The goal of this study is to address a key health inequity - lack of community access to evidence-based programs to prevent chronic health conditions (e.g., Type 2 Diabetes) - by tailoring and delivering a family-based lifestyle and stress management intervention, Health Without Barriers/Salud Sin Barreras, for adolescents and their families living in rural Southwest Colorado. The intervention is a lifestyle program that addresses healthy lifestyle habits within the family context to support adolescent mental health (mindfulness intervention) and healthy weight (physical activity, nutrition, and parent education).

开始日期2022-09-21

申办/合作机构

Colorado State University

[+3]

NCT01936311

/ CompletedN/AIIT

Study of Screening for Patients Self-selected Health Goal and Treatment Modality Prior to Primary Care Visit and the Effect on Short-term Behavior Change

The purpose of this study is to test whether having patients identify a self-management goal (health goal), prior to a visit with their primary care provider, leads to health behavior improvement over six weeks.

开始日期2013-06-01

申办/合作机构

Denver Health & Hospital Authority

[+1]

NCT00003788

/ Unknown status临床3期IIT

Prospective Clinical Trials in the Use of Photodynamic Therapy (PDT) for the Treatment of Malignant Supratentorial Brain Tumors

RATIONALE: Photodynamic therapy uses light and drugs that make cancer cells more sensitive to light to kill tumor cells. It is not yet known if the addition of photodynamic therapy to combined therapy with surgery, radiation therapy, and chemotherapy is more effective than combined therapy alone for supratentorial gliomas.
PURPOSE: Randomized phase III trial to study the effectiveness of surgery, radiation therapy, and chemotherapy with or without photodynamic therapy in treating patients who have newly diagnosed or recurrent malignant supratentorial gliomas.

开始日期1998-04-01

申办/合作机构

The Colorado Health Foundation

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2019-01-01·JAAD Case Reports

An advanced case of extramammary Paget disease: Safe and effective treatment in an inoperable elderly patient using extensive en face electron irradiation

作者: Deig, Chris ; Valle, Luca ; Wright, Ralph ; High, Whitney

Extramammary Paget disease (EMPD) is an intraepithelial adenocarcinoma characterized by epithelial infiltration of large atypical cells with prominent nuclei.1 The disease process is hypothesized to originate in the apocrine sweat glands in the anogenital region. It is often diagnosed in postmenopausal women and most commonly affects the vulva, perianal skin, and axilla but can sometimes be associated with invasive visceral or adnexal adenocarcinoma.2 Standard therapy for EMPD is wide local excision. However, many of the elderly patients affected by EMPD may be medically unfit for aggressive surgery. Radiotherapy is rarely used, and there is a paucity of reports detailing the efficacy of electron beam radiotherapy for exceptionally large EMPD lesions.

2018-05-29·Radiation Research3区 · 医学

In Vitro Cell-free DNA Quantification: A Novel Method to Accurately Quantify Cell Survival after Irradiation

3区 · 医学

Article

作者: Lautenschlaeger, Tim ; Deig, Christopher R ; Chin-Sinex, Helen J ; Frye, Elizabeth D ; Mendonca, Marc S ; Thowe, Rachel T

Circulating tumor DNA (ctDNA) analysis has been shown to aid in both the detection of cancer and evaluation of somatic mutations in tumors. CtDNA concentration in plasma increases in proportion to tumor volume and/or metabolic activity and growth; however, this principle has yet to be applied to cell culture. We hypothesized that cell line-specific cell-free DNA (cfDNA) can be used to measure cell viability and cell survival in cell culture. Clonogenic assays on non-small cell lung cancer (NSCLC) cell lines H322, A549 and H322 were exposed to radiation doses of 0, 4 and 8 Gy. Prior to colony fixation and counting, cfDNA was extracted and quantified from cell culture media. The correlation between cell line-specific cfDNA and number of colonies grown on culture plates was examined. An H1299:A549 coculture model was used to evaluate the differential release of cell line-specific cfDNA. The results of this work indicate a strong correlation between CfDNA quantification from cell culture media and clonogenic survival at all radiation doses and in all cell lines tested (R² range = 0.77-0.99). Cell survival curves derived from cfDNA were virtually indistinguishable from matched traditional clonogenic survival data ( P > 0.05; no significant difference exists between clonogenic curves). CfDNA quantification also accurately estimates colony count in a two-cell-line coculture model. In conclusion, cell-free DNA quantification from cell culture media can be used to measure cell survival, and appears suitable for development in a high-throughput clonogenic assay and radiosensitizer screening platform.

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2015-10-14

·BioSpace

Prima-Temp Release: Priya, The Personal Fertility Sensor To Help Women Conceive, Is Selected For Digital Health Pilot Program

BOULDER, Colo., Oct. 14, 2015 /PRNewswire/ -- Prima-Temp, the company that has patented wireless, continuous temperature monitoring, announced today it was one of eight digital health companies chosen from a nationwide selection process to participate in a pilot program with top healthcare institutions. The pilot will focus on Priya, the company's personal fertility sensor, designed to help a woman get pregnant - . Prima-Temp Inc., headed by CEO Dr. Lauren Costantini, has developed a product that monitors continuous core body temperature, one of the most reliable indicators of female fertility. "Priya has well-accepted technology," Dr. Costantini told the audience at the 2015 Prime Digital Health Challenge. "Priya is truly effortless, discreet, and precise. When a woman is trying to get pregnant, she simply inserts the sensor that automatically sends data to the Priya app on her phone, then notifies her when she is most fertile." Hundreds of digital health enthusiasts filled the Denver Art Museum's Ponti Hall on the evening of September 30th. They gathered for Prime Health's Digital Health Challenge, the largest event in Colorado digital health this year. In a "Shark Tank" setting, 17 different healthcare payors and providers heard pitches from the CEO of each company, then bid on the opportunity to host a pilot program for that company's digital health product. Prima-Temp was seeking a 20-subject pilot to test customer preference of Priya when compared to traditional methods of ovulation detection, which are inaccurate, inconvenient, and costly. Priya may help couples avoid costly fertility treatments, including in vitro fertilization/IVF. Kaiser Permanente, Denver Health, Aetna Health, and University of Colorado Health all bid to host the Prima-Temp pilot. The pilots will be funded by the Colorado Health Foundation, which had generously donated $150,000 to Prime Health for the event. Pre-sales of Priya personal fertility sensor are available for the next 30 days at a discounted price on Indiegogo at - /. About Prima-Temp Prima-Temp brings new, innovative approaches to many of today's healthcare challenges through the application of 21st century thermometry. Prima-Temp's continuous temperature sensors and associated software allow the most precise method to measure true core body temperature, with the potential to address a multitude of applications including the PRIYA personal fertility sensor, early disease detection, sleep disorders, drug therapy, weight control and exercise. For additional information, visit . Contact: Alene Campbell 303-588-8031 Photo - To view the original version on PR Newswire, visit: SOURCE Prima-Temp Help employers find you! Check out all the jobs and post your resume.

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