Phase 2 Single Center, Randomized, Placebo-controlled, Double-blind, Parallel Group Study to Evaluate Efficacy of Para-Tyrosine Supplementation on the Survival and Clinical Outcome in Patients With Sepsis

Meta-and ortho-Tyrosine are known markers of oxidative stress, while the physiological isomer, para-Tyrosine is suggested the antagonize the effects of meta- and ortho-Tyrosine. The changes in the serum levels of meta- and ortho-Tyrosine have been found to be paralel to that of the common sepsis markers. The hypothesis of the study is, that supplementation of para-Tyrosine (p-Tyr) in the early phase of sepsis may diminish some specific inflammatory procedures and thus may have a favourable impact on the disease progress, and consequently on the mortality.

开始日期2027-01-01

申办/合作机构

University of Pecs

NCT05060731

/ Not yet recruiting临床4期IIT

Intravenous Ferric Carboxymaltose Versus Oral Ferrous Sulfate Replacement in Anaemia Due to Acute Nonvariceal Gastrointestinal Bleeding (FIERCE): Protocol of a Multicentre Randomised Controlled Trial

Anemia is a frequent complication of gastrointestinal bleeding, affecting 61% of the patients. Currently, anemia caused by gastrointestinal bleeding can be treated with iron supplementation. However, the dose and route of the administration are still a question. The FIERCE clinical trial aims to compare the effect of intravenous iron supplementation and oral iron replacement on mortality, unplanned emergency visits, and hospital readmissions in multimorbid patients with acute nonvariceal gastrointestinal bleeding.

开始日期2025-09-01

申办/合作机构

University of Pecs

NCT07101510

/ CompletedN/AIIT

Effectiveness of Video-assisted Cardiopulmonary Resuscitation Under Special Circumstances: a Randomized Controlled Simulation Study

Out-of-hospital cardiac arrest (OHCA) remains a major cause of death globally, with bystander CPR rates varying widely (13-82%) despite public health efforts. Early recognition, EMS activation, and immediate CPR are key to survival, often beginning with a layperson guided by an emergency dispatcher.
Telephone-assisted CPR (T-CPR), where dispatchers give verbal instructions, is common but limited-dispatchers can't see the scene or correct CPR technique. In contrast, video-assisted CPR (V-CPR) enables visual feedback, potentially improving performance in areas like compression rate and hand placement. However, evidence is mixed regarding its effect on compression depth, and initiating a video call may introduce delays.
While V-CPR's technical benefits have been studied, little is known about how real-world distractions-like noise or poor lighting-affect its effectiveness. Our simulation study aimed to compare T-CPR and V-CPR under both ideal and challenging conditions to assess the impact of environmental factors on layperson CPR quality and dispatcher support.

开始日期2025-08-10

申办/合作机构

University of Pecs

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7,519

项与 University of Pecs 相关的文献（医药）

2026-03-01·ENVIRONMENTAL RESEARCH

Effect of long-term air pollution reduction on insulin resistance and fasting glucose in children: A causal analysis

Article

作者: Buck, Christoph ; Moreno, Luis ; Pala, Valeria ; Nagrani, Rajini ; Dello Russo, Marika ; Molnár, Dénes ; Wolters, Maike ; Didelez, Vanessa ; De Henauw, Stefaan ; Lissner, Lauren ; Börnhorst, Claudia ; Ahrens, Wolfgang ; Vienneau, Danielle ; deHoogh, Kees

Observational studies have suggested that air pollution is associated with impaired glucose metabolism; yet randomized controlled trials to confirm the causality of this association are ethically and practically unfeasible. We emulated a hypothetical trial to evaluate the effects of sustained reductions in ambient air pollutants on homeostasis model assessment for insulin resistance (HOMA-IR) and fasting glucose (FG) in children and adolescents. Combining target trial emulation with g-computation, we estimated the effects of sustained hypothetical reductions of air pollutants on HOMA-IR and FG compared to no intervention (natural course). Our sample comprised 1417 children aged 2-9 years at baseline (2007/2008) participating in the pan-European IDEFICS/I.Family cohort. Ambient annual average levels of particulate matter<2.5 μm (PM_2.5), black carbon (BC), and NO₂ were estimated at residential addresses using land use regression models. We found a clear dose-response relationship between sustained reductions in PM_2.5 and BC and decreasing levels of HOMA-IR and FG. Hypothetically reducing PM_2.5 to WHO's recommended annual level of 5 μg/m³, the mean HOMA-IR z-score declined by -0.95 (95 % CI: -1.65; -0.44). Similarly, lowering BC to 0.8 × 10^-5/m reduced HOMA-IR by -0.36 (95 % CI: -0.61; -0.12) and FG by -0.28 (95 % CI: -0.50; -0.04). We found no clear evidence of NO₂ reductions on HOMA-IR and FG. Even at relatively low pollution levels in our cohort, further reductions in PM_2.5 and BC can improve HOMA-IR and FG levels in children and adolescents. Our findings provide evidence for the development of BC recommendations for air quality guidelines.

2026-02-01·JOURNAL OF ETHNOPHARMACOLOGY

Polygalae Radix extracts show anti-Parkinson's disease effects and reduce depression-like symptoms by modulating energy metabolism

Article

作者: Shi, Ruidie ; Ji, Xiuna ; Jin, Meng ; Kang, Huijun ; Jiao, Shouqing ; Stoika, Rostyslav ; Liu, Yanao ; Liu, Siyu ; Sik, Attila ; Yan, Jinfeng

ETHNOPHARMACOLOGICAL RELEVANCE:

Lately, herbs have evolved into promising therapeutic modalities for preventing and treating Parkinson's disease (PD). Polygalae Radix, a well-known traditional Chinese medicine (TCM), has long been utilized in TCM practice for its effects of opening orifices, dislodging phlegm, detoxifying, reducing swelling and calm the heart and mind. PD is a highly prevalent neurodegenerative disorder, with depression being one of its cardinal clinical manifestations. Roughly 40-50 % of people with PD may experience depression. However, drugs that can alleviate depressive symptoms in PD patients may exacerbate motor symptoms of PD. Therefore, therapeutic agents with low toxicity that are capable of ameliorating PD and its comorbid depressive symptoms represent a current research priority.

AIM OF THE STUDY:

Our study investigates the relieving effects and underlying mechanisms of Polygalae Radix extracts (PRE) on PD and its associated depressive symptoms.

MATERIAL AND METHODS:

1-methyl-4-phenyl-1-1,2,3,6-tetrahydropyridine (MPTP) was used to induce PD and its depressive symptoms in zebrafish. Alterations in dopamine (DA) neurons and cerebral vessels were visualized using transgenic zebrafish. The concentrations of DA were quantified by Enzyme-Linked Immunosorbent Assay (ELISA). Thigmotaxis tests and light-dark preference tests were utilized to investigate the depressive symptoms in PD zebrafish model. Glucose levels were measured to reflect the effect of PRE on glycolysis. In addition, multi-omics were used to reveal the underlying mechanism.

RESULTS:

PRE reduced Parkinsonian symptoms, including DA neurons and cerebral vasculature deficits, movement disorders, decreased responsiveness, and aberrant expression of PD-associated genes in zebrafish larvae. PRE also restored DA levels and abnormal expression of dat and autophagy-related genes in adult zebrafish PD models. Furthermore, it also alleviated depressive symptoms in this model. It improved the exploratory abilities of both larval and adult zebrafish in thigmotaxis behavior analyses and the light/dark preference tests, along with reversed the abnormal expression of genes related to depression. Transcriptomics and real-time qPCR revealed that PRE reduced glycolysis/gluconeogenesis and Tricarboxylic Acid (TCA) cycle disorders, which was further verified by metabolomics.

CONCLUSION:

PRE alleviated PD and depression-like symptoms, possibly by down-regulating pck1 expression, inducing normalization of glucose levels, thereby modulating glycolysis and TCA cycle related to energy metabolism.

2026-02-01·INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY

Safety and efficacy of maxillomandibular fixation techniques: a network meta-analysis

Review

作者: Varga, G ; Wenning, A S ; Németh, Z ; Papócsi, P ; Kerémi, B ; Gede, N ; Hegyi, P ; Pál, A ; Kelemen, K

Jaw fractures are prevalent facial injuries. Choosing the optimal intermaxillary/maxillomandibular fixation(IMF/MMF) technique is crucial for a successful conservative and surgical treatment, to achieve perfect occlusion.This network meta-analysis aimed to identify the most time-efficient and safe technique for IMF by comparing currently used techniques. A systematic search was performed in four databases, where 20,249 studies were identified; after the selection process 29 were included in the synthesis. Application time of IMF screws(IMFS)(MD -47,95% CI -62 to-33) and Hybrid Maxillomandibular Fixation(HMMF)(MD -33, 95% CI -48 to -19), and removal of IMFS (MD -16, 95% CI -23 to -8) were significantly shorter than Erich Arch Bar(EAB). EAB causes significantly fewer iatrogenic injuries than IMFS(OR: 0.30, 95% CI 0.09-0.93) or HMMF(OR 0.20, 95% CI 0.05-0.76). Both IMFS and HMMF were associated with a significantly lower risk of glove perforation and needlestick injury than EAB: OR 0.05(95% CI 0.02-0.12) and 0.08 (95% CI 0.03-0.23), respectively. In conclusion, IMF screws and HMMF are more effective than EAB in terms of application and removal time, oral hygiene, and patient acceptance. They also offer greater safety in terms of gloves and needlestick injuries, although there is a higher risk of iatrogenic injuries and hardware loosening.

项与 University of Pecs 相关的新闻（医药）

2024-08-02

·drugs

Semaglutide Products Being Sold Online Without Prescriptions

FRIDAY, Aug. 2, 2024 -- Semaglutide products are being sold online, with products likely unregistered or unlicensed, according to a research letter published online Aug. 2 in JAMA Network Open . Amir Reza Ashraf, Pharm.D., from the University of Pécs in Hungary, and colleagues conducted a risk assessment of semaglutide online sourcing. Websites advertising semaglutide without a prescription were cataloged in July 2023; those meeting inclusion criteria were selected for a product test buy protocol. Two 0.25-mg dose prefilled pens or equivalent injection vials were ordered from each website and compared to genuine Ozempic brand 1-mg semaglutide solution. Six online vendors classified as not recommended or rogue and offering parenteral semaglutide products were included in the test buys. Three offered prefilled 0.25-mg/dose semaglutide injection pens and three sold vials of lyophilized semaglutide. The researchers found that genuine Ozempic scored the full 22 points on the International Pharmaceutical Federation (FIP) checklist, while test purchased products scored 8 or 9; clear discrepancies were seen in regulatory registration information, accurate labeling, and evidence that products were likely unregistered or unlicensed. One sample had elevated endotoxin, indicating possible contamination. The presence of semaglutide was revealed in all samples, with considerably low purity levels (7 to 14 percent versus 99 percent advertised). In each sample, the measured semaglutide content substantially exceeded the labeled amount. "Semaglutide products are actively being sold without prescription by illegal online pharmacies, with vendors shipping unregistered and falsified products," the authors write. "Two websites evaluated were sent FDA warning letters for unlawful sale of unapproved and misbranded semaglutide." Abstract/Full Text Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.

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