的影响DOI: 10.1016/j.clnesp.2025.102878 Physiology & behavior IF: 02.500Ahead of Print.No.29Sexual activity before exercise influences physiological response and sports performance in high-level trained men athletes高水平训练男性运动员运动前性活动影响生理反应与运动表现DOI: 10.1016/j.physbeh.2025.115203 J Pediatr Adolesc Gynecol IF: 01.800Ahead of Print.No.30Adolescent and young adult (AYA) pregnancy outcomes in Texas during the COVID pandemic: a retrospective cohort studyCOVID-19大流行期间德克萨斯州青少年和年轻成人妊娠结局：一项回顾性队列研究DOI: 10.1016/j.jpag.2025.12.006 Journal of ISAKOS : IF: 03.300Ahead of Print.No.31Increased Risk of Postoperative Complications in Non-Alcoholic Cirrhosis Versus Non-Alcoholic Fatty Liver Disease Following Total Knee Arthroplasty: A National Matched Cohort Study全膝关节置换术后非酒精性肝硬化比非酒精性脂肪肝病患者并发症风险更高：一项全国性匹配队列研究DOI: 10.1016/j.jisako.2025.101051 Am J Prev Med IF: 04.500Ahead of Print.No.32Beyond anthropometry: the clinical role of epigenetics in prenatal programming of obesity超越人体测量学：表观遗传学在产前编程肥胖中的临床作用DOI: 10.1016/j.amepre.2025.108213 Sleep medicine IF: 03.400Ahead of Print.No.33Further evidence that painful and painless restless legs syndrome are contrasting phenotypes: a study of adult twins and their families进一步证据表明疼痛型与不痛型不宁腿综合征是对比鲜明的不同表现类型：一项针对成人双胞胎及其家庭的研究DOI: 10.1016/j.sleep.2025.108718 Gut : IF: 25.800Ahead of Print.No.34"DPP- 4 inhibitor alleviates gut-brain axis Parkinson's disease pathology" - can dipeptidyl peptidase 4 inhibitors be repurposed as disease-modifying drugs for body-first Parkinson's disease patients?DPP-4抑制剂缓解肠-脑轴帕金森病病理——二肽基肽酶4抑制剂能否被重新定位为体先型帕金森病患者的疾病修饰药物DOI: 10.1136/gutjnl-2025-336951 BMC veterinary research IF: 02.600Volume 21, Issue 1No.35Physiological effects of a pre-anesthetic single dose of gabapentin on Xylazine/Ketamine anesthesia in rabbits单次术前口服加巴喷丁对家兔赛拉嗪/氯胺酮麻醉的生理影响DOI: 10.1186/s12917-025-05142-8 J Am Acad Dermatol IF: 11.800Ahead of Print.No.36Glucagon-like peptide-1 receptor agonist therapy in patients with psoriasis is associated with decreased risk of psoriatic arthritis: A retrospective cohort study from TriNetX database胰高血糖素样肽-1受体激动剂疗法在银屑病患者中与降低的银屑病关节炎风险相关：一项来自TriNetX数据库的回顾性队列研究DOI: 10.1016/j.jaad.2025.12.035 Primary care diabetes IF: 02.300Ahead of Print.No.37Impact of real-time continuous glucose monitoring and personalized digital health coaching on glycemic control and lifestyle in patients with type 2 diabetes and prediabetes实时连续血糖监测与个性化数字健康指导对2型糖尿病及糖尿病前期患者血糖控制和生活方式的影响DOI: 10.1016/j.pcd.2025.12.002 Mol Cell Endocrinol IF: 03.600Ahead of Print.No.38Bone marrow transplantation attenuates inflammation and improves glycemic control in type 2 non-obese diabetic Goto-Kakizaki rats骨髓移植减轻2型非肥胖糖尿病Goto-Kakizaki大鼠炎症并改善血糖控制DOI: 10.1016/j.mce.2025.112716 CMGH IF: 07.400Ahead of Print.No.39DOCK10 Regulates Insulin Hypersecretion in Insulinoma and Serves as a Diagnostic and Therapeutic TargetDOCK10调控胰岛素瘤胰岛素高分泌并作为诊疗靶点DOI: 10.1016/j.jcmgh.2025.101705 Annals of the rheumatic diseases IF: 20.600Ahead of Print.No.40Th9-arterial endothelial cell crosstalk promotes psoriatic atherosclerosisTh9细胞-动脉内皮细胞相互作用促进银屑病动脉粥样硬化DOI: 10.1016/j.ard.2025.11.008 Journal of vascular nursing IF: 01.200Volume 43, Issue 4No.41Retrospective descriptive study of individuals with chronic limb-threatening ischemia (CLTI) admitted to the academic vascular surgery unit for a major lower limb amputation慢性肢体威胁性缺血患者因大截肢手术入住学术血管外科单位的回顾性描述研究DOI: 10.1016/j.jvn.2025.08.005 European neuropsychopharmacology IF: 06.700Ahead of Print.No.42Association between tirzepatide use and risk of mortality, hospitalization, and suicidal behavior in patients with schizophrenia spectrum disorders: A one-year retrospective cohort study of 3618 patients替尔泊肽使用与精神分裂症谱系障碍患者的死亡率、住院率和自杀行为风险之间的关联：一项对3618名患者为期一年的回顾性队列研究DOI: 10.1016/j.euroneuro.2025.11.016 Journal of animal science IF: 02.900Ahead of Print.No.43Diet format, protein, amino acids, salt, osmolytes, as well as water viscosity affect water consumption in domestic cats: A scoping review of 32 publications (published from 1975-2025) on water intake, hydration status, and related health outcomes饮食形式、蛋白质、氨基酸、盐、渗透剂及水粘度影响家猫饮水量：关于水摄入、水合状态及相关健康结果的32篇出版物（发表于1975-2025年）的范围综述DOI: 10.1093/jas/skaf434 Diabetic medicine IF: 03.400Ahead of Print.No.44'They use the little information they have to pass judgement': A framework analysis of type 1 diabetes stigma experienced by UK adults living with type 1 diabetes“他们仅凭有限的信息妄加评判”：对英国成年1型糖尿病患者经历1型糖尿病污名化的框架分析DOI: 10.1111/dme.70191 Hell J Nucl Med IF: 01.000Ahead of Print.No.45Factors predicting cure at one year after administration of radioactive iodine to patients with Graves' disease预测Graves病患者放射性碘治疗后一年治愈率的因素DOI: 10.1967/s002449912901 Maternal and child nutrition IF: 02.600Volume 22, Issue 1No.46Understanding Parents' Experiences of Using a Portion Guide for Young Children: A Qualitative Study理解父母使用幼儿食物份量指南的经历：一项质性研究DOI: 10.1111/mcn.70151 Fetal diagnosis and therapy : IF: 01.600Ahead of Print.No.47The impact of maternal body mass index on fetoscopic laser surgery for TTTS母体体重指数对双胎输血综合征胎儿镜激光手术结局的影响DOI: 10.1159/000550060 Kaohsiung J Med Sci IF: 03.100Ahead of Print.No.48Lysosome Evanescence Mediates Autophagic Flux Impairment in Glucose Imbalanced Environments葡萄糖失衡环境中溶酶体消逝介导自噬通量受损DOI: 10.1002/kjm2.70145 Naunyn Schmiedebergs Arch Pharmacol IF: 03.100Ahead of Print.No.49Bridging gut microbiota and renal health: Klotho as a promising therapeutic agent in DKD联结肠道菌群与肾脏健康：Klotho作为糖尿病肾病中前景广阔的治疗剂DOI: 10.1007/s00210-025-04897-z Community dental health IF: 01.000Ahead of Print.No.50Association between the single-point insulin sensitivity estimator (SPISE) index and periodontitis in Korean adults: Analysis from the Korea national health and nutrition examination survey (KNHANES) 2016-2018韩国成年人单点胰岛素敏感性估算值指数与牙周炎的关联：基于韩国国民健康营养调查（KNHANES）2016-2018年的分析DOI: 10.1177/0265539X251405067 Diabetic medicine IF: 03.400Ahead of Print.No.51Automated insulin delivery system use and physical activity levels in adults with type 1 diabetes: A BETTER registry analysis成人1型糖尿病患者中自动胰岛素输送系统的使用与体力活动水平：一项BETTER登记研究分析DOI: 10.1111/dme.70192 Psychopharmacologia IF: 03.300Ahead of Print.No.52Chronic unpredictable mild Stress- induced neurobehavioral and metabolic alteration: insights into molecular mechanisms and emerging therapeutic Strategies"慢性不可预知温和应激诱导的神经行为与代谢改变：分子机制见解与新兴治疗策略DOI: 10.1007/s00213-025-06990-w J Diabetes Complications IF: 03.100Ahead of Print.No.53Linking HbA1c and white blood cell counts to the development of diabetic macular edema in type 2 diabetes: A systematic review and meta-analysis探讨糖化血红蛋白与白细胞计数与2型糖尿病视网膜黄斑水肿发病的关联：一项系统综述与荟萃分析DOI: 10.1016/j.jdiacomp.2025.109237 Internal medicine journal IF: 01.500Ahead of Print.No.54Prognostic value of a plasma protein-based biomarker test for chronic kidney disease complicating diabetes in Aboriginal Australians血浆蛋白标志物检测对澳大利亚原住民糖尿病并发慢性肾脏病的预后价值DOI: 10.1111/imj.70275 Clinical autonomic research IF: 03.400Ahead of Print.No.55Correlation between right vagus nerve cross-sectional area and abnormal heart rate with deep breathing in Parkinson's disease帕金森病中右侧迷走神经横截面积与深呼吸异常心率反应的相关性DOI: 10.1007/s10286-025-01180-2 J Clin Endocrinol Metab IF: 05.100Ahead of Print.No.56Nocturnal melatonin secretion and risk of type 2 diabetes: a prospective cohort study夜间褪黑素分泌与2型糖尿病风险：一项前瞻性队列研究DOI: 10.1210/clinem/dgaf667 J Clin Endocrinol Metab IF: 05.100Ahead of Print.No.57Unequal distribution of plasma glucagon levels among clustering-based diabetes subtypes: a Japanese cohort基于聚类分析的糖尿病亚型中血浆胰高血糖素水平分布不均：一项日本队列研究DOI: 10.1210/clinem/dgaf654 The FASEB journal : IF: 04.200Volume 39, Issue 24No.58Whole-Genome Sequencing in Galicia Reveals Male-Biased Pre-Islamic North African Ancestry, Subtle Population Structure, and Microgeographic Patterns of Disease RiskGalicia全基因组测序揭示男性偏向的前伊斯兰时期北非血统、细微的人口结构与疾病风险的微观地理模式DOI: 10.1096/fj.202502634R Mol Nutr Food Res IF: 04.200Ahead of Print.No.59Unfermented High-Fiber Rye Crispbread Increases Plasma HDL and Reduces Hepatic Lipids Compared to Refined Wheat in Rats Fed a High-Fat Diet与精制小麦相比，未发酵高纤维黑麦脆面包在高脂饮食大鼠中升高血浆HDL并降低肝脏脂质DOI: 10.1002/mnfr.70352 Drug Dev Ind Pharm IF: 02.200Ahead of Print.No.60Deoxycholic acid as a permeability enhancer of two antidiabetic drugs with distinctive biopharmaceutical properties through biological barriers脱氧胆酸作为两种具独特生物药剂学特性的抗糖尿病药物跨生物屏障的渗透性增强剂DOI: 10.1080/03639045.2025.2604256 Future Cardiology IF: 01.000Ahead of Print.No.61Clinical implications of the interaction between metabolic risk factors, coronary artery disease and atrial fibrillation代谢风险因素、冠状动脉疾病与心房颤动相互作用的临床意义DOI: 10.1080/14796678.2025.2603066 Microsurgery IF: 01.700Volume 45, Issue 8No.62Defining BMI Thresholds for Free Flap Reconstruction Following Nipple-Sparing Mastectomy确定保留乳头乳房切除术后游离皮瓣重建的BMI阈值DOI: 10.1002/micr.70153 The FASEB journal : IF: 04.200Volume 39, Issue 24No.63Disruption of Mitochondrial Dynamics and Integrity Drives Divergent Metabolic Flexibility and Resilience in Podocytes线粒体动力学与完整性破坏驱动足细胞产生迥异的代谢灵活性与恢复力DOI: 10.1096/fj.202502934R G3 IF: 02.200Ahead of Print.No.64Insulin-like peptides play distinct roles in nutrient-dependent plasticity in Drosophila胰岛素样肽在果蝇营养依赖性可塑性中发挥独特作用DOI: 10.1093/g3journal/jkaf301 BMC infectious diseases IF: 03.000Ahead of Print.No.65Uncovering metabolic shifts: an ¹H-NMR study on the dual influence of HIV/TB coinfection and ART揭示代谢变化：¹H-NMR研究HIV/TB共感染与ART的双重影响DOI: 10.1186/s12879-025-12088-7 Future science OA IF: 02.100Volume 12, Issue 1No.66Systematic review of the literature: estimation of the most common gynecological disorders and associated factors among Kazakhstani adolescents文献系统综述：哈萨克斯坦青少年最常见妇科疾病评估及其关联因素DOI: 10.1080/20565623.2025.2599726 The FASEB journal : IF: 04.200Volume 39, Issue 24No.67Obesity Augments Necroinflammation and Worsens Injury With Folic Acid-Induced Acute Kidney Injury肥胖加剧叶酸诱导急性肾损伤的坏死性炎症与损伤严重程度DOI: 10.1096/fj.202503440R Future science OA IF: 02.100Volume 12, Issue 1No.68Body shape concerns among Jordanian university students: prevalence, correlates, and association with social media use约旦大学生身体形态关注：流行率、相关因素及与社交媒体使用的关联DOI: 10.1080/20565623.2025.2601632 Acta paediatrica IF: 02.100Ahead of Print.No.69Age- and Sex-Adjusted Body Mass Index Increases in Childhood Acute Lymphoblastic Leukaemia Patients From Diagnosis to Five-Year Follow-Up儿童急性淋巴细胞白血病患者从诊断至五年随访期间年龄与性别校正后的体重指数持续升高DOI: 10.1111/apa.70413 International journal of obesity IF: 03.800Ahead of Print.No.70Consideration on 'Exploring the link between dietary inflammatory index, inflammatory biomarkers, and sleep quality in adults with obesity: a pilot investigation'探讨'Exploring the link between dietary inflammatory index, inflammatory biomarkers, and sleep quality in adults with obesity: a pilot investigation'DOI: 10.1038/s41366-025-01976-2 International journal of obesity IF: 03.800Ahead of Print.No.71Is hyperdynamic circulation a hallmark of obesity?高动力循环是肥胖的标志吗？DOI: 10.1038/s41366-025-01981-5 Workplace health & safety IF: 02.100Ahead of Print.No.72Breathing Beyond Dust: Uncovering the Hidden Link Between Diabetes and Pulmonary Health in Mine Workers呼吸超尘：揭示矿工中糖尿病与肺部健康的隐藏关联DOI: 10.1177/21650799251407525 Endocrinol Diabetes Metab IF: 02.600Volume 9, Issue 1No.73Antihypertensive Effects of Curcumin/Turmeric Supplementation in Prediabetes and Diabetes: A Systematic Review and Meta-Analysis of Randomised Controlled Trials姜黄素/姜黄补充剂在糖尿病前期和糖尿病中的降压效果：随机对照试验的系统评价和荟萃分析DOI: 10.1002/edm2.70145 Diabetes, obesity & metabolism IF: 05.700Ahead of Print.No.74Disentangling the relationship between glucose, insulin and brain health: A UK Biobank study解析血糖、胰岛素与脑健康之间的关系：一项英国生物样本库研究DOI: 10.1111/dom.70353 J Paediatr Child Health IF: 01.400Ahead of Print.No.75Birth Prevalence and Characteristics of Septo-Optic Dysplasia in Australia: Results From the Australian Paediatric Surveillance Unit澳大利亚视隔发育不良的出生患病率与特征评估：基于澳大利亚儿科监测单位的研究结果DOI: 10.1111/jpc.70258 Internal medicine journal IF: 01.500Ahead of Print.No.76Author reply作者回复DOI: 10.1111/imj.70304 Endocrine regulationsVolume 59, Issue 1No.77Association between shift work and levels of thyroid hormones and interleukin-37轮班工作与甲状腺激素及白细胞介素-37水平的关系DOI: 10.2478/enr-2025-0026 Pharmacoepidemiol Drug Saf IF: 02.400Volume 34, Issue 12No.78National Trends and Disparities in Herpes Zoster Vaccination Among US Older Adults With Diabetes, 2008-2023美国老年糖尿病患者带状疱疹疫苗接种的国家趋势与差异(2008-2023)DOI: 10.1002/pds.70301 Trials IF: 02.000Ahead of Print.No.79Comparison of morning vs evening exercise on weight loss and related health behaviors in individuals with overweight or obesity: study protocol for a 56-week randomized controlled trial (TIMEX)比较早晚运动对超重或肥胖个体体重减轻及相关健康行为的影响：一项为期56周的随机对照试验（TIMEX）研究方案DOI: 10.1186/s13063-025-09306-7 Cell communication and signaling IF: 08.900Volume 23, Issue 1No.80Uncovering functional divergence and cellular clusters with specific gene signatures in HNSCC clonal spheroids在头颈鳞状细胞癌克隆球体中揭示功能差异及具有特定基因特征的细胞簇DOI: 10.1186/s12964-025-02360-3 BMC infectious diseases IF: 03.000Ahead of Print.No.81Association between HIV infection and type 2 diabetes mellitus: global incidence, prevalence, and risk factors - a systematic review and meta-analysisHIV感染与2型糖尿病相关性的全球发病率、患病率及危险因素：一项系统综述与荟萃分析DOI: 10.1186/s12879-025-12222-5 Systematic reviews IF: 03.900Volume 14, Issue 1No.82The effect of increased core body temperature on the vasomotor and sudomotor responses of patients with type 2 diabetes: protocol of a systematic literature review and meta-analysis核心体温升高对2型糖尿病患者血管舒缩与出汗反应的影响：一项系统评价与荟萃分析研究方案DOI: 10.1186/s13643-025-02991-0 BMC Med Inform Decis Mak IF: 03.800Ahead of Print.No.83Leveraging clinical decision support system tools for childhood overweight/obesity management利用临床决策支持系统工具优化儿童超重/肥胖管理DOI: 10.1186/s12911-025-03293-0 Diabetes, obesity & metabolism IF: 05.700Ahead of Print.No.84Hepatic GCGR is required for the superior weight loss and metabolic effects of a structurally related analogue of the dual GCGR/GLP-1R agonist survodutide in mice肝GCGR是双靶点激动剂survodutide结构类似物在小鼠中实现卓越减重与代谢改善效应的必要条件DOI: 10.1111/dom.70359 Internal medicine journal IF: 01.500Ahead of Print.No.85Evaluating the potential clinical practice impact of the PromarkerD blood test in people with type 2 diabetes in Australia在澳大利亚评估PromarkerD血液测试对2型糖尿病患者临床实践的潜在影响DOI: 10.1111/imj.70294 BMC pregnancy and childbirth IF: 02.700Volume 25, Issue 1No.86Prediction of spontaneous preterm birth before 34 weeks in twin pregnancies using first-trimester cervical length利用孕早期宫颈长度预测双胎妊娠34周前的自发性早产DOI: 10.1186/s12884-025-08461-8 AAPS PharmSciTech IF: 04.000Volume 27, Issue 1No.87Artificial Intelligence in Ocular Drug Delivery: Precision Drug Delivery's New Horizon人工智能在眼部给药中的应用：精准药物递送的新视野DOI: 10.1208/s12249-025-03271-9 Nature reviews. Endocrinology IF: 40.000Ahead of Print.No.88Advances in incretin-based drug discovery in 20252025年基于肠促胰岛素的药物发现进展DOI: 10.1038/s41574-025-01219-4 International journal of obesity IF: 03.800Ahead of Print.No.89The Physiology Of the WEight Reduced State (POWERS) study: overview and study design《减重后状态的生理学》（POWERS）研究：概述与研究设计DOI: 10.1038/s41366-025-01932-0 Diabetologia IF: 10.200Ahead of Print.No.90Superiority of 1 h plasma glucose vs fasting plasma glucose, 2 h plasma glucose and HbA(1c) for the diagnosis of type 2 diabetes诊断2型糖尿病：1小时血浆葡萄糖优于空腹血浆葡萄糖、2小时血浆葡萄糖及HbA1cDOI: 10.1007/s00125-025-06632-y Journal of eating disorders IF: 04.500Ahead of Print.No.91Food addiction in children: a network analysis of nutritional, metabolic, and sociodemographic factors儿童食物成瘾：一项营养、代谢及社会人口学因素的网络分析DOI: 10.1186/s40337-025-01495-5 Alzheimer's & dementia IF: 11.100Volume 21, Issue 12No.92Unraveling the oral microbiome's role in Alzheimer's disease: From pathophysiology to therapeutic potential揭示口腔微生物组在阿尔茨海默病中的作用：从病理生理学到治疗潜力DOI: 10.1002/alz.71011 Endocrine regulationsVolume 59, Issue 1No.93Endogenous intoxication and morpho-functional changes in the liver during experimental acute generalized peritonitis in diabetic rats糖尿病大鼠实验性急性弥漫性腹膜炎期间的内源性中毒与肝脏形态功能学改变DOI: 10.2478/enr-2025-0027 Diabetes, obesity & metabolism IF: 05.700Ahead of Print.No.94Use of sodium-glucose cotransporter-2 inhibitors among older adults with type 2 diabetes mellitus in British Columbia不列颠哥伦比亚省老年2型糖尿病患者钠-葡萄糖协同转运蛋白2抑制剂的使用情况DOI: 10.1111/dom.70375 Breast cancer research IF: 05.600Ahead of Print.No.95Metformin and its derivatives in breast cancer: from glycaemic control to tumor-intrinsic pathways二甲双胍及其衍生物在乳腺癌中的作用：从血糖控制到肿瘤内在通路DOI: 10.1186/s13058-025-02194-4 Endocrine regulationsVolume 59, Issue 1No.96Mitochondria-targeting compounds for management of metabolic and hemostatic abnormalities associated with heart dysfunctions in experimental type 2 diabetes线粒体靶向化合物对实验性2型糖尿病心脏功能障碍相关代谢和止血异常的管理DOI: 10.2478/enr-2025-0028 Cancer medicine IF: 03.100Volume 14, Issue 24No.97Glucagon-Like Peptide-1 Receptor Agonists and Hepatocellular Carcinoma Prevention: A Meta-Analysis and Clinical Decision Framework胰高血糖素样肽-1受体激动剂与肝细胞癌预防：一项荟萃分析及临床决策框架DOI: 10.1002/cam4.71434 Endocrine regulationsVolume 59, Issue 1No.98Mirtazapine for gastrointestinal side effects of glucagon-like peptide-1 receptor agonist therapy in older adults米氮平用于缓解老年患者胰高血糖素样肽-1受体激动剂治疗的胃肠道副作用DOI: 10.2478/enr-2025-0030 BMC Complement Med Ther IF: 03.400Volume 25, Issue 1No.99In vitro anti-diabetic activity and molecular docking studies of Amaranthus cruentus, Amaranthus hybridus and isolated compounds尾穗苋和绿穗苋及其分离化合物的体外抗糖尿病活性与分子对接研究DOI: 10.1186/s12906-025-05169-2 Endocrine regulationsVolume 59, Issue 1No.100LDL/HDL ratio and HOMA-IR as markers of severity of peripheral neuropathy in diabetic population低密度脂蛋白/高密度脂蛋白比值与胰岛素抵抗稳态模型评估作为糖尿病人群周围神经病变严重程度的标志物DOI: 10.2478/enr-2025-0025 Angiology IF: 02.200Ahead of Print.No.101Prognostic Value of HALP Score in Predicting Contrast-Induced Acute Kidney Injury in Elderly STEMI PatientsHALP评分对老年ST段抬高型心肌梗死患者对比剂急性肾损伤的预测价值DOI: 10.1177/00033197251395839 95 Diabetes Mellitus(DM) 糖尿病 51 Obesity 肥胖症 30 Insulin 胰岛素 9 Type 2 diabetes mellitus(T2DM) 2型糖尿病 5 Hypoglycemic Agents 降糖药 5 Metformin 二甲双胍 4 Gestational Diabetes Mellitus(GDM) 妊娠糖尿病 3 Metabolic Syndrome 代谢综合征 3 Glucagon-Like Peptide-1 Receptor Agonists(GLP-1RA) 胰高血糖素样肽-1受体激动剂 3 Tirzepatide 替尔泊肽 3 Diabetic Retinopathy 糖尿病视网膜病 2 Diabetic Kidney Disease(DKD) 糖尿病肾脏病 1 Semaglutide 司美格鲁肽 1 Empagliflozin 恩格列净 1 Diabetes Complications 糖尿病并发症 1 Diabetic acidosis 糖尿病性酸中毒 1 Diabetic Foot 糖尿病足 1 Type 1 diabetes mellitus(T1DM) 1型糖尿病 1 Dipeptidyl-Peptidase IV Inhibitors(DPP-4i) 二肽基肽酶-4抑制剂 1 Diabetic Neuropathies 糖尿病性神经病变 1 gamma-Aminobutyric Acid(GABA) γ-氨基丁酸 1 Gabapentin 加巴喷丁 编辑：丁克芳 审校：丁克芳

统计每周药品获批、上市申请、临床申请及审批情况（2025.12.6-2025.12.12） 注：周统计截止数据定为每周五，周六周日数据将统计入下周，依此类推。 本周超卷品种乙酰半胱氨酸注射液再加一家石家庄四药顺利过评，规格25ml:5g，适应症同样是解毒剂，乙酰半胱氨酸注射液目前过评已达三家：四川汇宇、四川海梦、石家庄四药，根据企业公开报道，三家适应症均是解毒剂，至今原研赞邦的祛痰适应症依旧是独家。 三家过评热门适应症依旧没被突破，实属罕见，以目前情况推测，赞邦的窗口期至少还有一年，此品种依旧有57家企业在审评上市，是今年最卷的品种。 齐鲁制药本周收获三款重磅药物，帕妥尤单抗N01注射液是国内首个全人源抗EGFR单克隆抗体，按照生物药3.4类获批，齐鲁一直想要再现贝伐珠单抗的业绩，在肿瘤用药领域布局很广。 另外两款布瑞哌唑片和恩扎卢胺片齐鲁在本周过评，都错失了首仿，但是齐鲁追平速度极快，布瑞哌唑片更是与首仿企业苑东只差了6天。 本周有多款新药获批，正大天晴的全球首个CDK2/4/6抑制剂库莫西利胶囊获批，健康元的又一流感新药玛帕西沙韦胶囊获批。 司美格鲁肽注射液本周有两条上市申报，石药集团申报减重适应症上市；正大天晴子公司连云港润众制药首次提交降糖适应症上市申请，国内司美格鲁肽提交上市申请企业已达10家。 ↓ 扫码加入药通社交流群 ↓ 1、一致性评价审批结论 2、其他获批 3、上市申请 4、临床申请 5、临床默示许可 数据来源：摩熵医药 ↓⭐关注药通社，洞见行业趋势↓ 投稿/企业合作/内容沟通： 药通社总编—华籍美人（Ww_150525） *添加请注明备注及来意