Delving into the Latest Updates on AstraZeneca R&D Charnwood with Synapse

The Association for Neurophyschopharmacology hosted a satellite meeting as part of the 14th Annual Meeting of the Psychoneuroimmunology Research Society. The meeting was entitled 'Cytokines and Depression III: Identification and Treatment of Symptoms Associated with Inflammation in Diseases with Inflammation in Medically Ill Patients' and was held in Bordeaux, France on 28 - 29 May, 2007. The meeting comprised approximately 40 participants from many leading laboratories and hospitals from around the world looking to understand some of the clinical issues associated with depression and behavioural changes, with the aims of exploring better ways of clinical monitoring and marshalling drug discovery efforts from bespoke and alternate indications in providing new therapeutic approaches.

2007-10-01·Xenobiotica4区 · 医学

In vitro-in vivo extrapolation of hepatic clearance involving active uptake: Theoretical and experimental aspects

4区 · 医学

作者: Denton, R. L. ; Webborn, P. J. H. ; Parker, A. J. ; Riley, R. J.

A review.The importance of hepatic uptake transporters in drug clearance is well recognized.The subject is reviewed with the intention of providing an overview of the concepts to link the increasing knowledge of transporter-mediated uptake into established models of hepatic clearance.In order to understand and quantify their impact, models of hepatic elimination that incorporate permeability barriers are required.Models that include both active and passive uptake into hepatocytes are discussed and simulations of the influence of active uptake and passive diffusion on hepatic clearance are presented.The advantages and weaknesses of a number of in vitro assays of hepatic uptake are described, and their ability to predict hepatic clearance is reviewed.

2006-06-01·Alternatives to Laboratory Animals4区 · 医学

Rapid Simultaneous Cloning of Drug Targets from Multiple Mammalian Species

4区 · 医学

Article

作者: Belfield, Graham P. ; McHale, Mark ; Dusanjh, Palminder K. ; Jupp, Rachael ; Delaney, Stephen J. ; Walding, Andrew

A method for the routine, rapid and simultaneous cloning of drug targets from multiple mammalian species is described. This expedites the generation of recombinant proteins and cell lines that can provide alternatives to animal experiments. This was achieved by the collection of RNA from a comprehensive range of tissues from a variety of species, and the optimisation of cDNA synthesis. This “zooplate” has been successfully used for the simultaneous amplification and cloning of drug targets from multiple species. These products have subsequently been used to develop in vitro assays that support efficacy and safety studies in new drug discovery programmes. Within the framework of the Three Rs, these reagents can reduce the number of animals required to provide material for ex vivo assays and can refine the in vivo studies that are still necessary.

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